Effect of lithium chloride on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture

Applied Microbiology and Biotechnology

Volumn 98, Issue 22, 2014, Pages 9239-9248

  Ha, Tae Kwang ^b   Kim, Yeon Gu ^a   Lee, Gyun Min ^b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Cell cycle; Chinese hamster ovary cell; Lithium chloride; Sialylation; Specific productivity

Indexed keywords

ADDITIVES; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; GLYCOSYLATION; LITHIUM CHLORIDE; PRODUCTIVITY; RECOMBINANT PROTEINS;

CELL CYCLE; CHINESE HAMSTER OVARY; CHINESE HAMSTER OVARY CELLS; DOSE-DEPENDENT MANNER; GLYCOGEN SYNTHASE KINASE-3; RECOMBINANT PROTEIN PRODUCTIONS; SIALYLATION; SPECIFIC PRODUCTIVITY;

GROWTH RATE;

HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; LITHIUM CHLORIDE;

ANIMAL; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; EPITHELIUM CELL; METABOLISM;

ANIMALS; CHO CELLS; CRICETULUS; EPITHELIAL CELLS; IMMUNOGLOBULIN FC FRAGMENTS; LITHIUM CHLORIDE; RECOMBINANT FUSION PROTEINS;

EID: 84920251431     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-014-6012-0     Document Type: Article

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