Addition of valproic acid to CHO cell fed-batch cultures improves monoclonal antibody titers

Molecular Biotechnology

Volumn 56, Issue 5, 2014, Pages 421-428

  Yang, William C ^a   Lu, Jiuyi ^a   Nguyen, Ngan B ^a   Zhang, An ^a   Healy, Nicholas V ^a   Kshirsagar, Rashmi ^a   Ryll, Thomas ^a   Huang, Yao Ming ^a  

^a BIOGEN   (United States)

Author keywords

Antibody; CHO cell culture; HDAC inhibitor; Product quality; Productivity; VPA

Indexed keywords

ANTIBODIES; BATCH CELL CULTURE; EXPERIMENTS; MONOCLONAL ANTIBODIES; OPTIMIZATION; PROTEINS;

CHINESE HAMSTER OVARY; CHO CELL CULTURES; FED-BATCH BIOREACTORS; HDAC INHIBITORS; MANUFACTURING CAPACITY; N-LINKED GLYCOSYLATION; SMALL MOLECULE ENHANCER; VPA;

PRODUCTIVITY;

GLUTAMATE AMMONIA LIGASE; VALPROIC ACID; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIBODY TITER; ARTICLE; CAPILLARY ISOELECTRIC FOCUSING; CELL AGGREGATION; CELL COUNTING; CELL GROWTH; CELL LINE; CELL LINEAGE; CELL SPECIFICITY; CELL VIABILITY; CHO CELL LINE; COPY NUMBER VARIATION; FED BATCH CULTURE; GROWTH INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGING; MONOCLONAL ANTIBODY TITER; NONHUMAN; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; BATCH CELL CULTURE; CRICETULUS; HAMSTER; PROCEDURES;

CRICETULUS GRISEUS;

ANIMALS; ANTIBODIES, MONOCLONAL; BATCH CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; VALPROIC ACID;

EID: 84899444987     PISSN: 10736085     EISSN: 15590305     Source Type: Journal    
DOI: 10.1007/s12033-013-9725-x     Document Type: Article

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