-
1
-
-
0019026208
-
Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase
-
Embi, N., Rylatt, D. B. and Cohen, P. (1980) Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur. J. Biochem. 107, 519-527.
-
(1980)
Eur. J. Biochem
, vol.107
, pp. 519-527
-
-
Embi, N.1
Rylatt, D.B.2
Cohen, P.3
-
2
-
-
0019025978
-
Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase
-
Rylatt, D. B., Aitken, A., Bilham, T., Condon, G. D., Embi, N. and Cohen, P. (1980) Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase. Eur. J. Biochem. 107, 529-537.
-
(1980)
Eur. J. Biochem
, vol.107
, pp. 529-537
-
-
Rylatt, D.B.1
Aitken, A.2
Bilham, T.3
Condon, G.D.4
Embi, N.5
Cohen, P.6
-
3
-
-
0035413614
-
Glycogen synthase kinase-3: Properties, functions, and regulation
-
Ali, A., Hoeflich, K. P. and Woodgett, J. R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem. Rev. 101, 2527-2540.
-
(2001)
Chem. Rev
, vol.101
, pp. 2527-2540
-
-
Ali, A.1
Hoeflich, K.P.2
Woodgett, J.R.3
-
4
-
-
0033821036
-
Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5
-
Andoh, T., Hirata, Y. and Kikuchi, A. (2000) Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5. Mol. Cell. Biol. 20, 6712-6720.
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 6712-6720
-
-
Andoh, T.1
Hirata, Y.2
Kikuchi, A.3
-
5
-
-
0025286104
-
Molecular cloning and expression of glycogen synthase kinase-3/factor A
-
Woodgett, J. R. (1990) Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J. 9, 2431-2438.
-
(1990)
EMBO J
, vol.9
, pp. 2431-2438
-
-
Woodgett, J.R.1
-
6
-
-
0036295233
-
Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites
-
Ryves, W. J., Dajani, R., Pearl, L. and Harwood, A. J. (2002) Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites. Biochem. Biophys. Res. Commun. 290, 967-972.
-
(2002)
Biochem. Biophys. Res. Commun
, vol.290
, pp. 967-972
-
-
Ryves, W.J.1
Dajani, R.2
Pearl, L.3
Harwood, A.J.4
-
7
-
-
0036281126
-
Expression of glycogen synthase kinase-3 isoforms in mouse tissues and their transcription in the brain
-
Yao, H. B., Shaw, P. C., Wong, C. C. and Wan, D. C. (2002) Expression of glycogen synthase kinase-3 isoforms in mouse tissues and their transcription in the brain. J. Chem. Neuroanat. 23, 291-297.
-
(2002)
J. Chem. Neuroanat
, vol.23
, pp. 291-297
-
-
Yao, H.B.1
Shaw, P.C.2
Wong, C.C.3
Wan, D.C.4
-
8
-
-
34447635652
-
-
26-7
-
Hoeflich, K. P., Luo, J., Rubie, E. A., Tsao, M.-S., Jin, O. and Woodgett, J. R. (2000) Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. 406, 26-7, 29.
-
(2000)
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
, vol.406
, pp. 29
-
-
Hoeflich, K.P.1
Luo, J.2
Rubie, E.A.3
Tsao, M.-S.4
Jin, O.5
Woodgett, J.R.6
-
9
-
-
0029059060
-
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
-
Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S. and Baltimore, D. (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376, 167-170.
-
(1995)
Nature
, vol.376
, pp. 167-170
-
-
Beg, A.A.1
Sha, W.C.2
Bronson, R.T.3
Ghosh, S.4
Baltimore, D.5
-
10
-
-
0033537739
-
Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
-
Li, Q., Van Antwerp, D., Mercurio, F., Lee, K. F. and Verma, I. M. (1999) Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 284, 321-325.
-
(1999)
Science
, vol.284
, pp. 321-325
-
-
Li, Q.1
Van Antwerp, D.2
Mercurio, F.3
Lee, K.F.4
Verma, I.M.5
-
11
-
-
33847405867
-
Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice
-
Liu, K. J., Arron, J. R., Stankunas, K., Crabtree, G. R. and Longaker, M. T. (2007) Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice. Nature 446, 79-82.
-
(2007)
Nature
, vol.446
, pp. 79-82
-
-
Liu, K.J.1
Arron, J.R.2
Stankunas, K.3
Crabtree, G.R.4
Longaker, M.T.5
-
12
-
-
0035983533
-
Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta
-
Mukai, F., Ishiguro, K., Sano, Y. and Fujita, S. C. (2002) Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta. J. Neurochem. 81, 1073-1083.
-
(2002)
J. Neurochem
, vol.81
, pp. 1073-1083
-
-
Mukai, F.1
Ishiguro, K.2
Sano, Y.3
Fujita, S.C.4
-
13
-
-
0029885419
-
Selective interaction of JNK protein kinase isoforms with transcription factors
-
Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Derijard, B. and Davis, R. J. (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15, 2760-2770.
-
(1996)
EMBO J
, vol.15
, pp. 2760-2770
-
-
Gupta, S.1
Barrett, T.2
Whitmarsh, A.J.3
Cavanagh, J.4
Sluss, H.K.5
Derijard, B.6
Davis, R.J.7
-
14
-
-
0028827450
-
Isolation of MEK5 and differential expression of alternatively spliced forms
-
English, J. M., Vanderbilt, C. A., Xu, S., Marcus, S. and Cobb, M. H. (1995) Isolation of MEK5 and differential expression of alternatively spliced forms. J. Biol. Chem. 270, 28897-28902.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 28897-28902
-
-
English, J.M.1
Vanderbilt, C.A.2
Xu, S.3
Marcus, S.4
Cobb, M.H.5
-
15
-
-
0029020282
-
Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
-
Hanks, S. K. and Hunter, T. (1995) Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9, 576-596.
-
(1995)
FASEB J
, vol.9
, pp. 576-596
-
-
Hanks, S.K.1
Hunter, T.2
-
16
-
-
0037413694
-
Gene structure and alternative splicing of glycogen synthase kinase 3 beta (GSK-3beta) in neural and non-neural tissues
-
Schaffer, B., Wiedau-Pazos, M. and Geschwind, D. H. (2003) Gene structure and alternative splicing of glycogen synthase kinase 3 beta (GSK-3beta) in neural and non-neural tissues. Gene 302, 73-81.
-
(2003)
Gene
, vol.302
, pp. 73-81
-
-
Schaffer, B.1
Wiedau-Pazos, M.2
Geschwind, D.H.3
-
17
-
-
0023656594
-
Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3
-
Fiol, C. J., Mahrenholz, A. M., Wang, Y., Roeske, R. W. and Roach, P. J. (1987) Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3. J. Biol. Chem. 262, 14042-14048.
-
(1987)
J. Biol. Chem
, vol.262
, pp. 14042-14048
-
-
Fiol, C.J.1
Mahrenholz, A.M.2
Wang, Y.3
Roeske, R.W.4
Roach, P.J.5
-
18
-
-
0037415737
-
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex
-
Dajani, R., Fraser, E., Roe, S. M., Yeo, M., Good, V. M., Thompson, V., Dale, T. C. and Pearl, L. H. (2003) Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. EMBO J. 22, 494-501.
-
(2003)
EMBO J
, vol.22
, pp. 494-501
-
-
Dajani, R.1
Fraser, E.2
Roe, S.M.3
Yeo, M.4
Good, V.M.5
Thompson, V.6
Dale, T.C.7
Pearl, L.H.8
-
19
-
-
0035665719
-
The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation
-
Bax, B., Carter, P. S., Lewis, C., Guy, A. R., Bridges, A., Tanner, R., Pettman, G., Mannix, C., Culbert, A. A., Brown, M. J., Smith, D. G. and Reith, A. D. (2001) The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. Structure 9, 1143-1152.
-
(2001)
Structure
, vol.9
, pp. 1143-1152
-
-
Bax, B.1
Carter, P.S.2
Lewis, C.3
Guy, A.R.4
Bridges, A.5
Tanner, R.6
Pettman, G.7
Mannix, C.8
Culbert, A.A.9
Brown, M.J.10
Smith, D.G.11
Reith, A.D.12
-
20
-
-
0035875098
-
Crystal structure of glycogen synthase kinase 3 beta: Structural basis for phosphate-primed substrate specificity and autoinhibition
-
Dajani, R., Fraser, E., Roe, S. M., Young, N., Good, V., Dale, T. C. and Pearl, L. H. (2001) Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition. Cell 105, 721-732.
-
(2001)
Cell
, vol.105
, pp. 721-732
-
-
Dajani, R.1
Fraser, E.2
Roe, S.M.3
Young, N.4
Good, V.5
Dale, T.C.6
Pearl, L.H.7
-
21
-
-
0034743516
-
Structure of GSK3beta reveals a primed phosphorylation mechanism
-
ter Haar, E., Coll, J. T., Austen, D. A., Hsiao, H. M., Swenson, L. and Jain, J. (2001) Structure of GSK3beta reveals a primed phosphorylation mechanism. Nat. Struct. Biol. 8, 593-596.
-
(2001)
Nat. Struct. Biol
, vol.8
, pp. 593-596
-
-
ter Haar, E.1
Coll, J.T.2
Austen, D.A.3
Hsiao, H.M.4
Swenson, L.5
Jain, J.6
-
22
-
-
0025241896
-
Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates
-
Fiol, C. J., Wang, A., Roeske, R. W. and Roach, P. J. (1990) Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates. J. Biol. Chem. 265, 6061-6065.
-
(1990)
J. Biol. Chem
, vol.265
, pp. 6061-6065
-
-
Fiol, C.J.1
Wang, A.2
Roeske, R.W.3
Roach, P.J.4
-
23
-
-
0037189487
-
Expression and characterization of GSK-3 mutants and their effect on beta-catenin phosphorylation in intact cells
-
Hagen, T., Di Daniel, E., Culbert, A. A. and Reith, A. D. (2002) Expression and characterization of GSK-3 mutants and their effect on beta-catenin phosphorylation in intact cells. J. Biol. Chem. 277, 23330-23335.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 23330-23335
-
-
Hagen, T.1
Di Daniel, E.2
Culbert, A.A.3
Reith, A.D.4
-
24
-
-
0034969088
-
A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation
-
Frame, S., Cohen, P. and Biondi, R. M. (2001) A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol. Cell 7, 1321-1327.
-
(2001)
Mol. Cell
, vol.7
, pp. 1321-1327
-
-
Frame, S.1
Cohen, P.2
Biondi, R.M.3
-
25
-
-
33745188027
-
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo
-
Cole, A. R., Causeret, F., Yaeirgi, G., Hastie, C. J., McLauchlan, H., McManus, E. J., Hernandez, F., Eickholt, B. J., Nikolic, M. and Sutherland, C. (2006) Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. J. Biol. Chem. 281, 16591-16598.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 16591-16598
-
-
Cole, A.R.1
Causeret, F.2
Yaeirgi, G.3
Hastie, C.J.4
McLauchlan, H.5
McManus, E.J.6
Hernandez, F.7
Eickholt, B.J.8
Nikolic, M.9
Sutherland, C.10
-
26
-
-
0032987650
-
Phosphorylation of tau protein by recombinant GSK-3beta: Pronounced phosphorylation at select Ser/Thr-Pro motifs but no phosphorylation at Ser262 in the repeat domain
-
Godemann, R., Biernat, J., Mandelkow, E. and Mandelkow, E. M. (1999) Phosphorylation of tau protein by recombinant GSK-3beta: pronounced phosphorylation at select Ser/Thr-Pro motifs but no phosphorylation at Ser262 in the repeat domain. FEBS Lett. 454, 157-164.
-
(1999)
FEBS Lett
, vol.454
, pp. 157-164
-
-
Godemann, R.1
Biernat, J.2
Mandelkow, E.3
Mandelkow, E.M.4
-
27
-
-
0028177965
-
The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro
-
Sutherland, C. and Cohen, P. (1994) The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro. FEBS Lett. 338, 37-42.
-
(1994)
FEBS Lett
, vol.338
, pp. 37-42
-
-
Sutherland, C.1
Cohen, P.2
-
28
-
-
0027515127
-
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: New kinase connections in insulin and growth-factor signalling
-
Sutherland, C., Leighton, I. A. and Cohen, P. (1993) Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem. J. 296, 15-19.
-
(1993)
Biochem. J
, vol.296
, pp. 15-19
-
-
Sutherland, C.1
Leighton, I.A.2
Cohen, P.3
-
29
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M. and Hemmings, B. A. (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
30
-
-
12944250922
-
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
-
Fang, X., Yu, S. X., Lu, Y., Bast, R. C. Jr., Woodgett, J. R. and Mills, G. B. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. USA 97, 11960-11965.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 11960-11965
-
-
Fang, X.1
Yu, S.X.2
Lu, Y.3
Bast Jr., R.C.4
Woodgett, J.R.5
Mills, G.B.6
-
31
-
-
0028021566
-
The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells
-
Saito, Y., Vandenheede, J. R. and Cohen, P. (1994) The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells. Biochem. J. 303, 27-31.
-
(1994)
Biochem. J
, vol.303
, pp. 27-31
-
-
Saito, Y.1
Vandenheede, J.R.2
Cohen, P.3
-
32
-
-
0035907390
-
Akt participation in the Wnt signaling pathway through Dishevelled
-
Fukumoto, S., Hsieh, C. M., Maemura, K., Layne, M. D., Yet, S. F., Lee, K. H., Matsui, T., Rosenzweig, A., Taylor, W. G., Rubin, J. S., Perrella, M. A. and Lee, M. E. (2001) Akt participation in the Wnt signaling pathway through Dishevelled. J. Biol. Chem. 276, 17479-17483.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 17479-17483
-
-
Fukumoto, S.1
Hsieh, C.M.2
Maemura, K.3
Layne, M.D.4
Yet, S.F.5
Lee, K.H.6
Matsui, T.7
Rosenzweig, A.8
Taylor, W.G.9
Rubin, J.S.10
Perrella, M.A.11
Lee, M.E.12
-
33
-
-
0032720620
-
Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation
-
Yuan, H., Mao, J., Li, L. and Wu, D. (1999) Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation. J. Biol. Chem. 274, 30419-30423.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 30419-30423
-
-
Yuan, H.1
Mao, J.2
Li, L.3
Wu, D.4
-
34
-
-
0037442990
-
A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment
-
Wakefield, J. G., Stephens, D. J. and Tavare, J. M. (2003) A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment. J. Cell Sci. 116, 637-646.
-
(2003)
J. Cell Sci
, vol.116
, pp. 637-646
-
-
Wakefield, J.G.1
Stephens, D.J.2
Tavare, J.M.3
-
35
-
-
33846946138
-
R-Ras controls axon specification upstream of GSK-3beta through integrin-linked kinase
-
Oinuma, I., Katoh, H. and Negishi, M. (2007) R-Ras controls axon specification upstream of GSK-3beta through integrin-linked kinase. J. Biol. Chem. 282, 303-318.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 303-318
-
-
Oinuma, I.1
Katoh, H.2
Negishi, M.3
-
36
-
-
18444399216
-
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
-
McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R. and Alessi, D. R. (2005) Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J. 24, 1571-1583.
-
(2005)
EMBO J
, vol.24
, pp. 1571-1583
-
-
McManus, E.J.1
Sakamoto, K.2
Armit, L.J.3
Ronaldson, L.4
Shpiro, N.5
Marquez, R.6
Alessi, D.R.7
-
37
-
-
2442676633
-
Functional studies of shaggy/glycogen synthase kinase 3 phosphorylation sites in Drosophila melanogaster
-
Papadopoulou, D., Bianchi, M. W. and Bourouis, M. (2004) Functional studies of shaggy/glycogen synthase kinase 3 phosphorylation sites in Drosophila melanogaster. Mol. Cell. Biol. 24, 4909-4919.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 4909-4919
-
-
Papadopoulou, D.1
Bianchi, M.W.2
Bourouis, M.3
-
38
-
-
3343024236
-
Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2alpha
-
Kannan, N. and Neuwald, A. F. (2004) Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2alpha. Protein Sci. 13, 2059-2077.
-
(2004)
Protein Sci
, vol.13
, pp. 2059-2077
-
-
Kannan, N.1
Neuwald, A.F.2
-
39
-
-
0027532627
-
Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro
-
Robbins, D. J., Zhen, E., Owaki, H., Vanderbilt, C. A., Ebert, D., Geppert, T. D. and Cobb, M. H. (1993) Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. J. Biol. Chem. 268, 5097-5106.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 5097-5106
-
-
Robbins, D.J.1
Zhen, E.2
Owaki, H.3
Vanderbilt, C.A.4
Ebert, D.5
Geppert, T.D.6
Cobb, M.H.7
-
40
-
-
0027475421
-
Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation
-
Hughes, K., Nikolakaki, E., Plyte, S. E., Totty, N. F. and Woodgett, J. R. (1993) Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation. EMBO J. 12, 803-808.
-
(1993)
EMBO J
, vol.12
, pp. 803-808
-
-
Hughes, K.1
Nikolakaki, E.2
Plyte, S.E.3
Totty, N.F.4
Woodgett, J.R.5
-
41
-
-
0032493042
-
Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin
-
Itoh, K., Krupnik, V. E. and Sokol, S. Y. (1998) Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin. Curr. Biol. 8, 591-594.
-
(1998)
Curr. Biol
, vol.8
, pp. 591-594
-
-
Itoh, K.1
Krupnik, V.E.2
Sokol, S.Y.3
-
42
-
-
1642494586
-
Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event
-
Cole, A., Frame, S. and Cohen, P. (2004) Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event. Biochem. J. 377, 249-255.
-
(2004)
Biochem. J
, vol.377
, pp. 249-255
-
-
Cole, A.1
Frame, S.2
Cohen, P.3
-
43
-
-
34247865533
-
A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation
-
Lochhead, P. A., Kinstrie, R., Sibbet, G., Rawjee, T., Morrice, N. and Cleghon, V. (2006) A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation. Mol. Cell 24, 627-633.
-
(2006)
Mol. Cell
, vol.24
, pp. 627-633
-
-
Lochhead, P.A.1
Kinstrie, R.2
Sibbet, G.3
Rawjee, T.4
Morrice, N.5
Cleghon, V.6
-
44
-
-
33745374264
-
GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction
-
Sayas, C. L., Ariaens, A., Ponsioen, B. and Moolenaar, W. H. (2006) GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction. Mol. Biol. Cell. 17, 1834-1844.
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 1834-1844
-
-
Sayas, C.L.1
Ariaens, A.2
Ponsioen, B.3
Moolenaar, W.H.4
-
45
-
-
0032963511
-
Glycogen synthase kinase-3 (GSK-3) is regulated during Dictyostelium development via the serpentine receptor cAR3
-
Plyte, S. E., O'Donovan, E., Woodgett, J. R. and Harwood, A. J. (1999) Glycogen synthase kinase-3 (GSK-3) is regulated during Dictyostelium development via the serpentine receptor cAR3. Development 126, 325-333.
-
(1999)
Development
, vol.126
, pp. 325-333
-
-
Plyte, S.E.1
O'Donovan, E.2
Woodgett, J.R.3
Harwood, A.J.4
-
46
-
-
0036775935
-
Receptor-dependent and tyrosine phosphatase-mediated inhibition of GSK3 regulates cell fate choice
-
Kim, L., Harwood, A. and Kimmel, A. R. (2002) Receptor-dependent and tyrosine phosphatase-mediated inhibition of GSK3 regulates cell fate choice. Dev. Cell 3, 523-532.
-
(2002)
Dev. Cell
, vol.3
, pp. 523-532
-
-
Kim, L.1
Harwood, A.2
Kimmel, A.R.3
-
47
-
-
0032734021
-
The novel tyrosine kinase ZAK1 activates GSK3 to direct cell fate specification
-
Kim, L., Liu, J. and Kimmel, A. R. (1999) The novel tyrosine kinase ZAK1 activates GSK3 to direct cell fate specification. Cell 99, 399-408.
-
(1999)
Cell
, vol.99
, pp. 399-408
-
-
Kim, L.1
Liu, J.2
Kimmel, A.R.3
-
48
-
-
3042558276
-
Glycogen synthase kinase 3: A drug target for CNS therapies
-
Bhat, R. V., Budd Haeberlein, S. L. and Avila, J. (2004) Glycogen synthase kinase 3: a drug target for CNS therapies. J. Neurochem. 89, 1313-1317.
-
(2004)
J. Neurochem
, vol.89
, pp. 1313-1317
-
-
Bhat, R.V.1
Budd Haeberlein, S.L.2
Avila, J.3
-
49
-
-
0141740215
-
Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment
-
Eldar-Finkelman, H. and Ilouz, R. (2003) Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment. Expert Opin. Investig. Drugs 12, 1511-1519.
-
(2003)
Expert Opin. Investig. Drugs
, vol.12
, pp. 1511-1519
-
-
Eldar-Finkelman, H.1
Ilouz, R.2
-
50
-
-
33745444341
-
Targeting glycogen synthase kinase-3 in insulin signalling
-
Frame, S. and Zheleva, D. (2006) Targeting glycogen synthase kinase-3 in insulin signalling. Expert Opin. Ther. Targets 10, 429-444.
-
(2006)
Expert Opin. Ther. Targets
, vol.10
, pp. 429-444
-
-
Frame, S.1
Zheleva, D.2
-
51
-
-
33745466922
-
Targeting glycogen synthase kinase-3 as an approach to develop novel mood-stabilising medications
-
Gould, T. D. (2006) Targeting glycogen synthase kinase-3 as an approach to develop novel mood-stabilising medications. Expert Opin. Ther. Targets 10, 377-392.
-
(2006)
Expert Opin. Ther. Targets
, vol.10
, pp. 377-392
-
-
Gould, T.D.1
-
52
-
-
0346875916
-
GSK-3-selective inhibitors derived from Tyrian purple indirubins
-
Meijer, L., Skaltsounis, A. L., Magiatis, P., Polychronopoulos, P., Knockaert, M., Leost, M., Ryan, X. P., Vonica, C. A., Brivanlou, A., Dajani, R., Crovace, C., Tarricone, C., Musacchio, A., Roe, S. M., Pearl, L. and Greengard, P. (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem. Biol. 10, 1255-1266.
-
(2003)
Chem. Biol
, vol.10
, pp. 1255-1266
-
-
Meijer, L.1
Skaltsounis, A.L.2
Magiatis, P.3
Polychronopoulos, P.4
Knockaert, M.5
Leost, M.6
Ryan, X.P.7
Vonica, C.A.8
Brivanlou, A.9
Dajani, R.10
Crovace, C.11
Tarricone, C.12
Musacchio, A.13
Roe, S.M.14
Pearl, L.15
Greengard, P.16
-
53
-
-
0037448375
-
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects
-
Mettey, Y., Gompel, M., Thomas, V., Garnier, M., Leost, M., Ceballos-Picot, I., Noble, M., Endicott, J., Vierfond, J. M. and Meijer, L. (2003) Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J. Med. Chem. 46, 222-236.
-
(2003)
J. Med. Chem
, vol.46
, pp. 222-236
-
-
Mettey, Y.1
Gompel, M.2
Thomas, V.3
Garnier, M.4
Leost, M.5
Ceballos-Picot, I.6
Noble, M.7
Endicott, J.8
Vierfond, J.M.9
Meijer, L.10
-
54
-
-
0034805180
-
Lithium inhibits glycogen synthase kinase-3 by competition for magnesium
-
Ryves, W. J. and Harwood, A. J. (2001) Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochem. Biophys. Res. Commun. 280, 720-725.
-
(2001)
Biochem. Biophys. Res. Commun
, vol.280
, pp. 720-725
-
-
Ryves, W.J.1
Harwood, A.J.2
-
55
-
-
8744224656
-
A molecular cell biology of lithium
-
Williams, R., Ryves, W. J., Dalton, E. C., Eickholt, B., Shaltiel, G., Agam, G. and Harwood, A. J. (2004) A molecular cell biology of lithium. Biochem. Soc. Trans. 32, 799-802.
-
(2004)
Biochem. Soc. Trans
, vol.32
, pp. 799-802
-
-
Williams, R.1
Ryves, W.J.2
Dalton, E.C.3
Eickholt, B.4
Shaltiel, G.5
Agam, G.6
Harwood, A.J.7
-
56
-
-
0037127255
-
Identification of the Axin and Frat binding region of glycogen synthase kinase-3
-
Fraser, E., Young, N., Dajani, R., Franca-Koh, J., Ryves, J., Williams, R. S., Yeo, M., Webster, M. T., Richardson, C., Smalley, M. J., Pearl, L. H., Harwood, A. and Dale, T. C. (2002) Identification of the Axin and Frat binding region of glycogen synthase kinase-3. J. Biol. Chem. 277, 2176-2185.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 2176-2185
-
-
Fraser, E.1
Young, N.2
Dajani, R.3
Franca-Koh, J.4
Ryves, J.5
Williams, R.S.6
Yeo, M.7
Webster, M.T.8
Richardson, C.9
Smalley, M.J.10
Pearl, L.H.11
Harwood, A.12
Dale, T.C.13
-
57
-
-
0032473355
-
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
-
Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S. and Kikuchi, A. (1998) Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J. 17, 1371-1384.
-
(1998)
EMBO J
, vol.17
, pp. 1371-1384
-
-
Ikeda, S.1
Kishida, S.2
Yamamoto, H.3
Murai, H.4
Koyama, S.5
Kikuchi, A.6
-
58
-
-
0032821768
-
A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin
-
Thomas, G. M., Frame, S., Goedert, M., Nathke, I., Polakis, P. and Cohen, P. (1999) A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin. FEBS Lett. 458, 247-251.
-
(1999)
FEBS Lett
, vol.458
, pp. 247-251
-
-
Thomas, G.M.1
Frame, S.2
Goedert, M.3
Nathke, I.4
Polakis, P.5
Cohen, P.6
-
59
-
-
0036079974
-
Glycogen and its metabolism
-
Roach, P. J. (2002) Glycogen and its metabolism. Curr. Mol. Med. 2, 101-120.
-
(2002)
Curr. Mol. Med
, vol.2
, pp. 101-120
-
-
Roach, P.J.1
-
60
-
-
0033611663
-
The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction
-
Cohen, P. (1999) The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 354, 485-495.
-
(1999)
Philos. Trans. R. Soc. Lond. B. Biol. Sci
, vol.354
, pp. 485-495
-
-
Cohen, P.1
-
61
-
-
0033971454
-
Biochemical interactions in the wnt pathway
-
Seidensticker, M. J. and Behrens, J. (2000) Biochemical interactions in the wnt pathway. Biochim. Biophys. Acta 1495, 168-182.
-
(2000)
Biochim. Biophys. Acta
, vol.1495
, pp. 168-182
-
-
Seidensticker, M.J.1
Behrens, J.2
-
62
-
-
0036295950
-
Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45
-
Hagen, T. and Vidal-Puig, A. (2002) Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45. Biochem. Biophys. Res. Commun. 294, 324-328.
-
(2002)
Biochem. Biophys. Res. Commun
, vol.294
, pp. 324-328
-
-
Hagen, T.1
Vidal-Puig, A.2
-
63
-
-
0028569010
-
Phosphorylation of the Drosophila adherens junction protein Armadillo: Roles for wingless signal and zeste-white 3 kinase
-
Peifer, M., Pai, L. M. and Casey, M. (1994) Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase. Dev. Biol. 166, 543-556.
-
(1994)
Dev. Biol
, vol.166
, pp. 543-556
-
-
Peifer, M.1
Pai, L.M.2
Casey, M.3
-
64
-
-
0029683606
-
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
-
Yost, C., Torres, M., Miller, J. R., Huang, E., Kimelman, D. and Moon, R. T. (1996) The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev. 10, 1443-1454.
-
(1996)
Genes Dev
, vol.10
, pp. 1443-1454
-
-
Yost, C.1
Torres, M.2
Miller, J.R.3
Huang, E.4
Kimelman, D.5
Moon, R.T.6
-
65
-
-
33646001713
-
Threonine 41 in beta-catenin serves as a key phosphorylation relay residue in beta-catenin degradation
-
Wu, G. and He, X. (2006) Threonine 41 in beta-catenin serves as a key phosphorylation relay residue in beta-catenin degradation. Biochemistry 45, 5319-5323.
-
(2006)
Biochemistry
, vol.45
, pp. 5319-5323
-
-
Wu, G.1
He, X.2
-
66
-
-
0036571011
-
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: A molecular switch for the Wnt pathway
-
Amit, S., Hatzubai, A., Birman, Y., Andersen, J. S., Ben-Shushan, E., Mann, M., Ben-Neriah, Y. and Alkalay, I. (2002) Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev. 16, 1066-1076.
-
(2002)
Genes Dev
, vol.16
, pp. 1066-1076
-
-
Amit, S.1
Hatzubai, A.2
Birman, Y.3
Andersen, J.S.4
Ben-Shushan, E.5
Mann, M.6
Ben-Neriah, Y.7
Alkalay, I.8
-
67
-
-
0032492954
-
-
Hart, M. J., de los Santos, R., Albert, I. N., Rubinfeld, B. and Polakis, P. (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr. Biol. 8, 573-581.
-
Hart, M. J., de los Santos, R., Albert, I. N., Rubinfeld, B. and Polakis, P. (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr. Biol. 8, 573-581.
-
-
-
-
68
-
-
0033574527
-
Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability
-
Yamamoto, H., Kishida, S., Kishida, M., Ikeda, S., Takada, S. and Kikuchi, A. (1999) Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability. J. Biol. Chem. 274, 10681-10684.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 10681-10684
-
-
Yamamoto, H.1
Kishida, S.2
Kishida, M.3
Ikeda, S.4
Takada, S.5
Kikuchi, A.6
-
69
-
-
0029664368
-
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
-
Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C., Munemitsu, S. and Polakis, P. (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272, 1023-1026.
-
(1996)
Science
, vol.272
, pp. 1023-1026
-
-
Rubinfeld, B.1
Albert, I.2
Porfiri, E.3
Fiol, C.4
Munemitsu, S.5
Polakis, P.6
-
70
-
-
0035914460
-
Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon
-
Rubinfeld, B., Tice, D. A. and Polakis, P. (2001) Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon. J. Biol. Chem. 276, 39037-39045.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 39037-39045
-
-
Rubinfeld, B.1
Tice, D.A.2
Polakis, P.3
-
71
-
-
4344684495
-
Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
-
Xing, Y., Clements, W. K., Le Trong, I., Hinds, T. R., Stenkamp, R., Kimelman, D. and Xu, W. (2004) Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function. Mol. Cell 15, 523-533.
-
(2004)
Mol. Cell
, vol.15
, pp. 523-533
-
-
Xing, Y.1
Clements, W.K.2
Le Trong, I.3
Hinds, T.R.4
Stenkamp, R.5
Kimelman, D.6
Xu, W.7
-
72
-
-
0344442773
-
Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex
-
Xing, Y., Clements, W. K., Kimelman, D. and Xu, W. (2003) Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex. Genes Dev. 17, 2753-2764.
-
(2003)
Genes Dev
, vol.17
, pp. 2753-2764
-
-
Xing, Y.1
Clements, W.K.2
Kimelman, D.3
Xu, W.4
-
73
-
-
4344562126
-
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
-
Ha, N. C., Tonozuka, T., Stamos, J. L., Choi, H. J. and Weis, W. I. (2004) Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol. Cell 15, 511-521.
-
(2004)
Mol. Cell
, vol.15
, pp. 511-521
-
-
Ha, N.C.1
Tonozuka, T.2
Stamos, J.L.3
Choi, H.J.4
Weis, W.I.5
-
74
-
-
30044439674
-
Kinase cogs go forward and reverse in the Wnt signaling machine
-
Dale, T. (2006) Kinase cogs go forward and reverse in the Wnt signaling machine. Nat. Struct. Mol. Biol. 13, 9-11.
-
(2006)
Nat. Struct. Mol. Biol
, vol.13
, pp. 9-11
-
-
Dale, T.1
-
75
-
-
28644439005
-
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
-
Zeng, X., Tamai, K., Doble, B., Li, S., Huang, H., Habas, R., Okamura, H., Woodgett, J. and He, X. (2005) A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 438, 873-877.
-
(2005)
Nature
, vol.438
, pp. 873-877
-
-
Zeng, X.1
Tamai, K.2
Doble, B.3
Li, S.4
Huang, H.5
Habas, R.6
Okamura, H.7
Woodgett, J.8
He, X.9
-
76
-
-
0032511194
-
GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis
-
Yost, C., Farr, G. H. 3rd, Pierce, S. B., Ferkey, D. M., Chen, M. M. and Kimelman, D. (1998) GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell 93, 1031-1041.
-
(1998)
Cell
, vol.93
, pp. 1031-1041
-
-
Yost, C.1
Farr 3rd, G.H.2
Pierce, S.B.3
Ferkey, D.M.4
Chen, M.M.5
Kimelman, D.6
-
77
-
-
13844292692
-
Frat is dispensable for canonical Wnt signaling in mammals
-
van Amerongen, R., Nawijn, M., Franca-Koh, J., Zevenhoven, J., van der Gulden, H., Jonkers, J. and Berns, A. (2005) Frat is dispensable for canonical Wnt signaling in mammals. Genes Dev. 19, 425-430.
-
(2005)
Genes Dev
, vol.19
, pp. 425-430
-
-
van Amerongen, R.1
Nawijn, M.2
Franca-Koh, J.3
Zevenhoven, J.4
van der Gulden, H.5
Jonkers, J.6
Berns, A.7
-
78
-
-
27844516613
-
Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins
-
Liu, X., Rubin, J. S. and Kimmel, A. R. (2005) Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. Curr. Biol. 15, 1989-1997.
-
(2005)
Curr. Biol
, vol.15
, pp. 1989-1997
-
-
Liu, X.1
Rubin, J.S.2
Kimmel, A.R.3
-
79
-
-
0344464720
-
Wnts and Hedgehogs: Lipid-modified proteins and similarities in signaling mechanisms at the cell surface
-
Nusse, R. (2003) Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development 130, 5297-5305.
-
(2003)
Development
, vol.130
, pp. 5297-5305
-
-
Nusse, R.1
-
80
-
-
0036849497
-
Similarities between the Hedgehog and Wnt signaling pathways
-
Kalderon, D. (2002) Similarities between the Hedgehog and Wnt signaling pathways. Trends Cell Biol. 12, 523-531.
-
(2002)
Trends Cell Biol
, vol.12
, pp. 523-531
-
-
Kalderon, D.1
-
81
-
-
0037155737
-
Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1
-
Price, M. A. and Kalderon, D. (2002) Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell 108, 823-835.
-
(2002)
Cell
, vol.108
, pp. 823-835
-
-
Price, M.A.1
Kalderon, D.2
-
82
-
-
0037041470
-
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
-
Jia, J., Amanai, K., Wang, G., Tang, J., Wang, B. and Jiang, J. (2002) Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 416, 548-552.
-
(2002)
Nature
, vol.416
, pp. 548-552
-
-
Jia, J.1
Amanai, K.2
Wang, G.3
Tang, J.4
Wang, B.5
Jiang, J.6
-
83
-
-
28444449828
-
Phosphorylation by doubletime/ CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing
-
Jia, J., Zhang, L., Zhang, Q., Tong, C., Wang, B., Hou, F., Amanai, K. and Jiang, J. (2005) Phosphorylation by doubletime/ CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev. Cell 9, 819-830.
-
(2005)
Dev. Cell
, vol.9
, pp. 819-830
-
-
Jia, J.1
Zhang, L.2
Zhang, Q.3
Tong, C.4
Wang, B.5
Hou, F.6
Amanai, K.7
Jiang, J.8
-
84
-
-
0031587830
-
Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
-
Aza-Blanc, P., Ramirez-Weber, F. A., Laget, M. P., Schwartz, C. and Kornberg, T. B. (1997) Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.
-
(1997)
Cell
, vol.89
, pp. 1043-1053
-
-
Aza-Blanc, P.1
Ramirez-Weber, F.A.2
Laget, M.P.3
Schwartz, C.4
Kornberg, T.B.5
-
85
-
-
0032585515
-
Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
-
Ohlmeyer, J. T. and Kalderon, D. (1998) Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 396, 749-753.
-
(1998)
Nature
, vol.396
, pp. 749-753
-
-
Ohlmeyer, J.T.1
Kalderon, D.2
-
86
-
-
13344261322
-
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
-
Zhang, W., Zhao, Y., Tong, C., Wang, G., Wang, B., Jia, J. and Jiang, J. (2005) Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev. Cell 8, 267-278.
-
(2005)
Dev. Cell
, vol.8
, pp. 267-278
-
-
Zhang, W.1
Zhao, Y.2
Tong, C.3
Wang, G.4
Wang, B.5
Jia, J.6
Jiang, J.7
-
88
-
-
0023905661
-
The establishment of polarity by hippocampal neurons in culture
-
Dotti, C. G., Sullivan, C. A. and Banker, G. A. (1988) The establishment of polarity by hippocampal neurons in culture. J. Neurosci. 8, 1454-1468.
-
(1988)
J. Neurosci
, vol.8
, pp. 1454-1468
-
-
Dotti, C.G.1
Sullivan, C.A.2
Banker, G.A.3
-
90
-
-
0035176077
-
Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation
-
Zumbrunn, J., Kinoshita, K., Hyman, A. A. and Nathke, I. S. (2001) Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr. Biol. 11, 44-49.
-
(2001)
Curr. Biol
, vol.11
, pp. 44-49
-
-
Zumbrunn, J.1
Kinoshita, K.2
Hyman, A.A.3
Nathke, I.S.4
-
91
-
-
0029994754
-
Phosphorylation of tau by glycogen synthase kinase-3 beta in intact mammalian cells: The effects on the organization and stability of microtubules
-
Lovestone, S., Hartley, C. L., Pearce, J. and Anderton, B. H. (1996) Phosphorylation of tau by glycogen synthase kinase-3 beta in intact mammalian cells: the effects on the organization and stability of microtubules. Neuroscience 73, 1145-1157.
-
(1996)
Neuroscience
, vol.73
, pp. 1145-1157
-
-
Lovestone, S.1
Hartley, C.L.2
Pearce, J.3
Anderton, B.H.4
-
92
-
-
0033625696
-
GSK3beta-mediated phosphorylation of the microtubule-associated protein 2C (MAP2C) prevents microtubule bundling
-
Sanchez, C., Perez, M. and Avila, J. (2000) GSK3beta-mediated phosphorylation of the microtubule-associated protein 2C (MAP2C) prevents microtubule bundling. Eur. J. Cell Biol. 79, 252-260.
-
(2000)
Eur. J. Cell Biol
, vol.79
, pp. 252-260
-
-
Sanchez, C.1
Perez, M.2
Avila, J.3
-
93
-
-
1642499116
-
A divergent canonical WNT-signaling pathway regulates microtubule dynamics: Dishevelled signals locally to stabilize microtubules
-
Ciani, L., Krylova, O., Smalley, M. J., Dale, T. C. and Salinas, P. C. (2004) A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J. Cell. Biol. 164, 243-253.
-
(2004)
J. Cell. Biol
, vol.164
, pp. 243-253
-
-
Ciani, L.1
Krylova, O.2
Smalley, M.J.3
Dale, T.C.4
Salinas, P.C.5
-
94
-
-
11844260672
-
Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3beta and its upstream regulators
-
Jiang, H., Guo, W., Liang, X. and Rao, Y. (2005) Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators. Cell 120, 123-135.
-
(2005)
Cell
, vol.120
, pp. 123-135
-
-
Jiang, H.1
Guo, W.2
Liang, X.3
Rao, Y.4
-
95
-
-
33750469653
-
Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3beta) independently of Akt/PKB serine phosphorylation
-
Gartner, A., Huang, X. and Hall, A. (2006) Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3beta) independently of Akt/PKB serine phosphorylation. J. Cell Sci. 119, 3927-3934.
-
(2006)
J. Cell Sci
, vol.119
, pp. 3927-3934
-
-
Gartner, A.1
Huang, X.2
Hall, A.3
-
96
-
-
0037092042
-
An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling
-
Eickholt, B. J., Walsh, F. S. and Doherty, P. (2002) An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling. J. Cell Biol. 157, 211-217.
-
(2002)
J. Cell Biol
, vol.157
, pp. 211-217
-
-
Eickholt, B.J.1
Walsh, F.S.2
Doherty, P.3
-
97
-
-
26844435227
-
Collapsin response mediator protein-4 regulates F-actin bundling
-
Rosslenbroich, V., Dai, L., Baader, S. L., Noegel, A. A., Gieselmann, V. and Kappler, J. (2005) Collapsin response mediator protein-4 regulates F-actin bundling. Exp. Cell Res. 310, 434-444.
-
(2005)
Exp. Cell Res
, vol.310
, pp. 434-444
-
-
Rosslenbroich, V.1
Dai, L.2
Baader, S.L.3
Noegel, A.A.4
Gieselmann, V.5
Kappler, J.6
-
98
-
-
20044370438
-
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: Implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease
-
Uchida, Y., Ohshima, T., Sasaki, Y., Suzuki, H., Yanai, S., Yamashita, N., Nakamura, F., Takei, K., Ihara, Y., Mikoshiba, K., Kolattukudy, P., Honnorat, J. and Goshima, Y. (2005) Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes Cells 10, 165-179.
-
(2005)
Genes Cells
, vol.10
, pp. 165-179
-
-
Uchida, Y.1
Ohshima, T.2
Sasaki, Y.3
Suzuki, H.4
Yanai, S.5
Yamashita, N.6
Nakamura, F.7
Takei, K.8
Ihara, Y.9
Mikoshiba, K.10
Kolattukudy, P.11
Honnorat, J.12
Goshima, Y.13
-
99
-
-
0025911366
-
A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1)
-
Shero, J. H. and Hieter, P. (1991) A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1). Genes Dev. 5, 549-560.
-
(1991)
Genes Dev
, vol.5
, pp. 549-560
-
-
Shero, J.H.1
Hieter, P.2
-
100
-
-
0033180094
-
Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell
-
Schlesinger, A., Shelton, C. A., Maloof, J. N., Meneghini, M. and Bowerman, B. (1999) Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell. Genes Dev. 13, 2028-2038.
-
(1999)
Genes Dev
, vol.13
, pp. 2028-2038
-
-
Schlesinger, A.1
Shelton, C.A.2
Maloof, J.N.3
Meneghini, M.4
Bowerman, B.5
-
101
-
-
0034789121
-
Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin
-
McCartney, B. M., McEwen, D. G., Grevengoed, E., Maddox, P., Bejsovec, A. and Peifer, M. (2001) Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. Nat. Cell Biol. 3, 933-938.
-
(2001)
Nat. Cell Biol
, vol.3
, pp. 933-938
-
-
McCartney, B.M.1
McEwen, D.G.2
Grevengoed, E.3
Maddox, P.4
Bejsovec, A.5
Peifer, M.6
-
102
-
-
2542452815
-
The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts
-
Dikovskaya, D., Newton, I. P. and Nathke, I. S. (2004) The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts. Mol. Biol. Cell 15, 2978-2991.
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 2978-2991
-
-
Dikovskaya, D.1
Newton, I.P.2
Nathke, I.S.3
-
103
-
-
0346849717
-
Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC
-
Green, R. A. and Kaplan, K. B. (2003) Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. J. Cell Biol. 163, 949-961.
-
(2003)
J. Cell Biol
, vol.163
, pp. 949-961
-
-
Green, R.A.1
Kaplan, K.B.2
-
104
-
-
33746096996
-
Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer
-
Hadjihannas, M. V., Bruckner, M., Jerchow, B., Birchmeier, W., Dietmaier, W. and Behrens, J. (2006) Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer. Proc. Natl. Acad. Sci. USA 103, 10747-10752.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 10747-10752
-
-
Hadjihannas, M.V.1
Bruckner, M.2
Jerchow, B.3
Birchmeier, W.4
Dietmaier, W.5
Behrens, J.6
-
105
-
-
0037062403
-
Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage
-
Watcharasit, P., Bijur, G. N., Zmijewski, J. W., Song, L., Zmijewska, A., Chen, X., Johnson, G. V. and Jope, R. S. (2002) Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage. Proc. Natl. Acad. Sci. USA 99, 7951-7955.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 7951-7955
-
-
Watcharasit, P.1
Bijur, G.N.2
Zmijewski, J.W.3
Song, L.4
Zmijewska, A.5
Chen, X.6
Johnson, G.V.7
Jope, R.S.8
-
106
-
-
0036830441
-
-
Loberg, R. D., Vesely, E. and Brosius, F. C. 3rd. (2002) Enhanced glycogen synthase kinase-3beta activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism. J. Biol. Chem. 277, 41667-41673.
-
Loberg, R. D., Vesely, E. and Brosius, F. C. 3rd. (2002) Enhanced glycogen synthase kinase-3beta activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism. J. Biol. Chem. 277, 41667-41673.
-
-
-
-
107
-
-
0032493729
-
Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway
-
Pap, M. and Cooper, G. M. (1998) Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J. Biol. Chem. 273, 19929-19932.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 19929-19932
-
-
Pap, M.1
Cooper, G.M.2
-
108
-
-
33644756798
-
Cumulative activation of akt and consequent inhibition of glycogen synthase kinase-3 by brain-derived neurotrophic factor and insulin-like growth factor-1 in cultured hippocampal neurons
-
Johnson-Farley, N. N., Travkina, T. and Cowen, D. S. (2006) Cumulative activation of akt and consequent inhibition of glycogen synthase kinase-3 by brain-derived neurotrophic factor and insulin-like growth factor-1 in cultured hippocampal neurons. J. Pharmacol. Exp. Ther. 316, 1062-1069.
-
(2006)
J. Pharmacol. Exp. Ther
, vol.316
, pp. 1062-1069
-
-
Johnson-Farley, N.N.1
Travkina, T.2
Cowen, D.S.3
-
109
-
-
0034677804
-
Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium
-
Bijur, G. N., De Sarno, P. and Jope, R. S. (2000) Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium. J. Biol. Chem. 275, 7583-7590.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 7583-7590
-
-
Bijur, G.N.1
De Sarno, P.2
Jope, R.S.3
-
110
-
-
0032541032
-
Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta
-
Chu, B., Zhong, R., Soncin, F., Stevenson, M. A. and Calderwood, S. K. (1998) Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta. J. Biol. Chem. 273, 18640-18646.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 18640-18646
-
-
Chu, B.1
Zhong, R.2
Soncin, F.3
Stevenson, M.A.4
Calderwood, S.K.5
-
111
-
-
0036136897
-
Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway
-
Pap, M. and Cooper, G. M. (2002) Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway. Mol. Cell. Biol. 22, 578-586.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 578-586
-
-
Pap, M.1
Cooper, G.M.2
-
112
-
-
0027430039
-
Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B
-
Welsh, G. I. and Proud, C. G. (1993) Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B. Biochem. J. 294, 625-629.
-
(1993)
Biochem. J
, vol.294
, pp. 625-629
-
-
Welsh, G.I.1
Proud, C.G.2
-
113
-
-
0027478346
-
Negative regulation of Jun/AP-1: Conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy
-
de Groot, R. P., Auwerx, J., Bourouis, M. and Sassone-Corsi, P. (1993) Negative regulation of Jun/AP-1: conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy. Oncogene 8, 841-847.
-
(1993)
Oncogene
, vol.8
, pp. 841-847
-
-
de Groot, R.P.1
Auwerx, J.2
Bourouis, M.3
Sassone-Corsi, P.4
-
114
-
-
0027512538
-
Glycogen synthase kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells
-
Nikolakaki, E., Coffer, P. J., Hemelsoet, R., Woodgett, J. R. and Defize, L. H. (1993) Glycogen synthase kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells. Oncogene 8, 833-840.
-
(1993)
Oncogene
, vol.8
, pp. 833-840
-
-
Nikolakaki, E.1
Coffer, P.J.2
Hemelsoet, R.3
Woodgett, J.R.4
Defize, L.H.5
-
115
-
-
0034306997
-
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
-
Sears, R., Nuckolls, F., Haura, E., Taya, Y., Tamai, K. and Nevins, J. R. (2000) Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev. 14, 2501-2514.
-
(2000)
Genes Dev
, vol.14
, pp. 2501-2514
-
-
Sears, R.1
Nuckolls, F.2
Haura, E.3
Taya, Y.4
Tamai, K.5
Nevins, J.R.6
-
116
-
-
34248163605
-
Glycogen synthase kinase-3 represses cyclic AMP response element-binding protein (CREB)-targeted immediate early genes in quiescent cells
-
Tullai, J. W., Chen, J., Schaffer, M. E., Kamenetsky, E., Kasif, S. and Cooper, G. M. (2007) Glycogen synthase kinase-3 represses cyclic AMP response element-binding protein (CREB)-targeted immediate early genes in quiescent cells. J. Biol. Chem. 282, 9482-9491.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 9482-9491
-
-
Tullai, J.W.1
Chen, J.2
Schaffer, M.E.3
Kamenetsky, E.4
Kasif, S.5
Cooper, G.M.6
-
117
-
-
0030890234
-
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
-
Beals, C. R., Sheridan, C. M., Turck, C. W., Gardner, P. and Crabtree, G. R. (1997) Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275, 1930-1934.
-
(1997)
Science
, vol.275
, pp. 1930-1934
-
-
Beals, C.R.1
Sheridan, C.M.2
Turck, C.W.3
Gardner, P.4
Crabtree, G.R.5
-
118
-
-
0035793570
-
Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc
-
Neal, J. W. and Clipstone, N. A. (2001) Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc. J. Biol. Chem. 276, 3666-3673.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 3666-3673
-
-
Neal, J.W.1
Clipstone, N.A.2
-
119
-
-
0034666164
-
Glycogen synthase kinase 3beta negatively regulates both DNA-binding and transcriptional activities of heat shock factor 1
-
Xavier, I. J., Mercier, P. A., McLoughlin, C. M., Ali, A., Woodgett, J. R. and Ovsenek, N. (2000) Glycogen synthase kinase 3beta negatively regulates both DNA-binding and transcriptional activities of heat shock factor 1. J. Biol. Chem. 275, 29147-29152.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 29147-29152
-
-
Xavier, I.J.1
Mercier, P.A.2
McLoughlin, C.M.3
Ali, A.4
Woodgett, J.R.5
Ovsenek, N.6
-
120
-
-
0026029808
-
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
-
Boyle, W. J., Smeal, T., Defize, L. H., Angel, P., Woodgett, J. R., Karin, M. and Hunter, T. (1991) Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 64, 573-584.
-
(1991)
Cell
, vol.64
, pp. 573-584
-
-
Boyle, W.J.1
Smeal, T.2
Defize, L.H.3
Angel, P.4
Woodgett, J.R.5
Karin, M.6
Hunter, T.7
-
121
-
-
0034806590
-
CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium
-
Grimes, C. A. and Jope, R. S. (2001) CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium. J. Neurochem. 78, 1219-1232.
-
(2001)
J. Neurochem
, vol.78
, pp. 1219-1232
-
-
Grimes, C.A.1
Jope, R.S.2
-
122
-
-
1542297761
-
Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin
-
Cong, F. and Varmus, H. (2004) Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proc. Natl. Acad. Sci. USA 101, 2882-2887.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 2882-2887
-
-
Cong, F.1
Varmus, H.2
-
123
-
-
0037113982
-
The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP
-
Franca-Koh, J., Yeo, M., Fraser, E., Young, N. and Dale, T. C. (2002) The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP. J. Biol. Chem. 277, 43844-43848.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 43844-43848
-
-
Franca-Koh, J.1
Yeo, M.2
Fraser, E.3
Young, N.4
Dale, T.C.5
-
124
-
-
0034693230
-
Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling
-
Ding, V. W., Chen, R. H. and McCormick, F. (2000) Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling. J. Biol. Chem. 275, 32475-32481.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 32475-32481
-
-
Ding, V.W.1
Chen, R.H.2
McCormick, F.3
-
125
-
-
0032967514
-
Glycogen synthase kinase-3 is the predominant insulin-regulated eukaryotic initiation factor 2B kinase in skeletal muscle
-
Jefferson, L. S., Fabian, J. R. and Kimball, S. R. (1999) Glycogen synthase kinase-3 is the predominant insulin-regulated eukaryotic initiation factor 2B kinase in skeletal muscle. Int. J. Biochem. Cell Biol. 31, 191-200.
-
(1999)
Int. J. Biochem. Cell Biol
, vol.31
, pp. 191-200
-
-
Jefferson, L.S.1
Fabian, J.R.2
Kimball, S.R.3
-
126
-
-
0036302005
-
Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: Insight into the insulin-mimetic action of zinc
-
Ilouz, R., Kaidanovich, O., Gurwitz, D. and Eldar-Finkelman, H. (2002) Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc. Biochem. Biophys. Res. Commun. 295, 102-106.
-
(2002)
Biochem. Biophys. Res. Commun
, vol.295
, pp. 102-106
-
-
Ilouz, R.1
Kaidanovich, O.2
Gurwitz, D.3
Eldar-Finkelman, H.4
-
127
-
-
0034010742
-
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent
-
Meijer, L., Thunnissen, A. M., White, A. W., Garnier, M., Nikolic, M., Tsai, L. H., Walter, J., Cleverley, K. E., Salinas, P. C., Wu, Y. Z., Biernat, J., Mandelkow, E. M., Kim, S. H. and Pettit, G. R. (2000) Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chem. Biol. 7, 51-63.
-
(2000)
Chem. Biol
, vol.7
, pp. 51-63
-
-
Meijer, L.1
Thunnissen, A.M.2
White, A.W.3
Garnier, M.4
Nikolic, M.5
Tsai, L.H.6
Walter, J.7
Cleverley, K.E.8
Salinas, P.C.9
Wu, Y.Z.10
Biernat, J.11
Mandelkow, E.M.12
Kim, S.H.13
Pettit, G.R.14
-
128
-
-
0037122752
-
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1)
-
Tasdemir, D., Mallon, R., Greenstein, M., Feldberg, L. R., Kim, S. C., Collins, K., Wojciechowicz, D., Mangalindan, G. C., Concepcion, G. P., Harper, M. K. and Ireland, C. M. (2002) Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1) J. Med. Chem. 45, 529-532.
-
(2002)
J. Med. Chem
, vol.45
, pp. 529-532
-
-
Tasdemir, D.1
Mallon, R.2
Greenstein, M.3
Feldberg, L.R.4
Kim, S.C.5
Collins, K.6
Wojciechowicz, D.7
Mangalindan, G.C.8
Concepcion, G.P.9
Harper, M.K.10
Ireland, C.M.11
-
129
-
-
0033776383
-
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
-
Coghlan, M. P., Culbert, A. A., Cross, D. A., Corcoran, S. L., Yates, J. W., Pearce, N. J., Rausch, O. L., Murphy, G. J., Carter, P. S., Roxbee Cox, L., Mills, D., Brown, M. J., Haigh, D., Ward, R. W., Smith, D. G., Murray, K. J., Reith, A. D. and Holder, J. C. (2000) Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem. Biol. 7, 793-803.
-
(2000)
Chem. Biol
, vol.7
, pp. 793-803
-
-
Coghlan, M.P.1
Culbert, A.A.2
Cross, D.A.3
Corcoran, S.L.4
Yates, J.W.5
Pearce, N.J.6
Rausch, O.L.7
Murphy, G.J.8
Carter, P.S.9
Roxbee Cox, L.10
Mills, D.11
Brown, M.J.12
Haigh, D.13
Ward, R.W.14
Smith, D.G.15
Murray, K.J.16
Reith, A.D.17
Holder, J.C.18
-
130
-
-
0035848403
-
3-Anilino-4-arylmaleimides: Potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)
-
Smith, D. G., Buffet, M., Fenwick, A. E., Haigh, D., Ife, R. J., Saunders, M., Slingsby, B. P., Stacey, R. and Ward, R. W. (2001) 3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3) Bioorg. Med. Chem. Lett. 11, 635-639.
-
(2001)
Bioorg. Med. Chem. Lett
, vol.11
, pp. 635-639
-
-
Smith, D.G.1
Buffet, M.2
Fenwick, A.E.3
Haigh, D.4
Ife, R.J.5
Saunders, M.6
Slingsby, B.P.7
Stacey, R.8
Ward, R.W.9
-
131
-
-
0043022153
-
6-heteroaryl-pyrazolo[3,4-b]pyridines: Potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)
-
Witherington, J., Bordas, V., Gaiba, A., Naylor, A., Rawlings, A. D., Slingsby, B. P., Smith, D. G., Takle, A. K. and Ward, R. W. (2003) 6-heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3). Bioorg. Med. Chem. Lett. 13, 3059-3062.
-
(2003)
Bioorg. Med. Chem. Lett
, vol.13
, pp. 3059-3062
-
-
Witherington, J.1
Bordas, V.2
Gaiba, A.3
Naylor, A.4
Rawlings, A.D.5
Slingsby, B.P.6
Smith, D.G.7
Takle, A.K.8
Ward, R.W.9
-
132
-
-
0032705583
-
The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
-
Hers, I., Tavare, J. M. and Denton, R. M. (1999) The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity. FEBS Lett. 460, 433-436.
-
(1999)
FEBS Lett
, vol.460
, pp. 433-436
-
-
Hers, I.1
Tavare, J.M.2
Denton, R.M.3
-
133
-
-
0142060928
-
Thienyl and phenyl alpha-halomethyl ketones: New inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching
-
Conde, S., Perez, D. I., Martinez, A., Perez, C. and Moreno, F. J. (2003) Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching. J. Med. Chem. 46, 4631-4633.
-
(2003)
J. Med. Chem
, vol.46
, pp. 4631-4633
-
-
Conde, S.1
Perez, D.I.2
Martinez, A.3
Perez, C.4
Moreno, F.J.5
-
134
-
-
0035808457
-
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
-
Leclerc, S., Garnier, M., Hoessel, R., Marko, D., Bibb, J. A., Snyder, G. L., Greengard, P., Biernat, J., Wu, Y. Z., Mandelkow, E. M., Eisenbrand, G. and Meijer, L. (2001) Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J. Biol. Chem. 276, 251-260.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 251-260
-
-
Leclerc, S.1
Garnier, M.2
Hoessel, R.3
Marko, D.4
Bibb, J.A.5
Snyder, G.L.6
Greengard, P.7
Biernat, J.8
Wu, Y.Z.9
Mandelkow, E.M.10
Eisenbrand, G.11
Meijer, L.12
-
135
-
-
0037067733
-
Intracellular targets of paullones. Identification following affinity purification on immobilized inhibitor
-
Knockaert, M., Wieking, K., Schmitt, S., Leost, M., Grant, K. M., Mottram, J. C., Kunick, C. and Meijer, L. (2002) Intracellular targets of paullones. Identification following affinity purification on immobilized inhibitor. J. Biol. Chem. 277, 25493-25501.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 25493-25501
-
-
Knockaert, M.1
Wieking, K.2
Schmitt, S.3
Leost, M.4
Grant, K.M.5
Mottram, J.C.6
Kunick, C.7
Meijer, L.8
-
136
-
-
0033798031
-
Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25
-
Leost, M., Schultz, C., Link, A., Wu, Y. Z., Biernat, J., Mandelkow, E. M., Bibb, J. A., Snyder, G. L., Greengard, P., Zaharevitz, D. W., Gussio, R., Senderowicz, A. M., Sausville, E. A., Kunick, C. and Meijer, L. (2000) Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. Eur. J. Biochem. 267, 5983-5994.
-
(2000)
Eur. J. Biochem
, vol.267
, pp. 5983-5994
-
-
Leost, M.1
Schultz, C.2
Link, A.3
Wu, Y.Z.4
Biernat, J.5
Mandelkow, E.M.6
Bibb, J.A.7
Snyder, G.L.8
Greengard, P.9
Zaharevitz, D.W.10
Gussio, R.11
Senderowicz, A.M.12
Sausville, E.A.13
Kunick, C.14
Meijer, L.15
-
137
-
-
0036242381
-
Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors
-
Ortega, M. A., Montoya, M. E., Zarranz, B., Jaso, A., Aldana, I., Leclerc, S., Meijer, L. and Monge, A. (2002) Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg. Med. Chem. 10, 2177-2184.
-
(2002)
Bioorg. Med. Chem
, vol.10
, pp. 2177-2184
-
-
Ortega, M.A.1
Montoya, M.E.2
Zarranz, B.3
Jaso, A.4
Aldana, I.5
Leclerc, S.6
Meijer, L.7
Monge, A.8
-
138
-
-
0036273020
-
Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation
-
Martinez, A., Castro, A., Dorronsoro, I. and Alonso, M. (2002) Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation. Med. Res. Rev. 22, 373-384.
-
(2002)
Med. Res. Rev
, vol.22
, pp. 373-384
-
-
Martinez, A.1
Castro, A.2
Dorronsoro, I.3
Alonso, M.4
|