-
1
-
-
8844220536
-
Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series
-
Landles C, Bates GP (2004) Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series. EMBO Rep 5: 958-963.
-
(2004)
EMBO Rep
, vol.5
, pp. 958-963
-
-
Landles, C.1
Bates, G.P.2
-
2
-
-
0344961865
-
The use of transgenic and knock-in mice to study Huntington's disease
-
Hickey MA, Chesselet MF (2003) The use of transgenic and knock-in mice to study Huntington's disease. Cytogenet Genome Res 100: 276-286.
-
(2003)
Cytogenet Genome Res
, vol.100
, pp. 276-286
-
-
Hickey, M.A.1
Chesselet, M.F.2
-
3
-
-
0036720019
-
Mouse and fly models of neurodegeneration
-
Zoghbi HY, Botas J (2002) Mouse and fly models of neurodegeneration. Trends Genet 18: 463-471.
-
(2002)
Trends Genet
, vol.18
, pp. 463-471
-
-
Zoghbi, H.Y.1
Botas, J.2
-
4
-
-
0037373633
-
Dying for a cause: Invertebrate genetics takes on human neurodegeneration
-
Driscoll M, Gerstbrein B (2003) Dying for a cause: Invertebrate genetics takes on human neurodegeneration. Nat Rev Genet 4: 181-194.
-
(2003)
Nat Rev Genet
, vol.4
, pp. 181-194
-
-
Driscoll, M.1
Gerstbrein, B.2
-
5
-
-
0028989602
-
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
-
DiFiglia M, Sapp E, Chase K, Schwarz C, Meloni A, et al. (1995) Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 14: 1075-1081.
-
(1995)
Neuron
, vol.14
, pp. 1075-1081
-
-
DiFiglia, M.1
Sapp, E.2
Chase, K.3
Schwarz, C.4
Meloni, A.5
-
6
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
Davies SW, Turmaine M, Cozens BA, DiFiglia M, Sharp AH, et al. (1997) Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90: 537-548.
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.W.1
Turmaine, M.2
Cozens, B.A.3
DiFiglia, M.4
Sharp, A.H.5
-
7
-
-
0031838352
-
Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1
-
Cummings CJ, Mancini MA, Antalffy B, DeFranco DB, Orr HT, et al. (1998) Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1. Nat Genet 19: 148-154.
-
(1998)
Nat Genet
, vol.19
, pp. 148-154
-
-
Cummings, C.J.1
Mancini, M.A.2
Antalffy, B.3
DeFranco, D.B.4
Orr, H.T.5
-
8
-
-
0032517816
-
Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation
-
Perez MK, Paulson HL, Pendse SJ, Saionz SJ, Bonini NM, et al. (1998) Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation. J Cell Biol 143: 1457-1470.
-
(1998)
J Cell Biol
, vol.143
, pp. 1457-1470
-
-
Perez, M.K.1
Paulson, H.L.2
Pendse, S.J.3
Saionz, S.J.4
Bonini, N.M.5
-
9
-
-
0033613212
-
Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells
-
Kazantsev A, Preisinger E, Dranovsky A, Goldgaber D, Housman D (1999) Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells. Proc Natl Acad Sci U S A 96: 11404-11409.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 11404-11409
-
-
Kazantsev, A.1
Preisinger, E.2
Dranovsky, A.3
Goldgaber, D.4
Housman, D.5
-
10
-
-
0035897405
-
Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression
-
Suhr ST, Senut MC, Whitelegge JP, Faull KF, Cuizon DB, et al. (2001) Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression. J Cell Biol 153: 283-294.
-
(2001)
J Cell Biol
, vol.153
, pp. 283-294
-
-
Suhr, S.T.1
Senut, M.C.2
Whitelegge, J.P.3
Faull, K.F.4
Cuizon, D.B.5
-
11
-
-
0035937523
-
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
-
Nucifora FC Jr., Sasaki M, Peters MF, Huang H, Cooper JK, et al. (2001) Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science 291: 2423-2428.
-
(2001)
Science
, vol.291
, pp. 2423-2428
-
-
Nucifora Jr., F.C.1
Sasaki, M.2
Peters, M.F.3
Huang, H.4
Cooper, J.K.5
-
12
-
-
0032833981
-
Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin
-
Boutell JM, Thomas P, Neal JW, Weston VJ, Duce J, et al. (1999) Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. Hum Mol Genet 8: 1647-1655.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 1647-1655
-
-
Boutell, J.M.1
Thomas, P.2
Neal, J.W.3
Weston, V.J.4
Duce, J.5
-
13
-
-
12944263711
-
The Huntington's disease protein interacts with p53 and CREBbinding protein and represses transcription
-
Steffan JS, Kazantsev A, Spasic-Boskovic O, Greenwald M, Zhu YZ, et al. (2000) The Huntington's disease protein interacts with p53 and CREBbinding protein and represses transcription. Proc Natl Acad Sci U S A 97: 6763-6768.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 6763-6768
-
-
Steffan, J.S.1
Kazantsev, A.2
Spasic-Boskovic, O.3
Greenwald, M.4
Zhu, Y.Z.5
-
14
-
-
3042717240
-
Cellular toxicity of polyglutamine expansion proteins: Mechanism of transcription factor deactivation
-
Schaffar G, Breuer P, Boteva R, Behrends C, Tzvetkov N, et al. (2004) Cellular toxicity of polyglutamine expansion proteins: Mechanism of transcription factor deactivation. Mol Cell 15: 95-105.
-
(2004)
Mol Cell
, vol.15
, pp. 95-105
-
-
Schaffar, G.1
Breuer, P.2
Boteva, R.3
Behrends, C.4
Tzvetkov, N.5
-
15
-
-
0037150687
-
Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease
-
Dunah AW, Jeong H, Griffin A, Kim YM, Standaert DG, et al. (2002) Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. Science 296: 2238-2243.
-
(2002)
Science
, vol.296
, pp. 2238-2243
-
-
Dunah, A.W.1
Jeong, H.2
Griffin, A.3
Kim, Y.M.4
Standaert, D.G.5
-
16
-
-
0035909330
-
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
-
Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, et al. (2001) Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413: 739-743.
-
(2001)
Nature
, vol.413
, pp. 739-743
-
-
Steffan, J.S.1
Bodai, L.2
Pallos, J.3
Poelman, M.4
McCampbell, A.5
-
17
-
-
7244236320
-
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
-
Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S (2004) Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431: 805-810.
-
(2004)
Nature
, vol.431
, pp. 805-810
-
-
Arrasate, M.1
Mitra, S.2
Schweitzer, E.S.3
Segal, M.R.4
Finkbeiner, S.5
-
18
-
-
23844472610
-
Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions
-
Slow EJ, Graham RK, Osmand AP, Devon RS, Lu G, et al. (2005) Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions. Proc Natl Acad Sci U S A 102: 11402-11407.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 11402-11407
-
-
Slow, E.J.1
Graham, R.K.2
Osmand, A.P.3
Devon, R.S.4
Lu, G.5
-
19
-
-
27744443276
-
Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment
-
Zala D, Benchoua A, Brouillet E, Perrin V, Gaillard MC, et al. (2005) Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment. Neurobiol Dis 20: 785-798.
-
(2005)
Neurobiol Dis
, vol.20
, pp. 785-798
-
-
Zala, D.1
Benchoua, A.2
Brouillet, E.3
Perrin, V.4
Gaillard, M.C.5
-
20
-
-
1542674455
-
Huntingtin: Alive and well and working in middle management
-
MacDonald ME (2003) Huntingtin: Alive and well and working in middle management. Sci STKE 2003: pe48.
-
(2003)
Sci STKE 2003: Pe48
-
-
MacDonald, M.E.1
-
21
-
-
0029392854
-
HEAT repeats in the Huntington's disease protein
-
Andrade MA, Bork P (1995) HEAT repeats in the Huntington's disease protein. Nat Genet 11: 115-116.
-
(1995)
Nat Genet
, vol.11
, pp. 115-116
-
-
Andrade, M.A.1
Bork, P.2
-
22
-
-
0041656292
-
The hunt for huntingtin function: Interaction partners tell many different stories
-
Harjes P, Wanker EE (2003) The hunt for huntingtin function: Interaction partners tell many different stories. Trends Biochem Sci 28: 425-433.
-
(2003)
Trends Biochem Sci
, vol.28
, pp. 425-433
-
-
Harjes, P.1
Wanker, E.E.2
-
23
-
-
1242338856
-
Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends Genet
-
Li SH, Li XJ (2004) Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends Genet 20: 146-154.
-
(2004)
, vol.20
, pp. 146-154
-
-
Li, S.H.1
Li, X.J.2
-
24
-
-
28644433087
-
Normal huntingtin function: An alternative approach to Huntington's disease
-
Cattaneo E, Zuccato C, Tartari M (2005) Normal huntingtin function: An alternative approach to Huntington's disease. Nat Rev Neurosci 6: 919-930.
-
(2005)
Nat Rev Neurosci
, vol.6
, pp. 919-930
-
-
Cattaneo, E.1
Zuccato, C.2
Tartari, M.3
-
25
-
-
0037050026
-
Functional organization of the yeast proteome by systematic analysis of protein complexes
-
Gavin AC, Bosche M, Krause R, Grandi P, Marzioch M, et al. (2002) Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415: 141-147.
-
(2002)
Nature
, vol.415
, pp. 141-147
-
-
Gavin, A.C.1
Bosche, M.2
Krause, R.3
Grandi, P.4
Marzioch, M.5
-
26
-
-
0037050004
-
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
-
Ho Y, Gruhler A, Heilbut A, Bader GD, Moore L, et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415: 180-183.
-
(2002)
Nature
, vol.415
, pp. 180-183
-
-
Ho, Y.1
Gruhler, A.2
Heilbut, A.3
Bader, G.D.4
Moore, L.5
-
27
-
-
0035836765
-
A comprehensive two-hybrid analysis to explore the yeast protein interactome
-
Ito T, Chiba T, Ozawa R, Yoshida M, Hattori M, et al. (2001) A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A 98: 4569-4574.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 4569-4574
-
-
Ito, T.1
Chiba, T.2
Ozawa, R.3
Yoshida, M.4
Hattori, M.5
-
28
-
-
0034628508
-
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
-
Uetz P, Giot L, Cagney G, Mansfield TA, Judson RS, et al. (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403: 623-627.
-
(2000)
Nature
, vol.403
, pp. 623-627
-
-
Uetz, P.1
Giot, L.2
Cagney, G.3
Mansfield, T.A.4
Judson, R.S.5
-
29
-
-
33646687963
-
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
-
Lim J, Hao T, Shaw C, Patel AJ, Szabo G, et al. (2006) A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 125: 801-814.
-
(2006)
Cell
, vol.125
, pp. 801-814
-
-
Lim, J.1
Hao, T.2
Shaw, C.3
Patel, A.J.4
Szabo, G.5
-
30
-
-
27144530248
-
Towards a proteome-scale map of the human protein-protein interaction network
-
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437: 1173-1178.
-
(2005)
Nature
, vol.437
, pp. 1173-1178
-
-
Rual, J.F.1
Venkatesan, K.2
Hao, T.3
Hirozane-Kishikawa, T.4
Dricot, A.5
-
31
-
-
27644484749
-
A protein interaction network of the malaria parasite Plasmodium falciparum
-
Lacount DJ, Vignali M, Chettier R, Phansalkar A, Bell R, et al. (2005) A protein interaction network of the malaria parasite Plasmodium falciparum. Nature 438: 103-107.
-
(2005)
Nature
, vol.438
, pp. 103-107
-
-
Lacount, D.J.1
Vignali, M.2
Chettier, R.3
Phansalkar, A.4
Bell, R.5
-
32
-
-
0030455820
-
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
-
James P, Halladay J, Craig EA (1996) Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144: 1425-1436.
-
(1996)
Genetics
, vol.144
, pp. 1425-1436
-
-
James, P.1
Halladay, J.2
Craig, E.A.3
-
33
-
-
0037432528
-
How reliable are experimental protein-protein interaction data?
-
Sprinzak E, Sattath S, Margalit H (2003) How reliable are experimental protein-protein interaction data? J Mol Biol 327: 919-923.
-
(2003)
J Mol Biol
, vol.327
, pp. 919-923
-
-
Sprinzak, E.1
Sattath, S.2
Margalit, H.3
-
34
-
-
0037161731
-
Comparative assessment of large-scale data sets of protein-protein interactions
-
von Mering C, Krause R, Snel B, Cornell M, Oliver SG, et al. (2002) Comparative assessment of large-scale data sets of protein-protein interactions. Nature 417: 399-403.
-
(2002)
Nature
, vol.417
, pp. 399-403
-
-
von Mering, C.1
Krause, R.2
Snel, B.3
Cornell, M.4
Oliver, S.G.5
-
35
-
-
0035880457
-
The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptinbinding protein involved in receptor-mediated endocytosis
-
Waelter S, Scherzinger E, Hasenbank R, Nordhoff E, Lurz R, et al. (2001) The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptinbinding protein involved in receptor-mediated endocytosis. Hum Mol Genet 10: 1807-1817.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1807-1817
-
-
Waelter, S.1
Scherzinger, E.2
Hasenbank, R.3
Nordhoff, E.4
Lurz, R.5
-
36
-
-
0029664992
-
Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH
-
Burke JR, Enghild JJ, Martin ME, Jou YS, Myers RM, et al. (1996) Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nat Med 2: 347-350.
-
(1996)
Nat Med
, vol.2
, pp. 347-350
-
-
Burke, J.R.1
Enghild, J.J.2
Martin, M.E.3
Jou, Y.S.4
Myers, R.M.5
-
37
-
-
20044396187
-
A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth
-
Laviolette MJ, Nunes P, Peyre JB, Aigaki T, Stewart BA (2005) A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth. Genetics 170: 779-792.
-
(2005)
Genetics
, vol.170
, pp. 779-792
-
-
Laviolette, M.J.1
Nunes, P.2
Peyre, J.B.3
Aigaki, T.4
Stewart, B.A.5
-
38
-
-
26444600338
-
Genetic interaction of Lobe with its modifiers in dorsoventral patterning and growth of the Drosophila eye
-
Singh A, Chan J, Chern JJ, Choi KW (2005) Genetic interaction of Lobe with its modifiers in dorsoventral patterning and growth of the Drosophila eye. Genetics 171: 169-183.
-
(2005)
Genetics
, vol.171
, pp. 169-183
-
-
Singh, A.1
Chan, J.2
Chern, J.J.3
Choi, K.W.4
-
39
-
-
0034629073
-
Genetic suppression of polyglutamine toxicity in Drosophila
-
Kazemi-Esfarjani P, Benzer S (2000) Genetic suppression of polyglutamine toxicity in Drosophila. Science 287: 1837-1840.
-
(2000)
Science
, vol.287
, pp. 1837-1840
-
-
Kazemi-Esfarjani, P.1
Benzer, S.2
-
40
-
-
0034597833
-
Identification of genes that modify ataxin-1-induced neurodegeneration
-
Fernandez-Funez P, Nino-Rosales ML, de Gouyon B, She WC, Luchak JM, et al. (2000) Identification of genes that modify ataxin-1-induced neurodegeneration. Nature 408: 101-106.
-
(2000)
Nature
, vol.408
, pp. 101-106
-
-
Fernandez-Funez, P.1
Nino-Rosales, M.L.2
de Gouyon, B.3
She, W.C.4
Luchak, J.M.5
-
41
-
-
33644770187
-
Structure and function of SNARE and SNARE-interacting proteins
-
Brunger AT (2005) Structure and function of SNARE and SNARE-interacting proteins. Q Rev Biophys 38: 1-47.
-
(2005)
Q Rev Biophys
, vol.38
, pp. 1-47
-
-
Brunger, A.T.1
-
42
-
-
2942556680
-
The synaptic vesicle cycle
-
Sudhof TC (2004) The synaptic vesicle cycle. Annu Rev Neurosci 27: 509-547.
-
(2004)
Annu Rev Neurosci
, vol.27
, pp. 509-547
-
-
Sudhof, T.C.1
-
43
-
-
0031867231
-
Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways
-
Velier J, Kim M, Schwarz C, Kim TW, Sapp E, et al. (1998) Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways. Exp Neurol 152: 34-40.
-
(1998)
Exp Neurol
, vol.152
, pp. 34-40
-
-
Velier, J.1
Kim, M.2
Schwarz, C.3
Kim, T.W.4
Sapp, E.5
-
44
-
-
0842322740
-
Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction
-
Qin ZH, Wang Y, Sapp E, Cuiffo B, Wanker E, et al. (2004) Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction. J Neurosci 24: 269-281.
-
(2004)
J Neurosci
, vol.24
, pp. 269-281
-
-
Qin, Z.H.1
Wang, Y.2
Sapp, E.3
Cuiffo, B.4
Wanker, E.5
-
45
-
-
33644873184
-
BioGRID: A general repository for interaction datasets
-
Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, et al. (2006) BioGRID: A general repository for interaction datasets. Nucleic Acids Res 34: D535-D539.
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Stark, C.1
Breitkreutz, B.J.2
Reguly, T.3
Boucher, L.4
Breitkreutz, A.5
-
46
-
-
33644877439
-
Human protein reference database-2006 update
-
Mishra GR, Suresh M, Kumaran K, Kannabiran N, Suresh S, et al. (2006) Human protein reference database-2006 update. Nucleic Acids Res 34: D411-D414.
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Mishra, G.R.1
Suresh, M.2
Kumaran, K.3
Kannabiran, N.4
Suresh, S.5
-
47
-
-
10744224197
-
Development of human protein reference database as an initial platform for approaching systems biology in humans
-
Peri S, Navarro JD, Amanchy R, Kristiansen TZ, Jonnalagadda CK, et al. (2003) Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res 13: 2363-2371.
-
(2003)
Genome Res
, vol.13
, pp. 2363-2371
-
-
Peri, S.1
Navarro, J.D.2
Amanchy, R.3
Kristiansen, T.Z.4
Jonnalagadda, C.K.5
-
48
-
-
10744227174
-
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
-
Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, et al. (2003) Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum Mol Genet 12: 1555-1567.
-
(2003)
Hum Mol Genet
, vol.12
, pp. 1555-1567
-
-
Slow, E.J.1
van Raamsdonk, J.2
Rogers, D.3
Coleman, S.H.4
Graham, R.K.5
-
49
-
-
33644775636
-
Mutant huntingtin: Nuclear translocation and cytotoxicity mediated by GAPDH
-
Bae BI, Hara MR, Cascio MB, Wellington CL, Hayden MR, et al. (2006) Mutant huntingtin: Nuclear translocation and cytotoxicity mediated by GAPDH. Proc Natl Acad Sci U S A 103: 3405-3409.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 3405-3409
-
-
Bae, B.I.1
Hara, M.R.2
Cascio, M.B.3
Wellington, C.L.4
Hayden, M.R.5
-
50
-
-
1842766144
-
Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins
-
Venkatraman P, Wetzel R, Tanaka M, Nukina N, Goldberg AL (2004) Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. Mol Cell 14: 95-104.
-
(2004)
Mol Cell
, vol.14
, pp. 95-104
-
-
Venkatraman, P.1
Wetzel, R.2
Tanaka, M.3
Nukina, N.4
Goldberg, A.L.5
-
51
-
-
0030919567
-
Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia
-
Browne SE, Bowling AC, MacGarvey U, Baik MJ, Berger SC, et al. (1997) Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia. Ann Neurol 41: 646-653.
-
(1997)
Ann Neurol
, vol.41
, pp. 646-653
-
-
Browne, S.E.1
Bowling, A.C.2
MacGarvey, U.3
Baik, M.J.4
Berger, S.C.5
-
52
-
-
0036327065
-
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
-
Panov AV, Gutekunst CA, Leavitt BR, Hayden MR, Burke JR, et al. (2002) Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines. Nat Neurosci 5: 731-736.
-
(2002)
Nat Neurosci
, vol.5
, pp. 731-736
-
-
Panov, A.V.1
Gutekunst, C.A.2
Leavitt, B.R.3
Hayden, M.R.4
Burke, J.R.5
-
53
-
-
0041963057
-
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1
-
Tang TS, Tu H, Chan EY, Maximov A, Wang Z, et al. (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron 39: 227-239.
-
(2003)
Neuron
, vol.39
, pp. 227-239
-
-
Tang, T.S.1
Tu, H.2
Chan, E.Y.3
Maximov, A.4
Wang, Z.5
-
54
-
-
0141750470
-
Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila
-
Gunawardena S, Her LS, Brusch RG, Laymon RA, Niesman IR, et al. (2003) Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron 40: 25-40.
-
(2003)
Neuron
, vol.40
, pp. 25-40
-
-
Gunawardena, S.1
Her, L.S.2
Brusch, R.G.3
Laymon, R.A.4
Niesman, I.R.5
-
56
-
-
26244435766
-
Crosstalk between huntingtin and syntaxin 1A regulates N-type calcium channels
-
Swayne LA, Chen L, Hameed S, Barr W, Charlesworth E, et al. (2005) Crosstalk between huntingtin and syntaxin 1A regulates N-type calcium channels. Mol Cell Neurosci 30: 339-351.
-
(2005)
Mol Cell Neurosci
, vol.30
, pp. 339-351
-
-
Swayne, L.A.1
Chen, L.2
Hameed, S.3
Barr, W.4
Charlesworth, E.5
-
57
-
-
4644231870
-
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease
-
Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, et al. (2004) A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Mol Cell 15: 853-865.
-
(2004)
Mol Cell
, vol.15
, pp. 853-865
-
-
Goehler, H.1
Lalowski, M.2
Stelzl, U.3
Waelter, S.4
Stroedicke, M.5
-
58
-
-
0031662269
-
Huntingtin interacts with a family of WW domain proteins
-
Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, et al. (1998) Huntingtin interacts with a family of WW domain proteins. Hum Mol Genet 7: 1463-1474.
-
(1998)
Hum Mol Genet
, vol.7
, pp. 1463-1474
-
-
Faber, P.W.1
Barnes, G.T.2
Srinidhi, J.3
Chen, J.4
Gusella, J.F.5
-
59
-
-
33749176269
-
Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state
-
Kitamura A, Kubota H, Pack CG, Matsumoto G, Hirayama S, et al. (2006) Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state. Nat Cell Biol 8: 1163-1170.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1163-1170
-
-
Kitamura, A.1
Kubota, H.2
Pack, C.G.3
Matsumoto, G.4
Hirayama, S.5
-
60
-
-
33749177252
-
The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions
-
Tam S, Geller R, Spiess C, Frydman J (2006) The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions. Nat Cell Biol 8: 1155-1162.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1155-1162
-
-
Tam, S.1
Geller, R.2
Spiess, C.3
Frydman, J.4
-
61
-
-
17344388163
-
The complete set of predicted genes from Saccharomyces cerevisiae in a readily usable form
-
Hudson JR Jr., Dawson EP, Rushing KL, Jackson CH, Lockshon D, et al. (1997) The complete set of predicted genes from Saccharomyces cerevisiae in a readily usable form. Genome Res 7: 1169-1173.
-
(1997)
Genome Res
, vol.7
, pp. 1169-1173
-
-
Hudson Jr., J.R.1
Dawson, E.P.2
Rushing, K.L.3
Jackson, C.H.4
Lockshon, D.5
-
62
-
-
8444243667
-
An integrated strategy for the discovery of drug targets by the analysis of protein-protein interactions
-
Peltier JM, Askovic S, Becklin RR, Chepanoske CL, Ho Y-SJ, et al. (2004) An integrated strategy for the discovery of drug targets by the analysis of protein-protein interactions. Int J Mass Spectrom 238: 119-130.
-
(2004)
Int J Mass Spectrom
, vol.238
, pp. 119-130
-
-
Peltier, J.M.1
Askovic, S.2
Becklin, R.R.3
Chepanoske, C.L.4
Ho, Y.-S.J.5
-
63
-
-
12944269065
-
Rapid identification of proteins by peptide-mass fingerprinting
-
Pappin DJ, Hojrup P, Bleasby AJ (1993) Rapid identification of proteins by peptide-mass fingerprinting. Curr Biol 3: 327-332.
-
(1993)
Curr Biol
, vol.3
, pp. 327-332
-
-
Pappin, D.J.1
Hojrup, P.2
Bleasby, A.J.3
-
64
-
-
0033434080
-
Probability-based protein identification by searching sequence databases using mass spectrometry data
-
Perkins DN, Pappin DJ, Creasy DM, Cottrell JS (1999) Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 20: 3551-3567.
-
(1999)
Electrophoresis
, vol.20
, pp. 3551-3567
-
-
Perkins, D.N.1
Pappin, D.J.2
Creasy, D.M.3
Cottrell, J.S.4
-
65
-
-
0027160708
-
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
-
Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
-
(1993)
Development
, vol.118
, pp. 401-415
-
-
Brand, A.H.1
Perrimon, N.2
-
66
-
-
0033054555
-
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin
-
Schilling G, Becher MW, Sharp AH, Jinnah HA, Duan K, et al. (1999) Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet 8: 397-407.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 397-407
-
-
Schilling, G.1
Becher, M.W.2
Sharp, A.H.3
Jinnah, H.A.4
Duan, K.5
-
67
-
-
0037444445
-
Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease
-
Yu ZX, Li SH, Evans J, Pillarisetti A, Li H, et al. (2003) Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease. J Neurosci 23: 2193-2202.
-
(2003)
J Neurosci
, vol.23
, pp. 2193-2202
-
-
Yu, Z.X.1
Li, S.H.2
Evans, J.3
Pillarisetti, A.4
Li, H.5
-
68
-
-
0018103643
-
On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster
-
Ganetzky B, Flanagan JR (1978) On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster. Exp Gerontol 13: 189-196.
-
(1978)
Exp Gerontol
, vol.13
, pp. 189-196
-
-
Ganetzky, B.1
Flanagan, J.R.2
|