Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells

Cancer Research

Volumn 61, Issue 15, 2001, Pages 5710-5713

  Smilenov, L B ^a   Brenner, D J ^a   Hall, E J ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; ATAXIA TELANGIECTASIA; CANCER; CANCER RISK; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RADIOSENSITIVITY;

NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER;

ANIMALS; ATAXIA TELANGIECTASIA; CELL CYCLE PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; EMBRYO; FEMALE; FIBROBLASTS; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; MALE; MICE; MICE, KNOCKOUT; NEOPLASMS, RADIATION-INDUCED; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0035422201     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. ATM and ATR: Networking cellular responses to DNA damage
2. Cancer risk and the ATM gene: A continuing debate
3. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
4. The many substrates and functions of ATM
5. Enhanced chromatid damage in blood lymphocytes after G2 phase x irradiation, a marker of the ataxia-telangiectasia gene
6. Increased initial levels of chromosome damage and heterogeneous chromosome repair in ataxia telangiectasia heterozygote cells
7. A comparison of the radiosensitivity of lymphocytes from normal donors, cancer patients, individuals with ataxia-telangiectasia, A-T) and A-T heterozygotes
8. Atm haploin-sufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice
9. Role of the ataxia-telangiectasia gene, ATM, in breast cancer. A-T heterozygotes seem to have an increased risk but its size is unknown
10. Breast and other cancers in families with ataxia-telangiectasia
11. Increased risk of breast cancer following irradiation for Hodgkin's disease is not a result of ATM germline mutations
12. Heterozygous germline ATM mutations do not contribute to radiation-associated malignancies after Hodgkin's disease
13. Prevalence of germline truncating mutations in ATM in women with a second breast cancer after radiation therapy for a contralateral tumor
14. The how and why of in vitro oncogenic transformation
15. Atm-deficient mice: A paradigm of ataxia telangiectasia
16. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
17. The analysis of several 2 × 2 contingency tables
18. BRCA1/2 germline mutations: A marker for radioresistance or radiosensitivity?
19. Benefits versus risks from mammography: A critical reassessment