Early and late events induced by polyQ-expanded proteins: Identification of a common pathogenic property of polyQ-expanded proteins

Journal of Biological Chemistry

Volumn 286, Issue 6, 2011, Pages 4727-4741

  Bertoni, Alessandra ^a   Giuliano, Paola ^a   Galgani, Mario ^a   Rotoli, Deborah ^b   Ulianich, Luca ^b   Adornetto, Annagrazia ^a   Santillo, Maria Rosaria ^a   Porcellini, Antonio ^c,d   Avvedimento, Vittorio Enrico ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

^c School of Medicine Federico II University of Naples ^*  (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR REACTIVE OXYGEN SPECIES; CONDITIONAL EXPRESSIONS; DNA DAMAGES; ELECTROCHEMICAL GRADIENTS; ENDOPLASMIC RETICULUM STRESS; HISTONE DEACETYLASES; HUNTINGTIN; LIPID RAFT; MEMBRANE COMPARTMENT; NADPH OXIDASE; PC12 CELLS; PRIMARY MECHANISM; SELECTIVE INHIBITION; STRESS RESPONSE GENES; WILD-TYPE PROTEINS;

AUTOMATIC TELLER MACHINES; DNA; GENES; INTERNET PROTOCOLS; NUCLEIC ACIDS; OXYGEN; TRANSCRIPTION;

PROTEINS;

ATAXIN 2; ATM PROTEIN; HUNTINGTIN; HYBRID PROTEIN; NUCLEIC ACID BINDING PROTEIN; POLYGLUTAMINE; POLYQ EXPANDED PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CYBB PROTEIN, HUMAN; CYBB PROTEIN, MOUSE; CYBB PROTEIN, RAT; DNA BINDING PROTEIN; HD PROTEIN, HUMAN; HISTONE DEACETYLASE; HUNTINGTIN PROTEIN, RAT; HUNTINGTON PROTEIN, MOUSE; MAPK1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NERVE PROTEIN; NUCLEAR PROTEIN; PEPTIDE; PROTEIN P21; PROTEIN SERINE THREONINE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCA2 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FIBROBLAST; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIPID RAFT; MITOCHONDRIAL MEMBRANE; NERVE CELL; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; ANIMAL; CELL STRAIN; GENETICS; METABOLISM; MOUSE; RAT;

ANIMALS; CELL CYCLE PROTEINS; DNA DAMAGE; DNA-BINDING PROTEINS; HISTONE DEACETYLASES; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NADPH OXIDASE; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PC12 CELLS; PEPTIDES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS P21(RAS); RATS; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEINS;

EID: 79952997676     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.156521     Document Type: Article

References (53)

1. Bauer, P. O., and Nukina, N. (2009) J. Neurochem. 110, 1737-1765
2. Davies, S. W., Turmaine, M., Cozens, B. A., DiFiglia, M., Sharp, A. H., Ross, C. A., Scherzinger, E., Wanker, E. E., Mangiarini, L., and Bates, G. P. (1997) Cell 90, 537-548
3. Ross, C. A., and Poirier, M. A. (2004) Nat. Med. 10, S10-S17
4. Gatchel, J. R., and Zoghbi, H. Y. (2005) Nat. Rev. Genet. 6, 743-755
5. Giuliano, P., De Cristofaro, T., Affaitati, A., Pizzulo, G. M., Feliciello, A., Criscuolo, C., De Michele, G., Filla, A., Avvedimento, E. V., and Varrone, S. (2003) Hum. Mol. Genet. 12, 2301-2309
6. Rey, F. E., Cifuentes, M. E., Kiarash, A., Quinn, M. T., and Pagano, P. J. (2001) Circ. Res. 89, 408-414
7. Abramov, A. Y., Canevari, L., and Duchen, M. R. (2004) Biochim. Biophys. Acta 1742, 81-87
8. Svegliati, S., Cancello, R., Sambo, P., Luchetti, M., Paroncini, P., Orlandini, G., Discepoli, G., Paterno, R., Santillo, M., Cuozzo, C., Cassano, S., Avvedimento, E. V., and Gabrielli, A. (2005) J. Biol. Chem. 280, 36474-36482
9. Perillo, B., Ombra, M. N., Bertoni, A., Cuozzo, C., Sacchetti, S., Sasso, A., Chiariotti, L., Malorni, A., Abbondanza, C., and Avvedimento, E. V. (2008) Science 319, 202-206
10. Dotti, C. G., Parton, R. G., and Simons, K. (1991) Nature 349, 158-161
11. Sarnataro, D., Paladino, S., Campana, V., Grassi, J., Nitsch, L., and Zurzolo, C. (2002) Traffic 3, 810-821
12. Quintanilla, R. A., and Johnson, G. V. (2009) Brain Res. Bull. 80, 242-247
13. Livigni, A., Scorziello, A., Agnese, S., Adornetto, A., Carlucci, A., Garbi, C., Castaldo, I., Annunziato, L., Avvedimento, E. V., and Feliciello, A. (2006) Mol. Biol. Cell 17, 263-271
14. Hilditch-Maguire, P., Trettel, F., Passani, L. A., Auerbach, A., Persichetti, F., and MacDonald, M. E. (2000) Hum. Mol. Genet 9, 2789-2797
15. Reiner, A., Dragatsis, I., Zeitlin, S., and Goldowitz, D. (2003) Mol. Neurobiol. 28, 259-276
16. Atwal, R. S., Xia, J., Pinchev, D., Taylor, J., Epand, R. M., and Truant, R. (2007) Hum. Mol. Genet. 16, 2600-2615
17. Noh, J. Y., Lee, H., Song, S., Kim, N. S., Im, W., Kim, M., Seo, H., Chung, C. W., Chang, J. W., Ferrante, R. J., Yoo, Y. J., Ryu, H., and Jung, Y. K. (2009) J. Biol. Chem. 284, 11318-11325
18. Back, S. H., Schröder, M., Lee, K., Zhang, K., and Kaufman, R. J. (2005) Methods 35, 395-416
19. Diatchuk, V., Lotan, O., Koshkin, V., Wikstroem, P., and Pick, E. (1997) J. Biol. Chem. 272, 13292-13301
20. Sim, S., Yong, T. S., Park, S. J., Im, K. I., Kong, Y., Ryu, J. S., Min, D. Y., and Shin, M. H. (2005) J. Immunol. 174, 4279-4288
21. Illuzzi, J., Yerkes, S., Parekh-Olmedo, H., and Kmiec, E. B. (2009) J. Neurosci. Res. 87, 733-747
22. Cowan, C. M., and Raymond, L. A. (2006) Curr. Top Dev. Biol. 75, 25-71
23. McCampbell, A., Taye, A. A., Whitty, L., Penney, E., Steffan, J. S., and Fischbeck, K. H. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 15179-15184
24. Steffan, J. S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B. L., Kazantsev, A., Schmidt, E., Zhu, Y. Z., Greenwald, M., Kurokawa, R., Housman, D. E., Jackson, G. R., Marsh, J. L., and Thompson, L. M. (2001) Nature 413, 739-743
25. Storici, F., Bebenek, K., Kunkel, T. A., Gordenin, D. A., and Resnick, M. A. (2007) Nature 447, 338-341
26. Koshikawa, N., Hayashi, J., Nakagawara, A., and Takenaga, K. (2009) J. Biol. Chem. 284, 33185-33194
27. Guo, C., Mi, J., Brautigan, D. L., and Larner, J. M. (2007) Cell. Signal. 19, 504-510
28. Lefrançois-Martinez, A. M., Bertherat, J., Val, P., Tournaire, C., Gallo-Payet, N., Hyndman, D., Veyssière, G., Bertagna, X., Jean, C., and Martinez, A. (2004) J. Clin. Endocrinol. Metab. 89, 3010-3019
29. Wyttenbach, A., Swartz, J., Kita, H., Thykjaer, T., Carmichael, J., Bradley, J., Brown, R., Maxwell, M., Schapira, A., Orntoft, T. F., Kato, K., and Rubinsztein, D. C. (2001) Hum. Mol. Genet. 10, 1829-1845
30. Hu, H., McCaw, E. A., Hebb, A. L., Gomez, G. T., and Denovan-Wright, E. M. (2004) Eur. J. Neurosci. 20, 3351-3363
31. Olofsson, B. A., Kelly, C. M., Kim, J., Hornsby, S. M., and Azizkhan-Clifford, J. (2007) Mol. Cancer Res. 5, 1319-1330
32. Iwahori, S., Yasui, Y., Kudoh, A., Sato, Y., Nakayama, S., Murata, T., Isomura, H., and Tsurumi, T. (2008) Cell. Signal. 20, 1795-1803
33. Cui, L., Jeong, H., Borovecki, F., Parkhurst, C. N., Tanese, N., and Krainc, D. (2006) Cell 127, 59-69
34. Shanware, N. P., Trinh, A. T., Williams, L. M., and Tibbetts, R. S. (2007) J. Biol. Chem. 282, 6283-6291
35. Fuhler, G. M., Blom, N. R., Coffer, P. J., Drayer, A. L., and Vellenga, E. (2007) J. Leukoc. Biol. 81, 449-457
36. Naslavsky, N., Shmeeda, H., Friedlander, G., Yanai, A., Futerman, A. H., Barenholz, Y., and Taraboulos, A. (1999) J. Biol. Chem. 274, 20763-20771
37. Simons, K., and Ikonen, E. (1997) Nature 387, 569-572
38. Brown, D. A., and London, E. (1998) Annu. Rev. Cell Dev. Biol. 14, 111-136
39. Hunter, T. (2000) Cell 100, 113-127
40. Simons, K., and Gruenberg, J. (2000) Trends Cell Biol. 10, 459-462
41. Vacca, F., Amadio, S., Sancesario, G., Bernardi, G., and Volonté, C. (2004) J. Neurosci. Res. 76, 653-661
42. Hilenski, L. L., Clempus, R. E., Quinn, M. T., Lambeth, J. D., and Griendling, K. K. (2004) Arterioscler. Thromb. Vasc. Biol. 24, 677-683
43. Serù, R., Mondola, P., Damiano, S., Svegliati, S., Agnese, S., Avvedimento, E. V., and Santillo, M. (2004) J. Neurochem. 91, 613-622
44. Jin, S., Zhang, Y., Yi, F., and Li, P. L. (2008) Arterioscler. Thromb. Vasc. Biol. 28, 485-490
45. Bence, N. F., Sampat, R. M., and Kopito, R. R. (2001) Science 292, 1552-1555
46. Hsiao, H. Y., and Chern, Y. (2010) Mol. Neurobiol 41, 248-255
47. Calabresi, P., Centonze, D., Pisani, A., Sancesario, G., Gubellini, P., Marfia, G. A., and Bernardi, G. (1998) Ann. Neurol 43, 586-597
48. Bedard, K., and Krause, K. H. (2007) Physiol. Rev. 87, 245-313
49. Bedard, K., Lardy, B., and Krause, K. H. (2007) Biochimie 89, 1107-1112
50. Gidalevitz, T., Ben-Zvi, A., Ho, K. H., Brignull, H. R., and Morimoto, R. I. (2006) Science 311, 1471-1474
51. Ishii, T., Sakurai, T., Usami, H., and Uchida, K. (2005) Biochemistry 44, 13893-13901
52. Das, R., Ponnappan, S., and Ponnappan, U. (2007) Free Radic. Biol. Med. 42, 541-551
53. Bennett, E. J., Shaler, T. A., Woodman, B., Ryu, K. Y., Zaitseva, T. S., Becker, C. H., Bates, G. P., Schulman, H., and Kopito, R. R. (2007) Nature 448, 704-708