Anthocyanins in corn: a wealth of genes for human health

Planta

Volumn 240, Issue 5, 2014, Pages 901-911

  Petroni, Katia ^a   Pilu, Roberto ^a   Tonelli, Chiara ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Chronic diseases; Functional food; Maize; Model food; Nutrigenomics

Indexed keywords

ANIMALIA; ZEA MAYS;

ANTHOCYANIN;

ANIMAL; ANIMAL FOOD; BIOSYNTHESIS; BREEDING; CHRONIC DISEASE; CROP; GENETICS; HUMAN; MAIZE; METABOLISM; PROCEDURES; TRANSGENIC PLANT;

ANIMAL FEED; ANIMALS; ANTHOCYANINS; BIOSYNTHETIC PATHWAYS; BREEDING; CHRONIC DISEASE; CROPS, AGRICULTURAL; HUMANS; PLANTS, GENETICALLY MODIFIED; ZEA MAYS;

EID: 84919439071     PISSN: 00320935     EISSN: 14322048     Source Type: Journal    
DOI: 10.1007/s00425-014-2131-1     Document Type: Review

References (72)

1. Andersen ØM, Fossen T (1995) Anthocyanins with an unusual acylation pattern from stem of Allium victorialis. Phytochemistry 40:1809–1812
2. Berman J, Zhu C, Perez-Massot E, Arjo´ G, Zorrilla-Lopez U, Masip G, Banakar R, Sanahuja G, Farre´ G, Miralpeix B, Bai C, Vamvaka E, Sabalza M, Twyman RM, Bassie´ L, Capell T, Christou P (2013) Can the world afford to ignore biotechnology solutions that address food insecurity? Plant Mol Biol 83:5–19
3. Brandolini A, Brandolini A (2009) Maize introduction, evolution and diffusion in Italy. Maydica 54:233–242
4. Butelli E, Titta L, Giorgio M, Mock HP, Matros A, Peterek S, Schijlen EGWM, Hall RD, Bovy AG, Luo J, Martin C (2008) Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Nat Biotechnol 26:1301–1308
5. Carey CC, Strahle JT, Selinger DA, Chandler VL (2004) Mutations in the pale aleurone color1 regulatory gene of the Zea mays anthocyanin pathway have distinct phenotypes relative to the functionally similar TRANSPARENT TESTA GLABRA1 gene in Arabidopsis thaliana. Plant Cell 16:450–464
6. Cassidy A, Mukamal KJ, Liu L, Franz M, Eliassen AH, Rimm EB (2013) High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation 127:188–196
7. Cevallos-Casals BA, Cisneros-Zevallos L (2003) Stoichiometric and kinetic studies of phenolic antioxidants from Andean purple corn and red-fleshed sweet potato. J Agr Food Chem 51:3313–3319
8. Chandler VL, Radicella JP, Robbins Chen JC, Turks D (1989) Two regulatory genes of the maize anthocyanin pathway are homologous: isolation of B utilizing R genomic sequences. Plant Cell 1:1175–1183
9. Chapman JS, Steele FM, Eggett DL, Johnston NP, Dunn ML (2010) Stability of native folate and added folic acid in micronutrient-fortified corn masa and tortillas. Cereal Chem 87:434–438
10. Cocciolone SM, Cone KC (1993) Pl-Bh, an anthocyanin regulatory gene of maize that leads to variegated pigmentation. Genetics 135:575–588
11. Dooner HK, Robbins TP, Jorgensen RA (1991) Genetic and developmental control of anthocyanin biosynthesis. Annu Rev Genet 25:173–199
12. Escribano-Bailόn MT, Santos-Buelga C, Rivas-Gonzalo JC (2004) Anthocyanins in cereals. J Chromatogr A 1054:129–141
13. Ferreyra ML, Rius S, Emiliani J, Pourcel L, Feller A, Morohashi K et al (2010) Cloning and characterization of a UV-B-inducible maize flavonol synthase. Plant J 62:77–91
14. Food and Agriculture Organization of the United Nations (2009) Crops Production. http://faostat.fao.org/site/567/DesktopDefault.aspx?PageID=567. Accessed 20 April 2011
15. Fossen T, Slimestad R, Andersen OM (2001) Anthocyanins from maize (Zea mays) and reed canary grass (Phalaris arundinacea). J Agric Food Chem 49:2318–2321
16. Fossen T, Slimestad R, Øvstedal DO, Andersen ØM (2002) Anthocyanins of grasses. Biochem Syst Ecol 30:855–864
17. Fukamachi K, Imada T, Ohshima Y, Xu J, Tsuda H (2008) Purple corn color suppresses Ras protein level and inhibits 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in the rat. Cancer Sci 99:1841–1846
18. Giusti MM, Wrolstad RE (2003) Acylated anthocyanins from edible sources and their applications in food systems. Biochem Eng J 14:217–225
19. Goff SA, Cone KC, Chandler VL (1992) Functional analysis of the transcriptional activator encoded by the maize B gene: evidence for a direct functional interaction between two classes of regulatory proteins. Genes Dev 6:864–875
20. Grotewold E, Drummond BJ, Bowen B, Peterson T (1994) The myb-homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subset. Cell 76:543–553
21. Hagiwara A, Miyashita K, Nakanishi T, Sano M, Tamano S, Kadota T, Koda T, Nakamura M, Imaida K, Ito N, Shirai T (2001) Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine. Cancer Lett 171:17–25
22. Hollick JB, Patterson GI, Coe EH Jr, Cone KC, Chandler VL (1995) Allelic interactions heritably alter the activity of a metastable maize pl1 allele. Genetics 141:709–719
23. Humble CG, Malarcher AM, Tyroler HA (1993) Dietary fiber and coronary heart disease in middle-aged hypercholesterolemic men. Am J Prev Med 9:197–202
24. Jennings A, Welch AA, Spector T, Macgregor A, Cassidy A (2014) Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. J Nutr 144:202–208
25. Juvik JA, Yousef GG, Han TH, Tadmor Y, Azanza F, Tracy WF, Barzur A, Rocheford TR (2003) QTL influencing kernel chemical composition and seedling stand establishment in sweet corn with the shrunken2 and sugary enhancer1 endosperm mutations. J Am Soc Hort Sci 128:864–875
26. Kang MK, Li J, Kim JL, Gong JH, Kwak SN, Park JH, Lee JY, Lim SS, Kang YH (2012) Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration. Am J Physiol Renal Physiol 303:F1060–F1069
27. Kang MK, Lim SS, Lee JY, Yeo KM, Kang YH (2013) Anthocyanin-rich purple corn extract inhibit diabetes-associated glomerular angiogenesis. PLoS One 8:e79823
28. Karababa E (2006) Physical properties of popcorn kernels. J Food Eng 72:100–107
29. Kong Q, Pattanaik S, Feller A, Werkman JR, Chai C, Wang Y et al (2012) Regulatory switch enforced by basic helix-loop-helix and ACT-domain mediated dimerizations of the maize transcription factor R. Proc Natl Acad Sci USA 109:E2091–E2097
30. Lago C, Landoni M, Cassani E, Doria E, Nielsen E, Pilu R (2013) Study and characterization of a novel functional food: purple popcorn. Mol Breeding 31:575–585
31. Lago C, Cassani E, Zanzi C, Landoni M, Trovato R, Pilu R (2014) Development and study of a maize cultivar rich in anthocyanins: coloured polenta, a new functional food. Plant Breeding. doi:10.1111/pbr.12153
32. Li J, Kang MK, Kim JK, Kim JL, Kang SW, Lim SS et al (2012a) Purple corn anthocyanins retard diabetes-associated glomerulosclerosis in mesangial cells and db/db mice. Eur J Nutr 51:961–973
33. Li J, Lim SS, Lee JY, Kim JK, Kang SW, Kim JL et al (2012b) Purple corn anthocyanins dampened high-glucose-induced mesangial fibrosis and inflammation: possible renoprotective role in diabetic nephropathy. J Nutr Biochem 23:320–331
34. Liu S, Stampfer MJ, Hu FB, Giovannucci E, Rimm E, Manson JE et al (1999) Whole-grain consumption and risk of coronary heart disease: results from the Nurses’ Health Study. Am J Clin Nutr 70:412–419
35. Long N, Suzuki S, Sato S, Naiki-Ito A, Sakatani K, Shirai T, Takahashi S (2013) Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways. Cancer Sci 104:298–303
36. Martin C, Butelli E, Petroni K, Tonelli C (2011) How can research on plants contribute to promoting human health? Plant Cell 23:1685–1699
37. Martin C, Zhang Y, Tonelli C, Petroni K (2013) Plants, diet, and health. Annu Rev Plant Biol 64:19–46
38. McCarty DR, Carson CB, Stinard PS, Robertson DS (1989) Molecular analysis of viviparous-1: an abscisic acid-insensitive mutant of maize. Plant Cell 1:523–532
39. McCullough ML, Feskanich D, Stampfer MJ, Giovannucci EL, Rimm EB, Hu FB et al (2002) Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am J Clin Nutr 76:1261–1271
40. Meyer KA, Kushi LH, Jacobs DR Jr, Slavin J, Sellers TA, Folsom AR (2000) Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr 71:921–930
41. Muller M, Kersten S (2003) Nutrigenomics: goals and strategies. Nat Rev Genet 4:315–322
42. Nakayama M, Koshioka M, Shibata M, Hiradate S, Sugie H, Yamaguchi M (1997) Identification of cyaniding 3-O-(3″,6″-O-dimalonyl-β-glucopyranoside) as a flower pigment of chrysanthemum (Dendranthema grandiflorum). Biosci Biotechnol Biochem 61:1607–1608
43. Nakayama T, Suzuki H, Nishino T (2003) Anthocyanin acyltransferases: specificities, mechanism, phylogenetics, and applications. J Mol Catal B Enzym 23:117–132
44. Panzeri D, Cesari V, Toschi I, Pilu R (2011) Seed calorific value in different maize genotypes. Energy Sources Part A Recover Utilization Environ Effects 33:1700–1705
45. Petroni K, Tonelli C (2011) Recent advances on the regulation of anthocyanin synthesis in reproductive organs. Plant Sci 181:219–229
46. Petroni K, Cominelli E, Consonni G, Gusmaroli G, Gavazzi G, Tonelli C (2000) The developmental expression of the maize regulatory gene Hopi determines germination-dependent anthocyanin accumulation. Genetics 155:323–336
47. Pilu R (2011) Paramutation: just a curiosity or fine tuning of gene expression in the next generation? Curr Genomics 12:298–306
48. Pilu R, Piazza P, Petroni K, Ronchi A, Martin C, Tonelli C (2003) pl-bol3, a complex allele of the anthocyanin regulatory pl1 locus that arose in a naturally occurring maize population. Plant J 36:510–521
49. Pilu R, Cassani E, Sirizzotti A, Petroni K, Tonelli C (2011) Effect of flavonoid pigments on the accumulation of fumonisin B1 in the maize kernel. J Appl Genet 52:145–152
50. Procissi A, Dolfini S, Ronchi A, Tonelli C (1997) Light-dependent spatial and temporal expression of pigment regulatory genes in developing maize seeds. Plant Cell 9:1547–1557
51. Renaud S, de Lorgeril M (1992) Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339:1523–1526
52. Rodriguez-Amaya DB, Kimura M, Godoy HT, Amaya-Farfan J (2008) Updated Brazilian database on food carotenoids: factors affecting carotenoid composition. J Food Compos Anal 21:445–463
53. Sainz MB, Grotewold E, Chandler VL (1997) Evidence for direct activation of an anthocyanin promoter by the maize C1 protein and comparison of DNA binding by related Myb domain proteins. Plant Cell 9:611–625
54. Saito D, Maeshima Y, Nasu T, Yamasaki H, Tanabe K, Sugiyama H, Sonoda H, Sato Y, Makino H (2011) Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis. Am J Physiol Renal Physiol 300:F873–F886
55. Schwarz M, Hillebrand S, Habben S, Degenhardt A, Winterhalter P (2003) Application of high-speed countercurrent chromatography to the large-scale isolation of anthocyanins. Biochem Eng J 14:179–189
56. Sebrell WH (1981) History of pellagra. Federation Proc 40:1520–1522
57. Selinger DA, Chandler VL (1999) A mutation in the pale aleurone color1 gene identifies a novel regulator of the maize anthocyanin pathway. Plant Cell 11:5–14
58. Sharma M, Cortes-Cruz M, Ahern KR, McMullen M, Brutnell TP, Chopra S (2011) Identification of the Pr1 gene product completes the anthocyanin biosynthesis pathway of maize. Genetics 188:69–79
59. Sharma M, Chai C, Morohashi K, Grotewold E, Snook ME, Chopra S (2012) Expression of flavonoid 3′-hydroxylase is controlled by P1, the regulator of 3-deoxyflavonoid biosynthesis in maize. BMC Plant Biol 12:196
60. Suzuki H, Nakayama T, Yamaguchi M-A, Nishino T (2004) cDNA cloning and characterization of two Dendranthema x morifolium anthocyanin malonyltransferases with different functional activities. Plant Sci 166:89–96
61. Tonelli C, Consonni G, Dolfini SF, Dellaporta SL, Viotti A, Gavazzi G (1991) Genetic and molecular analysis of Sn, a light-inducible, tissue specific regulatory gene in maize. Mol Gen Genet 225:401–410
62. Toufektsian MC, de Lorgeril M, Nagy N, Salen P, Donati MB, Giordano L et al (2008) Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury. J Nutr 138:747–752
63. Toufektsian MC, Salen P, Laporte F, Tonelli C, de Lorgeril M (2011) Dietary flavonoids increase plasma very long-chain (n-3) fatty acids in rats. J Nutr 141:37–41
64. Tsuda T (2012) Dietary anthocyanin-rich plants: biochemical basis and recent progress in health benefits studies. Mol Nutr Food Res 56:159–170
65. Tsuda T, Horio F, Uchida K, Aoki H, Osawa T (2003) Dietary cyanidin 3-O-β-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 133:2125–2130
66. Villalpando S (2004) Tortilla fortification working group meeting. El problema de la biodisponibilidad de hierro en harina de maiz nixtamalizada. National Institute of Public Health, Mexico City
67. Werner MS (1997) Encyclopedia of Mexico: history, society and culture. Fitzroy Dearborn, Chicago
68. Winkel-Shirley B (2002) Biosynthesis of flavonoids and effects of stress. Curr Opin Plant Biol 5:218–223
69. Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL (2006) Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 54:4069–4075
70. Zent R, Pozzi A (2007) Angiogenesis in diabetic nephropathy. Semin Nephrol 27:161–171
71. Zeppa G, Bertolino M, Rolle L (2012) Quantitative descriptive analysis of Italian polenta produced with different corn cultivars. J Sci Food Agr 92:412–417
72. Ziegler KE, Ashman RB, White GM, Wysong DS (1984) Popcorn production and marketing. National corn handbook, NCH-5, Purdue University, West Lafayette, Indiana