Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine

Cancer Letters

Volumn 171, Issue 1, 2001, Pages 17-25

  Hagiwara, Akihiro ^a   Miyashita, Kayoko ^a,b   Nakanishi, Takumi ^a,b   Sano, Masashi ^a   Tamano, Seiko ^a   Kadota, Tadaomi ^a   Koda, Takatoshi ^c   Nakamura, Mikio ^c   Imaida, Katsumi ^b   Ito, Nobuyuki ^d   Shirai, Tomoyuki ^b  

^a Daiyukai Research Institute for Medical Science   (Japan)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^c SAN EI GEN F F I INC   (Japan)

^d NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

1,2 Dimethylhydrazine; 2 Amino 1 methyl 6 phenylimidazo 4,5 b pyridine; Anthocyanin; Colorectal carcinogenesis; F344 rats; Inhibition; Purple corn color

Indexed keywords

1,2 DIMETHYLHYDRAZINE; 2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; ANTHOCYANIN; FOOD DYE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CARCINOGENESIS; CLINICAL FEATURE; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORN; FOOD INTAKE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

1,2-DIMETHYLHYDRAZINE; ADENOCARCINOMA; ADENOCARCINOMA, MUCINOUS; ADENOMA; ADMINISTRATION, ORAL; ANIMALS; ANTHOCYANINS; ANTICARCINOGENIC AGENTS; BODY WEIGHT; CARCINOGENS; COCARCINOGENESIS; COLONIC DISEASES; COLORECTAL NEOPLASMS; DRUG ADMINISTRATION SCHEDULE; DRUG SCREENING ASSAYS, ANTITUMOR; GLUCOSIDES; HYPERPLASIA; IMIDAZOLES; INTESTINAL MUCOSA; JEJUNAL NEOPLASMS; MALE; PRECANCEROUS CONDITIONS; PROSTATIC NEOPLASMS; RATS; RATS, INBRED F344; SEMINAL VESICLES; ZEA MAYS;

EID: 0035964461     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00510-9     Document Type: Article

References (33)

1. Anthocyanins
2. 13-Week oral toxicity study of pigments extracted from the purple sweet potato in F344/DuCrj rats
3. In vitro effect of vegetable and fruit juices on the mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline and 2-amino-3,8-methylimidazo[4,5-f]quinoxaline
4. Modifying actions of solvent extracts from fruit and vegetable residues on 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoxaline (MeIQx) induced mutagenesis in Salmonella typhimurium TA 98
5. Antimutagenicity of sweet potato (Ipomoea batas) roots
6. Antitumor effect of hydrolyzed anthocyanin from grape rinds and red rice
7. Antitumor effect of anthocyanin fractions extracted from red soybeans and red beans in vitro and in vivo
8. Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis in rats
9. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
10. The prostate: A target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods
11. Occurrence, identification, and potential mutagenicity of heterocyclic amines in cooked food
12. Cancer risk of heterocyclic amines in cooked foods: An analysis and implications for research
13. Food-derived mutagens and carcinogens
14. Experimental intestinal cancer research with special reference to human pathology
15. Rodent models for carcinoma of the colon
16. Modification by five antioxidants of 1,2-dimethylhydrazine-initiated colon carcinogenesis in F344 rats
17. Prevention by 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ) of PhIP-associated intestinal carcinogenesis in rats pretreated with DMH
18. Analysis of anthocyanin colors in food
19. Proliferative lesions of the intestine, salivary glands, oral cavity, and esophagus in rats
20. Role of aberrant crypt foci in understanding the pathogenesis of colon cancer
21. Aberrant crypt foci: A review
22. Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate
23. Influence of different diets on development of DMH-induced aberrant crypt foci and colon tumor incidence in Wistar rats
24. Histomorphological and immunohistochemical characterization of colonic aberrant crypt foci in rats: Relationship to growth factor expression
25. Chemoprevention of colorectal cancer
26. Chemoprevention of gastrointestinal cancer
27. Preclinical drug development paradigms for chemopreventives
28. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels
29. Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent
30. Polyethylene-glycol, a potent suppressor of azoxymethane-induced aberrant crypt foci in rats
31. Consistent and fast inhibition of colon carcinogenesis by polyethylene glycol in mice and rats given various carcinogens
32. Inhibition of azoxymethane initiated colon tumor and aberrant crypt foci development by bovine lactoferrin administration in F344 rats
33. Assessment of the human exposure to heterocyclic amines