Purple corn color suppresses Ras protein level and inhibits 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in the rat

Cancer Science

Volumn 99, Issue 9, 2008, Pages 1841-1846

  Fukamachi, Katsumi ^a   Imada, Takafumi ^a,b   Ohshima, Yutaka ^a,c   Xu, Jiegou ^a   Tsuda, Hiroyuki ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b SAN EI GEN F F I INC   (Japan)

^c CHEMICALS EVALUATION AND RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ANTHOCYANIN; ANTINEOPLASTIC AGENT; BETA ACTIN; CASPASE 3; CYANIDIN 3 GLUCOSIDE; H RAS PROTEIN; K RAS PROTEIN; ONCOPROTEIN; PROTEIN N RAS; PURPLE CORN COLOR; RAS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CANCER PREVENTION; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFICACY; DRUG SCREENING; ENZYME ACTIVATION; FEMALE; GENE MUTATION; NONHUMAN; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE N RAS; PRIORITY JOURNAL; RAT;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTHOCYANINS; ANTICARCINOGENIC AGENTS; APOPTOSIS; CARCINOGENS; CASPASE 3; DOWN-REGULATION; FEMALE; GLUCOSIDES; MAMMARY NEOPLASMS, EXPERIMENTAL; RAS PROTEINS; RATS; ZEA MAYS;

EID: 50149087894     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2008.00895.x     Document Type: Article

References (53)

1. Edenharder R, Kurz P, John K, Burgard S, Seeger K. In vitro effect of vegetable and fruit juices on the mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,4-dimethylimidazo [4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Food Chem Toxicol 1994; 32: 443-59.
2. Edenharder R, Leopold C, Kries M. Modifying actions of solvent extracts from fruit and vegetable residues on 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoxaline (MeIQx) induced mutagenesis in Salmonella typhimurium TA 98. Mutat Res 1995; 341: 303-18.
3. Yoshimoto M, Okuno S, Yoshinaga M, Yamakawa O, Yamaguchi M, Yamada J. Antimutagenicity of sweetpotato (Ipomoea batatas) Roots Biosci Biotechnol Biochem 1999; 63: 537-41.
4. Hagiwara A, Miyashita K, Nakanishi T et al. Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine. Cancer Lett 2001; 171: 17-25.
5. Hagiwara A, Yoshino H, Ichihara T et al. Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine. J Toxicol Sci 2002; 27: 57-68.
6. Jung KJ, Wallig MA, Singletary KW. Purple grape juice inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 2006; 233: 279-88.
7. Cooke D, Schwarz M, Boocock D et al. Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis -relationship with tissue anthocyanin levels. Int J Cancer 2006; 119: 2213-20.
8. Nomoto H, Iigo M, Hamada H, Kojima S, Tsuda H. Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis. Nutr Cancer 2004; 49: 81-8.
9. Iigo M, Shimamura M, Hirano S, Tokutake S, Alexander DB, Tsuda H. Cancer prevention and anti-metastatic effects by oral administration of procyanidins. In: Tanaka T, ed. Cancer: Disease Progression and Chemoprevention. Kerala, India: Research Signpost, 2007; 277-97.
10. Tsuda T, Ohshima K, Kawakishi S, Osawa T. Oxidation products of cyanidin 3-O-beta-D-glucoside with a free radical initiator. Lipids 1996; 31: 1259-63.
11. Tsuda T, Horio F, Osawa T. Absorption and metabolism of cyanidin 3-O-beta-D-glucoside in rats. FEBS Lett 1999; 449: 179-82.
12. Asamoto M, Ochiya T, Toriyama-Baba H et al. Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N -methyl- N -nitrosourea mammary carcinogenesis. Carcinogenesis 2000; 21: 243-9.
13. Tsuda H, Asamoto M, Ochiya T et al. High susceptibility of transgenic rats carrying the human c-Ha-ras proto-oncogene to chemically-induced mammary carcinogenesis. Mutat Res 2001; 477: 173-82.
14. Tsuda H, Fukamachi K, Ohshima Y et al. High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: A cancer-prone animal model. Cancer Sci 2005; 96: 309-16.
15. Ota T, Asamoto M, Toriyama-Baba H et al. Transgenic rats carrying copies of the human c-Ha-ras proto-oncogene exhibit enhanced susceptibility to N -butyl- N -(4-hydroxybutyl) nitrosamine bladder carcinogenesis. Carcinogenesis 2000; 21: 1391-6.
16. Park CB, Fukamachi K, Takasuka N et al. Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats by treatment with 7,12-dimethylbenz[a]anthracene followed by 12- O -tetradecanoylphorbol 13-acetate. Cancer Sci 2004; 95: 205-10.
17. Suzuki R, Kohno H, Suzui M et al. An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: Its potential use for preclinical chemoprevention studies. Carcinogenesis 2006; 27: 619-30.
18. Matsuoka Y, Fukamachi K, Hamaguchi T et al. Rapid emergence of mammary preneoplastic and malignant lesions in human c-Ha-ras proto-oncogene transgenic rats: Possible application for screening of chemopreventive agents. Toxicol Pathol 2003; 31: 632-7.
19. Ohnishi T, Fukamachi K, Ohshima Y et al. Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogens. Toxicol Pathol 2007; 35: 436-43.
20. Fukamachi K, Han BS, Kim CK et al. Possible enhancing effects of atrazine and nonylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats. Cancer Sci 2004; 95: 404-10.
21. Hamaguchi T, Matsuoka Y, Bechberger J et al. Establishment of an apoptosis-sensitive rat mammary carcinoma cell line with a mutation in the DNA-binding region of p53. Cancer Lett 2006; 232: 279-88.
22. Asamoto M, Toriyama-Baba H, Ohnishi T et al. Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N -nitrosomethylbenzylamine induction of esophageal tumorigenesis. Jpn J Cancer Res 2002; 93: 744-51.
23. Ueda S, Fukamachi K, Matsuoka Y et al. Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas. Carcinogenesis 2006; 27: 2497-510.
24. Nabae K, Hayashi SM, Kawabe M et al. A 90-day oral toxicity study of purple corn color, a natural food colorant, in F344 rats. Food Chem Toxicol 2008; 46: 774-80.
25. Ding M, Feng R, Wang SY et al. Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. J Biol Chem 2006; 281: 17359-68.
26. Mori H, Tanaka T, Sugie S et al. Chemoprevention by naturally occurring and synthetic agents in oral, liver, and large bowel carcinogenesis. J Cell Biochem Suppl 1997; 27: 35-41.
27. Hirose Y, Tanaka T, Kawamori T et al. Chemoprevention of urinary bladder carcinogenesis by the natural phenolic compound protocatechuic acid in rats. Carcinogenesis 1995; 16: 2337-42.
28. Tanaka T, Kawamori T, Ohnishi M, Okamoto K, Mori H, Hara A. Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary protocatechuic acid during initiation and postinitiation phases. Cancer Res 1994; 54: 2359-65.
29. Tanaka T, Kojima T, Kawamori T, Yoshimi N, Mori H. Chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis by a simple phenolic acid protocatechuic acid in rats. Cancer Res 1993; 53: 2775-9.
30. Tanaka T, Kojima T, Suzui M, Mori H. Chemoprevention of colon carcinogenesis by the natural product of a simple phenolic compound protocatechuic acid: Suppressing effects on tumor development and biomarkers expression of colon tumorigenesis. Cancer Res 1993; 53: 3908-13.
31. Svegliati S, Cancello R, Sambo P et al. Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts. J Biol Chem 2005; 280: 36474-82.
32. Kahkonen MP, Heinonen M. Antioxidant activity of anthocyanins and their aglycons. J Agric Food Chem 2003; 51: 628-33.
33. Tsuda T, Horio F, Osawa T. The role of anthocyanins as an antioxidant under oxidative stress in rats. Biofactors 2000; 13: 133-9.
34. Tsuda T, Horio F, Osawa T. Dietary cyanidin 3- O -beta- d -glucoside increases ex vivo oxidation resistance of serum in rats. Lipids 1998; 33: 583-8.
35. Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E et al. Suppression of c-Myc-induced apoptosis by Ras signalling through PI (3) K and PKB. Nature 1997; 385: 544-8.
36. Peli J, Schroter M, Rudaz C et al. Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas. Embo J 1999; 18: 1824-31.
37. Kazama H, Yonehara S. Oncogenic K-Ras and basic fibroblast growth factor prevent Fas-mediated apoptosis in fibroblasts through activation of mitogen-activated protein kinase. J Cell Biol 2000; 148: 557-66.
38. Ries S, Biederer C, Woods D et al. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell 2000; 103: 321-30.
39. Irani K, Xia Y, Zweier JL et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 1997; 275: 1649-52.
40. Vafa O, Wade M, Kern S et al. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability. Mol Cell 2002; 9: 1031-44.
41. Jura N, Scotto-Lavino E, Sobczyk A, Bar-Sagi D. Differential modification of Ras proteins by ubiquitination. Mol Cell 2006; 21: 679-87.
42. Bos JL. ras oncogenes in human cancer: A review. Cancer Res 1989; 49: 4682-9.
43. Bieche I, Lidereau R. Genetic alterations in breast cancer. Genes Chromosomes Cancer 1995; 14: 227-51.
44. Miyakis S, Sourvinos G, Spandidos DA. Differential expression and mutation of the ras family genes in human breast cancer. Biochem Biophys Res Commun 1998; 251: 609-12.
45. Knepper JE, Kittrell FS, Medina D, Butel JS. Spontaneous progression of hyperplastic outgrowths of the D1 lineage to mammary tumors: Expression of mouse mammary tumor virus and cellular proto-oncogenes. Mol Carcinog 1989; 1: 229-38.
46. Hamaguchi T, Matsuoka Y, Kawaguchi H et al. Terminal endbuds and acini as the respective major targets for chemical and sporadic carcinogenesis in the mammary glands of human c-Ha-ras protooncogene transgenic rats. Breast Cancer Res Treat 2004; 83: 43-56.
47. Macaluso M, Russo G, Cinti C, Bazan V, Gebbia N, Russo A. Ras family genes: An interesting link between cell cycle and cancer. J Cell Physiol 2002; 192: 125-30.
48. Hou DX, Kai K, Li JJ et al. Anthocyanidins inhibit activator protein 1 activity and cell transformation: Structure-activity relationship and molecular mechanisms. Carcinogenesis 2004; 25: 29-36.
49. Zi X, Grasso AW, Kung HJ, Agarwal R. A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells. Cancer Res 1998; 58: 1920-9.
50. Gould MN, Moore CJ, Zhang R, Wang B, Kennan WS, Haag JD. Limonene chemoprevention of mammary carcinoma induction following direct in situ transfer of v-Ha-ras. Cancer Res 1994; 54: 3540-3.
51. Asamoto M, Ota T, Toriyama-Baba H, Hokaiwado N, Naito A, Tsuda H. Mammary carcinomas induced in human c-Ha-ras proto-oncogene transgenic rats are estrogen-independent, but responsive to d -limonene treatment. Jpn J Cancer Res 2002; 93: 32-5.
52. Chin L, Tam A, Pomerantz J et al. Essential role for oncogenic Ras in tumour maintenance. Nature 1999; 400: 468-72.
53. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267: 1456-62.