메뉴 건너뛰기




Volumn 20, Issue 4, 2015, Pages 796-813

Nutritional and regulatory roles of leucine in muscle growth and fat reduction

Author keywords

AMPK; Energy partitioning; Leucine; Mitochondrial biogenesis; mTOR; Review

Indexed keywords

ANIMALIA; EUKARYOTA; MAMMALIA;

EID: 84918833454     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4338     Document Type: Review
Times cited : (61)

References (135)
  • 3
  • 5
    • 68149162719 scopus 로고    scopus 로고
    • Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes
    • X Sun, M B Zemel: Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes. Nutr Metab (Lond) 6, 26 (2009) DOI: 10.1186/1743-7075-6-26
    • (2009) Nutr Metab (Lond) , vol.6 , pp. 26
    • Sun, X.1    Zemel, M.B.2
  • 6
    • 78449289396 scopus 로고    scopus 로고
    • Supplementing L-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs
    • Y L Yin, K Yao, Z J Liu, M Gong, Z Ruan, D Deng, B E Tan, Z Q Liu, G Y Wu: Supplementing L-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs. Amino Acids 39: 1477-1486 (2010) DOI: 10.1007/s00726-010-0612-5
    • (2010) Amino Acids , vol.39 , pp. 1477-1486
    • Yin, Y.L.1    Yao, K.2    Liu, Z.J.3    Gong, M.4    Ruan, Z.5    Deng, D.6    Tan, B.E.7    Liu, Z.Q.8    Wu, G.Y.9
  • 7
    • 0016824053 scopus 로고
    • Leucine. A possible regulator of protein turnover in muscle
    • M G Buse, S S Reid: Leucine. A possible regulator of protein turnover in muscle. J Clin Invest 56(5), 1250-1261 (1975) DOI: 10.1172/JCI108201
    • (1975) J Clin Invest , vol.56 , Issue.5 , pp. 1250-1261
    • Buse, M.G.1    Reid, S.S.2
  • 8
    • 0035090371 scopus 로고    scopus 로고
    • Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine
    • doi not found
    • J C Anthony, T G Anthony, S R Kimball, L S Jefferson: Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr 131(3), 856S-860S (2001) doi not found
    • (2001) J Nutr , vol.131 , Issue.3 , pp. 856S-860S
    • Anthony, J.C.1    Anthony, T.G.2    Kimball, S.R.3    Jefferson, L.S.4
  • 9
    • 84860468095 scopus 로고    scopus 로고
    • Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
    • C Appenzeller-Herzog, M N Hall: Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends Cell Biol 22(5), 274-282 (2012) DOI: 10.1016/j.tcb.2012.02.006
    • (2012) Trends Cell Biol , vol.22 , Issue.5 , pp. 274-282
    • Appenzeller-Herzog, C.1    Hall, M.N.2
  • 10
    • 84899984684 scopus 로고    scopus 로고
    • Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease
    • Y Xu, C Liu, S Chen, Y Ye, M Guo, Q Ren, L Liu, H Zhang, C Xu, Q Zhou, S Huang, L Chen: Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease. Cell Signal 26(8), 1680-1689 (2014) DOI: 10.1016/j.cellsig.2014.04.009
    • (2014) Cell Signal , vol.26 , Issue.8 , pp. 1680-1689
    • Xu, Y.1    Liu, C.2    Chen, S.3    Ye, Y.4    Guo, M.5    Ren, Q.6    Liu, L.7    Zhang, H.8    Xu, C.9    Zhou, Q.10    Huang, S.11    Chen, L.12
  • 11
    • 84862757927 scopus 로고    scopus 로고
    • Insulin resistance and the metabolism of branched-chain amino acids in humans
    • M M Adeva, J Calvino, G Souto and C Donapetry: Insulin resistance and the metabolism of branched-chain amino acids in humans. Amino Acids 43(1), 171-181 (2012) DOI: 10.1007/s00726-011-1088-7
    • (2012) Amino Acids , vol.43 , Issue.1 , pp. 171-181
    • Adeva, M.M.1    Calvino, J.2    Souto, G.3    Donapetry, C.4
  • 12
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • S Wullschleger, R Loewith, M N Hall: TOR signaling in growth and metabolism. Cell 124, 471-484 (2006) DOI: 10.1016/j.cell.2006.01.016
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 14
    • 0037178786 scopus 로고    scopus 로고
    • mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • D-H Kim, D D Sarbassov, S M Ali, J E King, R R Latek, H Erdjument-Bromage, P Tempst, D M Sabatini: mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110, 163-175 (2002) DOI: 10.1016/S0092-8674(02)00808-5
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.-H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 15
    • 0037224768 scopus 로고    scopus 로고
    • The role of leucine in weight loss diets and glucose homeostasis
    • doi not found
    • D K Layman: The role of leucine in weight loss diets and glucose homeostasis. J Nutr 133(1), 261S-267S (2003) doi not found
    • (2003) J Nutr , vol.133 , Issue.1 , pp. 261S-267S
    • Layman, D.K.1
  • 16
    • 65649152957 scopus 로고    scopus 로고
    • Amino acid transceptors: Gate keepers of nutrient exchange and regulators of nutrient signaling
    • H S Hundal, P M Taylor: Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling. Am J Physiol Endocrinol Metab 296, E603-E613 (2009) DOI: 10.1152/ajpendo.91002.2008
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , pp. E603-E613
    • Hundal, H.S.1    Taylor, P.M.2
  • 18
    • 79959445342 scopus 로고    scopus 로고
    • The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes
    • P Gran, D Cameron-Smith: The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes. BMC Physiol 11, 10 (2011) DOI: 10.1186/1472-6793-11-10
    • (2011) BMC Physiol , vol.11 , pp. 10
    • Gran, P.1    Cameron-Smith, D.2
  • 19
    • 84865100829 scopus 로고    scopus 로고
    • Arginine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells
    • X F Kong, B E Tan, Y L Yin, X L Li, L A Jaeger, F W Bazer, G Y Wu: Arginine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells. J Nutr Biochem 23: 1178-1183 (2012) DOI: 10.1016/j.jnutbio.2011.06.012
    • (2012) J Nutr Biochem , vol.23 , pp. 1178-1183
    • Kong, X.F.1    Tan, B.E.2    Yin, Y.L.3    Li, X.L.4    Jaeger, L.A.5    Bazer, F.W.6    Wu, G.Y.7
  • 20
    • 0035744708 scopus 로고    scopus 로고
    • Regulation of protein synthesis by branched-chain amino acids
    • S R Kimball, L S Jefferson: Regulation of protein synthesis by branched-chain amino acids. Curr Opin Clin Nutr Metab Care 4(1), 39-43 (2001) DOI: 10.1097/00075197-200101000-00008
    • (2001) Curr Opin Clin Nutr Metab Care , vol.4 , Issue.1 , pp. 39-43
    • Kimball, S.R.1    Jefferson, L.S.2
  • 21
    • 0033679673 scopus 로고    scopus 로고
    • 4E-BP1 and S6K1: Translational integration sites for nutritional and hormonal information in muscle
    • doi not found
    • O J Shah, J C Anthony, S R Kimball, L S Jefferson: 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle. Am J Physiol Endocrinol Metab 279(4), E715-729 (2000) doi not found
    • (2000) Am J Physiol Endocrinol Metab , vol.279 , Issue.4 , pp. E715-E729
    • Shah, O.J.1    Anthony, J.C.2    Kimball, S.R.3    Jefferson, L.S.4
  • 22
    • 34247573364 scopus 로고    scopus 로고
    • Leucine and Protein Synthesis: MTOR and Beyond
    • M H Stipanuk: Leucine and Protein Synthesis: mTOR and Beyond. Nutr Rev 65(3), 122-129 (2007) DOI: 10.1111/j.1753-4887.2007.tb00289.x
    • (2007) Nutr Rev , vol.65 , Issue.3 , pp. 122-129
    • Stipanuk, M.H.1
  • 23
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • N Hay, N Sonenberg: Upstream and downstream of mTOR. Genes Dev 18(16), 1926-1945 (2004) DOI: 10.1101/gad.1212704
    • (2004) Genes Dev , vol.18 , Issue.16 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 27
    • 0033980371 scopus 로고    scopus 로고
    • Orally administered leucine stimulates protein synthesis in skeletal muscle of post-absorptive rats in association with increased eIF4F formation
    • doi not found
    • J C Anthony, T G Anthony, S R Kimball, T C Vary, L S Jefferson: Orally administered leucine stimulates protein synthesis in skeletal muscle of post-absorptive rats in association with increased eIF4F formation. J Nutr 130, 139-145 (2000) doi not found
    • (2000) J Nutr , vol.130 , pp. 139-145
    • Anthony, J.C.1    Anthony, T.G.2    Kimball, S.R.3    Vary, T.C.4    Jefferson, L.S.5
  • 28
    • 0033808169 scopus 로고    scopus 로고
    • Leucine stimulates translation initiation in skeletal muscle of post-absorptive rats via a rapamycin-sensitive pathway
    • doi not found
    • J C Anthony, F Yoshizawa, T G Anthony, T C Vary, S R Kimball, L S Jefferson: Leucine stimulates translation initiation in skeletal muscle of post-absorptive rats via a rapamycin-sensitive pathway. J Nutr 130, 2413-2419. (2000) doi not found
    • (2000) J Nutr , vol.130 , pp. 2413-2419
    • Anthony, J.C.1    Yoshizawa, F.2    Anthony, T.G.3    Vary, T.C.4    Kimball, S.R.5    Jefferson, L.S.6
  • 30
    • 31544457307 scopus 로고    scopus 로고
    • Investigations of branch-chain amino acids and their metabolites in animal models of cancer
    • doi not found
    • V E Baracos, M L Mackenzie: Investigations of branch-chain amino acids and their metabolites in animal models of cancer. J Nutr 136 Suppl, 237S-242S (2006) doi not found
    • (2006) J Nutr , vol.136 , pp. 237S-242S
    • Baracos, V.E.1    Mackenzie, M.L.2
  • 32
    • 84855219620 scopus 로고    scopus 로고
    • Leucine nutrition in animals and humans: MTOR signaling and beyond
    • F N Li, Y L Yin, B E Tan, X F Kong, G Y Wu: Leucine nutrition in animals and humans: mTOR signaling and beyond. Amino Acids 41(5), 1185-1193 (2011) DOI: 10.1007/s00726-011-0983-2
    • (2011) Amino Acids , vol.41 , Issue.5 , pp. 1185-1193
    • Li, F.N.1    Yin, Y.L.2    Tan, B.E.3    Kong, X.F.4    Wu, G.Y.5
  • 34
    • 0346996344 scopus 로고    scopus 로고
    • Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids
    • S R Kimball, L S Jefferson: Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids. Biochem Biophys Res Commun 313(2), 423-427 (2004) DOI: 10.1016/j.bbrc.2003.07.014
    • (2004) Biochem Biophys Res Commun , vol.313 , Issue.2 , pp. 423-427
    • Kimball, S.R.1    Jefferson, L.S.2
  • 35
    • 0036230645 scopus 로고    scopus 로고
    • Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation
    • J C Anthony, A K Reiter, T G Anthony, S J Crozier, C H Lang, D A MacLean, S R Kimball, L S Jefferson: Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes 51(4), 928-936 (2002) DOI: 10.2337/diabetes.51.4.928
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 928-936
    • Anthony, J.C.1    Reiter, A.K.2    Anthony, T.G.3    Crozier, S.J.4    Lang, C.H.5    MacLean, D.A.6    Kimball, S.R.7    Jefferson, L.S.8
  • 36
    • 52449095361 scopus 로고    scopus 로고
    • The RSK family of kinases: Emerging roles in cellular signalling
    • R Anjum, J Blenis: The RSK family of kinases: emerging roles in cellular signalling. Nat Rev Mol Cell Biol 9(10), 747-758 (2008) DOI: 10.1038/nrm2509
    • (2008) Nat Rev Mol Cell Biol , vol.9 , Issue.10 , pp. 747-758
    • Anjum, R.1    Blenis, J.2
  • 37
  • 38
    • 21244480367 scopus 로고    scopus 로고
    • The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
    • E M Smith, S G Finn, A R Tee, G J Browne, C G Proud: The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J Biol Chem 280, 18717-18727 (2005) DOI: 10.1074/jbc.M414499200
    • (2005) J Biol Chem , vol.280 , pp. 18717-18727
    • Smith, E.M.1    Finn, S.G.2    Tee, A.R.3    Browne, G.J.4    Proud, C.G.5
  • 39
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • J X Huang, B D Manning: A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 37, 217-222 (2009) DOI: 10.1042/BST0370217
    • (2009) Biochem Soc Trans , vol.37 , pp. 217-222
    • Huang, J.X.1    Manning, B.D.2
  • 40
    • 0033006694 scopus 로고    scopus 로고
    • Leucine supplementation enhances skeletal muscle recovery in rats following exercise
    • doi not found
    • J C Anthony, T G Anthony, D K Layman: Leucine supplementation enhances skeletal muscle recovery in rats following exercise. J Nutr 129(6), 1102-1106 (1999) doi not found
    • (1999) J Nutr , vol.129 , Issue.6 , pp. 1102-1106
    • Anthony, J.C.1    Anthony, T.G.2    Layman, D.K.3
  • 42
    • 0034830022 scopus 로고    scopus 로고
    • Leucine and insulin activate p70S6 kinase through different pathways in human skeletal muscle
    • doi not found
    • J S Greiwe, G Kwon, M L McDaniel, C F Semenkovich: Leucine and insulin activate p70S6 kinase through different pathways in human skeletal muscle. Am J Physiol Endocrinol Metab 281, E466-471 (2001) doi not found
    • (2001) Am J Physiol Endocrinol Metab , vol.281 , pp. E466-E471
    • Greiwe, J.S.1    Kwon, G.2    McDaniel, M.L.3    Semenkovich, C.F.4
  • 43
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • G S Hotamisligil: Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140(6), 900-917 (2010) DOI: 10.1016/j.cell.2010.02.034
    • (2010) Cell , vol.140 , Issue.6 , pp. 900-917
    • Hotamisligil, G.S.1
  • 44
    • 77953153048 scopus 로고    scopus 로고
    • Regulation of basal cellular physiology by the homeostatic unfolded protein response
    • D T Rutkowski, R S Hegde: Regulation of basal cellular physiology by the homeostatic unfolded protein response. J Cell Biol 189(5), 783-794 (2010) DOI: 10.1083/jcb.201003138
    • (2010) J Cell Biol , vol.189 , Issue.5 , pp. 783-794
    • Rutkowski, D.T.1    Hegde, R.S.2
  • 45
    • 79952264011 scopus 로고    scopus 로고
    • Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
    • I Tabas, D Ron: Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 13(3), 184-190 (2011) DOI: 10.1038/ncb0311-184
    • (2011) Nat Cell Biol , vol.13 , Issue.3 , pp. 184-190
    • Tabas, I.1    Ron, D.2
  • 46
    • 33644967119 scopus 로고    scopus 로고
    • The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity
    • 1
    • D J Dyck, G J F Heigenhauser, C R Bruce1: The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Acta Physiol 186, 5-16 (2006) DOI: 10.1111/j.1748-1716.2005.01502.x
    • (2006) Acta Physiol , vol.186 , pp. 5-16
    • Dyck, D.J.1    Heigenhauser, G.J.F.2    Bruce, C.R.3
  • 47
    • 1842405349 scopus 로고    scopus 로고
    • Leptin directly alters lipid partitioning in skeletal muscle
    • D M Muoio, G L Dohm, F T Fiedorek Jr, E B Tapscott, R A Coleman: Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46(8), 1360-1363 (1997) DOI: 10.2337/diab.46.8.1360
    • (1997) Diabetes , vol.46 , Issue.8 , pp. 1360-1363
    • Muoio, D.M.1    Dohm, G.L.2    Fiedorek, F.T.3    Tapscott, E.B.4    Coleman, R.A.5
  • 48
    • 0035069433 scopus 로고    scopus 로고
    • Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats
    • doi not found
    • T G Anthony, J C Anthony, F Yoshizawa, S R Kimball, L S Jefferson: Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats. J Nutr 131, 1171-1176 (2001) doi not found
    • (2001) J Nutr , vol.131 , pp. 1171-1176
    • Anthony, T.G.1    Anthony, J.C.2    Yoshizawa, F.3    Kimball, S.R.4    Jefferson, L.S.5
  • 49
    • 14944341734 scopus 로고    scopus 로고
    • Oral leucine administration stimulates protein synthesis in rat skeletal muscle
    • doi not found
    • S J Crozier, S R Kimball, S W Emmert, J C Anthony, L S Jefferson: Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr 135(3), 376-382 (2005) doi not found
    • (2005) J Nutr , vol.135 , Issue.3 , pp. 376-382
    • Crozier, S.J.1    Kimball, S.R.2    Emmert, S.W.3    Anthony, J.C.4    Jefferson, L.S.5
  • 50
    • 33645996993 scopus 로고    scopus 로고
    • Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction
    • J Donato Jr, R G Pedrosa, V F Cruzat, I S Pires, J Tirapegui: Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction. Nutrition 22(5), 520-527 (2006) DOI: 10.1016/j.nut.2005.12.008
    • (2006) Nutrition , vol.22 , Issue.5 , pp. 520-527
    • Donato, J.1    Pedrosa, R.G.2    Cruzat, V.F.3    Pires, I.S.4    Tirapegui, J.5
  • 51
    • 17444390819 scopus 로고    scopus 로고
    • Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation
    • J Escobar, J W Frank, A Suryawan, H V Nguyen, S R Kimball, L S Jefferson, T A Davis: Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation. Am J Physiol Endocrinol Metab 288(5), E914-921 (2005) DOI: 10.1152/ajpendo.00510.2004
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , Issue.5 , pp. E914-E921
    • Escobar, J.1    Frank, J.W.2    Suryawan, A.3    Nguyen, H.V.4    Kimball, S.R.5    Jefferson, L.S.6    Davis, T.A.7
  • 52
  • 53
    • 0347627142 scopus 로고    scopus 로고
    • Regulation of protein synthesis by branched-chain amino acids in vivo
    • F Yoshizawa: Regulation of protein synthesis by branched-chain amino acids in vivo. Biochem Biophys Res Commun 313(2), 417-422 (2004) DOI: 10.1016/j.bbrc.2003.07.013
    • (2004) Biochem Biophys Res Commun , vol.313 , Issue.2 , pp. 417-422
    • Yoshizawa, F.1
  • 54
    • 34249680883 scopus 로고    scopus 로고
    • Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms
    • Y Zhang, K Guo, R E LeBlanc, D Loh, G J Schwartz, Y H Yu: Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 56(6), 1647-1654 (2007) DOI: 10.2337/db07-0123
    • (2007) Diabetes , vol.56 , Issue.6 , pp. 1647-1654
    • Zhang, Y.1    Guo, K.2    LeBlanc, R.E.3    Loh, D.4    Schwartz, G.J.5    Yu, Y.H.6
  • 55
    • 34247579321 scopus 로고    scopus 로고
    • Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells
    • X Sun, M B Zemel: Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells. Lipids 42(4), 297-305 (2007) DOI: 10.1007/s11745-007-3029-5
    • (2007) Lipids , vol.42 , Issue.4 , pp. 297-305
    • Sun, X.1    Zemel, M.B.2
  • 56
    • 84855215932 scopus 로고    scopus 로고
    • Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats
    • D Vianna, G F Resende, F L Torres-Leal, L C Pantaleao, J Donato Jr, J Tirapegui: Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats. Nutrition 28(2), 182-189 (2012) DOI: 10.1016/j.nut.2011.04.004
    • (2012) Nutrition , vol.28 , Issue.2 , pp. 182-189
    • Vianna, D.1    Resende, G.F.2    Torres-Leal, F.L.3    Pantaleao, L.C.4    Donato, J.5    Tirapegui, J.6
  • 57
    • 24944584210 scopus 로고    scopus 로고
    • Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: Role of fatty acid beta-oxidation and glucose
    • S Vankoningsloo, M Piens, C Lecocq, A Gilson, A De Pauw, P Renard, C Demazy, A Houbion, M Raes, T Arnould: Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: role of fatty acid beta-oxidation and glucose. J Lipid Res 46(6), 1133-1149 (2005) DOI: 10.1194/jlr.M400464-JLR200
    • (2005) J Lipid Res , vol.46 , Issue.6 , pp. 1133-1149
    • Vankoningsloo, S.1    Piens, M.2    Lecocq, C.3    Gilson, A.4    De Pauw, A.5    Renard, P.6    Demazy, C.7    Houbion, A.8    Raes, M.9    Arnould, T.10
  • 59
    • 25844432311 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipidinduced mitochondrial inefficiency
    • T R Koves, P Li, J An, T Akimoto, D Slentz, O Ilkayeva, G L Dohm, Z Yan, C B Newgard, D M Muoio: Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipidinduced mitochondrial inefficiency. J Biol Chem 280(39), 33588-33598 (2005) DOI: 10.1074/jbc.M507621200
    • (2005) J Biol Chem , vol.280 , Issue.39 , pp. 33588-33598
    • Koves, T.R.1    Li, P.2    An, J.3    Akimoto, T.4    Slentz, D.5    Ilkayeva, O.6    Dohm, G.L.7    Yan, Z.8    Newgard, C.B.9    Muoio, D.M.10
  • 60
    • 42049114658 scopus 로고    scopus 로고
    • Activation of Peroxisome Proliferator-Activated Receptor Pathway Stimulates the Mitochondrial Respiratory Chain and Can Correct Deficiencies in Patients' Cells Lacking Its Components
    • J Bastin, F Aubey, A Rötig, A Munnich, F Djouadi: Activation of Peroxisome Proliferator-Activated Receptor Pathway Stimulates the Mitochondrial Respiratory Chain and Can Correct Deficiencies in Patients' Cells Lacking Its Components. J Clin Endocrinol Metab 93, 1433-1441 (2008) DOI: 10.1210/jc.2007-1701
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1433-1441
    • Bastin, J.1    Aubey, F.2    Rötig, A.3    Munnich, A.4    Djouadi, F.5
  • 61
    • 0038810035 scopus 로고    scopus 로고
    • An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle
    • C Handschin, J Rhee, J Lin, P T Tarr, B M Spiegelman: An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci U S A 100(12), 7111-7116 (2003) DOI: 10.1073/pnas.1232352100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.12 , pp. 7111-7116
    • Handschin, C.1    Rhee, J.2    Lin, J.3    Tarr, P.T.4    Spiegelman, B.M.5
  • 62
    • 31544435440 scopus 로고    scopus 로고
    • Modulations of muscle protein metabolism by branchedchain amino acids in normal and muscleatrophying rats
    • doi not found
    • H Kobayashi, H Kato, Y Hirabayashi, H Murakami, H Suzuki: Modulations of muscle protein metabolism by branchedchain amino acids in normal and muscleatrophying rats. J Nutr 136(1 Suppl), 234S-236S (2006) doi not found
    • (2006) J Nutr 136 , Issue.1 , pp. 234S-236S
    • Kobayashi, H.1    Kato, H.2    Hirabayashi, Y.3    Murakami, H.4    Suzuki, H.5
  • 63
    • 0016431688 scopus 로고
    • Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm
    • doi not found
    • R M Fulks, J B Li, A L Goldberg: Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. J Biol Chem 250(1), 290-298 (1975) doi not found
    • (1975) J Biol Chem , vol.250 , Issue.1 , pp. 290-298
    • Fulks, R.M.1    Li, J.B.2    Goldberg, A.L.3
  • 65
    • 84916891563 scopus 로고    scopus 로고
    • Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes
    • Y H Li, F N Li, B B Lin, X F Kong, Y L Tang, Y L Yin: Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes. Mol Biol Rep (2014) DOI: 10.1.007/s11033-014-3646-z
    • (2014) Mol Biol Rep
    • Li, Y.H.1    Li, F.N.2    Lin, B.B.3    Kong, X.F.4    Tang, Y.L.5    Yin, Y.L.6
  • 67
    • 0033638542 scopus 로고    scopus 로고
    • Development of leptin resistance in rat soleus muscle in response to high-fat diets
    • doi not found
    • G R Steinberg, D J Dyck: Development of leptin resistance in rat soleus muscle in response to high-fat diets. Am J Physiol Endocrinol Metab 279(6), E1374-1382 (2000) doi not found
    • (2000) Am J Physiol Endocrinol Metab , vol.279 , Issue.6 , pp. E1374-E1382
    • Steinberg, G.R.1    Dyck, D.J.2
  • 68
    • 0346996343 scopus 로고    scopus 로고
    • Branched-chain amino acids as a protein- and energysource in liver cirrhosis
    • H Moriwaki, Y Miwa, M Tajika, M Kato, H Fukushima, M Shiraki: Branched-chain amino acids as a protein- and energysource in liver cirrhosis. Biochem Biophys Res Commun 313(2), 405-409 (2004) DOI: 10.1016/j.bbrc.2003.07.016
    • (2004) Biochem Biophys Res Commun , vol.313 , Issue.2 , pp. 405-409
    • Moriwaki, H.1    Miwa, Y.2    Tajika, M.3    Kato, M.4    Fukushima, H.5    Shiraki, M.6
  • 69
    • 34547097768 scopus 로고    scopus 로고
    • Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by highcalorie diet
    • S Otabe, X Yuan, T Fukutani, N Wada, T Hashinaga, H Nakayama, N Hirota, M Kojima, K Yamada: Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by highcalorie diet. Am J Physiol Endocrinol Metab 293, E210-E218 (2007) DOI: 10.1152/ajpendo.00645.2006
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , pp. E210-E218
    • Otabe, S.1    Yuan, X.2    Fukutani, T.3    Wada, N.4    Hashinaga, T.5    Nakayama, H.6    Hirota, N.7    Kojima, M.8    Yamada, K.9
  • 72
    • 23044481429 scopus 로고    scopus 로고
    • Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: Evidence for a skeletal muscle-to-fat signaling pathway
    • L S Quinn, L Strait-Bodey, B G Anderson, J M Argiles, P J Havel: Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: evidence for a skeletal muscle-to-fat signaling pathway. Cell Biol Int 29(6), 449-457 (2005) DOI: 10.1016/j.cellbi.2005.02.005
    • (2005) Cell Biol Int , vol.29 , Issue.6 , pp. 449-457
    • Quinn, L.S.1    Strait-Bodey, L.2    Anderson, B.G.3    Argiles, J.M.4    Havel, P.J.5
  • 75
    • 0037084989 scopus 로고    scopus 로고
    • Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: Evidence for direct IL-15 action on adipose tissue
    • B Alvarez, N Carbo, J Lopez-Soriano, R H Drivdahl, S Busquets, F J Lopez-Soriano, J M Argiles, L S Quinn: Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: evidence for direct IL-15 action on adipose tissue. Biochim Biophys Acta 1570(1), 33-37 (2002) DOI: 10.1016/S0304-4165(02)00148-4
    • (2002) Biochim Biophys Acta , vol.1570 , Issue.1 , pp. 33-37
    • Alvarez, B.1    Carbo, N.2    Lopez-Soriano, J.3    Drivdahl, R.H.4    Busquets, S.5    Lopez-Soriano, F.J.6    Argiles, J.M.7    Quinn, L.S.8
  • 76
    • 84877802993 scopus 로고    scopus 로고
    • Branched chain amino acids and metabolic regulation
    • C X Wang, F F Guo: Branched chain amino acids and metabolic regulation. Chinese Sci Bull 58(11), 1228-1235 (2013) DOI: 10.1007/s11434-013-5681-x
    • (2013) Chinese Sci Bull , vol.58 , Issue.11 , pp. 1228-1235
    • Wang, C.X.1    Guo, F.F.2
  • 77
    • 33745204479 scopus 로고    scopus 로고
    • AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
    • B Z Xue, B B Kahn: AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol-London 574(1), 73-83 (2006) DOI: 10.1113/jphysiol.2006.113217
    • (2006) J Physiol-London , vol.574 , Issue.1 , pp. 73-83
    • Xue, B.Z.1    Kahn, B.B.2
  • 78
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • D G Hardie, D Carling, M Carlson: The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67, 821-855 (1998) DOI: 10.1146/annurev.biochem.67.1.821
    • (1998) Annu Rev Biochem , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 80
    • 77957567397 scopus 로고    scopus 로고
    • Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle
    • A K Saha, X J Xu, E Lawson, R Deoliveira, A E Brandon, E W Kraegen, N B Ruderman: Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes 59(10), 2426-2434 (2010) DOI: 10.2337/db09-1870
    • (2010) Diabetes , vol.59 , Issue.10 , pp. 2426-2434
    • Saha, A.K.1    Xu, X.J.2    Lawson, E.3    Deoliveira, R.4    Brandon, A.E.5    Kraegen, E.W.6    Ruderman, N.B.7
  • 82
    • 26444485985 scopus 로고    scopus 로고
    • Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
    • D P Koonen, J F Glatz, A Bonen, J J Luiken: Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle. Biochim Biophys Acta 1736(3), 163-180 (2005) DOI: 10.1016/j.bbalip.2005.08.018
    • (2005) Biochim Biophys Acta , vol.1736 , Issue.3 , pp. 163-180
    • Koonen, D.P.1    Glatz, J.F.2    Bonen, A.3    Luiken, J.J.4
  • 83
    • 33745221937 scopus 로고    scopus 로고
    • Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise
    • S B Jorgensen, E A Richter, J F Wojtaszewski: Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise. J Physiol 574(Pt 1), 17-31 (2006) DOI: 10.1113/jphysiol.2006.109942
    • (2006) J Physiol , vol.574 , pp. 17-31
    • Jorgensen, S.B.1    Richter, E.A.2    Wojtaszewski, J.F.3
  • 86
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • Y Minokoshi, Y B Kim, O D Peroni, L G Fryer, C Muller, D Carling, B B Kahn: Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415(6869), 339-343 (2002) DOI: 10.1038/415339a
    • (2002) Nature , vol.415 , Issue.6869 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.B.2    Peroni, O.D.3    Fryer, L.G.4    Muller, C.5    Carling, D.6    Kahn, B.B.7
  • 87
    • 33745183847 scopus 로고    scopus 로고
    • Functions of AMP-activated protein kinase in adipose tissue
    • M Daval, F Foufelle, P Ferre: Functions of AMP-activated protein kinase in adipose tissue. J Physiol 574(Pt 1), 55-62 (2006) DOI: 10.1113/jphysiol.2006.111484
    • (2006) J Physiol , vol.574 , pp. 55-62
    • Daval, M.1    Foufelle, F.2    Ferre, P.3
  • 88
    • 0035145602 scopus 로고    scopus 로고
    • Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells
    • G Xu, G Kwon, W S Cruz, C A Marshall, M L McDaniel: Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells. Diabetes 50(2), 353-360 (2001) DOI: 10.2337/diabetes.50.2.353
    • (2001) Diabetes , vol.50 , Issue.2 , pp. 353-360
    • Xu, G.1    Kwon, G.2    Cruz, W.S.3    Marshall, C.A.4    McDaniel, M.L.5
  • 89
    • 84882606757 scopus 로고    scopus 로고
    • Nutritionally essential amino acids and metabolic signaling in aging
    • E L Dillon: Nutritionally essential amino acids and metabolic signaling in aging. Amino Acids 45, 431-441 (2013) DOI: 10.1007/s00726-012-1438-0
    • (2013) Amino Acids , vol.45 , pp. 431-441
    • Dillon, E.L.1
  • 90
    • 84882653868 scopus 로고    scopus 로고
    • Functional amino acids in nutrition and health
    • G Wu: Functional amino acids in nutrition and health. Amino Acids 45, 407-411 (2013) DOI: 10.1007/s00726-013-1500-6
    • (2013) Amino Acids , vol.45 , pp. 407-411
    • Wu, G.1
  • 92
    • 84882668156 scopus 로고    scopus 로고
    • Abundance of amino acid transporters involved in mTORC1 activation in skeletal muscle of neonatal pigs is developmentally regulated
    • A Suryawan, H V Nguyen, R D Almonaci, T A Davis: Abundance of amino acid transporters involved in mTORC1 activation in skeletal muscle of neonatal pigs is developmentally regulated. Amino Acids 45, 523-530 (2013) DOI: 10.1007/s00726-012-1326-7
    • (2013) Amino Acids , vol.45 , pp. 523-530
    • Suryawan, A.1    Nguyen, H.V.2    Almonaci, R.D.3    Davis, T.A.4
  • 93
    • 84882663611 scopus 로고    scopus 로고
    • Regulation of intestinal protein metabolism by amino acids
    • J Bertrand, A Goichon, P Déchelotte, M Coëffier: Regulation of intestinal protein metabolism by amino acids. Amino Acids 45, 443-450 (2013) DOI: 10.1007/s00726-012-1325-8
    • (2013) Amino Acids , vol.45 , pp. 443-450
    • Bertrand, J.1    Goichon, A.2    Déchelotte, P.3    Coëffier, M.4
  • 94
    • 84903519958 scopus 로고    scopus 로고
    • Amino acid nutrition in animals: Protein synthesis and beyond
    • G Wu, F W Bazer, Z L Dai, D F Li, J J Wang, Z L Wu: Amino acid nutrition in animals: protein synthesis and beyond. Annu Rev Anim Biosci 2, 387-417 (2014) DOI:10.1146/annurev-animal-022513-114113
    • (2014) Annu Rev Anim Biosci , vol.2 , pp. 387-417
    • Wu, G.1    Bazer, F.W.2    Dai, Z.L.3    Li, D.F.4    Wang, J.J.5    Wu, Z.L.6
  • 95
    • 33746941255 scopus 로고    scopus 로고
    • Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates
    • W S Jobgen, S K Fried, W J Fu, C J Meininger, G Wu: Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. J Nutr Biochem 17, 571-588 (2006) DOI: 10.1016/j.jnutbio.2005.12.001
    • (2006) J Nutr Biochem , vol.17 , pp. 571-588
    • Jobgen, W.S.1    Fried, S.K.2    Fu, W.J.3    Meininger, C.J.4    Wu, G.5
  • 96
    • 77956501826 scopus 로고    scopus 로고
    • Beneficial effects of L-arginine on reducing obesity: Potential mechanisms and important implications for human health
    • J R McKnight, M C Satterfield, W S Jobgen, S B Smith, T E Spencer, C J Meininger, C J McNeal, G Wu: Beneficial effects of L-arginine on reducing obesity: Potential mechanisms and important implications for human health. Amino Acids 39, 349-357 (2010) DOI: 10.1007/s00726-010-0598-z
    • (2010) Amino Acids , vol.39 , pp. 349-357
    • McKnight, J.R.1    Satterfield, M.C.2    Jobgen, W.S.3    Smith, S.B.4    Spencer, T.E.5    Meininger, C.J.6    McNeal, C.J.7    Wu, G.8
  • 97
    • 84868239129 scopus 로고    scopus 로고
    • Regulation of brown adipose tissue development and white fat reduction by L-arginine
    • Z L Wu, M C Satterfield, F W Bazer, G Wu: Regulation of brown adipose tissue development and white fat reduction by L-arginine. Curr Opin Clin Nutr Metab Care 15, 529-538 (2012) DOI: 10.1097/MCO.0b013e3283595cff
    • (2012) Curr Opin Clin Nutr Metab Care , vol.15 , pp. 529-538
    • Wu, Z.L.1    Satterfield, M.C.2    Bazer, F.W.3    Wu, G.4
  • 98
    • 84882582161 scopus 로고    scopus 로고
    • Arginine nutrition and fetal brown adipose tissue development in nutrient-restricted sheep
    • M C Satterfield, K A Dunlap, D H Keisler, F W Bazer, G Wu: Arginine nutrition and fetal brown adipose tissue development in nutrient-restricted sheep. Amino Acids 45, 489-499 (2013) DOI: 10.1007/s00726-011-1168-8
    • (2013) Amino Acids , vol.45 , pp. 489-499
    • Satterfield, M.C.1    Dunlap, K.A.2    Keisler, D.H.3    Bazer, F.W.4    Wu, G.5
  • 101
    • 84876683503 scopus 로고    scopus 로고
    • Dietary requirements of "nutritionally nonessential amino acids" by animals and humans
    • G Wu, Z L Wu, Z L Dai, Y Yang, W W Wang, C Liu, B Wang, J J Wang, Y L Yin: Dietary requirements of "nutritionally nonessential amino acids" by animals and humans. Amino Acids 44, 1107-1113 (2013) DOI: 10.1007/s00726-012-1444-2
    • (2013) Amino Acids , vol.44 , pp. 1107-1113
    • Wu, G.1    Wu, Z.L.2    Dai, Z.L.3    Yang, Y.4    Wang, W.W.5    Liu, C.6    Wang, B.7    Wang, J.J.8    Yin, Y.L.9
  • 102
    • 84904763502 scopus 로고    scopus 로고
    • Glycine is a nutritionally essential amino acid for maximal growth of milk-fed young pigs
    • W W Wang, Z L Dai, Z L Wu, G Lin, S C Jia, S D Hu, S Dahanayaka, G Wu: Glycine is a nutritionally essential amino acid for maximal growth of milk-fed young pigs. Amino Acids 46, 2037-2045 (2014) DOI: 10.1007/s00726-014-1758-3
    • (2014) Amino Acids , vol.46 , pp. 2037-2045
    • Wang, W.W.1    Dai, Z.L.2    Wu, Z.L.3    Lin, G.4    Jia, S.C.5    Hu, S.D.6    Dahanayaka, S.7    Wu, G.8
  • 103
    • 84964548193 scopus 로고    scopus 로고
    • Dietary requirements of synthesizable amino acids by animals: A paradigm shift in protein nutrition
    • G Wu: Dietary requirements of synthesizable amino acids by animals: A paradigm shift in protein nutrition. J Anim Sci Biotechnol 5, 34 (2014) DOI: 10.1186/2049-1891-5-34
    • (2014) J Anim Sci Biotechnol , vol.5 , pp. 34
    • Wu, G.1
  • 104
    • 84882659696 scopus 로고    scopus 로고
    • Glutamate: A truly functional amino acid
    • J T Brosnan, M E Brosnan: Glutamate: a truly functional amino acid. Amino Acids 45, 413-418 (2013) DOI: 10.1007/s00726-012-1280-4
    • (2013) Amino Acids , vol.45 , pp. 413-418
    • Brosnan, J.T.1    Brosnan, M.E.2
  • 107
    • 34249827735 scopus 로고    scopus 로고
    • Amino acids and immune function
    • P Li, Y L Yin, D F Li, S W Kim, G Y Wu: Amino acids and immune function. Br J Nutr 98, 237-252 (2007) DOI: 10.1017/S000711450769936X
    • (2007) Br J Nutr , vol.98 , pp. 237-252
    • Li, P.1    Yin, Y.L.2    Li, D.F.3    Kim, S.W.4    Wu, G.Y.5
  • 108
    • 33847094225 scopus 로고    scopus 로고
    • Functional amino acids and fatty acids for enhancing production performance of sows and piglets
    • S W Kim, R D Mateo, Y L Yin, G Y Wu: Functional amino acids and fatty acids for enhancing production performance of sows and piglets. Asian Australas J Anim Sci 20: 295-306 (2007) DOI: 10.5713/ajas.2007.295
    • (2007) Asian Australas J Anim Sci , vol.20 , pp. 295-306
    • Kim, S.W.1    Mateo, R.D.2    Yin, Y.L.3    Wu, G.Y.4
  • 109
    • 84882705118 scopus 로고    scopus 로고
    • Amino acid sensing in the gastrointestinal tract
    • A San Gabriel, H Uneyama: Amino acid sensing in the gastrointestinal tract. Amino Acids 45, 451-461 (2013) DOI: 10.1007/s00726-012-1371-2
    • (2013) Amino Acids , vol.45 , pp. 451-461
    • San Gabriel, A.1    Uneyama, H.2
  • 111
    • 79954579609 scopus 로고    scopus 로고
    • Dietary L-arginine supplementation differentially regulates expression of fat-metabolic genes in porcine adipose tissue and skeletal muscle
    • B E Tan, Y L Yin, Z Q Liu, W J Tang, H J Xu, X F Kong, X G Li, K Yao, W T Gu, S B Smith, G Y Wu: Dietary L-arginine supplementation differentially regulates expression of fat-metabolic genes in porcine adipose tissue and skeletal muscle. J Nutr Biochem 22, 441-445 (2011) DOI: 10.1016/j.jnutbio.2010.03.012
    • (2011) J Nutr Biochem , vol.22 , pp. 441-445
    • Tan, B.E.1    Yin, Y.L.2    Liu, Z.Q.3    Tang, W.J.4    Xu, H.J.5    Kong, X.F.6    Li, X.G.7    Yao, K.8    Gu, W.T.9    Smith, S.B.10    Wu, G.Y.11
  • 112
    • 84898669954 scopus 로고    scopus 로고
    • Dietary arginine supplementation enhances intestinal expression of SLC7A7 and SLC7A1 and ameliorates growth depression in mycotoxin-challenged pigs
    • J Yin, W K Ren, J L Duan, L Wu, S Chen, T J Li, Y L Yin, G Y Wu: Dietary arginine supplementation enhances intestinal expression of SLC7A7 and SLC7A1 and ameliorates growth depression in mycotoxin-challenged pigs. Amino Acids 46, 883-892 (2014) DOI: 10.1007/s00726-013-1643-5
    • (2014) Amino Acids , vol.46 , pp. 883-892
    • Yin, J.1    Ren, W.K.2    Duan, J.L.3    Wu, L.4    Chen, S.5    Li, T.J.6    Yin, Y.L.7    Wu, G.Y.8
  • 113
    • 84898634401 scopus 로고    scopus 로고
    • Both Dietary Supplementation with Monosodium L-Glutamate and Fat Modify Circulating and Tissue Amino Acid Pools in Growing Pigs, but with Little Interactive Effect
    • Z M Feng, X L Zhou, F Wu, K Yao, X F Kong, T J Li, F Blachier, Y L Yin: Both Dietary Supplementation with Monosodium L-Glutamate and Fat Modify Circulating and Tissue Amino Acid Pools in Growing Pigs, but with Little Interactive Effect. Plos One 9(1), e84533 (2014) DOI: 10.1371/journal.pone.0084533
    • (2014) Plos One , vol.9 , Issue.1 , pp. e84533
    • Feng, Z.M.1    Zhou, X.L.2    Wu, F.3    Yao, K.4    Kong, X.F.5    Li, T.J.6    Blachier, F.7    Yin, Y.L.8
  • 114
    • 84895526817 scopus 로고    scopus 로고
    • Serum Amino Acids Profile and the Beneficial Effects of L-Arginine or L-Glutamine Supplementation in Dextran Sulfate Sodium Colitis
    • W K Ren J Yin, M M Wu, G Liu, G Yang, Y Xiong, D D Su, L Wu, T J Li, S Chen, J L Duan, Y L Yin, G Y Wu: Serum Amino Acids Profile and the Beneficial Effects of L-Arginine or L-Glutamine Supplementation in Dextran Sulfate Sodium Colitis. Plos One 9(2), e88335 (2014) DOI: 10.1371/journal.pone.0088335
    • (2014) Plos One , vol.9 , Issue.2 , pp. e88335
    • Ren, W.K.1    Yin, J.2    Wu, M.M.3    Liu, G.4    Yang, G.5    Xiong, Y.6    Su, D.D.7    Wu, L.8    Li, T.J.9    Chen, S.10    Duan, J.L.11    Yin, Y.L.12    Wu, G.Y.13
  • 115
    • 84893247129 scopus 로고    scopus 로고
    • Oral MSG administration alters hepatic expression of genesfor lipid and nitrogen metabolism in suckling piglets
    • G Chen, J Zhang, Y Z Zhang, P Liao, T J Li, L X Chen, Y L Yin, J Q Wang, G Y Wu: Oral MSG administration alters hepatic expression of genesfor lipid and nitrogen metabolism in suckling piglets. Amino Acids 46, 245-250 (2014) DOI: 10.1007/s00726-013-1615-9
    • (2014) Amino Acids , vol.46 , pp. 245-250
    • Chen, G.1    Zhang, J.2    Zhang, Y.Z.3    Liao, P.4    Li, T.J.5    Chen, L.X.6    Yin, Y.L.7    Wang, J.Q.8    Wu, G.Y.9
  • 116
    • 84886249619 scopus 로고    scopus 로고
    • Oral administration of MSG increases expression of glutamate receptors and transporters in the gastrointestinal tract of young piglets
    • J Zhang, Y L Yin, X Shu, T J Li, F N Li, B E Tan, Z L Wu, G Y Wu: Oral administration of MSG increases expression of glutamate receptors and transporters in the gastrointestinal tract of young piglets. Amino Acids 45, 1169-1177 (2013) DOI: 10.1007/s00726-013-1573-2
    • (2013) Amino Acids , vol.45 , pp. 1169-1177
    • Zhang, J.1    Yin, Y.L.2    Shu, X.3    Li, T.J.4    Li, F.N.5    Tan, B.E.6    Wu, Z.L.7    Wu, G.Y.8
  • 117
    • 84880811310 scopus 로고    scopus 로고
    • Effects of Dietary Arginine and Glutamine on Alleviating the Impairment Induced by Deoxynivalenol Stress and Immune Relevant Cytokines in Growing Pigs
    • L Wu, W C Wang, K Yao, T Zhou, J Yin, T J Li, L Yang, L Q He, X J Yang, H F Zhang, Q Wang, R L Huang, Y L Yin: Effects of Dietary Arginine and Glutamine on Alleviating the Impairment Induced by Deoxynivalenol Stress and Immune Relevant Cytokines in Growing Pigs. Plos One 8(7), e69502 (2013) DOI: 10.1371/journal.pone.0069502
    • (2013) Plos One , vol.8 , Issue.7 , pp. e69502
    • Wu, L.1    Wang, W.C.2    Yao, K.3    Zhou, T.4    Yin, J.5    Li, T.J.6    Yang, L.7    He, L.Q.8    Yang, X.J.9    Zhang, H.F.10    Wang, Q.11    Huang, R.L.12    Yin, Y.L.13
  • 118
    • 84882687602 scopus 로고    scopus 로고
    • Dietary supplementation with N-carbamylglutamate increases the expression of intestinal amino acid transporters in weaned Huanjiang minipig piglets
    • H S Yang, D Z Fu, X F Kong, W C Wang, X J Yang, C M Nyachoti, Y L Yin: Dietary supplementation with N-carbamylglutamate increases the expression of intestinal amino acid transporters in weaned Huanjiang minipig piglets. J Anim Sci 91, 2740-2748 (2013) DOI: 10.2527/jas.2012-5795
    • (2013) J Anim Sci , vol.91 , pp. 2740-2748
    • Yang, H.S.1    Fu, D.Z.2    Kong, X.F.3    Wang, W.C.4    Yang, X.J.5    Nyachoti, C.M.6    Yin, Y.L.7
  • 119
    • 84880803290 scopus 로고    scopus 로고
    • Effects of dietary L-lysine intake on the intestinal mucosa and expression of CAT genes in weaned piglets
    • L Q He, H S Yang, Y Q Hou, T J Li, J Fang, X H Zhou, Y L Yin, L Wu, M Nyachoti, G Y Wu: Effects of dietary L-lysine intake on the intestinal mucosa and expression of CAT genes in weaned piglets. Amino Acids 45, 383-391 (2013) DOI: 10.1007/s00726-013-1514-0
    • (2013) Amino Acids , vol.45 , pp. 383-391
    • He, L.Q.1    Yang, H.S.2    Hou, Y.Q.3    Li, T.J.4    Fang, J.5    Zhou, X.H.6    Yin, Y.L.7    Wu, L.8    Nyachoti, M.9    Wu, G.Y.10
  • 120
    • 84882695426 scopus 로고    scopus 로고
    • L-Glutamine regulates amino acid utilization by intestinal bacteria
    • Z L Dai, X L Li, P B Xi, J Zhang, G Wu, W Y Zhu: L-Glutamine regulates amino acid utilization by intestinal bacteria. Amino Acids 45, 501-512 (2013) DOI: 10.1007/s00726-012-1264-4
    • (2013) Amino Acids , vol.45 , pp. 501-512
    • Dai, Z.L.1    Li, X.L.2    Xi, P.B.3    Zhang, J.4    Wu, G.5    Zhu, W.Y.6
  • 121
    • 84882677526 scopus 로고    scopus 로고
    • Large neutral amino acids: Dietary effects on brain neurochemistry and function
    • J D Fernstrom: Large neutral amino acids: Dietary effects on brain neurochemistry and function. Amino Acids 45, 419-430 (2013) DOI: 10.1007/s00726-012-1330-y
    • (2013) Amino Acids , vol.45 , pp. 419-430
    • Fernstrom, J.D.1
  • 122
    • 84880919496 scopus 로고    scopus 로고
    • N-Acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling
    • Y Q Hou, L Wang, D Yi, B Y Ding, Z G Yang, J Li, X Chen, Y S Qiu, G Wu: N-Acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling. Amino Acids 45, 513-522 (2013) DOI: 10.1007/s00726-012-1295-x
    • (2013) Amino Acids , vol.45 , pp. 513-522
    • Hou, Y.Q.1    Wang, L.2    Yi, D.3    Ding, B.Y.4    Yang, Z.G.5    Li, J.6    Chen, X.7    Qiu, Y.S.8    Wu, G.9
  • 123
    • 84882596612 scopus 로고    scopus 로고
    • Dietary L-glutamine supplementation improves pregnancy outcome in mice infected with type-2 porcine circovirus
    • W K Ren, W Luo, M M Wu, G Liu, X L Yu, F Jun, T J Li, Y L Yin, G Y Wu: Dietary L-glutamine supplementation improves pregnancy outcome in mice infected with type-2 porcine circovirus. Amino Acids 45, 479-488 (2013) DOI: 10.1007/s00726-011-1134-5
    • (2013) Amino Acids , vol.45 , pp. 479-488
    • Ren, W.K.1    Luo, W.2    Wu, M.M.3    Liu, G.4    Yu, X.L.5    Jun, F.6    Li, T.J.7    Yin, Y.L.8    Wu, G.Y.9
  • 124
    • 84882582161 scopus 로고    scopus 로고
    • Arginine nutrition and fetal brown adipose tissue development in nutrient-restricted sheep
    • M C Satterfield, K A Dunlap, D H Keisler, F W Bazer, G Y Wu: Arginine nutrition and fetal brown adipose tissue development in nutrient-restricted sheep. Amino Acids 45, 489-499 (2013) DOI: 10.1007/s00726-011-1168-8
    • (2013) Amino Acids , vol.45 , pp. 489-499
    • Satterfield, M.C.1    Dunlap, K.A.2    Keisler, D.H.3    Bazer, F.W.4    Wu, G.Y.5
  • 125
    • 84882568778 scopus 로고    scopus 로고
    • Glycine metabolism in animals and humans: Implications for nutrition and health
    • W W Wang, Z L Wu, Z L Dai, Y Yang, J J Wang, G Y Wu: Glycine metabolism in animals and humans: implications for nutrition and health. Amino Acids 45, 463-477 (2013) DOI: 10.1007/s00726-013-1493-1
    • (2013) Amino Acids , vol.45 , pp. 463-477
    • Wang, W.W.1    Wu, Z.L.2    Dai, Z.L.3    Yang, Y.4    Wang, J.J.5    Wu, G.Y.6
  • 126
    • 84882710239 scopus 로고    scopus 로고
    • Acute alcohol exposure, acidemia or glutamine administration impacts amino acid homeostasis in ovine maternal and fetal plasma
    • S E Washburn, O B Sawant, E R Lunde, G Y Wu, T A Cudd: Acute alcohol exposure, acidemia or glutamine administration impacts amino acid homeostasis in ovine maternal and fetal plasma. Amino Acids 45, 543-554 (2013) DOI: 10.1007/s00726-012-1453-1
    • (2013) Amino Acids , vol.45 , pp. 543-554
    • Washburn, S.E.1    Sawant, O.B.2    Lunde, E.R.3    Wu, G.Y.4    Cudd, T.A.5
  • 128
    • 84886289866 scopus 로고    scopus 로고
    • Supplementation with branched-chain amino acids to a low-protein diet regulates intestinal expression of amino acid and peptide transporters in weanling pigs
    • S H Zhang, S Y Qiao, M Ren, X F Zeng, X Ma, Z L Wu, P Thacker, G Wu: Supplementation with branched-chain amino acids to a low-protein diet regulates intestinal expression of amino acid and peptide transporters in weanling pigs. Amino Acids 45, 1191-1205 (2013) DOI: 10.1007/s00726-013-1577-y
    • (2013) Amino Acids , vol.45 , pp. 1191-1205
    • Zhang, S.H.1    Qiao, S.Y.2    Ren, M.3    Zeng, X.F.4    Ma, X.5    Wu, Z.L.6    Thacker, P.7    Wu, G.8
  • 129
    • 84903546400 scopus 로고    scopus 로고
    • Analysis of amino acid composition in proteins of animal tissues and foods as pre-column o-phthaldialdehyde derivatives by HPLC with fluorescence detection
    • Z L Dai, Z L Wu, S C Jia, G Wu: Analysis of amino acid composition in proteins of animal tissues and foods as pre-column o-phthaldialdehyde derivatives by HPLC with fluorescence detection. J Chromatogr B 964, 116-127 (2014) DOI: 10.1016/j.jchromb.2014.03.025
    • (2014) J Chromatogr B , vol.964 , pp. 116-127
    • Dai, Z.L.1    Wu, Z.L.2    Jia, S.C.3    Wu, G.4
  • 130
    • 84906057493 scopus 로고    scopus 로고
    • Production and supply of high-quality food protein for human consumption: Sustainability, challenges and innovations
    • G Wu, J Fanzo, D D Miller, P Pingali, M Post, J L Steiner, A E Thalacker-Mercer: Production and supply of high-quality food protein for human consumption: sustainability, challenges and innovations. Ann N Y Acad Sci 1321, 1-19 (2014) DOI: 10.1111/nyas.12500
    • (2014) Ann N Y Acad Sci , vol.1321 , pp. 1-19
    • Wu, G.1    Fanzo, J.2    Miller, D.D.3    Pingali, P.4    Post, M.5    Steiner, J.L.6    Thalacker-Mercer, A.E.7
  • 131
    • 80052590329 scopus 로고    scopus 로고
    • Functional amino acids in growth, reproduction and health
    • G Wu: Functional amino acids in growth, reproduction and health. Adv Nutr 1, 31-37 (2010) DOI: 10.3945/an.110.1008
    • (2010) Adv Nutr , vol.1 , pp. 31-37
    • Wu, G.1
  • 133
    • 84903618351 scopus 로고    scopus 로고
    • Improving amino acid nutrition to prevent intrauterine growth restriction in mammals
    • G Lin, X Q Wang, G Wu, C P Feng, H J Zhou, D F Li, J J Wang: Improving amino acid nutrition to prevent intrauterine growth restriction in mammals. Amino Acids 46, 1605-1623 (2014) DOI: 10.1007/s00726-014-1725-z
    • (2014) Amino Acids , vol.46 , pp. 1605-1623
    • Lin, G.1    Wang, X.Q.2    Wu, G.3    Feng, C.P.4    Zhou, H.J.5    Li, D.F.6    Wang, J.J.7
  • 134
    • 84894535905 scopus 로고    scopus 로고
    • Regulation of protein degradation pathways by amino acids and insulin in skeletal muscle of neonatal pigs
    • A Suryawan, T A Davis: Regulation of protein degradation pathways by amino acids and insulin in skeletal muscle of neonatal pigs. J Anim Sci Biotechnol 5(1), 8 (2014) DOI: 10.1186/2049-1891-5-8
    • (2014) J Anim Sci Biotechnol , vol.5 , Issue.1 , pp. 8
    • Suryawan, A.1    Davis, T.A.2
  • 135
    • 79955013712 scopus 로고    scopus 로고
    • Regulation of protein synthesis by amino acids in muscle of neonates
    • A Suryawan, T A Davis: Regulation of protein synthesis by amino acids in muscle of neonates. Front Biosci (Landmark Ed) 16, 1445-1460 (2011) DOI: 10.2741/3798
    • (2011) Front Biosci (Landmark Ed) , vol.16 , pp. 1445-1460
    • Suryawan, A.1    Davis, T.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.