Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine

Journal of Nutrition

Volumn 131, Issue 3, 2001, Pages

  Anthony, Joshua C ^a   Anthony, Tracy G ^a   Kimball, Scot R ^a   Jefferson, Leonard S ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Insulin; Leucine; Protein synthesis; Skeletal muscle; Translation initiation

Indexed keywords

BRANCHED CHAIN AMINO ACID; INITIATION FACTOR 1; LEUCINE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; BIOSYNTHESIS; CALCIUM SIGNALING; CONFERENCE PAPER; CONTROLLED STUDY; NONHUMAN; NUTRITIONAL STATUS; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; RAT; RNA TRANSLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TARGET CELL; TRANSLATION INITIATION; TRANSLATION REGULATION;

ANIMALIA; EUKARYOTA; MAMMALIA;

EID: 0035090371     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/131.3.856s     Document Type: Conference Paper

References (34)

1. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased elF4F formation
2. Leucine supplementation enhances skeletal muscle recovery in rats following exercise
3. Leucine stimulates translation initiation in skeletal muscle of post-absorptive rats via a rapamycin-sensitive pathway
4. Raft 1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
5. In vitro effect of branched chain amino acids on the ribosomal cycle in muscles of fasted rats
6. Leucine: A possible regulator of protein turnover in muscle
7. The protein kinase C and protein kinase C related families
8. Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm
9. In vivo effect of L-leucine administration on protein synthesis in mice
10. The effect of insulin infusion and food intake on muscle protein synthesis in postabsorptive rats
11. Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin
12. Availability of elF4E regulates skeletal muscle protein synthesis during recovery from exercise
13. Amino acid sufficiency and mTOR regulate p70 S6 kinase and elF-4E BP1 through a common effector mechanism
14. Effects of leucine on in vitro protein synthesis and degradation in rat skeletal muscles
15. Ribosomal protein S6 phosphorylation and signal transduction
16. Mechanisms of translational control in liver and skeletal muscle
17. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of elF4E and phosphorylation of ribosomal protein S6
18. Functional interaction between RAFT1/FRAP/mTOR and protein kinase Cδ in the regulation of cap-dependent initiation of translation
19. Influence of amino acid availability on protein turnover in perfused skeletal muscle
20. Branched chain amino and keto acids as regulators of insulin and glucagon release
21. Failure of leucine to stimulate protein synthesis in vivo
22. Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
23. Translational dynamics. Interactions between the translational factors, tRNA and ribosomes during eukaryotic protein synthesis
24. Initiation of protein synthesis in eukaryotic cells
25. Mammalian TOR controls one of two kinase pathways acting upon nPKCδ and nPKCε
26. Bidirectional modulation of insulin action by amino acids
27. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
28. Glucocorticoids oppose translational control by leucine in skeletal muscle
29. Postprandial stimulation of muscle protein synthesis is independent of changes in insulin
30. Initiation of protein synthesis in eukaryotes
31. Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S^ kinase by pancreatic β-cells
32. Translational regulation of protein synthesis in the liver and skeletal muscle of mice in response to refeeding
33. Modulation of translation initiation in rat skeletal muscle and liver in response to food intake
34. Effect of dietary protein on translation initiation in rat skeletal muscle and liver