Supplementing l-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs

Amino Acids

Volumn 39, Issue 5, 2010, Pages 1477-1486

  Yin, Yulong ^a,b   Yao, Kang ^b   Liu, Zhaojin ^b   Gong, Min ^a   Ruan, Zheng ^a   Deng, Dun ^b   Tan, Bie ^b   Liu, Zhiqiang ^b   Wu, Guoyao ^b,c,d  

^a NANCHANG UNIVERSITY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c CHINA AGRICULTURAL UNIVERSITY   (China)

^d TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Food; Protein synthesis; Tissues; Weanling pigs

Indexed keywords

GLUCOSE; INITIATION FACTOR 4E; INSULIN; LEUCINE;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; GLUCOSE BLOOD LEVEL; GROWTH INHIBITION; HEART; INSULIN BLOOD LEVEL; KIDNEY; LIVER; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN RESTRICTION; PROTEIN SYNTHESIS; SKELETAL MUSCLE; SMALL INTESTINE; SPLEEN; STOMACH; SWINE; TRANSLATION INITIATION; WEANING; WEIGHT GAIN;

AMINO ACIDS; ANIMALS; BLOOD GLUCOSE; DIETARY PROTEINS; DIETARY SUPPLEMENTS; EUKARYOTIC INITIATION FACTOR-4E; INSULIN; LEUCINE; MUSCLE PROTEINS; MUSCLE, SKELETAL; ORGAN SIZE; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6 KINASES; SIROLIMUS; SWINE; WEANING;

MAMMALIA; SUIDAE;

EID: 78449289396     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-010-0612-5     Document Type: Article

References (80)

1. JC Anthony TG Anthony SR Kimball, et al. 2000 Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation J Nutr 130 139 145 1:CAS:528:DC%2BD3cXhtVSmsbY%3D 10720160
2. L Asnaghi P Bruno M Priulla, et al. 2004 mTOR: a protein kinase switching between life and death Pharmacol Res 50 545 549 1:CAS:528:DC%2BD2cXovVyqsr4%3D 10.1016/j.phrs.2004.03.007 15501691
3. DH Baker 2009 Advances in protein-amino acid nutrition of poultry Amino Acids 37 29 41 1:CAS:528:DC%2BD1MXltlemtLk%3D 10.1007/s00726-008-0198-3 19009229
4. RO Ball FX Aherne 1982 Effect of diet complexity and feed restriction on the incidence and severity of diarrhea in early-weaned pigs Can J Anim Sci 62 907 913 10.4141/cjas82-109
5. 5]phenylalanine in pigs J Nutr 134 2722 2728 1:CAS:528:DC%2BD2cXosV2juro%3D 15465773
6. Chen L, Yin YL, Jobgen WS, Jobgen SC, Knabe DA, Hu WX, Wu G (2007) In vitro oxidation of essential amino acids by jejunal mucosal cells of growing pigs. Livest Sci 109:19-23
7. LX Chen P Li JJ Wang, et al. 2009 Catabolism of nutritionally essential amino acids in developing porcine enterocytes Amino Acids 37 143 152 1:CAS:528:DC%2BD1MXltlemtb8%3D 10.1007/s00726-009-0268-1 19291365
8. M Culea D Hachey 1995 Determination of multi-labeled serine and glycine isotopomers in human plasma by isotope dilution negative-ion chemical ionization mass spectrometry Mass Spectrom 9 655 659 1:CAS:528:DyaK2MXmvFOitbc%3D
9. D Dardevet C Sornet M Balage, et al. 2000 Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age J Nutr 130 2630 2635 1:CAS:528:DC%2BD3cXnvVOlsbs%3D 11053498
10. D Dardevet C Sornet G Bayle, et al. 2002 Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal J Nutr 132 95 100 1:CAS:528:DC%2BD38Xjt1emsA%3D%3D 11773514
11. TA Davis ML Fiorotto 2009 Regulation of muscle growth in neonates Curr Opin Nutr Metab Care 12 78 85 1:CAS:528:DC%2BD1cXhsVKntLnP 10.1097/MCO. 0b013e32831cef9f
12. D Deng RL Huang TJ Li, et al. 2007 Nitrogen balance in barrows fed low-protein diets supplemented with essential amino acids Livest Sci 109 220 223 10.1016/j.livsci.2007.01.122
13. D Deng AK Li WY Chu, et al. 2007 Growth performance and metabolic responses in barrows fed low-protein diets supplemented with essential amino acids Livest Sci 109 224 227 10.1016/j.livsci.2007.01.104
14. D Deng YL Yin WY Chu, et al. 2009 Impaired translation initiation activation and reduced protein synthesis in weaned piglets fed a low-protein diet J Nutr Biochem 20 544 552 1:CAS:528:DC%2BD1MXnt1Gls7s%3D 10.1016/j.jnutbio.2008.05.014 18789668
15. Deng J, Wu X, Bin S, Li TJ, Huang R, Liu Z, Liu Y, Ruan Z, Deng Z, Hou Y, Yin YL (2010) Dietary amylose and amylopectin ratio and resistant starch content affects plasma glucose, lactic acid, hormone levels and protein synthesis in splanchnic tissues. Zeitschrift für Tierphysiologie Tierernährung und Futtermittelkunde 94:220-226
16. LTH Dien JM Ravel W Shive 1954 Some inhibitory interrelationships among leucine, isoleucine and valine Arch Biochem Biophys 49 283 291 1:CAS:528:DyaG2cXks1OmsQ%3D%3D 10.1016/0003-9861(54)90199-X 13159277
17. MS Edmonds DH Baker 1987 Amino acid excesses for young pigs: effects of excess methionine, tryptophan, threonine or leucine J Anim Sci 64 1664 1669 1:CAS:528:DyaL2sXkslKlt74%3D 3110116
18. R Elango RO Ball PB Pencharz 2009 Amino acid requirements in humans: with a special emphasis on the metabolic availability of amino acids Amino Acids 37 19 27 1:CAS:528:DC%2BD1MXltlemtbw%3D 10.1007/s00726-009-0234-y 19156481
19. J Escobar JW Frank A Suryawan, et al. 2005 Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation Am J Physiol 288 E914 E921 1:CAS:528:DC%2BD2MXktlSgu7k%3D
20. Fan MZ, Chiba LI, Matzat PD, Yang X, Yin YL, Mine Y, Stein HH (2006) Measuring synthesis rates of nitrogen-containing polymers by using stable isotope tracers. J Anim Sci 84(E. Suppl.):E79-E93
21. JL Figueroa AJ Lewis PS Miller, et al. 2003 Growth, carcass traits, and plasma amino acid concentrations of gilts fed low-protein diets supplemented with amino acids including histidine, isoleucine, and valine J Anim Sci 81 1529 1537 1:CAS:528:DC%2BD3sXksFeqtLw%3D 12817501
22. NE Flynn JG Bird AS Guthrie 2009 Glucocorticoid regulation of amino acid and polyamine metabolism in the small intestine Amino Acids 37 123 129 1:CAS:528:DC%2BD1MXltlemtbo%3D 10.1007/s00726-008-0206-7 19034608
23. JW Frank J Escobar HV Nguyen, et al. 2007 Oral N-carbamoylglutamate supplementation increases protein synthesis in skeletal muscle of piglets J Nutr 137 315 319 1:CAS:528:DC%2BD2sXhsVWjtb8%3D 17237304
24. R Gatnau DR Zirnmerman SL Nissen, et al. 1995 Effects of excess dietary leucine and leucine catabolites on growth and immune responses in weanling pigs J Anim Sci 73 159 165 1:CAS:528:DyaK2MXjtVKhtLk%3D 7601729
25. AC Gingras SP Gygi B Raught 1999 Regulation of 4E-BP1 phosphorylation: a novel 2-step mechanism Gene Dev 13 1422 1437 1:CAS:528:DyaK1MXjvVahsLc%3D 10.1101/gad.13.11.1422 10364159
26. J Han YL Liu W Fan, et al. 2009 Dietary l-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs Amino Acids 37 643 651 1:CAS:528:DC%2BD1MXhtFyqt7fP 10.1007/s00726-008-0184-9 18821052
27. JA Hansen DA Knaba KG Burgoon 1993 Amino acid supplementation of low-protein sorghum-soybean meal diets for 5- to 20-kilogram swine J Anim Sci 71 452 458 1:CAS:528:DyaK3sXhs1yitrc%3D 8440666
28. AE Harper DA Benton ME Winje, et al. 1954 Leucine-isoleucine antagonism in the rat Arch Biochem Biophys 51 523 526 1:CAS:528:DyaG2cXnt1yjsA%3D%3D 10.1016/0003-9861(54)90509-3
29. TE Haynes P Li XL Li, et al. 2009 l-Glutamine or l-alanyl-l-glutamine prevents oxidant- or endotoxin-induced death of neonatal enterocytes Amino Acids 37 131 142 1:CAS:528:DC%2BD1MXltlemtb0%3D 10.1007/s00726-009-0243-x 19189199
30. QH He XF Kong GY Wu, et al. 2009 Metabolomic analysis of the response of growing pigs to dietary l-arginine supplementation Amino Acids 37 199 208 1:CAS:528:DC%2BD1MXltlemtLY%3D 10.1007/s00726-008-0192-9 18989615
31. Hou YQ, Wang L, Ding BY et al (2010) Dietary α-ketoglutarate supplementation ameliorates intestinal injury in lipopolysaccharide-challenged piglets. Amino Acids. doi: 10.1007/s00726-010-0473-y
32. W Jobgen WJ Fu H Gao, et al. 2009 High fat feeding and dietary l-arginine supplementation differentially regulate gene expression in rat white adipose tissue Amino Acids 37 187 198 1:CAS:528:DC%2BD1MXltlemtLs%3D 10.1007/s00726-009-0246-7 19212806
33. Kang P, Toms D, Yin Y, Cheung Q, Gong J, De Lange K, Li J (2010) Epidermal growth factor-expressing Lactococcus lactis enhances intestinal development of early-weaned pigs. J Nutr 140:806-811
34. SW Kim G Wu 2009 Regulatory role for amino acids in mammary gland growth and milk synthesis Amino Acids 37 89 95 1:CAS:528:DC%2BD1MXltlemt7g%3D 10.1007/s00726-008-0151-5 18683019
35. SR Kimball LS Jefferson 2006 New functions for amino acids: effects on gene transcription and translation Am J Clin Nutr 83 500S 507S 1:CAS:528:DC%2BD28Xhs1eisbo%3D 16470021
36. XF Kong GY Wu YP Liao, et al. 2007 Effects of Chinese herbal ultra-fine powder as a dietary additive on growth performance, serum metabolites and intestinal health in early-weaned piglets Livest Sci 108 272 275 10.1016/j.livsci.2007.01.079
37. XF Kong YL Yin QH He, et al. 2009 Dietary supplementation with Chinese herbal powder enhances ileal digestibilities and serum concentrations of amino acids in young pigs Amino Acids 37 573 582 1:CAS:528:DC%2BD1MXhtFyqt7nE 10.1007/s00726-008-0176-9 18763018
38. JP Lalles P Bosi H Smidt, et al. 2007 Weaning-a challenge to gut physiologists Livest Sci 108 82 93 10.1016/j.livsci.2007.01.091
39. P Li YL Yin DF Li, et al. 2007 Amino acids and immune function Br J Nutr 98 237 252 1:CAS:528:DC%2BD2sXpsFentrg%3D 10.1017/S000711450769936X 17403271
40. TJ Li QZ Dai YL Yin, et al. 2008 Dietary starch sources affect net portal appearance of amino acids and glucose in growing pigs Animal 2 723 729 1:CAS:528:DC%2BD1MXhvFertb4%3D 10.1017/S1751731108001614
41. XL Li FW Bazer HJ Gao, et al. 2009 Amino acids and gaseous signaling Amino Acids 37 65 78 10.1007/s00726-009-0264-5 19266154
42. P Li SW Kim XL Li, et al. 2009 Dietary supplementation with cholesterol and docosahexaenoic acid affects concentrations of amino acids in tissues of young pigs Amino Acids 37 709 716 10.1007/s00726-008-0196-5 18972185
43. Li L, Peng H, Zhang B, Wu G, Yin Y, Yang K, Li T, Li A, Hou Z, Zhang P, Liu C (2009c) The effect of dietary addition of a polysaccharide from Atractylodes macrophala koidz on growth performance, immunoglobulin concentration and IL-1βexpression in weaned pigs. J Agric Sci 147:625-631
44. CJ Lynch SM Hutson BJ Patson, et al. 2002 Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats Am J Physiol 283 E824 E835 1:CAS:528:DC%2BD38XotV2qsrk%3D
45. SL MacKenzie 1987 Gas chromatographic analysis of amino acids as the n-heptafluorobutyl isobutyl esters Assoc Official Anal Chem 70 151 160 1:CAS:528:DyaL2sXhtFGrt78%3D
46. AJ Meijer PF Dubbelhuis 2004 Amino acid signaling and the integration of metabolism Biochem Biophys Res Commun 313 397 403 1:CAS:528:DC%2BD3sXpvVWmtbs%3D 10.1016/j.bbrc.2003.07.012 14684175
47. SS Palii CE Kays C Deval, et al. 2009 Specificity of amino acid regulated gene expression: analysis of gene subjected to either complete or single amino acid deprivation Amino Acids 37 79 88 1:CAS:528:DC%2BD1MXltlemtLw%3D 10.1007/s00726-008-0199-2 19009228
48. B Raught AC Gingras 1999 eIF4E is regulated at multiple levels Int J Biochem Cell Biol 31 43 57 1:CAS:528:DyaK1MXhvFSlu7g%3D 10.1016/S1357-2725(98) 00131-9 10216943
49. B Raught AC Gingas N Sonenberg 2001 The target of rapamycin(TOR) proteins Proc Natl Acad Sci USA 98 7037 7044 1:CAS:528:DC%2BD3MXkslWmsb4%3D 10.1073/pnas.121145898 11416184
50. JM Rhoads G Wu 2009 Glutamine, arginine, and leucine signaling in the intestine Amino Acids 37 111 122 1:CAS:528:DC%2BD1MXltlemt7k%3D 10.1007/s00726-008-0225-4
51. A Romanelli VC Dreisbach J Blenis 2002 Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1 J Biol Chem 277 40281 40289 1:CAS:528:DC%2BD38XnvFyns7g%3D 10.1074/jbc.M205168200 12183455
52. CA Rotz 2004 Management to reduce nitrogen losses in animal production J Anim Sci 82 119S 137S
53. Ruan Z, Zang G, Yin YL, Li TJ, Huang RL, Kim SW, Wu GY, Deng ZY (2007) Dietary requirement of true digestible phosphorus and total calcium for growing pigs. Asian Aust J Anim Sci 20:1236-1242
54. SAS (Statistical Analysis System Inc) (2002) SAS/STAT user's guide, version 9. SAS Institute, Cary
55. MH Stipanuk I Ueki JE Dominy, et al. 2009 Cysteine dioxygenase: a robust system for regulation of cellular cysteine levels Amino Acids 37 55 63 1:CAS:528:DC%2BD1MXltlemtLg%3D 10.1007/s00726-008-0202-y 19011731
56. A Suryawan PMJ O'Connor JA Bush, et al. 2009 Differential regulation of protein synthesis by amino acids and insulin in peripheral and visceral tissues of neonatal pigs Amino Acids 37 97 104 1:CAS:528:DC%2BD1MXltlemtb4%3D 10.1007/s00726-008-0149-z 18683020
57. BE Tan XG Li XF Kong, et al. 2009 Dietary l-arginine supplementation enhances the immune status in early-weaned piglets Amino Acids 37 323 331 1:CAS:528:DC%2BD1MXotVKisrg%3D 10.1007/s00726-008-0155-1 18712273
58. BE Tan YL Yin ZQ Liu, et al. 2009 Dietary l-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs Amino Acids 37 169 175 1:CAS:528:DC%2BD1MXltlemt7Y%3D 10.1007/s00726-008-0148-0 18683021
59. B Tan Y Yin X Kong, et al. 2010 l-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells Amino Acids 38 1227 1235 1:CAS:528:DC%2BC3cXkt12qsbo%3D 10.1007/s00726-009-0334-8 19669080
60. Tang ZR, Yin YL, Nyachoti CM, Huang RL, Li TJ, Yang C, Yang X, Gong J, Peng J, Qi DS, Xing JJ, Sun ZH, Fan MZ (2005) Effect of dietary supplementation of chitosan and galacto-mannan-oligosaccharide on serum parameters and the insulin like growth factor-I mRNA expression in early-weaned piglets. Domest Anim Endocrinol 28:430-441
61. Tang ZR, Yin YL, Zhang Y, Huang R, Sun Z, Li T, Chu W, Kong X, Li L, Geng M, Tu Q (2009) Effects of dietary supplementation with an expressed fusion peptide bovine lactoferricin-lactoferrampin on performance, immune function and intestinal mucosal morphology in piglets weaned at age 21 d. Bri J Nutr 101:998-1005
62. ME Tischler M Desautels AL Goldberg 1982 Does leucine, leucyl-transfer RNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle? J Biol Chem 257 1613 1621 1:CAS:528: DyaL38XhtF2ktLc%3D 6915936
63. SH Um F Frigerio M Watanabe 2004 Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity Nature 431 200 205 1:CAS:528:DC%2BD2cXntlGks7g%3D 10.1038/nature02866 15306821
64. TC Vary CJ Lynch 2005 Meal feeding enhances formation of eIF4F in skeletal muscle: role of increased eIF4F availability and eIF4G phosphorylation Am J Physiol 290 E631 E642
65. X Wang SY Qiao YL Yin, et al. 2007 A deficiency or excess of dietary threonine reduces protein synthesis in jejunum and skeletal muscle of young pigs J Nutr 137 1442 1446 1:CAS:528:DC%2BD2sXmt1eks78%3D 17513404
66. XQ Wang DY Ou JD Yin, et al. 2009 Proteomic analysis reveals altered expression of proteins related to glutathione metabolism and apoptosis in the small intestine of zinc oxide-supplemented piglets Amino Acids 37 209 218 10.1007/s00726-009-0242-y 19184341
67. WW Wang SY Qiao DF Li 2009 Amino acids and gut function Amino Acids 37 105 110 1:CAS:528:DC%2BD1MXltlemtLo%3D 10.1007/s00726-008-0152-4 18670730
68. G Wu 2009 Amino acids: metabolism, functions, and nutrition Amino Acids 37 1 17 10.1007/s00726-009-0269-0 19301095
69. G Wu JR Thompson 1988 The effect of ketone bodies on alanine and glutamine metabolism in isolated skeletal muscle from the fasted chick Biochem J 255 139 144 1:CAS:528:DyaL1cXls1Oruro%3D 2904261
70. G Wu JR Thompson G Sedgwick, et al. 1989 Formation of alanine and glutamine in chick (Gallus domesticus) skeletal muscle Comp Biochem Physiol 93B 609 613 1:CAS:528:DyaL1MXltFantr8%3D
71. Wu X, Ruan Z, Zhang G, Hou YQ, Yin YL, Li TJ, Huang RL, Kong XF, Chu WY, Chen LX, Hou YQ, Ruan Z, Gao B, Chen LX (2008) True digestibility of phosphorus in different resources of phosphorus ingredients in growing pigs. Asian Aust J Anim Sci 21:107
72. G Wu FW Bazer TA Davis, et al. 2009 Arginine metabolism and nutrition in growth, health and disease Amino Acids 37 153 168 1:CAS:528:DC%2BD1MXltlemtL0%3D 10.1007/s00726-008-0210-y 19030957
73. G Wu FW Bazer RC Burghardt, et al. 2010 Impacts of amino acid nutrition on pregnancy outcome in pigs: mechanisms and implications for swine production J Anim Sci 88 E195 E204 1:STN:280:DC%2BC3c3pslOrsA%3D%3D 10.2527/jas.2009-2446 19854987
74. Wu X, Yin YL, Li TJ, Wang L, Ruan Z, Liu ZQ, Hou YQ (2010b) Dietary protein, energy and arginine affect LAT1 expression in forebrain white matter differently. Animal. doi: 10.1017/S1751731110000534
75. Wu X, Ruan Z, Gao Y, Yin Y, Zhou X, Wang L, Geng M, Hou Y, Wu G (2010c) Dietary supplementation with l-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a corn- and soybean meal-based diet. Amino Acids. doi: 10.1007/s00726-010-0538-y
76. Yin YL, Huang RL, Zhong HY (1993) Comparison of the ileorectal anastomsis and conventional method for the measurement of ileal digestibility of protein sources and mixed diets in growing pigs. Anim Feed Sci Technol 42:297-308
77. Yin YL, Baidoo SK, Schulze H, Simmins PH (2001) Effect of supplementing diets containing hulless barley varieties having different levels of non-starch polysaccharides with β-glucanase and xylanase on the physiological status of gastrointestinal tract and nutrient digestibility of weaned pigs. Livest Prod Sci 71:97-107
78. Yin YL, Huang C, Wu X, Li T, Huang R, Kang P, Hu Q, Chu W, Kong X (2008) Nutrient digestibility response to graded dietary levels of sodium chloride in weanling pigs. J Sci Food Agric 88:940-944
79. FG Yin YL Liu YL Yin, et al. 2009 Dietary supplementation with Astragalus polysaccharide enhances ileal digestibilities and serum concentrations of amino acids in early weaned piglets Amino Acids 37 263 270 1:CAS:528: DC%2BD1MXotVKis7g%3D 10.1007/s00726-008-0142-6 18622730
80. K Yonezawa KI Yoshino C Tokunaga, et al. 2004 Kinase activities associated with mTOR Curr Top Microbiol Immunol 279 271 282 1:CAS:528: DC%2BD3sXpt1Skurc%3D 14560963