메뉴 건너뛰기




Volumn 58, Issue 11, 2013, Pages 1228-1235

Branched chain amino acids and metabolic regulation

Author keywords

amino acid sensor; branched chain amino acids; diabetes; energy homeostasis; glucose metabolism; lipid metabolism; obesity

Indexed keywords


EID: 84877802993     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1007/s11434-013-5681-x     Document Type: Review
Times cited : (26)

References (78)
  • 1
    • 27244438028 scopus 로고    scopus 로고
    • Emerging pharmacological approaches to the treatment of obesity
    • Wasan K M, Looije N A. Emerging pharmacological approaches to the treatment of obesity. J Pharm Pharm Sci, 2005, 8: 259-271.
    • (2005) J Pharm Pharm Sci , vol.8 , pp. 259-271
    • Wasan, K.M.1    Looije, N.A.2
  • 2
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care, 2004, 27: 1047-1053.
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3
  • 3
    • 77952126921 scopus 로고    scopus 로고
    • Characteristics of obesity and its related disorders in China
    • Jia W P, Wang C, Jiang S, et al. Characteristics of obesity and its related disorders in China. Biomed Environ Sci, 2010, 23: 4-11.
    • (2010) Biomed Environ Sci , vol.23 , pp. 4-11
    • Jia, W.P.1    Wang, C.2    Jiang, S.3
  • 4
    • 77950263954 scopus 로고    scopus 로고
    • Prevalence of diabetes among men and women in China
    • Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China. N Engl J Med, 2010, 362: 1090-1101.
    • (2010) N Engl J Med , vol.362 , pp. 1090-1101
    • Yang, W.1    Lu, J.2    Weng, J.3
  • 5
    • 56949097660 scopus 로고    scopus 로고
    • Epidemiology of non-alcoholic fatty liver disease in China
    • Fan J G, Farrell G C. Epidemiology of non-alcoholic fatty liver disease in China. J Hepatol, 2009, 50: 204-210.
    • (2009) J Hepatol , vol.50 , pp. 204-210
    • Fan, J.G.1    Farrell, G.C.2
  • 6
    • 0036736212 scopus 로고    scopus 로고
    • Molecular pathways to obesity
    • Hofbauer K G. Molecular pathways to obesity. Int J Obes Relat Metab Disord, 2002, 26(Suppl 2): S18-27.
    • (2002) Int J Obes Relat Metab Disord , vol.26 , Issue.SUPPL. 2
    • Hofbauer, K.G.1
  • 7
    • 84859511147 scopus 로고    scopus 로고
    • Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass
    • Maejima Y, Iwasaki Y, Yamahara Y, et al. Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY), 2011, 3: 1169-1177.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1169-1177
    • Maejima, Y.1    Iwasaki, Y.2    Yamahara, Y.3
  • 8
    • 0032706513 scopus 로고    scopus 로고
    • Amino acid limitation regulates gene expression
    • Bruhat A, Jousse C, Fafournoux P. Amino acid limitation regulates gene expression. Proc Nutr Soc, 1999, 58: 625-632.
    • (1999) Proc Nutr Soc , vol.58 , pp. 625-632
    • Bruhat, A.1    Jousse, C.2    Fafournoux, P.3
  • 9
    • 0036517376 scopus 로고    scopus 로고
    • Effect of a high-protein, high-monounsaturated fat weight loss diet on glycemic control and lipid levels in type 2 diabetes
    • Parker B, Noakes M, Luscombe N, et al. Effect of a high-protein, high-monounsaturated fat weight loss diet on glycemic control and lipid levels in type 2 diabetes. Diabetes Care, 2002, 25: 425-430.
    • (2002) Diabetes Care , vol.25 , pp. 425-430
    • Parker, B.1    Noakes, M.2    Luscombe, N.3
  • 10
    • 0037317087 scopus 로고    scopus 로고
    • A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women
    • Layman D K, Boileau R A, Erickson D J, et al. A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women. J Nutr, 2003, 133: 411-417.
    • (2003) J Nutr , vol.133 , pp. 411-417
    • Layman, D.K.1    Boileau, R.A.2    Erickson, D.J.3
  • 11
    • 31544440119 scopus 로고    scopus 로고
    • Potential importance of leucine in treatment of obesity and the metabolic syndrome
    • Layman D K, Walker D A. Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr, 2006, 136: 319S-323S.
    • (2006) J Nutr , vol.136
    • Layman, D.K.1    Walker, D.A.2
  • 12
    • 0014669160 scopus 로고
    • Plasma amino acid levels and insulin secretion in obesity
    • Felig P, Marliss E, Cahill G F Jr. Plasma amino acid levels and insulin secretion in obesity. N Engl J Med, 1969, 281: 811-816.
    • (1969) N Engl J Med , vol.281 , pp. 811-816
    • Felig, P.1    Marliss, E.2    Cahill Jr., G.F.3
  • 13
    • 63449111894 scopus 로고    scopus 로고
    • A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
    • Newgard C B, An J, Bain J R, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab, 2009, 9: 311-326.
    • (2009) Cell Metab , vol.9 , pp. 311-326
    • Newgard, C.B.1    An, J.2    Bain, J.R.3
  • 14
    • 34249680883 scopus 로고    scopus 로고
    • Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms
    • Zhang Y, Guo K, LeBlanc R E, et al. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes, 2007, 56: 1647-1654.
    • (2007) Diabetes , vol.56 , pp. 1647-1654
    • Zhang, Y.1    Guo, K.2    LeBlanc, R.E.3
  • 15
    • 64049117998 scopus 로고    scopus 로고
    • Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice
    • Nairizi A, She P, Vary T C, et al. Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice. J Nutr, 2009, 139: 715-719.
    • (2009) J Nutr , vol.139 , pp. 715-719
    • Nairizi, A.1    She, P.2    Vary, T.C.3
  • 16
    • 33846602706 scopus 로고    scopus 로고
    • 2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid
    • 2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab, 2007, 5: 103-114.
    • (2007) Cell Metab , vol.5 , pp. 103-114
    • Guo, F.1    Cavener, D.R.2
  • 17
    • 33646582664 scopus 로고    scopus 로고
    • Hypothalamic mTOR signaling regulates food intake
    • Cota D, Proulx K, Smith K A, et al. Hypothalamic mTOR signaling regulates food intake. Science, 2006, 312: 927-930.
    • (2006) Science , vol.312 , pp. 927-930
    • Cota, D.1    Proulx, K.2    Smith, K.A.3
  • 18
    • 77449124765 scopus 로고    scopus 로고
    • Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue
    • Cheng Y, Meng Q, Wang C, et al. Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue. Diabetes, 2010, 59: 17-25.
    • (2010) Diabetes , vol.59 , pp. 17-25
    • Cheng, Y.1    Meng, Q.2    Wang, C.3
  • 19
    • 80052295292 scopus 로고    scopus 로고
    • Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system
    • Cheng Y, Zhang Q, Meng Q, et al. Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system. Mol Endocrinol, 2011, 25: 1624-1635.
    • (2011) Mol Endocrinol , vol.25 , pp. 1624-1635
    • Cheng, Y.1    Zhang, Q.2    Meng, Q.3
  • 20
    • 27744436291 scopus 로고    scopus 로고
    • Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
    • Elmquist J K, Coppari R, Balthasar N, et al. Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol, 2005, 493: 63-71.
    • (2005) J Comp Neurol , vol.493 , pp. 63-71
    • Elmquist, J.K.1    Coppari, R.2    Balthasar, N.3
  • 21
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess A M, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med, 2009, 360: 1509-1517.
    • (2009) N Engl J Med , vol.360 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3
  • 22
    • 84864753443 scopus 로고    scopus 로고
    • Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT
    • Du Y, Meng Q, Zhang Q, et al. Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT. Amino Acids, 2012, 43: 725-734.
    • (2012) Amino Acids , vol.43 , pp. 725-734
    • Du, Y.1    Meng, Q.2    Zhang, Q.3
  • 23
    • 34548251464 scopus 로고    scopus 로고
    • Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle
    • She P, Reid T M, Bronson S K, et al. Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab, 2007, 6: 181-194.
    • (2007) Cell Metab , vol.6 , pp. 181-194
    • She, P.1    Reid, T.M.2    Bronson, S.K.3
  • 24
    • 79953737332 scopus 로고    scopus 로고
    • Metabolite profiles and the risk of developing diabetes
    • Wang T J, Larson M G, Vasan R S, et al. Metabolite profiles and the risk of developing diabetes. Nat Med, 2011, 17: 448-453.
    • (2011) Nat Med , vol.17 , pp. 448-453
    • Wang, T.J.1    Larson, M.G.2    Vasan, R.S.3
  • 25
    • 22144472524 scopus 로고    scopus 로고
    • Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis
    • Muto Y, Sato S, Watanabe A, et al. Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis. Clin Gastroenterol Hepatol, 2005, 3: 705-713.
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 705-713
    • Muto, Y.1    Sato, S.2    Watanabe, A.3
  • 26
    • 24144446404 scopus 로고    scopus 로고
    • Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
    • Tremblay F, Krebs M, Dombrowski L, et al. Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes, 2005, 54: 2674-2684.
    • (2005) Diabetes , vol.54 , pp. 2674-2684
    • Tremblay, F.1    Krebs, M.2    Dombrowski, L.3
  • 27
    • 79952374033 scopus 로고    scopus 로고
    • Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways
    • Xiao F, Huang Z, Li H, et al. Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes, 2011, 60: 746-756.
    • (2011) Diabetes , vol.60 , pp. 746-756
    • Xiao, F.1    Huang, Z.2    Li, H.3
  • 28
    • 75749085802 scopus 로고    scopus 로고
    • Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle
    • Iwanaka N, Egawa T, Satoubu N, et al. Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle. J Appl Physiol, 2010, 108: 274-282.
    • (2010) J Appl Physiol , vol.108 , pp. 274-282
    • Iwanaka, N.1    Egawa, T.2    Satoubu, N.3
  • 29
    • 78651293205 scopus 로고    scopus 로고
    • Potential role of branched-chain amino acids in glucose metabolism through the accelerated induction of the glucose-sensing apparatus in the liver
    • Higuchi N, Kato M, Miyazaki M, et al. Potential role of branched-chain amino acids in glucose metabolism through the accelerated induction of the glucose-sensing apparatus in the liver. J Cell Biochem, 2011, 112: 30-38.
    • (2011) J Cell Biochem , vol.112 , pp. 30-38
    • Higuchi, N.1    Kato, M.2    Miyazaki, M.3
  • 30
    • 0033125406 scopus 로고    scopus 로고
    • Amino acid-dependent signal transduction and insulin sensitivity
    • Meijer A J, Sauerwein H P. Amino acid-dependent signal transduction and insulin sensitivity. Curr Opin Clin Nutr Metab Care, 1999, 2: 207-211.
    • (1999) Curr Opin Clin Nutr Metab Care , vol.2 , pp. 207-211
    • Meijer, A.J.1    Sauerwein, H.P.2
  • 31
    • 0029006391 scopus 로고
    • The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids
    • Wek S A, Zhu S, Wek R C. The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids. Mol Cell Biol, 1995, 15: 4497-4506.
    • (1995) Mol Cell Biol , vol.15 , pp. 4497-4506
    • Wek, S.A.1    Zhu, S.2    Wek, R.C.3
  • 32
    • 23944431858 scopus 로고    scopus 로고
    • Nutritional control of gene expression: How mammalian cells respond to amino acid limitation
    • Kilberg M S, Pan Y X, Chen H, et al. Nutritional control of gene expression: How mammalian cells respond to amino acid limitation. Annu Rev Nutr, 2005, 25: 59-85.
    • (2005) Annu Rev Nutr , vol.25 , pp. 59-85
    • Kilberg, M.S.1    Pan, Y.X.2    Chen, H.3
  • 33
    • 0026728645 scopus 로고
    • Molecular cloning of human CREB-2: An ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element
    • Karpinski B A, Morle G D, Huggenvik J, et al. Molecular cloning of human CREB-2: An ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. Proc Natl Acad Sci USA, 1992, 89: 4820-4824.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4820-4824
    • Karpinski, B.A.1    Morle, G.D.2    Huggenvik, J.3
  • 34
    • 0027155881 scopus 로고
    • C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements
    • Vallejo M, Ron D, Miller C P, et al. C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc Natl Acad Sci USA, 1993, 90: 4679-4683.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4679-4683
    • Vallejo, M.1    Ron, D.2    Miller, C.P.3
  • 36
    • 72049124015 scopus 로고    scopus 로고
    • ATF4-dependent transcription mediates signaling of amino acid limitation
    • Kilberg M S, Shan J, Su N. ATF4-dependent transcription mediates signaling of amino acid limitation. Trends Endocrinol Metab, 2009, 20: 436-443.
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 436-443
    • Kilberg, M.S.1    Shan, J.2    Su, N.3
  • 38
    • 0033634654 scopus 로고    scopus 로고
    • Regulated translation initiation controls stress-induced gene expression in mammalian cells
    • Harding H P, Novoa I, Zhang Y, et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell, 2000, 6: 1099-1108.
    • (2000) Mol Cell , vol.6 , pp. 1099-1108
    • Harding, H.P.1    Novoa, I.2    Zhang, Y.3
  • 39
    • 0036464604 scopus 로고    scopus 로고
    • Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice
    • Masuoka H C, Townes T M. Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood, 2002, 99: 736-745.
    • (2002) Blood , vol.99 , pp. 736-745
    • Masuoka, H.C.1    Townes, T.M.2
  • 40
    • 22844433907 scopus 로고    scopus 로고
    • cAMP-response elements in Aplysia creb1, creb2, and Ap-uch promoters: Implications for feedback loops modulating long term memory
    • Mohamed H A, Yao W, Fioravante D, et al. cAMP-response elements in Aplysia creb1, creb2, and Ap-uch promoters: Implications for feedback loops modulating long term memory. J Biol Chem, 2005, 280: 27035-27043.
    • (2005) J Biol Chem , vol.280 , pp. 27035-27043
    • Mohamed, H.A.1    Yao, W.2    Fioravante, D.3
  • 41
    • 11144357428 scopus 로고    scopus 로고
    • ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome
    • Yang X, Matsuda K, Bialek P, et al. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell, 2004, 117: 387-398.
    • (2004) Cell , vol.117 , pp. 387-398
    • Yang, X.1    Matsuda, K.2    Bialek, P.3
  • 42
    • 84863985147 scopus 로고    scopus 로고
    • Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway
    • Cao J, Dai D L, Yao L, et al. Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. Mol Cell Biochem, 2012, 364: 115-129.
    • (2012) Mol Cell Biochem , vol.364 , pp. 115-129
    • Cao, J.1    Dai, D.L.2    Yao, L.3
  • 43
    • 17144417669 scopus 로고    scopus 로고
    • TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
    • Ohoka N, Yoshii S, Hattori T, et al. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J, 2005, 24: 1243-1255.
    • (2005) EMBO J , vol.24 , pp. 1243-1255
    • Ohoka, N.1    Yoshii, S.2    Hattori, T.3
  • 44
    • 70350539531 scopus 로고    scopus 로고
    • Atf4 regulates obesity, glucose homeostasis, and energy expenditure
    • Seo J, Fortuno E S, 3rd, Suh J M, et al. Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes, 2009, 58: 2565-2573.
    • (2009) Diabetes , vol.58 , pp. 2565-2573
    • Seo, J.1    Fortuno III, E.S.2    Suh, J.M.3
  • 45
    • 70349226800 scopus 로고    scopus 로고
    • The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts
    • Yoshizawa T, Hinoi E, Jung D Y, et al. The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest, 2009, 119: 2807-2817.
    • (2009) J Clin Invest , vol.119 , pp. 2807-2817
    • Yoshizawa, T.1    Hinoi, E.2    Jung, D.Y.3
  • 46
    • 84858611085 scopus 로고    scopus 로고
    • FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis
    • Kode A, Mosialou I, Silva B C, et al. FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis. J Biol Chem, 2012, 287: 8757-8768.
    • (2012) J Biol Chem , vol.287 , pp. 8757-8768
    • Kode, A.1    Mosialou, I.2    Silva, B.C.3
  • 47
    • 76449101799 scopus 로고    scopus 로고
    • ATF4 regulates lipid metabolism and thermogenesis
    • Wang C, Huang Z, Du Y, et al. ATF4 regulates lipid metabolism and thermogenesis. Cell Res, 2010, 20: 174-184.
    • (2010) Cell Res , vol.20 , pp. 174-184
    • Wang, C.1    Huang, Z.2    Du, Y.3
  • 48
    • 80051686720 scopus 로고    scopus 로고
    • ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis
    • Li H, Meng Q, Xiao F, et al. ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis. Biochem J, 2011, 438: 283-289.
    • (2011) Biochem J , vol.438 , pp. 283-289
    • Li, H.1    Meng, Q.2    Xiao, F.3
  • 49
    • 84872683946 scopus 로고    scopus 로고
    • Effects of ATF4 on PGC1? expression in brown adipose tissue and metabolic responses to cold stress
    • Wang C, Xia T, Du Y, et al. Effects of ATF4 on PGC1? expression in brown adipose tissue and metabolic responses to cold stress. Metabolism, 2012, doi: 10. 1016/j. metabol. 2012. 07. 017.
    • (2012) Metabolism
    • Wang, C.1    Xia, T.2    Du, Y.3
  • 50
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall M N. TOR signaling in growth and metabolism. Cell, 2006, 124: 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 51
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • Inoki K, Corradetti M N, Guan K L. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet, 2005, 37: 19-24.
    • (2005) Nat Genet , vol.37 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.L.3
  • 52
    • 0035094978 scopus 로고    scopus 로고
    • Role of leucine in the regulation of mTOR by amino acids: Revelations from structure-activity studies
    • Lynch C J. Role of leucine in the regulation of mTOR by amino acids: Revelations from structure-activity studies. J Nutr, 2001, 131: 861S-865S.
    • (2001) J Nutr , vol.131
    • Lynch, C.J.1
  • 53
    • 3342958797 scopus 로고    scopus 로고
    • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    • Harrington L S, Findlay G M, Gray A, et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol, 2004, 166: 213-223.
    • (2004) J Cell Biol , vol.166 , pp. 213-223
    • Harrington, L.S.1    Findlay, G.M.2    Gray, A.3
  • 54
    • 1542616960 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation
    • Carlson C J, White M F, Rondinone C M. Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem Biophys Res Commun, 2004, 316: 533-539.
    • (2004) Biochem Biophys Res Commun , vol.316 , pp. 533-539
    • Carlson, C.J.1    White, M.F.2    Rondinone, C.M.3
  • 55
    • 0035836770 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
    • Ozes O N, Akca H, Mayo L D, et al. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci USA, 2001, 98: 4640-4645.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4640-4645
    • Ozes, O.N.1    Akca, H.2    Mayo, L.D.3
  • 56
    • 35348832340 scopus 로고    scopus 로고
    • Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
    • Tremblay F, Brule S, Hee Um S, et al. Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proc Natl Acad Sci USA, 2007, 104: 14056-14061.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14056-14061
    • Tremblay, F.1    Brule, S.2    Hee Um, S.3
  • 57
    • 33749342069 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance: Serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: The two sides of a coin
    • Draznin B. Molecular mechanisms of insulin resistance: Serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: The two sides of a coin. Diabetes, 2006, 55: 2392-2397.
    • (2006) Diabetes , vol.55 , pp. 2392-2397
    • Draznin, B.1
  • 58
    • 0035155272 scopus 로고    scopus 로고
    • Serine/threonine phosphorylation of IRS-1 triggers its degradation: Possible regulation by tyrosine phosphorylation
    • Pederson T M, Kramer D L, Rondinone C M. Serine/threonine phosphorylation of IRS-1 triggers its degradation: Possible regulation by tyrosine phosphorylation. Diabetes, 2001, 50: 24-31.
    • (2001) Diabetes , vol.50 , pp. 24-31
    • Pederson, T.M.1    Kramer, D.L.2    Rondinone, C.M.3
  • 59
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • Um S H, Frigerio F, Watanabe M, et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature, 2004, 431: 200-205.
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1    Frigerio, F.2    Watanabe, M.3
  • 60
    • 34249679233 scopus 로고    scopus 로고
    • The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man
    • Krebs M, Brunmair B, Brehm A, et al. The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man. Diabetes, 2007, 56: 1600-1607.
    • (2007) Diabetes , vol.56 , pp. 1600-1607
    • Krebs, M.1    Brunmair, B.2    Brehm, A.3
  • 61
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie D G, Ross F A, Hawley S A. AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol, 2012, 13: 251-262.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 62
    • 33644943620 scopus 로고    scopus 로고
    • AMPK: A key sensor of fuel and energy status in skeletal muscle
    • Hardie D G, Sakamoto K. AMPK: A key sensor of fuel and energy status in skeletal muscle. Physiology (Bethesda), 2006, 21: 48-60.
    • (2006) Physiology (Bethesda) , vol.21 , pp. 48-60
    • Hardie, D.G.1    Sakamoto, K.2
  • 63
    • 0035861644 scopus 로고    scopus 로고
    • 5′-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside
    • Jakobsen S N, Hardie D G, Morrice N, et al. 5′-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside. J Biol Chem, 2001, 276: 46912-46916.
    • (2001) J Biol Chem , vol.276 , pp. 46912-46916
    • Jakobsen, S.N.1    Hardie, D.G.2    Morrice, N.3
  • 64
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan K L. TSC2 mediates cellular energy response to control cell growth and survival. Cell, 2003, 115: 577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 65
    • 65349177200 scopus 로고    scopus 로고
    • AMPK: An emerging drug target for diabetes and the metabolic syndrome
    • Zhang B B, Zhou G, Li C. AMPK: An emerging drug target for diabetes and the metabolic syndrome. Cell Metab, 2009, 9: 407-416.
    • (2009) Cell Metab , vol.9 , pp. 407-416
    • Zhang, B.B.1    Zhou, G.2    Li, C.3
  • 66
    • 3843061592 scopus 로고    scopus 로고
    • AMP kinase and malonyl-CoA: Targets for therapy of the metabolic syndrome
    • Ruderman N, Prentki M. AMP kinase and malonyl-CoA: Targets for therapy of the metabolic syndrome. Nat Rev Drug Discov, 2004, 3: 340-351.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 340-351
    • Ruderman, N.1    Prentki, M.2
  • 67
    • 33745815985 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling in metabolic regulation
    • Long Y C, Zierath J R. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest, 2006, 116: 1776-1783.
    • (2006) J Clin Invest , vol.116 , pp. 1776-1783
    • Long, Y.C.1    Zierath, J.R.2
  • 68
    • 9444249257 scopus 로고    scopus 로고
    • AMP-activated protein kinase: A new beta-cell glucose sensor? Regulation by amino acids and calcium ions
    • Leclerc I, Rutter G A. AMP-activated protein kinase: A new beta-cell glucose sensor? Regulation by amino acids and calcium ions. Diabetes, 2004, 53(Suppl 3): S67-74.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Leclerc, I.1    Rutter, G.A.2
  • 69
    • 0014824538 scopus 로고
    • Effects of ingestion of disproportionate amounts of amino acids
    • Harper A E, Benevenga N J, Wohlhueter R M. Effects of ingestion of disproportionate amounts of amino acids. Physiol Rev, 1970, 50: 428-558.
    • (1970) Physiol Rev , vol.50 , pp. 428-558
    • Harper, A.E.1    Benevenga, N.J.2    Wohlhueter, R.M.3
  • 70
    • 36048985768 scopus 로고    scopus 로고
    • Mechanisms of food intake repression in indispensable amino acid deficiency
    • Gietzen D W, Hao S, Anthony T G. Mechanisms of food intake repression in indispensable amino acid deficiency. Annu Rev Nutr, 2007, 27: 63-78.
    • (2007) Annu Rev Nutr , vol.27 , pp. 63-78
    • Gietzen, D.W.1    Hao, S.2    Anthony, T.G.3
  • 71
    • 0015125961 scopus 로고
    • Importance of prepyriform cortex in food-intake response of rats to amino acids
    • Leung P M, Rogers Q R. Importance of prepyriform cortex in food-intake response of rats to amino acids. Am J Physiol, 1971, 221: 929-935.
    • (1971) Am J Physiol , vol.221 , pp. 929-935
    • Leung, P.M.1    Rogers, Q.R.2
  • 72
    • 71849102490 scopus 로고    scopus 로고
    • The sensing of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not rapamycin
    • Hao S, Ross-Inta C M, Gietzen D W. The sensing of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not rapamycin. Pharmacol Biochem Behav, 2010, 94: 333-340.
    • (2010) Pharmacol Biochem Behav , vol.94 , pp. 333-340
    • Hao, S.1    Ross-Inta, C.M.2    Gietzen, D.W.3
  • 73
    • 0035851851 scopus 로고    scopus 로고
    • The hypothalamus and the control of energy homeostasis: Different circuits, different purposes
    • Williams G, Bing C, Cai X J, et al. The hypothalamus and the control of energy homeostasis: Different circuits, different purposes. Physiol Behav, 2001, 74: 683-701.
    • (2001) Physiol Behav , vol.74 , pp. 683-701
    • Williams, G.1    Bing, C.2    Cai, X.J.3
  • 74
    • 0029758229 scopus 로고    scopus 로고
    • Neuropeptide Y, the hypothalamus and the regulation of energy homeostasis
    • Tomaszuk A, Simpson C, Williams G. Neuropeptide Y, the hypothalamus and the regulation of energy homeostasis. Horm Res, 1996, 46: 53-58.
    • (1996) Horm Res , vol.46 , pp. 53-58
    • Tomaszuk, A.1    Simpson, C.2    Williams, G.3
  • 75
    • 0021697844 scopus 로고
    • The hypothalamus and metabolic regulation, especially hypothalamic regulation of lipid metabolism and its disorder
    • Shimazu T. The hypothalamus and metabolic regulation, especially hypothalamic regulation of lipid metabolism and its disorder. Tanpakushitsu Kakusan Koso, 1984, 29: 1589-1599.
    • (1984) Tanpakushitsu Kakusan Koso , vol.29 , pp. 1589-1599
    • Shimazu, T.1
  • 76
    • 77249131674 scopus 로고    scopus 로고
    • Hypothalamic nutrient sensing in the control of energy homeostasis
    • Blouet C, Schwartz G J. Hypothalamic nutrient sensing in the control of energy homeostasis. Behav Brain Res, 2010, 209: 1-12.
    • (2010) Behav Brain Res , vol.209 , pp. 1-12
    • Blouet, C.1    Schwartz, G.J.2
  • 77
    • 34247886103 scopus 로고    scopus 로고
    • The role of CNS fuel sensing in energy and glucose regulation
    • Cota D, Proulx K, Seeley R J. The role of CNS fuel sensing in energy and glucose regulation. Gastroenterology, 2007, 132: 2158-2168.
    • (2007) Gastroenterology , vol.132 , pp. 2158-2168
    • Cota, D.1    Proulx, K.2    Seeley, R.J.3
  • 78
    • 84866607486 scopus 로고    scopus 로고
    • S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid
    • Xia T, Cheng Y, Zhang Q, et al. S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid. Diabetes, 2012, 61: 2461-2471.
    • (2012) Diabetes , vol.61 , pp. 2461-2471
    • Xia, T.1    Cheng, Y.2    Zhang, Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.