Investigations of branched-chain amino acids and their metabolites in animal models of cancer

Journal of Nutrition

Volumn 136, Issue 1, 2006, Pages

  Baracos, Vickie E ^a   Mackenzie, Michelle L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Amino acids; Cachexia; Muscle wasting; Supplementation; Tumor

Indexed keywords

3 HYDROXYBUTYRIC ACID; BRANCHED CHAIN AMINO ACID; CARBON 11; ISOLEUCINE; LEUCINE; VALINE;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANOREXIA; BREAST CANCER; CANCER; CANCER CELL CULTURE; CONFERENCE PAPER; DIET SUPPLEMENTATION; DIETARY INTAKE; GLIOMA; GLUCONEOGENESIS; INFLAMMATION; MUSCLE ATROPHY; MUSCLE METABOLISM; NONHUMAN; OXIDATION; POSITRON EMISSION TOMOGRAPHY; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SKELETAL MUSCLE; TUMOR GROWTH;

ANIMALIA;

EID: 31544457307     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.1.237s     Document Type: Conference Paper

References (57)

1. Dewys WD, Begg C, Lavin PT, Band PR, Bennett JM, Bertino JR, Cohen MH, Douglass HO, Engstrom PF, et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Am J Med. 1980;69:491-7.
2. Mackenzie M, Baracos VE. Cancer-associated cachexia: altered metabolism of protein and amino acids. In: Cynober LA, editor. Metabolic and Therapeutic Aspects of Amino Acids in Clinical Nutrition. Boca Raton, FL: CRC Press; 2003. p. 339-54.
3. Kalantar-Zadeh K, Mehrotra R, Fouque D, Kopple JD. Metabolic acidosis and malnutrition-inflammation complex syndrome in chronic renal failure. Semin Dial. 2004;17:455-65.
4. Harris RA, Joshi M, Jeoung NH. Mechanisms responsible for regulation of branched-chain amino acid catabolism. Biochem Biophys Res Commun. 2004;313:391-6.
5. Shimomura Y, Obayashi M, Murakami T, Harris RA. Regulation of branched-chain amino acid catabolism: nutritional and hormonal regulation of activity and expression of the branched-chain α-keto acid dehydrogenase kinase. Curr Opin Clin Nutr Metab Care. 2001;4:419-23.
6. Smith HJ, Mukerji P, Tisdale MJ. Attenuation of proteasome-induced proteolysis in skeletal muscle by β-hydroxy-β-methylbutyrate in cancer-induced muscle loss. Cancer Res. 2005;65:277-83.
7. Nishihira T, Takagi T, Kawarabayashi Y, Izumi U, Ohkuma S, Koike N, Toyoda T, Mori S. Anti-cancer therapy with valine-depleted amino acid imbalance solution. Tohoku J Exp Med. 1988;156:259-70.
8. Ishiwata K, Kubota K, Murakami M, Kubota R, Senda M. A comparative study on protein incorporation of L-[methyl-3H]methionine, L-[1-14C]leucine and L-2-[18F]fluorotyrosine in tumor bearing mice. Nucl Med Biol. 1993;20:895-9.
9. Paxton K, Ward LC, Wilce PA. Amino acid oxidation in the tumor-bearing rat. Cancer Biochem Biophys. 1988;9:343-51.
10. Le Bricon T, Cynober L, Field CJ, Baracos VE. Supplemental nutrition with ornithine α-ketoglutarate in rats with cancer-associated cachexia: surgical treatment of the tumor improves efficacy of nutritional support. J Nutr. 1995;125:2999-3010.
11. Kawamura I, Sato H, Ogoshi S, Blackburn GL. Use of an intravenous branched chain amino acid enriched diet in the tumor-bearing rat. Jpn J Surg. 1985;15:471-6.
12. Argiles JM, Lopez-Soriano FJ. The oxidation of leucine in tumour-bearing rats. Biochem J. 1990;268:241-4.
13. Siddiqui RA, Williams JF. The regulation of fatty acid and branched-chain amino acid oxidation in cancer cachectic rats: a proposed role for a cytokine, eicosanoid, and hormone trilogy. Biochem Med Metab Biol. 1989;42:71-86.
14. Goodlad GAJ, Tee MK, Clark CM. Leucine oxidation and protein degradation in extensor digitorum longus and soleus of the tumor-bearing host. Biochem Med. 1981;26:143-7.
15. Argiles JM, Lopez-Soriano FJ. Oxidation of branched-chain amino acids in tumor-bearing rats. Biochem Soc Trans. 1989;17:1044-5.
16. Gomes-Marcondes MC, Ventrucci G, Toledo MT, Cury L, Cooper JC. A leucine-supplemented diet improved protein content of skeletal muscle in young tumor-bearing rats. Braz J Med Biol Res. 2003;36:1589-94.
17. Ventrucci G, Mello MA, Gomes-Marcondes MC. Effect of a leucine-supplemented diet on body composition changes in pregnant rats bearing Walker 256 tumor. Braz J Med Biol Res. 2001;34:333-8.
18. Ventrucci G, de Mello MA, Gomes-Marcondes MC. Effects of leucine supplemented diet on intestinal absorption in tumor bearing pregnant rats. BMC Cancer. 2002;2:7.
19. Ventrucci G, Mello MA, Gomes-Marcondes MC. Proteasome activity is altered in skeletal muscle tissue of tumour-bearing rats fed a leucine-rich diet. Endocr Relat Cancer. 2004;11:887-95.
20. Costelli P, Llovera M, Garcia-Martinez C, Carbo N, Lopez-Soriano FJ, Argiles JM. Enhanced leucine oxidation in rats bearing an ascites hepatoma (Yoshida AH-130) and its reversal by clenbuterol. Cancer Lett. 1995;91:73-8.
21. Busquets S, Alvarez B, Lopez-Soriano FJ, Argiles JM. Branched-chain amino acids: a role in skeletal muscle proteolysis in catabolic states? J Cell Physiol. 2002;191:283-9.
22. Komatsu H, Nishihira T, Chin M, Doi H, Shineha R, Mori S, Satomi S. Effect of valine-depleted total parenteral nutrition on fatty liver development in tumor-bearing rats. Nutrition. 1998;14:276-81.
23. Crosby LE, Bistrian BR, Ling P, Istfan NW, Blackburn GL, Hoffman SB. Effects of branched chain amino acid-enriched total parenteral nutrition on amino acid utilization in rats bearing Yoshida sarcoma. Cancer Res. 1988;48:2698-702.
24. Kim do K, Kim IJ, Hwang S, Kook JH, Lee MC, Shin BA, Bae CS, Yoon JH, Ahn SG, et al. System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells. Neurosci Res. 2004;50:437-46.
25. Shennan DB, Thomson J, Gow IF, Travers MT, Barber MC. L-leucine transport in human breast cancer cells (MCF-7 and MDA-MB-231): kinetics, regulation by estrogen and molecular identity of the transporter. Biochim Biophys Acta. 2004;1664:206-16.
26. Kirikae M, Diksic M, Yamamoto YL. Quantitative measurements of regional glucose utilization and rate of valine incorporation into proteins by double-tracer autoradiography in the rat brain tumor model. J Cereb Blood Flow Metab. 1989;9:87-95.
27. Smith CB, Schmidt KC, Qin M, Burlin TV, Cook MP, Kang J, Saunders RC, Bacher JD, Carson RE, et al. Measurement of regional rates of cerebral protein synthesis with L-[1-11C]leucine and PET with correction for recycling of tissue amino acids: II. Validation in rhesus monkeys. J Cereb Blood Flow Metab. 2005;25:629-40.
28. Sweatt AJ, Wood M, Suryawan A, Wallin R, Willingham MC, Hutson SM. Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves. Am J Physiol Endocrinol Metab. 2004;286:E64-76.
29. Norton JA, Shamberger R, Stein TP, Milne GWA, Brennan MF. The influence of tumor-bearing on protein metabolism in the rat. J Surg Res. 1981;30:456-62.
30. Heys SD, Park KG, McNurlan MA, Calder AG, Buchan V, Blessing K, Eremin O, Garlick PJ. Measurement of tumour protein synthesis in vivo in human colorectal and breast cancer and its variability in separate biopsies from the same tumor. Clin Sci. 1991;80:587-93.
31. Baracos VE, LeBricon T. Animal models for nutrition in cancer. In: Mason JB and Nitenberg G, editors. Cancer and Nutrition: Prevention and Treatment. Nestle Nutrition Workshop Series Clinical and Performance Program, Vol. 4. Switzerland and New York: Nestle Ltd.; 2000. p. 167-82.
32. Shiraki M, Shimomura Y, Miwa Y, Fukushima H, Murakami T, Tamura T, Tamura N, Moriwaki H. Activation of hepatic branched-chain alpha-keto acid dehydrogenase complex by tumor necrosis factor-alpha in rats. Biochem Biophys Res Commun. 2005;328:973-8.
33. Fearon KC, Barber MD, Falconer JS, McMillan DC, Ross JA, Preston T. Pancreatic cancer as a model: inflammatory mediators, acute-phase response and cancer cachexia. World J Surg. 1999;23:584-8.
34. Scott HR, McMillan DC, Forrest LM, Brown DJF, McArdle CS, Milroy R. The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer. Br J Cancer. 2002;87:264-7.
35. Fearon KC, McMillan DC, Preston T, Winstanley FP, Cruickshank AM, Shenkin A. Elevated circulating interleukin-6 is associated with an acute-phase response but reduced fixed hepatic protein synthesis in patients with cancer. Ann Surg. 1991;213:26-31.
36. Wigmore SJ, McMahon AJ, Sturgeon CM, Fearon KCH. Acute-phase protein response, survival and tumour recurrence in patients with colorectal cancer. Br J Surg. 2001;88:255-60.
37. Falconer JS, Fearon KCH, Ross JA, Elton R, Wigmore SJ, Garden OJ, Carter DC. Acute-phase protein response and survival duration of patients with pancreatic cancer. Cancer. 1995;75:2077-82.
38. Barber MD, Fearon KCH, Ross JA. Relationship of serum levels of interleukin-6, soluble interleukin-6 receptor and tumour necrosis factor receptors to the acute-phase response in advanced pancreatic cancer. Clin Sci. 1999;96:83-7.
39. Staal-van den Brekel AJ, Schols AM, ten Velde GP, Buurman WA, Wouters EF. Analysis of the energy balance in lung cancer patients. Cancer Res. 1994;54:6430-3.
40. Laviano A, Meguid MM, Rossi-Fanelli F. Improving food intake in anorectic cancer patients. Curr Opin Clin Nutr Metab Care. 2003;6:421-6.
41. Cangiano C, Laviano A, Meguid MM, Mulieri M, Conversano L, Preziosa I, Rossi-Fanelli F. Effects of administration of oral branched-chain amino acids on anorexia and caloric intake in cancer patients. J Natl Cancer Inst. 1996;88:550-2.
42. MacDonald N, Easson AM, Mazurak VC, Dunn GP, Baracos VE. Understanding and managing cancer cachexia. J Am Coll Surg. 2003;197:143-61.
43. Baracos VE. Regulation of skeletal-muscle-protein turnover in cancer-associated cachexia. Nutrition. 2000;16:1015-8.
44. Shaw JH, Wolfe RR. Glucose and urea kinetics in patients with early and advanced gastrointestinal cancer: the response to glucose infusion, parenteral feeding, and surgical resection. Surgery. 1987;101:181-91.
45. 31P magnetic resonance spectroscopy in vivo. Clin Sci. 2000;98:167-74.
46. Harper AE. Balance and imbalance of amino acids. Ann N Y Acad Sci. 1958;69:1025-38.
47. Gonzalez GG, Byus CV. Effect of dietary arginine restriction upon ornithine and polyamine metabolism during two-stage epidermal carcinogenesis in the mouse. Cancer Res. 1991;51:2932-9.
48. Goseki N, Yamazaki S, Endo M, Onodera T, Kosaki G, Hibino Y, Kuwahata T. Antitumor effect of methionine-depleting total parenteral nutrition with doxorubicin administration on Yoshida sarcoma-bearing rats. Cancer. 1992;69:1865-72.
49. Okada K, Takehara H, Okada A. Tumor glutamine level is negatively correlated with tumor weight in tumor-bearing rats administered a glutamine antagonist and a new imbalanced amino acid solution. J Clin Biochem Nutr. 1992;12:183-91.
50. Hunter DC, Weintraub M, Blackburn GL, Bistrian BR. Branched chain amino acids as the protein component of parenteral nutrition in cancer cachexia. Br J Surg. 1989;76:149-53.
51. Tayek JA, Bistrian BR, Hehir DJ, Martin R, Moldawer LL, Blackburn GL. Improved protein kinetics and albumin synthesis by branched chain amino acid-enriched total parenteral nutrition in cancer cachexia. Cancer. 1986;58:147-57.
52. Heys SD, Park KGM, McNurlan MA, Milne E, Eremin O, Wernerman J, Keenan RA, Garlick PJ. Stimulation of protein synthesis in human tumours by parenteral nutrition: evidence for modulation of tumour growth. Br J Surg. 1991;78:483-7.
53. McNurlan MA, Heys SD, Park KGM, Broom J, Brown DS, Eremin O, Garlick PJ. Tumour and host tissue responses to branched-chain amino acid supplementation of patients with cancer. Clin Sci. 1994;86:339-45.
54. Mitch WE, Clark AS. Specificity of the effects of leucine and its metabolites on protein degradation in skeletal muscle. Biochem J. 1984;222:579-86.
55. Van Koevering M, Nissen S. Oxidation of leucine and α- ketoisocaproate to β-hydroxy-β-methylbutyrate in vivo. Am J Physiol. 1992;262:E27-31.
56. May PE, Barber A, D'Olimpio JT, Hourihane A, Abumrad NN. Reversal of cancer-related wasting using oral supplementation with a combination of β-hydroxy-β-methylbutyrate, arginine and glutamine. Am J Surg. 2002;183:471-9.
57. Smith HJ, Wyke SM, Tisdale MJ. Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by β-hydroxy-β-methylbutyrate. Cancer Res. 2004;64:8731-5.