Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells

Journal of Medicinal Chemistry

Volumn 57, Issue 23, 2014, Pages 9870-9888

  Seifert, Tina ^a   Malo, Marcus ^a   Kokkola, Tarja ^b   Engen, Karin ^a   Fridén Saxin, Maria ^a   Wallén, Erik A A ^c   Lahtela Kakkonen, Maija ^b   Jarho, Elina M ^b   Luthman, Kristina ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 OXO 1,2 DIHYDROQUINOLIN 6 YL)PROPANAL; 3 (AMINOMETHYLENE) 8 BROMO 6 CHLORO 2 PHENETHYLCHOMAN 4 ONE; 3 (QUINOLIN 6 YL)PROPANAL; 3 MORPHOLINOPROPANAL; 3 [TERT BUTYLDIMETHYLSILYLOXY)PROPANAL; 4 (8 BROMO 6 CHLORO 4 OXO CHROMAN 2 YL)BUTANOIC ACID; 4 (8 BROMO 6 CHLORO 4 OXOCHROMAN 2 YL) N METHYLBUTANAMIDE; 4 (8 BROMO 6 CHLORO 4 OXOCHROMAN 2 YL) N,N DIMETHYLBUTANAMIDE; 4 CHROMANONE DERIVATIVE; 6 [2 (8 BROMO 6 CHLORO 4 OXOCHROMAN 2 YL)ETHYL]QUINOLIN 1 (H)ONE; 8 BROMO 6 CHLORO 2 (3 MORPHOLINOPROPYL)CHROMAN 4 ONE; 8 BROMO 6 CHLORO 2 [2 (3 METHYL 1,2,4 OXADIAZOL 5 YL)ETHYL]CHROMAN 4 ONE; 8 BROMO 6 CHLORO 2 [2 (QUINOLIN 6 YL)ETHYL]CHROMAN 4 ONE; 8 BROMO 6 CHLORO 2 [3 (3 METHYL 1,2,4 OXADIAZOL 5 YL)PROPYL]CHROMAN 4 ONE; ALPHA TUBULIN; ANTINEOPLASTIC AGENT; ESTER DERIVATIVE; N (8 BROMO 6 CHLORO 4 OXO 2 PHENETHYL 4H CHROMEN 3 YL)ACETAMIDE; N BENZYL 4 (8 BROMO 6 CHLORO 4 OXOCHROMAN 2 YL)BUTANAMIDE; SIRTUIN 2; UNCLASSIFIED DRUG; CHROMAN DERIVATIVE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; TUBULIN;

ACETYLATION; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING SITE; BREAST CANCER; CANCER CELL; CONTROLLED STUDY; DEACETYLATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LUNG CARCINOMA; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECTS; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMANS; CHROMONES; ENZYME INHIBITORS; HUMANS; SIRTUIN 2; TUBULIN;

EID: 84918570490     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500930h     Document Type: Article

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