Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change

Structure

Volumn 22, Issue 2, 2014, Pages 345-352

  Yamagata, Kenichiro ^a   Goto, Yuki ^b   Nishimasu, Hiroshi ^b   Morimoto, Jumpei ^b   Ishitani, Ryuichiro ^b   Dohmae, Naoshi ^c   Takeda, Norihiko ^a   Nagai, Ryozo ^d   Komuro, Issei ^a   Suga, Hiroaki ^b   Nureki, Osamu ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c RIKEN   (Japan)

^d JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; ENZYME INHIBITOR; PEPTIDE DERIVATIVE; SIRTUIN 2; SIRTUIN 2 INHIBITOR; UNCLASSIFIED DRUG; PEPTIDE;

ARTICLE; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; CONFORMATIONAL TRANSITION; DEACETYLATION; HUMAN; MOLECULAR DYNAMICS; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

ADENOSINE DIPHOSPHATE RIBOSE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA MUTATIONAL ANALYSIS; HUMANS; KINETICS; MACROCYCLIC COMPOUNDS; MODELS, MOLECULAR; PEPTIDES; PEPTIDES, CYCLIC; PROTEIN BINDING; SIRTUIN 2; SURFACE PLASMON RESONANCE;

EID: 84893805133     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2013.12.001     Document Type: Article

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