Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 2, 2014, Pages 703-710

  Yoon, Yeong Keng ^a   Ali, Mohamed Ashraf ^a,b,c   Wei, Ang Chee ^a   Choon, Tan Soo ^a   Osman, Hasnah ^d   Parang, Keykavous ^e   Shirazi, Amir Nasrolahi ^e  

^a INSTITUTE FOR RESEARCH IN MOLECULAR MEDICINE INFORMM   (Malaysia)

^b Alwar Pharmacy College   (India)

^c Sunrise University   (India)

^d SCHOOL OF PHYSICS   (Malaysia)

^e UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Anti proliferative; Benzimidazole; Breast cancer; Electron donating; Sirtuin

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; ENZYME INHIBITOR; SIRTUIN 1; SIRTUIN 2; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE; SIRT1 PROTEIN, HUMAN; SIRT2 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING COMPETITION; BREAST CANCER; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MCF 7 CELL LINE; METABOLISM; SYNTHESIS;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SIRTUIN 1; SIRTUIN 2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84892367434     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.12.029     Document Type: Article

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