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Volumn 41, Issue 6, 2014, Pages 919-933

The E3 Ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING

Author keywords

[No Author keywords available]

Indexed keywords

AMFR PROTEIN, HUMAN; AUTOCRINE MOTILITY FACTOR RECEPTOR; INSIG1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TBK1 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

EID: 84918565372     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2014.11.011     Document Type: Article
Times cited : (284)

References (60)
  • 1
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 2
    • 79951679142 scopus 로고    scopus 로고
    • Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses
    • Barber G.N. Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Curr. Opin. Immunol. 2011, 23:10-20.
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 10-20
    • Barber, G.N.1
  • 3
    • 80053031961 scopus 로고    scopus 로고
    • STING-dependent signaling
    • Barber G.N. STING-dependent signaling. Nat. Immunol. 2011, 12:929-930.
    • (2011) Nat. Immunol. , vol.12 , pp. 929-930
    • Barber, G.N.1
  • 4
    • 84893637182 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing pathways
    • Barber G.N. STING-dependent cytosolic DNA sensing pathways. Trends Immunol. 2014, 35:88-93.
    • (2014) Trends Immunol. , vol.35 , pp. 88-93
    • Barber, G.N.1
  • 5
  • 6
    • 33847709027 scopus 로고    scopus 로고
    • SREBP in signal transduction: cholesterol metabolism and beyond
    • Bengoechea-Alonso M.T., Ericsson J. SREBP in signal transduction: cholesterol metabolism and beyond. Curr. Opin. Cell Biol. 2007, 19:215-222.
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 215-222
    • Bengoechea-Alonso, M.T.1    Ericsson, J.2
  • 7
    • 84899131835 scopus 로고    scopus 로고
    • The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling
    • Cai X., Chiu Y.H., Chen Z.J. The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Mol. Cell 2014, 54:289-296.
    • (2014) Mol. Cell , vol.54 , pp. 289-296
    • Cai, X.1    Chiu, Y.H.2    Chen, Z.J.3
  • 8
    • 84861678659 scopus 로고    scopus 로고
    • Induction of type I IFNs by intracellular DNA-sensing pathways
    • Cavlar T., Ablasser A., Hornung V. Induction of type I IFNs by intracellular DNA-sensing pathways. Immunol. Cell Biol. 2012, 90:474-482.
    • (2012) Immunol. Cell Biol. , vol.90 , pp. 474-482
    • Cavlar, T.1    Ablasser, A.2    Hornung, V.3
  • 9
    • 84855320818 scopus 로고    scopus 로고
    • Protein quality control in the ER: balancing the ubiquitin checkbook
    • Claessen J.H., Kundrat L., Ploegh H.L. Protein quality control in the ER: balancing the ubiquitin checkbook. Trends Cell Biol. 2012, 22:22-32.
    • (2012) Trends Cell Biol. , vol.22 , pp. 22-32
    • Claessen, J.H.1    Kundrat, L.2    Ploegh, H.L.3
  • 11
    • 0035807839 scopus 로고    scopus 로고
    • The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum
    • Fang S., Ferrone M., Yang C., Jensen J.P., Tiwari S., Weissman A.M. The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 2001, 98:14422-14427.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 14422-14427
    • Fang, S.1    Ferrone, M.2    Yang, C.3    Jensen, J.P.4    Tiwari, S.5    Weissman, A.M.6
  • 12
    • 84875224757 scopus 로고    scopus 로고
    • DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
    • Ferguson B.J., Mansur D.S., Peters N.E., Ren H., Smith G.L. DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. eLife 2012, 1:e00047.
    • (2012) eLife , vol.1 , pp. e00047
    • Ferguson, B.J.1    Mansur, D.S.2    Peters, N.E.3    Ren, H.4    Smith, G.L.5
  • 14
    • 84881027832 scopus 로고    scopus 로고
    • Innate immune detection of microbial nucleic acids
    • Gürtler C., Bowie A.G. Innate immune detection of microbial nucleic acids. Trends Microbiol. 2013, 21:413-420.
    • (2013) Trends Microbiol. , vol.21 , pp. 413-420
    • Gürtler, C.1    Bowie, A.G.2
  • 16
    • 75649106430 scopus 로고    scopus 로고
    • Intracellular DNA recognition
    • Hornung V., Latz E. Intracellular DNA recognition. Nat. Rev. Immunol. 2010, 10:123-130.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 123-130
    • Hornung, V.1    Latz, E.2
  • 18
    • 53349178089 scopus 로고    scopus 로고
    • STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    • Ishikawa H., Barber G.N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 2008, 455:674-678.
    • (2008) Nature , vol.455 , pp. 674-678
    • Ishikawa, H.1    Barber, G.N.2
  • 19
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    • Ishikawa H., Ma Z., Barber G.N. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009, 461:788-792.
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 20
    • 84655176306 scopus 로고    scopus 로고
    • The role of ubiquitylation in immune defence and pathogen evasion
    • Jiang X., Chen Z.J. The role of ubiquitylation in immune defence and pathogen evasion. Nat. Rev. Immunol. 2012, 12:35-48.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 35-48
    • Jiang, X.1    Chen, Z.J.2
  • 21
    • 84862994793 scopus 로고    scopus 로고
    • Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response
    • Jiang X., Kinch L.N., Brautigam C.A., Chen X., Du F., Grishin N.V., Chen Z.J. Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. Immunity 2012, 36:959-973.
    • (2012) Immunity , vol.36 , pp. 959-973
    • Jiang, X.1    Kinch, L.N.2    Brautigam, C.A.3    Chen, X.4    Du, F.5    Grishin, N.V.6    Chen, Z.J.7
  • 22
    • 49449115516 scopus 로고    scopus 로고
    • MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals
    • Jin L., Waterman P.M., Jonscher K.R., Short C.M., Reisdorph N.A., Cambier J.C. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol. Cell. Biol. 2008, 28:5014-5026.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 5014-5026
    • Jin, L.1    Waterman, P.M.2    Jonscher, K.R.3    Short, C.M.4    Reisdorph, N.A.5    Cambier, J.C.6
  • 23
    • 81355146737 scopus 로고    scopus 로고
    • Cytosolic DNA sensors regulating type I interferon induction
    • Keating S.E., Baran M., Bowie A.G. Cytosolic DNA sensors regulating type I interferon induction. Trends Immunol. 2011, 32:574-581.
    • (2011) Trends Immunol. , vol.32 , pp. 574-581
    • Keating, S.E.1    Baran, M.2    Bowie, A.G.3
  • 26
    • 84884675857 scopus 로고    scopus 로고
    • Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects
    • Li X.D., Wu J., Gao D., Wang H., Sun L., Chen Z.J. Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 2013, 341:1390-1394.
    • (2013) Science , vol.341 , pp. 1390-1394
    • Li, X.D.1    Wu, J.2    Gao, D.3    Wang, H.4    Sun, L.5    Chen, Z.J.6
  • 27
    • 84879546850 scopus 로고    scopus 로고
    • Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6
    • Liu X., Chen W., Wang Q., Li L., Wang C. Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6. PLoS Pathog. 2013, 9:e1003480.
    • (2013) PLoS Pathog. , vol.9 , pp. e1003480
    • Liu, X.1    Chen, W.2    Wang, Q.3    Li, L.4    Wang, C.5
  • 28
    • 84888292851 scopus 로고    scopus 로고
    • Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins
    • Liu X., Wang Q., Chen W., Wang C. Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins. Cytokine Growth Factor Rev. 2013, 24:559-570.
    • (2013) Cytokine Growth Factor Rev. , vol.24 , pp. 559-570
    • Liu, X.1    Wang, Q.2    Chen, W.3    Wang, C.4
  • 29
    • 79956314622 scopus 로고    scopus 로고
    • Immune signaling by RIG-I-like receptors
    • Loo Y.M., Gale M. Immune signaling by RIG-I-like receptors. Immunity 2011, 34:680-692.
    • (2011) Immunity , vol.34 , pp. 680-692
    • Loo, Y.M.1    Gale, M.2
  • 30
    • 84860499060 scopus 로고    scopus 로고
    • Emerging role of ubiquitination in antiviral RIG-I signaling
    • Maelfait J., Beyaert R. Emerging role of ubiquitination in antiviral RIG-I signaling. Microbiol. Mol. Biol. Rev. 2012, 76:33-45.
    • (2012) Microbiol. Mol. Biol. Rev. , vol.76 , pp. 33-45
    • Maelfait, J.1    Beyaert, R.2
  • 32
    • 69949108452 scopus 로고    scopus 로고
    • RIG-I-like receptors: sensing and responding to RNA virus infection
    • Nakhaei P., Genin P., Civas A., Hiscott J. RIG-I-like receptors: sensing and responding to RNA virus infection. Semin. Immunol. 2009, 21:215-222.
    • (2009) Semin. Immunol. , vol.21 , pp. 215-222
    • Nakhaei, P.1    Genin, P.2    Civas, A.3    Hiscott, J.4
  • 33
    • 73549097331 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation
    • Nakhaei P., Mesplede T., Solis M., Sun Q., Zhao T., Yang L., Chuang T.H., Ware C.F., Lin R., Hiscott J. The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation. PLoS Pathog. 2009, 5:e1000650.
    • (2009) PLoS Pathog. , vol.5 , pp. e1000650
    • Nakhaei, P.1    Mesplede, T.2    Solis, M.3    Sun, Q.4    Zhao, T.5    Yang, L.6    Chuang, T.H.7    Ware, C.F.8    Lin, R.9    Hiscott, J.10
  • 35
    • 58049220365 scopus 로고    scopus 로고
    • Pattern recognition receptors and control of adaptive immunity
    • Palm N.W., Medzhitov R. Pattern recognition receptors and control of adaptive immunity. Immunol. Rev. 2009, 227:221-233.
    • (2009) Immunol. Rev. , vol.227 , pp. 221-233
    • Palm, N.W.1    Medzhitov, R.2
  • 36
    • 84878190840 scopus 로고    scopus 로고
    • Immune sensing of DNA
    • Paludan S.R., Bowie A.G. Immune sensing of DNA. Immunity 2013, 38:870-880.
    • (2013) Immunity , vol.38 , pp. 870-880
    • Paludan, S.R.1    Bowie, A.G.2
  • 37
    • 84918775897 scopus 로고    scopus 로고
    • MITA/STING: A central and multifaceted mediator in innate immune response
    • Published online May 20, 2014
    • Ran Y., Shu H.B., Wang Y.Y. MITA/STING: A central and multifaceted mediator in innate immune response. Cytokine Growth Factor Rev. 2014, Published online May 20, 2014. 10.1016/j.cytogfr.2014.05.003.
    • (2014) Cytokine Growth Factor Rev.
    • Ran, Y.1    Shu, H.B.2    Wang, Y.Y.3
  • 39
    • 79955746123 scopus 로고    scopus 로고
    • The control of adaptive immune responses by the innate immune system
    • Schenten D., Medzhitov R. The control of adaptive immune responses by the innate immune system. Adv. Immunol. 2011, 109:87-124.
    • (2011) Adv. Immunol. , vol.109 , pp. 87-124
    • Schenten, D.1    Medzhitov, R.2
  • 40
    • 77649225756 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
    • Shembade N., Ma A., Harhaj E.W. Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science 2010, 327:1135-1139.
    • (2010) Science , vol.327 , pp. 1135-1139
    • Shembade, N.1    Ma, A.2    Harhaj, E.W.3
  • 41
    • 79958042278 scopus 로고    scopus 로고
    • Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action
    • Shi H.X., Liu X., Wang Q., Tang P.P., Liu X.Y., Shan Y.F., Wang C. Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action. PLoS Pathog. 2011, 7:e1002057.
    • (2011) PLoS Pathog. , vol.7 , pp. e1002057
    • Shi, H.X.1    Liu, X.2    Wang, Q.3    Tang, P.P.4    Liu, X.Y.5    Shan, Y.F.6    Wang, C.7
  • 42
    • 84918564143 scopus 로고    scopus 로고
    • The mechanism of double-stranded DNAsensing through the cGAS-STING pathway
    • Published online June 22, 2014
    • Shu C., Li X., Li P. The mechanism of double-stranded DNAsensing through the cGAS-STING pathway. Cytokine Growth Factor Rev. 2014, Published online June 22, 2014. 10.1016/j.cytogfr.2014.06.006.
    • (2014) Cytokine Growth Factor Rev.
    • Shu, C.1    Li, X.2    Li, P.3
  • 43
    • 24944591120 scopus 로고    scopus 로고
    • Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
    • Song B.L., Sever N., DeBose-Boyd R.A. Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. Mol. Cell 2005, 19:829-840.
    • (2005) Mol. Cell , vol.19 , pp. 829-840
    • Song, B.L.1    Sever, N.2    DeBose-Boyd, R.A.3
  • 45
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
    • Sun L., Wu J., Du F., Chen X., Chen Z.J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013, 339:786-791.
    • (2013) Science , vol.339 , pp. 786-791
    • Sun, L.1    Wu, J.2    Du, F.3    Chen, X.4    Chen, Z.J.5
  • 47
    • 78650214109 scopus 로고    scopus 로고
    • The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA
    • Tsuchida T., Zou J., Saitoh T., Kumar H., Abe T., Matsuura Y., Kawai T., Akira S. The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 2010, 33:765-776.
    • (2010) Immunity , vol.33 , pp. 765-776
    • Tsuchida, T.1    Zou, J.2    Saitoh, T.3    Kumar, H.4    Abe, T.5    Matsuura, Y.6    Kawai, T.7    Akira, S.8
  • 49
    • 84918539112 scopus 로고    scopus 로고
    • Unmasking immune sensing of retroviruses: Interplay between innate sensors and host effectors
    • Published online September 3, 2014
    • van Montfoort N., Olagnier D., Hiscott J. Unmasking immune sensing of retroviruses: Interplay between innate sensors and host effectors. Cytokine Growth Factor Rev. 2014, Published online September 3, 2014. 10.1016/j.cytogfr.2014.08.006.
    • (2014) Cytokine Growth Factor Rev.
    • van Montfoort, N.1    Olagnier, D.2    Hiscott, J.3
  • 50
    • 84908353501 scopus 로고    scopus 로고
    • RIG-I-like receptors and negative-strandRNA viruses: RLRly bird catches some worms
    • Published online May 20, 2014
    • Weber M., Weber F. RIG-I-like receptors and negative-strandRNA viruses: RLRly bird catches some worms. Cytokine Growth Factor Rev. 2014, Published online May 20, 2014. 10.1016/j.cytogfr.2014.05.004.
    • (2014) Cytokine Growth Factor Rev.
    • Weber, M.1    Weber, F.2
  • 51
    • 84896958063 scopus 로고    scopus 로고
    • Innate immune sensing and signaling of cytosolic nucleic acids
    • Wu J., Chen Z.J. Innate immune sensing and signaling of cytosolic nucleic acids. Annu. Rev. Immunol. 2014, 32:461-488.
    • (2014) Annu. Rev. Immunol. , vol.32 , pp. 461-488
    • Wu, J.1    Chen, Z.J.2
  • 52
    • 84880426658 scopus 로고    scopus 로고
    • The cGAS-STING pathway for DNA sensing
    • Xiao T.S., Fitzgerald K.A. The cGAS-STING pathway for DNA sensing. Mol. Cell 2013, 51:135-139.
    • (2013) Mol. Cell , vol.51 , pp. 135-139
    • Xiao, T.S.1    Fitzgerald, K.A.2
  • 53
    • 75749089555 scopus 로고    scopus 로고
    • Recognition of viral nucleic acids in innate immunity
    • Yoneyama M., Fujita T. Recognition of viral nucleic acids in innate immunity. Rev. Med. Virol. 2010, 20:4-22.
    • (2010) Rev. Med. Virol. , vol.20 , pp. 4-22
    • Yoneyama, M.1    Fujita, T.2
  • 54
    • 70350004240 scopus 로고    scopus 로고
    • Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
    • Zeng W., Xu M., Liu S., Sun L., Chen Z.J. Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. Mol. Cell 2009, 36:315-325.
    • (2009) Mol. Cell , vol.36 , pp. 315-325
    • Zeng, W.1    Xu, M.2    Liu, S.3    Sun, L.4    Chen, Z.J.5
  • 55
    • 77951708374 scopus 로고    scopus 로고
    • Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity
    • Zeng W., Sun L., Jiang X., Chen X., Hou F., Adhikari A., Xu M., Chen Z.J. Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell 2010, 141:315-330.
    • (2010) Cell , vol.141 , pp. 315-330
    • Zeng, W.1    Sun, L.2    Jiang, X.3    Chen, X.4    Hou, F.5    Adhikari, A.6    Xu, M.7    Chen, Z.J.8
  • 56
    • 80052969639 scopus 로고    scopus 로고
    • The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
    • Zhang Z., Yuan B., Bao M., Lu N., Kim T., Liu Y.J. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat. Immunol. 2011, 12:959-965.
    • (2011) Nat. Immunol. , vol.12 , pp. 959-965
    • Zhang, Z.1    Yuan, B.2    Bao, M.3    Lu, N.4    Kim, T.5    Liu, Y.J.6
  • 57
    • 84865270570 scopus 로고    scopus 로고
    • TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination
    • Zhang J., Hu M.M., Wang Y.Y., Shu H.B. TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination. J.Biol. Chem. 2012, 287:28646-28655.
    • (2012) J.Biol. Chem. , vol.287 , pp. 28646-28655
    • Zhang, J.1    Hu, M.M.2    Wang, Y.Y.3    Shu, H.B.4
  • 59
    • 62049084519 scopus 로고    scopus 로고
    • The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA
    • Zhong B., Zhang L., Lei C., Li Y., Mao A.P., Yang Y., Wang Y.Y., Zhang X.L., Shu H.B. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity 2009, 30:397-407.
    • (2009) Immunity , vol.30 , pp. 397-407
    • Zhong, B.1    Zhang, L.2    Lei, C.3    Li, Y.4    Mao, A.P.5    Yang, Y.6    Wang, Y.Y.7    Zhang, X.L.8    Shu, H.B.9
  • 60
    • 77953445772 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation
    • Zhong B., Zhang Y., Tan B., Liu T.T., Wang Y.Y., Shu H.B. The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. J.Immunol. 2010, 184:6249-6255.
    • (2010) J.Immunol. , vol.184 , pp. 6249-6255
    • Zhong, B.1    Zhang, Y.2    Tan, B.3    Liu, T.T.4    Wang, Y.Y.5    Shu, H.B.6


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