-
1
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
-
Kawai T, Akira S, (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384.
-
(2010)
Nat Immunol
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
2
-
-
35349016235
-
Recognition of microorganisms and activation of the immune response
-
Medzhitov R, (2007) Recognition of microorganisms and activation of the immune response. Nature 449: 819-826.
-
(2007)
Nature
, vol.449
, pp. 819-826
-
-
Medzhitov, R.1
-
3
-
-
5444254408
-
Toll-like receptors in the pathogenesis of human disease
-
Cook DN, Pisetsky DS, Schwartz DA, (2004) Toll-like receptors in the pathogenesis of human disease. Nat Immunol 5: 975-979.
-
(2004)
Nat Immunol
, vol.5
, pp. 975-979
-
-
Cook, D.N.1
Pisetsky, D.S.2
Schwartz, D.A.3
-
4
-
-
3142654210
-
Inferences, questions and possibilities in Toll-like receptor signalling
-
Beutler B, (2004) Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430: 257-263.
-
(2004)
Nature
, vol.430
, pp. 257-263
-
-
Beutler, B.1
-
5
-
-
3142724031
-
Toll-like receptor signalling
-
Akira S, Takeda K, (2004) Toll-like receptor signalling. Nat Rev Immunol 4: 499-511.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
6
-
-
0033595893
-
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex
-
Karin M, (1999) How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene 18: 6867-6874.
-
(1999)
Oncogene
, vol.18
, pp. 6867-6874
-
-
Karin, M.1
-
7
-
-
0030613551
-
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
-
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M, (1997) The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91: 243-252.
-
(1997)
Cell
, vol.91
, pp. 243-252
-
-
Zandi, E.1
Rothwarf, D.M.2
Delhase, M.3
Hayakawa, M.4
Karin, M.5
-
8
-
-
0034175930
-
The IKK complex: an integrator of all signals that activate NF-kappa B?
-
Israel A, (2000) The IKK complex: an integrator of all signals that activate NF-kappa B? Trends in Cell Biology 10: 129-133.
-
(2000)
Trends in Cell Biology
, vol.10
, pp. 129-133
-
-
Israel, A.1
-
9
-
-
0032541657
-
IKK-gamma is an essential regulatory subunit of the I kappa B kinase complex
-
Rothwarf DM, Zandi E, Natoli G, Karin M, (1998) IKK-gamma is an essential regulatory subunit of the I kappa B kinase complex. Nature 395: 297-300.
-
(1998)
Nature
, vol.395
, pp. 297-300
-
-
Rothwarf, D.M.1
Zandi, E.2
Natoli, G.3
Karin, M.4
-
10
-
-
33645703930
-
NEMO is a sensor of Lys 63-linked polyubiquitination and functions in NF-kappa B activation
-
Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD, (2006) NEMO is a sensor of Lys 63-linked polyubiquitination and functions in NF-kappa B activation. Nature Cell Biology 8: 398-U358.
-
(2006)
Nature Cell Biology
, vol.8
, pp. 358-398
-
-
Wu, C.J.1
Conze, D.B.2
Li, T.3
Srinivasula, S.M.4
Ashwell, J.D.5
-
11
-
-
70350020147
-
NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain
-
Laplantine E, Fontan E, Chiaravalli J, Lopez T, Lakisic G, et al. (2009) NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain. Embo Journal 28: 2885-2895.
-
(2009)
Embo Journal
, vol.28
, pp. 2885-2895
-
-
Laplantine, E.1
Fontan, E.2
Chiaravalli, J.3
Lopez, T.4
Lakisic, G.5
-
12
-
-
0141621240
-
A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha
-
Tang ED, Wang CY, Xiong Y, Guan KL, (2003) A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem 278: 37297-37305.
-
(2003)
J Biol Chem
, vol.278
, pp. 37297-37305
-
-
Tang, E.D.1
Wang, C.Y.2
Xiong, Y.3
Guan, K.L.4
-
13
-
-
59649103156
-
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
-
Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, et al. (2009) Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol 11: 123-132.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 123-132
-
-
Tokunaga, F.1
Sakata, S.2
Saeki, Y.3
Satomi, Y.4
Kirisako, T.5
-
14
-
-
0041967054
-
The tumour suppressor CYLD negatively regulates NF-kappa B signalling by deubiquitination
-
Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, et al. (2003) The tumour suppressor CYLD negatively regulates NF-kappa B signalling by deubiquitination. Nature 424: 801-805.
-
(2003)
Nature
, vol.424
, pp. 801-805
-
-
Kovalenko, A.1
Chable-Bessia, C.2
Cantarella, G.3
Israel, A.4
Wallach, D.5
-
15
-
-
0344305376
-
Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress
-
Huang TT, Wuerzberger-Davis SM, Wu ZH, Miyamoto S, (2003) Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell 115: 565-576.
-
(2003)
Cell
, vol.115
, pp. 565-576
-
-
Huang, T.T.1
Wuerzberger-Davis, S.M.2
Wu, Z.H.3
Miyamoto, S.4
-
16
-
-
0032135131
-
SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation
-
Desterro JM, Rodriguez MS, Hay RT, (1998) SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell 2: 233-239.
-
(1998)
Mol Cell
, vol.2
, pp. 233-239
-
-
Desterro, J.M.1
Rodriguez, M.S.2
Hay, R.T.3
-
17
-
-
77957252647
-
The IKK complex, a central regulator of NF-kappaB activation
-
Israel A, (2010) The IKK complex, a central regulator of NF-kappaB activation. Cold Spring Harb Perspect Biol 2: a000158.
-
(2010)
Cold Spring Harb Perspect Biol
, vol.2
-
-
Israel, A.1
-
18
-
-
15944406765
-
SUMO: a history of modification
-
Hay RT, (2005) SUMO: a history of modification. Mol Cell 18: 1-12.
-
(2005)
Mol Cell
, vol.18
, pp. 1-12
-
-
Hay, R.T.1
-
20
-
-
34249880519
-
Modification in reverse: the SUMO proteases
-
Mukhopadhyay D, Dasso M, (2007) Modification in reverse: the SUMO proteases. Trends Biochem Sci 32: 286-295.
-
(2007)
Trends Biochem Sci
, vol.32
, pp. 286-295
-
-
Mukhopadhyay, D.1
Dasso, M.2
-
21
-
-
63549129144
-
SUMOylation and De-SUMOylation: wrestling with life's processes
-
Yeh ET, (2009) SUMOylation and De-SUMOylation: wrestling with life's processes. J Biol Chem 284: 8223-8227.
-
(2009)
J Biol Chem
, vol.284
, pp. 8223-8227
-
-
Yeh, E.T.1
-
22
-
-
35548935098
-
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
-
Cheng J, Kang X, Zhang S, Yeh ET, (2007) SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell 131: 584-595.
-
(2007)
Cell
, vol.131
, pp. 584-595
-
-
Cheng, J.1
Kang, X.2
Zhang, S.3
Yeh, E.T.4
-
23
-
-
77950686220
-
Control of adipogenesis by the SUMO-specific protease SENP2
-
Chung SS, Ahn BY, Kim M, Choi HH, Park HS, et al. (2010) Control of adipogenesis by the SUMO-specific protease SENP2. Mol Cell Biol 30: 2135-2146.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 2135-2146
-
-
Chung, S.S.1
Ahn, B.Y.2
Kim, M.3
Choi, H.H.4
Park, H.S.5
-
24
-
-
77950907937
-
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development
-
Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, et al. (2010) SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell 38: 191-201.
-
(2010)
Mol Cell
, vol.38
, pp. 191-201
-
-
Kang, X.1
Qi, Y.2
Zuo, Y.3
Wang, Q.4
Zou, Y.5
-
25
-
-
79960468868
-
NF-kappaB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress
-
Lee MH, Mabb AM, Gill GB, Yeh ET, Miyamoto S, (2011) NF-kappaB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell 43: 180-191.
-
(2011)
Mol Cell
, vol.43
, pp. 180-191
-
-
Lee, M.H.1
Mabb, A.M.2
Gill, G.B.3
Yeh, E.T.4
Miyamoto, S.5
-
26
-
-
0034284715
-
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex
-
May MJ, D'Acquisto F, Madge LA, Glockner J, Pober JS, et al. (2000) Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science 289: 1550-1554.
-
(2000)
Science
, vol.289
, pp. 1550-1554
-
-
May, M.J.1
D'Acquisto, F.2
Madge, L.A.3
Glockner, J.4
Pober, J.S.5
-
27
-
-
77955475870
-
Regulation of DNA Repair through DeSUMOylation and SUMOylation of Replication Protein A Complex
-
Dou H, Huang C, Singh M, Carpenter PB, Yeh ET, (2010) Regulation of DNA Repair through DeSUMOylation and SUMOylation of Replication Protein A Complex. Mol Cell 39: 333-345.
-
(2010)
Mol Cell
, vol.39
, pp. 333-345
-
-
Dou, H.1
Huang, C.2
Singh, M.3
Carpenter, P.B.4
Yeh, E.T.5
-
28
-
-
40949163764
-
TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation
-
Shi M, Deng W, Bi E, Mao K, Ji Y, et al. (2008) TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation. Nat Immunol 9: 369-377.
-
(2008)
Nat Immunol
, vol.9
, pp. 369-377
-
-
Shi, M.1
Deng, W.2
Bi, E.3
Mao, K.4
Ji, Y.5
-
30
-
-
78650903043
-
Expanding role of ubiquitination in NF-kappaB signaling
-
Liu S, Chen ZJ, (2011) Expanding role of ubiquitination in NF-kappaB signaling. Cell Res 21: 6-21.
-
(2011)
Cell Res
, vol.21
, pp. 6-21
-
-
Liu, S.1
Chen, Z.J.2
-
31
-
-
3943054838
-
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappa B signalling
-
Wertz IE, O'Rourke KM, Zhou HL, Eby M, Aravind L, et al. (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappa B signalling. Nature 430: 694-699.
-
(2004)
Nature
, vol.430
, pp. 694-699
-
-
Wertz, I.E.1
O'Rourke, K.M.2
Zhou, H.L.3
Eby, M.4
Aravind, L.5
-
32
-
-
43749122598
-
NF-kappa B suppression by the deubiquitinating enzyme Cezanne - A novel negative feedback loop in pro-inflammatory signaling
-
Enesa K, Zakkar M, Chaudhury H, Luong LA, Rawlinson L, et al. (2008) NF-kappa B suppression by the deubiquitinating enzyme Cezanne- A novel negative feedback loop in pro-inflammatory signaling. Journal of Biological Chemistry 283: 7036-7045.
-
(2008)
Journal of Biological Chemistry
, vol.283
, pp. 7036-7045
-
-
Enesa, K.1
Zakkar, M.2
Chaudhury, H.3
Luong, L.A.4
Rawlinson, L.5
-
33
-
-
27944471038
-
Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation
-
Zhou HL, Monack DM, Kayagaki N, Wertz I, Yin JP, et al. (2005) Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation. Journal of Experimental Medicine 202: 1327-1332.
-
(2005)
Journal of Experimental Medicine
, vol.202
, pp. 1327-1332
-
-
Zhou, H.L.1
Monack, D.M.2
Kayagaki, N.3
Wertz, I.4
Yin, J.P.5
-
34
-
-
77951168849
-
Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6
-
Li S, Zheng H, Mao AP, Zhong B, Li Y, et al. (2010) Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. J Biol Chem 285: 4291-4297.
-
(2010)
J Biol Chem
, vol.285
, pp. 4291-4297
-
-
Li, S.1
Zheng, H.2
Mao, A.P.3
Zhong, B.4
Li, Y.5
-
35
-
-
46249124976
-
Deubiquitylation and regulation of the immune response
-
Sun SC, (2008) Deubiquitylation and regulation of the immune response. Nat Rev Immunol 8: 501-511.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 501-511
-
-
Sun, S.C.1
-
36
-
-
79551574982
-
Inducible SUMO modification of TANK alleviates its repression of TLR7 signalling
-
Renner F, Saul VV, Pagenstecher A, Wittwer T, Schmitz ML, (2011) Inducible SUMO modification of TANK alleviates its repression of TLR7 signalling. EMBO Rep 12: 129-135.
-
(2011)
EMBO Rep
, vol.12
, pp. 129-135
-
-
Renner, F.1
Saul, V.V.2
Pagenstecher, A.3
Wittwer, T.4
Schmitz, M.L.5
-
37
-
-
84866565809
-
The small ubiquitin-like modifier-deconjugating enzyme sentrin-specific peptidase 1 switches IFN regulatory factor 8 from a repressor to an activator during macrophage activation
-
Chang TH, Xu S, Tailor P, Kanno T, Ozato K, (2012) The small ubiquitin-like modifier-deconjugating enzyme sentrin-specific peptidase 1 switches IFN regulatory factor 8 from a repressor to an activator during macrophage activation. J Immunol 189: 3548-3556.
-
(2012)
J Immunol
, vol.189
, pp. 3548-3556
-
-
Chang, T.H.1
Xu, S.2
Tailor, P.3
Kanno, T.4
Ozato, K.5
-
38
-
-
80455129191
-
SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation
-
Ran Y, Liu TT, Zhou Q, Li S, Mao AP, et al. (2011) SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation. J Mol Cell Biol 3: 283-292.
-
(2011)
J Mol Cell Biol
, vol.3
, pp. 283-292
-
-
Ran, Y.1
Liu, T.T.2
Zhou, Q.3
Li, S.4
Mao, A.P.5
-
39
-
-
0001720254
-
A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs
-
Kim KI, Baek SH, Jeon YJ, Nishimori S, Suzuki T, et al. (2000) A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. J Biol Chem 275: 14102-14106.
-
(2000)
J Biol Chem
, vol.275
, pp. 14102-14106
-
-
Kim, K.I.1
Baek, S.H.2
Jeon, Y.J.3
Nishimori, S.4
Suzuki, T.5
-
40
-
-
79251581846
-
Negative Feedback Regulation of NF-kappa B Action by CITED2 in the Nucleus
-
Lou XW, Sun SG, Chen W, Zhou Y, Huang YF, et al. (2011) Negative Feedback Regulation of NF-kappa B Action by CITED2 in the Nucleus. Journal of Immunology 186: 539-548.
-
(2011)
Journal of Immunology
, vol.186
, pp. 539-548
-
-
Lou, X.W.1
Sun, S.G.2
Chen, W.3
Zhou, Y.4
Huang, Y.F.5
-
41
-
-
79958042278
-
Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action
-
Shi HX, Liu X, Wang Q, Tang PP, Liu XY, et al. (2011) Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action. PLoS Pathog 7: e1002057.
-
(2011)
PLoS Pathog
, vol.7
-
-
Shi, H.X.1
Liu, X.2
Wang, Q.3
Tang, P.P.4
Liu, X.Y.5
-
42
-
-
70449636444
-
Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge
-
van Zijl F, Mair M, Csiszar A, Schneller D, Zulehner G, et al. (2009) Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge. Oncogene 28: 4022-4033.
-
(2009)
Oncogene
, vol.28
, pp. 4022-4033
-
-
van Zijl, F.1
Mair, M.2
Csiszar, A.3
Schneller, D.4
Zulehner, G.5
-
43
-
-
0034070414
-
Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4
-
Su GL, Klein RD, Aminlari A, Zhang HY, Steinstraesser L, et al. (2000) Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology 31: 932-936.
-
(2000)
Hepatology
, vol.31
, pp. 932-936
-
-
Su, G.L.1
Klein, R.D.2
Aminlari, A.3
Zhang, H.Y.4
Steinstraesser, L.5
-
44
-
-
33748066632
-
Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib
-
Carey KD, Garton AJ, Romero MS, Kahler J, Thomson S, et al. (2006) Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib. Cancer Res 66: 8163-8171.
-
(2006)
Cancer Res
, vol.66
, pp. 8163-8171
-
-
Carey, K.D.1
Garton, A.J.2
Romero, M.S.3
Kahler, J.4
Thomson, S.5
|