-
1
-
-
79959481888
-
Protein folding and modification in the mammalian endoplasmic reticulum
-
Braakman I., Bulleid N.J. Protein folding and modification in the mammalian endoplasmic reticulum. Annu. Rev. Biochem. 2011, 80:71-99.
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 71-99
-
-
Braakman, I.1
Bulleid, N.J.2
-
2
-
-
0028006681
-
Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins
-
Ward C.L., Kopito R.R. Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins. J. Biol. Chem. 1994, 269:25710-25718.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 25710-25718
-
-
Ward, C.L.1
Kopito, R.R.2
-
3
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D., Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 2007, 8:519-529.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
4
-
-
65649115267
-
Recognition and processing of ubiquitin-protein conjugates by the proteasome
-
Finley D. Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu. Rev. Biochem. 2009, 78:477-513.
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 477-513
-
-
Finley, D.1
-
5
-
-
36749001066
-
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes
-
Rapoport T.A. Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes. Nature 2007, 450:663-669.
-
(2007)
Nature
, vol.450
, pp. 663-669
-
-
Rapoport, T.A.1
-
6
-
-
34547216748
-
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum
-
Ploegh H.L. A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum. Nature 2007, 448:435-438.
-
(2007)
Nature
, vol.448
, pp. 435-438
-
-
Ploegh, H.L.1
-
7
-
-
33845480131
-
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response
-
Bernales S., et al. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol. 2006, 4:e423.
-
(2006)
PLoS Biol.
, vol.4
-
-
Bernales, S.1
-
8
-
-
80051540452
-
Lipid droplet formation is dispensable for endoplasmic reticulum-associated degradation
-
Olzmann J.A., Kopito R.R. Lipid droplet formation is dispensable for endoplasmic reticulum-associated degradation. J. Biol. Chem. 2011, 286:27872-27874.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 27872-27874
-
-
Olzmann, J.A.1
Kopito, R.R.2
-
9
-
-
79953147165
-
Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region
-
Spandl J., et al. Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region. J. Biol. Chem. 2011, 286:5599-5606.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 5599-5606
-
-
Spandl, J.1
-
10
-
-
80054801259
-
The dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and ER protein quality control
-
Klemm E.J., et al. The dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and ER protein quality control. J. Biol. Chem. 2011, 10.1074/jbc.M111.284794.
-
(2011)
J. Biol. Chem.
-
-
Klemm, E.J.1
-
11
-
-
55949137911
-
Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines
-
Engel A., Walter P. Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines. J. Cell Biol. 2008, 183:181-186.
-
(2008)
J. Cell Biol.
, vol.183
, pp. 181-186
-
-
Engel, A.1
Walter, P.2
-
12
-
-
80053299005
-
Cdc48, a power machine in protein degradation
-
Stolz A., et al. Cdc48, a power machine in protein degradation. Trends Biochem. Sci. 2011, 6:515-523.
-
(2011)
Trends Biochem. Sci.
, vol.6
, pp. 515-523
-
-
Stolz, A.1
-
13
-
-
70349778618
-
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER
-
Ernst R., et al. The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol. Cell 2009, 36:28-38.
-
(2009)
Mol. Cell
, vol.36
, pp. 28-38
-
-
Ernst, R.1
-
14
-
-
67650087753
-
The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates
-
Hassink G.C., et al. The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates. EMBO Rep. 2009, 10:755-761.
-
(2009)
EMBO Rep.
, vol.10
, pp. 755-761
-
-
Hassink, G.C.1
-
15
-
-
33748988214
-
Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3
-
Wang Q., et al. Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3. J. Cell Biol. 2006, 174:963-971.
-
(2006)
J. Cell Biol.
, vol.174
, pp. 963-971
-
-
Wang, Q.1
-
16
-
-
79953687692
-
Enzymatic blockade of the ubiquitin-proteasome pathway
-
Ernst R., et al. Enzymatic blockade of the ubiquitin-proteasome pathway. PLoS Biol. 2011, 8:e1000605.
-
(2011)
PLoS Biol.
, vol.8
-
-
Ernst, R.1
-
17
-
-
34447523329
-
Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors
-
Boutet S.C., et al. Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors. Cell 2007, 130:349-362.
-
(2007)
Cell
, vol.130
, pp. 349-362
-
-
Boutet, S.C.1
-
19
-
-
33749346301
-
Modification of proteins by ubiquitin and ubiquitin-like proteins
-
Kerscher O., et al. Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu. Rev. Cell Dev. Biol. 2006, 22:159-180.
-
(2006)
Annu. Rev. Cell Dev. Biol.
, vol.22
, pp. 159-180
-
-
Kerscher, O.1
-
20
-
-
78149482323
-
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p
-
Carvalho P., et al. Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell 2010, 143:579-591.
-
(2010)
Cell
, vol.143
, pp. 579-591
-
-
Carvalho, P.1
-
21
-
-
64749087257
-
Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase
-
Sato B.K., et al. Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Mol. Cell 2009, 34:212-222.
-
(2009)
Mol. Cell
, vol.34
, pp. 212-222
-
-
Sato, B.K.1
-
22
-
-
33746675669
-
Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator
-
Younger J.M., et al. Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator. Cell 2006, 126:571-582.
-
(2006)
Cell
, vol.126
, pp. 571-582
-
-
Younger, J.M.1
-
23
-
-
37749032764
-
Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum
-
Binette J., et al. Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum. Retrovirology 2007, 4:75.
-
(2007)
Retrovirology
, vol.4
, pp. 75
-
-
Binette, J.1
-
24
-
-
0029915568
-
The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
-
Wiertz E.J., et al. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell 1996, 84:769-779.
-
(1996)
Cell
, vol.84
, pp. 769-779
-
-
Wiertz, E.J.1
-
25
-
-
79952133558
-
HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation
-
Burr M.L., et al. HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:2034-2039.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 2034-2039
-
-
Burr, M.L.1
-
26
-
-
78650253267
-
Ubiquitylation of an ERAD substrate occurs on multiple types of amino acids
-
Shimizu Y., et al. Ubiquitylation of an ERAD substrate occurs on multiple types of amino acids. Mol. Cell 2010, 40:917-926.
-
(2010)
Mol. Cell
, vol.40
, pp. 917-926
-
-
Shimizu, Y.1
-
27
-
-
79952433637
-
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
-
Chen X., et al. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J. Cell Biol. 2011, 192:825-838.
-
(2011)
J. Cell Biol.
, vol.192
, pp. 825-838
-
-
Chen, X.1
-
28
-
-
77954904488
-
Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein
-
Ishikura S., et al. Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein. J. Biol. Chem. 2010, 285:23916-23924.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 23916-23924
-
-
Ishikura, S.1
-
29
-
-
34249042608
-
Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3
-
Wang X., et al. Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3. J. Cell Biol. 2007, 177:613-624.
-
(2007)
J. Cell Biol.
, vol.177
, pp. 613-624
-
-
Wang, X.1
-
30
-
-
76649123968
-
Ubiquitin not only serves as a tag but also assists degradation by inducing protein unfolding
-
Hagai T., Levy Y. Ubiquitin not only serves as a tag but also assists degradation by inducing protein unfolding. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:2001-2006.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 2001-2006
-
-
Hagai, T.1
Levy, Y.2
-
31
-
-
63049125531
-
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation
-
Xu P., et al. Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell 2009, 137:133-145.
-
(2009)
Cell
, vol.137
, pp. 133-145
-
-
Xu, P.1
-
32
-
-
60549107173
-
Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome
-
Saeki Y., et al. Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome. EMBO J. 2009, 28:359-371.
-
(2009)
EMBO J.
, vol.28
, pp. 359-371
-
-
Saeki, Y.1
-
33
-
-
79952290609
-
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2
-
Wickliffe K.E., et al. The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell 2011, 144:769-781.
-
(2011)
Cell
, vol.144
, pp. 769-781
-
-
Wickliffe, K.E.1
-
34
-
-
49549117842
-
Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies
-
Newton K., et al. Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell 2008, 134:668-678.
-
(2008)
Cell
, vol.134
, pp. 668-678
-
-
Newton, K.1
-
35
-
-
77955516435
-
K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody
-
Matsumoto M.L., et al. K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody. Mol. Cell 2010, 39:477-484.
-
(2010)
Mol. Cell
, vol.39
, pp. 477-484
-
-
Matsumoto, M.L.1
-
36
-
-
22744456680
-
The protein translocation channel binds proteasomes to the endoplasmic reticulum membrane
-
Kalies K.U., et al. The protein translocation channel binds proteasomes to the endoplasmic reticulum membrane. EMBO J. 2005, 24:2284-2293.
-
(2005)
EMBO J.
, vol.24
, pp. 2284-2293
-
-
Kalies, K.U.1
-
37
-
-
33947301163
-
Characterization of the proteasome interaction with the Sec61 channel in the endoplasmic reticulum
-
Ng W., et al. Characterization of the proteasome interaction with the Sec61 channel in the endoplasmic reticulum. J. Cell Sci. 2007, 120:682-691.
-
(2007)
J. Cell Sci.
, vol.120
, pp. 682-691
-
-
Ng, W.1
-
38
-
-
3042543543
-
Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein
-
Lee R.J., et al. Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein. EMBO J. 2004, 23:2206-2215.
-
(2004)
EMBO J.
, vol.23
, pp. 2206-2215
-
-
Lee, R.J.1
-
39
-
-
0347192985
-
X-ray structure of a protein-conducting channel
-
Van den Berg B., et al. X-ray structure of a protein-conducting channel. Nature 2004, 427:36-44.
-
(2004)
Nature
, vol.427
, pp. 36-44
-
-
Van den Berg, B.1
-
40
-
-
79851515002
-
Protein dislocation from the ER
-
Bagola K., et al. Protein dislocation from the ER. Biochim. Biophys. Acta 2011, 1808:925-936.
-
(2011)
Biochim. Biophys. Acta
, vol.1808
, pp. 925-936
-
-
Bagola, K.1
-
41
-
-
0035875921
-
Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p
-
Walter J., et al. Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p. EMBO J. 2001, 20:3124-3131.
-
(2001)
EMBO J.
, vol.20
, pp. 3124-3131
-
-
Walter, J.1
-
42
-
-
3042677637
-
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
-
Ye Y., et al. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature 2004, 429:841-847.
-
(2004)
Nature
, vol.429
, pp. 841-847
-
-
Ye, Y.1
-
43
-
-
33750472289
-
Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation
-
Liang J., et al. Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. J. Cell Sci. 2006, 119:4011-4024.
-
(2006)
J. Cell Sci.
, vol.119
, pp. 4011-4024
-
-
Liang, J.1
-
44
-
-
79958134700
-
Hierarchical binding of cofactors to the AAA ATPase p97
-
Hanzelmann P., et al. Hierarchical binding of cofactors to the AAA ATPase p97. Structure 2011, 19:833-843.
-
(2011)
Structure
, vol.19
, pp. 833-843
-
-
Hanzelmann, P.1
-
45
-
-
50449107542
-
SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins
-
Mueller B., et al. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:12325-12330.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 12325-12330
-
-
Mueller, B.1
-
46
-
-
77957797495
-
The p97 ATPase dislocates MHC class I heavy chain in US2-expressing cells via a Ufd1-Npl4-independent mechanism
-
Soetandyo N., Ye Y. The p97 ATPase dislocates MHC class I heavy chain in US2-expressing cells via a Ufd1-Npl4-independent mechanism. J. Biol. Chem. 2010, 285:32352-32359.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 32352-32359
-
-
Soetandyo, N.1
Ye, Y.2
-
47
-
-
34547419767
-
Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation
-
Zhao G., et al. Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:8785-8790.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 8785-8790
-
-
Zhao, G.1
-
48
-
-
75349101096
-
Structural and functional implications of phosphorylation and acetylation in the regulation of the AAA+ protein p97
-
Ewens C.A., et al. Structural and functional implications of phosphorylation and acetylation in the regulation of the AAA+ protein p97. Biochem. Cell Biol. 2010, 88:41-48.
-
(2010)
Biochem. Cell Biol.
, vol.88
, pp. 41-48
-
-
Ewens, C.A.1
-
49
-
-
33646535590
-
Central pore residues mediate the p97/VCP activity required for ERAD
-
DeLaBarre B., et al. Central pore residues mediate the p97/VCP activity required for ERAD. Mol. Cell 2006, 22:451-462.
-
(2006)
Mol. Cell
, vol.22
, pp. 451-462
-
-
DeLaBarre, B.1
-
50
-
-
79952995078
-
The UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradation
-
LaLonde D.P., Bretscher A. The UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradation. J. Biol. Chem. 2011, 286:4892-4901.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 4892-4901
-
-
LaLonde, D.P.1
Bretscher, A.2
-
51
-
-
0033525589
-
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
-
Koegl M., et al. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell 1999, 96:635-644.
-
(1999)
Cell
, vol.96
, pp. 635-644
-
-
Koegl, M.1
-
52
-
-
37649025515
-
Dissecting the ER-associated degradation of a misfolded polytopic membrane protein
-
Nakatsukasa K., et al. Dissecting the ER-associated degradation of a misfolded polytopic membrane protein. Cell 2008, 132:101-112.
-
(2008)
Cell
, vol.132
, pp. 101-112
-
-
Nakatsukasa, K.1
-
53
-
-
78649357985
-
Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms
-
Buchberger A., et al. Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms. Mol. Cell 2010, 40:238-252.
-
(2010)
Mol. Cell
, vol.40
, pp. 238-252
-
-
Buchberger, A.1
-
54
-
-
77955878748
-
BAG-6 is essential for selective elimination of defective proteasomal substrates
-
Minami R., et al. BAG-6 is essential for selective elimination of defective proteasomal substrates. J. Cell Biol. 2010, 190:637-650.
-
(2010)
J. Cell Biol.
, vol.190
, pp. 637-650
-
-
Minami, R.1
-
55
-
-
79960637590
-
Protein targeting and degradation are coupled for elimination of mislocalized proteins
-
Hessa T., et al. Protein targeting and degradation are coupled for elimination of mislocalized proteins. Nature 2011, 475:394-397.
-
(2011)
Nature
, vol.475
, pp. 394-397
-
-
Hessa, T.1
-
56
-
-
79959347089
-
A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation
-
Wang Q., et al. A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. Mol. Cell 2011, 42:758-770.
-
(2011)
Mol. Cell
, vol.42
, pp. 758-770
-
-
Wang, Q.1
-
57
-
-
0029828991
-
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
-
Wiertz E.J., et al. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature 1996, 384:432-438.
-
(1996)
Nature
, vol.384
, pp. 432-438
-
-
Wiertz, E.J.1
-
58
-
-
70350564161
-
Sec61p is part of the endoplasmic reticulum-associated degradation machinery
-
Schafer A., Wolf D.H. Sec61p is part of the endoplasmic reticulum-associated degradation machinery. EMBO J. 2009, 28:2874-2884.
-
(2009)
EMBO J.
, vol.28
, pp. 2874-2884
-
-
Schafer, A.1
Wolf, D.H.2
-
59
-
-
0030041781
-
Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast
-
Knop M., et al. Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. EMBO J. 1996, 15:753-763.
-
(1996)
EMBO J.
, vol.15
, pp. 753-763
-
-
Knop, M.1
-
60
-
-
71149100878
-
Usa1 functions as a scaffold of the HRD-ubiquitin ligase
-
Horn S.C., et al. Usa1 functions as a scaffold of the HRD-ubiquitin ligase. Mol. Cell 2009, 36:782-793.
-
(2009)
Mol. Cell
, vol.36
, pp. 782-793
-
-
Horn, S.C.1
-
61
-
-
0036499973
-
Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein
-
Fiebiger E., et al. Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein. EMBO J. 2002, 21:1041-1053.
-
(2002)
EMBO J.
, vol.21
, pp. 1041-1053
-
-
Fiebiger, E.1
-
62
-
-
0037470054
-
Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation
-
Tirosh B., et al. Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. J. Biol. Chem. 2003, 278:6664-6672.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 6664-6672
-
-
Tirosh, B.1
-
63
-
-
24944583185
-
Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen
-
Bhamidipati A., et al. Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. Mol. Cell 2005, 19:741-751.
-
(2005)
Mol. Cell
, vol.19
, pp. 741-751
-
-
Bhamidipati, A.1
-
64
-
-
79960292775
-
TorsinA participates in endoplasmic reticulum-associated degradation
-
Nery F.C., et al. TorsinA participates in endoplasmic reticulum-associated degradation. Nat. Commun. 2011, 2:393.
-
(2011)
Nat. Commun.
, vol.2
, pp. 393
-
-
Nery, F.C.1
-
65
-
-
36248988054
-
Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation
-
Kostova Z., et al. Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation. Semin. Cell Dev. Biol. 2007, 18:770-779.
-
(2007)
Semin. Cell Dev. Biol.
, vol.18
, pp. 770-779
-
-
Kostova, Z.1
-
66
-
-
0035967883
-
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
-
Imai Y., et al. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 2001, 105:891-902.
-
(2001)
Cell
, vol.105
, pp. 891-902
-
-
Imai, Y.1
-
67
-
-
9144239817
-
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum
-
Kikkert M., et al. Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. J. Biol. Chem. 2004, 279:3525-3534.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 3525-3534
-
-
Kikkert, M.1
-
68
-
-
40249088336
-
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD
-
Christianson J.C., et al. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat. Cell Biol. 2008, 10:272-282.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 272-282
-
-
Christianson, J.C.1
-
69
-
-
78751621901
-
The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin and increases its solubility
-
Wang H., et al. The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin and increases its solubility. Mol. Cell. Biochem. 2011, 346:137-145.
-
(2011)
Mol. Cell. Biochem.
, vol.346
, pp. 137-145
-
-
Wang, H.1
-
70
-
-
63649161943
-
The ubiquitylation machinery of the endoplasmic reticulum
-
Hirsch C., et al. The ubiquitylation machinery of the endoplasmic reticulum. Nature 2009, 458:453-460.
-
(2009)
Nature
, vol.458
, pp. 453-460
-
-
Hirsch, C.1
-
71
-
-
79952433637
-
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
-
Chen X., et al. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J. Cell Biol. 2011, 192:825-838.
-
(2011)
J. Cell Biol.
, vol.192
, pp. 825-838
-
-
Chen, X.1
-
72
-
-
79957991349
-
The endoplasmic reticulum (ER)-associated degradation system regulates aggregation and degradation of mutant neuroserpin
-
Ying Z., et al. The endoplasmic reticulum (ER)-associated degradation system regulates aggregation and degradation of mutant neuroserpin. J. Biol. Chem. 2011, 286:20835-20844.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 20835-20844
-
-
Ying, Z.1
-
73
-
-
70449729362
-
Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1, cross-talk between E3s in the endoplasmic reticulum
-
Shmueli A., et al. Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1, cross-talk between E3s in the endoplasmic reticulum. Biochem. Biophys. Res. Commun. 2009, 390:758-762.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.390
, pp. 758-762
-
-
Shmueli, A.1
-
74
-
-
44949249968
-
Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508
-
Morito D., et al. Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508. Mol. Biol. Cell 2008, 19:1328-1336.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 1328-1336
-
-
Morito, D.1
-
75
-
-
78149241047
-
Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance
-
Kim S.M., et al. Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance. J. Biol. Chem. 2010, 285:35866-35877.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 35866-35877
-
-
Kim, S.M.1
-
76
-
-
33646185061
-
Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)
-
Kreft S.G., et al. Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). J. Biol. Chem. 2006, 281:4646-4653.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 4646-4653
-
-
Kreft, S.G.1
-
77
-
-
70349316465
-
The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase
-
Zavacki A.M., et al. The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. Mol. Cell. Biol. 2009, 29:5339-5347.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 5339-5347
-
-
Zavacki, A.M.1
-
78
-
-
34248160996
-
The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD
-
Lerner M., et al. The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD. Mol. Biol. Cell 2007, 18:1670-1682.
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 1670-1682
-
-
Lerner, M.1
-
79
-
-
79251585466
-
The Cavbeta subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels
-
Altier C., et al. The Cavbeta subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels. Nat. Neurosci. 2011, 14:173-180.
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 173-180
-
-
Altier, C.1
-
80
-
-
69949171887
-
The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER
-
Stagg H.R., et al. The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER. J. Cell Biol. 2009, 186:685-692.
-
(2009)
J. Cell Biol.
, vol.186
, pp. 685-692
-
-
Stagg, H.R.1
-
81
-
-
75149146624
-
The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways
-
Lee J.P., et al. The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways. Mol. Cancer Res. 2010, 8:93-106.
-
(2010)
Mol. Cancer Res.
, vol.8
, pp. 93-106
-
-
Lee, J.P.1
-
82
-
-
49449115438
-
Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway
-
Maruyama Y., et al. Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway. Biochem. Biophys. Res. Commun. 2008, 374:737-741.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.374
, pp. 737-741
-
-
Maruyama, Y.1
-
83
-
-
79959888488
-
RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation
-
Lu J.P., et al. RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation. J. Biol. Chem. 2011, 286:24426-24433.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 24426-24433
-
-
Lu, J.P.1
-
84
-
-
79953142340
-
A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis
-
Neutzner A., et al. A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. J. Biol. Chem. 2011, 286:8633-8643.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 8633-8643
-
-
Neutzner, A.1
-
85
-
-
77956537090
-
Interaction between parkin and mutant glucocerebrosidase variants: a possible link between Parkinson disease and Gaucher disease
-
Ron I., et al. Interaction between parkin and mutant glucocerebrosidase variants: a possible link between Parkinson disease and Gaucher disease. Hum. Mol. Genet. 2010, 19:3771-3781.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 3771-3781
-
-
Ron, I.1
-
86
-
-
70349663496
-
HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation
-
Mangeat B., et al. HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation. PLoS Pathog. 2009, 5:e1000574.
-
(2009)
PLoS Pathog.
, vol.5
-
-
Mangeat, B.1
-
87
-
-
18444413218
-
E3 ubiquitin ligase that recognizes sugar chains
-
Yoshida Y., et al. E3 ubiquitin ligase that recognizes sugar chains. Nature 2002, 418:438-442.
-
(2002)
Nature
, vol.418
, pp. 438-442
-
-
Yoshida, Y.1
-
88
-
-
17244381176
-
Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination
-
Kato A., et al. Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:5600-5605.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 5600-5605
-
-
Kato, A.1
-
89
-
-
78249267891
-
SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function
-
Gong B., et al. SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function. Aging Cell 2010, 9:1018-1031.
-
(2010)
Aging Cell
, vol.9
, pp. 1018-1031
-
-
Gong, B.1
-
90
-
-
0242321836
-
Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains
-
Yoshida Y., et al. Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. J. Biol. Chem. 2003, 278:43877-43884.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 43877-43884
-
-
Yoshida, Y.1
-
91
-
-
79955958397
-
The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum
-
Guo X., et al. The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum. J. Biol. Chem. 2011, 286:18037-18047.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 18037-18047
-
-
Guo, X.1
-
92
-
-
79960381005
-
Quantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulum
-
Fry W.H., et al. Quantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulum. Mol. Cell. Biol. 2011, 31:3009-3018.
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 3009-3018
-
-
Fry, W.H.1
-
93
-
-
77949351438
-
Modularity of the Hrd1 ERAD complex underlies its diverse client range
-
Kanehara K., et al. Modularity of the Hrd1 ERAD complex underlies its diverse client range. J. Cell Biol. 2010, 188:707-716.
-
(2010)
J. Cell Biol.
, vol.188
, pp. 707-716
-
-
Kanehara, K.1
-
94
-
-
77949461455
-
The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones
-
Buck T.M., et al. The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones. Mol. Biol. Cell 2010, 21:1047-1058.
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 1047-1058
-
-
Buck, T.M.1
-
95
-
-
68949133030
-
Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast
-
Hughes B.T., et al. Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast. J. Biol. Chem. 2009, 284:20512-20521.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 20512-20521
-
-
Hughes, B.T.1
-
96
-
-
0035887277
-
A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation
-
Swanson R., et al. A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation. Genes Dev. 2001, 15:2660-2674.
-
(2001)
Genes Dev.
, vol.15
, pp. 2660-2674
-
-
Swanson, R.1
-
97
-
-
4444355303
-
Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein
-
Huyer G., et al. Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein. J. Biol. Chem. 2004, 279:38369-38378.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 38369-38378
-
-
Huyer, G.1
-
98
-
-
0043026909
-
Substrate recognition in ER-associated degradation mediated by Eps1, a member of the protein disulfide isomerase family
-
Wang Q., Chang A. Substrate recognition in ER-associated degradation mediated by Eps1, a member of the protein disulfide isomerase family. EMBO J. 2003, 22:3792-3802.
-
(2003)
EMBO J.
, vol.22
, pp. 3792-3802
-
-
Wang, Q.1
Chang, A.2
-
99
-
-
32544437041
-
Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways
-
Ravid T., et al. Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways. EMBO J. 2006, 25:533-543.
-
(2006)
EMBO J.
, vol.25
, pp. 533-543
-
-
Ravid, T.1
-
100
-
-
21544450264
-
Structure of a peptide:N-glycanase-Rad23 complex: insight into the deglycosylation for denatured glycoproteins
-
Lee J.H., et al. Structure of a peptide:N-glycanase-Rad23 complex: insight into the deglycosylation for denatured glycoproteins. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:9144-9149.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 9144-9149
-
-
Lee, J.H.1
|