The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation

Nature Medicine

Volumn 13, Issue 12, 2007, Pages 1504-1509

  Tsai, Yien Che ^a   Mendoza, Arnulfo ^b   Mariano, Jennifer M ^a   Zhou, Ming ^a   Kostova, Zlatka ^a   Chen, Bo ^a,c   Veenstra, Timothy ^a   Hewitt, Stephen M ^b   Helman, Lee J ^b   Khanna, Chand ^b   Weissman, Allan M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c MEDIMMUNE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD82 ANTIGEN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CONTROLLED STUDY; ENZYME DEGRADATION; ENZYME REPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE MICROARRAY;

ANIMALS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; HUMANS; KANGAI-1 PROTEIN; MESODERM; MICE; NEOPLASM METASTASIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEINS; RECEPTORS, CYTOKINE; RING FINGER DOMAINS; SARCOMA; TRANSFECTION; UBIQUITIN-PROTEIN LIGASES;

EID: 36849051990     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1686     Document Type: Article

References (27)

1. Chen, B. et al. The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. Proc. Natl. Acad. Sci. USA 103, 341-346 (2006).
2. Fang, S. et al. The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 98, 14422-14427 (2001).
3. Lee, J.N., Song, B., DeBose-Boyd, R.A. & Ye, J. Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78. J. Biol. Chem. 281, 39308-39315 (2006).
4. Song, B.L., Sever, N. & DeBose-Boyd, R.A. Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. Mol. Cell 19, 829-840 (2005).
5. Shen, Y., Ballar, P. & Fang, S. Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of α-1- antitrypsin. Biochem. Biophys. Res. Commun. 349, 1285-1293 (2006).
6. Liang, J.S. et al. Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. J. Biol. Chem. 278, 23984-23988 (2003).
7. Shimizu, K. et al. The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett. 456, 295-300 (1999).
8. Watanabe, H. et al. Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. J. Biol. Chem. 266, 13442-13448 (1991).
9. Nabi, I.R., Watanabe, H. & Raz, A. Identification of B16-F1 melanoma autocrine motility-like factor receptor. Cancer Res. 50, 409-414 (1990).
10. Zhong, X. et al. AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. J. Biol. Chem. 279, 45676-45684 (2004).
11. Kauffman, E.C., Robinson, V.L., Stadler, W.M., Sokoloff, M.H. & Rinker-Schaeffer, C.W. Metastasis suppression: the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary site. J. Urol. 169, 1122-1133 (2003).
12. Khanna, C. et al. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat. Med. 10, 182-186 (2004).
13. Tonoli, H. & Barrett, J.C. CD82 metastasis suppressor gene: a potential target for new therapeutics? Trends Mol. Med. 11, 563-570 (2005).
14. Bass, R. et al. Regulation of urokinase receptor proteolytic function by the tetraspanin CD82. J. Biol. Chem. 280, 14811-14818 (2005).
15. Odintsova, E., Voortman, J., Gilbert, E. & Berditchevski, F. Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR. J. Cell Sci. 116, 4557-4566 (2003).
16. Ono, M., Handa, K., Withers, D.A. & Hakomori, S. Motility inhibition and apoptosis are induced by metastasis-suppressing gene product CD82 and its analogue CD9, with concurrent glycosylation. Cancer Res. 59, 2335-2339 (1999).
17. Schoenfeld, N., Bauer, M.K. & Grimm, S. The metastasis suppressor gene C33/CD82/KAI1 induces apoptosis through reactive oxygen intermediates. FASEB J. 18, 158-160 (2004).
18. Bandyopadhyay, S. et al. Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. Nat. Med. 12, 933-938 (2006).
19. Baek, S.H. et al. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-κB and β-amyloid precursor protein. Cell 110, 55-67 (2002).
20. Duriez, C., Falette, N., Cortes, U., Moyret-Lalle, C. & Puisieux, A. Absence of p53-dependent induction of the metastatic suppressor KAI1 gene after DNA damage. Oncogene 19, 2461-2464 (2000).
21. Kim, J.H. et al. Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis. Nat. Cell Biol. 8, 631-639 (2006).
22. Kim, J.H. et al. Transcriptional regulation of a metastasis suppressor gene by Tip60 and β-catenin complexes. Nature 434, 921-926 (2005).
23. Marreiros, A. et al. KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells. Oncogene 24, 637-649 (2005).
24. Berger, J.C., Vander Griend, D.J., Robinson, V.L., Hickson, J.A. & Rinker-Schaeffer, C.W. Metastasis suppressor genes: from gene identification to protein function and regulation. Cancer Biol. Ther. 4, 805-812 (2005).
25. Houle, C.D. et al. Loss of expression and altered localization of KAI1 and CD9 protein are associated with epithelial ovarian cancer progression. Gynecol. Oncol. 86, 69-78 (2002).
26. Hammond, C. et al. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules. J. Immunol. 161, 3282-3291 (1998).
27. Bruce, B. et al. Expression of the cytoskeleton linker protein ezrin in human cancers. Clin. Exp. Metastasis 24, 69-78 (2007).