The mechanism of double-stranded DNA sensing through the cGAS-STING pathway

Cytokine and Growth Factor Reviews

Volumn 25, Issue 6, 2014, Pages 641-648

  Shu, Chang ^a   Li, Xin ^a   Li, Pingwei ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Cyclic dinucleotides; Innate immunity; Nucleic acids; Pattern recognition receptors; Type I interferons

Indexed keywords

ADAPTOR PROTEIN; ADENOSINE PHOSPHATE SYNTHASE; BACTERIAL DNA; BACTERIAL PROTEIN; BETA INTERFERON; CYCLIC GMP; DOUBLE STRANDED DNA; INTERFERON REGULATORY FACTOR 3; PHOSPHOPROTEIN; PROTEIN KINASE; STING PROTEIN; SYNTHETASE; TBK1 PROTEIN; UNCLASSIFIED DRUG; DNA; IRF3 PROTEIN, HUMAN; MB21D1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE; PROTEIN SERINE THREONINE KINASE; TBK1 PROTEIN, HUMAN;

ANTIVIRAL ACTIVITY; BINDING SITE; CATALYSIS; CELL MEMBRANE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DNA BINDING; DNA MODIFICATION; DNA STRUCTURE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; LIGAND BINDING; NONHUMAN; OLIGOMERIZATION; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SHORT SURVEY; X RAY CRYSTALLOGRAPHY; ACTIVE TRANSPORT; ANIMAL; CELL NUCLEUS; GENETICS; HUMAN; IMMUNOLOGY; INTRACELLULAR MEMBRANE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL NUCLEUS; DNA; ENDOPLASMIC RETICULUM; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; INTRACELLULAR MEMBRANES; MEMBRANE PROTEINS; NUCLEOTIDYLTRANSFERASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION;

EID: 84918564143     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2014.06.006     Document Type: Short Survey

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