메뉴 건너뛰기




Volumn 31, Issue 1, 2015, Pages 81-88

Role of endoplasmic reticulum stress and autophagy as interlinking pathways in the pathogenesis of inflammatory bowel disease

Author keywords

Autophagy; Crohn's disease; Endoplasmic reticulum stress; Inflammatory bowel disease; Paneth cells

Indexed keywords

DEOXYRIBONUCLEASE I; X BOX BINDING PROTEIN 1;

EID: 84917728088     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0000000000000144     Document Type: Review
Times cited : (74)

References (65)
  • 1
    • 77958460117 scopus 로고    scopus 로고
    • Paneth cells and innate mucosal immunity
    • Ouellette AJ. Paneth cells and innate mucosal immunity. Curr Opin Gastroenterol 2010; 26:547-553.
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 547-553
    • Ouellette, A.J.1
  • 2
    • 74049122536 scopus 로고    scopus 로고
    • Enteric defensins are essential regulators of intestinal microbial ecology
    • Salzman NH, Hung K, Haribhai D, et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 2010; 11:76-83.
    • (2010) Nat Immunol , vol.11 , pp. 76-83
    • Salzman, N.H.1    Hung, K.2    Haribhai, D.3
  • 4
    • 84888201738 scopus 로고    scopus 로고
    • Enteroendocrine cells in gastrointestinal pathophysiology
    • Harrison E, Lal S, McLaughlin JT. Enteroendocrine cells in gastrointestinal pathophysiology. Curr Opin Pharmacol 2013; 13:941-945.
    • (2013) Curr Opin Pharmacol , vol.13 , pp. 941-945
    • Harrison, E.1    Lal, S.2    McLaughlin, J.T.3
  • 5
    • 84901258872 scopus 로고    scopus 로고
    • Protective mucosal immunity mediated by epithelial CD1d and IL-10
    • Olszak T, Neves JF, Dowds CM, et al. Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature 2014; 509:497-502.
    • (2014) Nature , vol.509 , pp. 497-502
    • Olszak, T.1    Neves, J.F.2    Dowds, C.M.3
  • 6
    • 50249116184 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress response in immunity and autoimmunity
    • Todd DJ, Lee A-H, Glimcher LH. The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol 2008; 8:663-674.
    • (2008) Nat Rev Immunol , vol.8 , pp. 663-674
    • Todd, D.J.1    Lee, A.-H.2    Glimcher, L.H.3
  • 7
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser A, Lee A-H, Franke A, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 2008; 134:743-756.
    • (2008) Cell , vol.134 , pp. 743-756
    • Kaser, A.1    Lee, A.-H.2    Franke, A.3
  • 8
    • 77952722353 scopus 로고    scopus 로고
    • ER stress and the unfolded protein response in intestinal inflammation
    • McGuckin MA, Eri RD, Das I, et al. ER stress and the unfolded protein response in intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 2010; 298:G820-G832.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298 , pp. G820-G832
    • McGuckin, M.A.1    Eri, R.D.2    Das, I.3
  • 9
    • 80054732968 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum stress in inflammatory bowel disease: A different implication for colonic and ileal disease?
    • Bogaert S, De Vos M, Olievier K, et al. Involvement of endoplasmic reticulum stress in inflammatory bowel disease: a different implication for colonic and ileal disease? PLoS One 2011; 6:e25589.
    • (2011) PLoS One , vol.6 , pp. e25589
    • Bogaert, S.1    De Vos, M.2    Olievier, K.3
  • 10
    • 84876998128 scopus 로고    scopus 로고
    • ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response
    • Heijmans J, van Lidth de Jeude Jooske F, Koo B-K, et al. ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Rep 2013; 3:1128-1139.
    • (2013) Cell Rep , vol.3 , pp. 1128-1139
    • Heijmans, J.1    Vanlidth Dejeudejooske, F.2    Koo, B.-K.3
  • 11
    • 84926260689 scopus 로고    scopus 로고
    • ER stress induces epithelial differentiation in the mouse oesophagus
    • [Epub ahead of print]
    • Rosekrans SL, Heijmans J, Buller NV, et al. ER stress induces epithelial differentiation in the mouse oesophagus. Gut 2014. [Epub ahead of print]
    • (2014) Gut
    • Rosekrans, S.L.1    Heijmans, J.2    Buller, N.V.3
  • 12
    • 77954144700 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: Implications for inflammatory bowel disease pathogenesis
    • Kaser A, Martínez-Naves E, Blumberg RS. Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol 2010; 26:318-326.
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 318-326
    • Kaser, A.1    Martínez-Naves, E.2    Blumberg, R.S.3
  • 13
    • 84881475553 scopus 로고    scopus 로고
    • The unfolded protein response and gastrointestinal disease
    • Kaser A, Adolph TE, Blumberg RS. The unfolded protein response and gastrointestinal disease. Semin Immunopathol 2013; 35:307-319.
    • (2013) Semin Immunopathol , vol.35 , pp. 307-319
    • Kaser, A.1    Adolph, T.E.2    Blumberg, R.S.3
  • 14
    • 0027324844 scopus 로고
    • Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
    • Cox JS, Shamu CE, Walter P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 1993; 73:1197-1206.
    • (1993) Cell , vol.73 , pp. 1197-1206
    • Cox, J.S.1    Shamu, C.E.2    Walter, P.3
  • 15
    • 0027305620 scopus 로고
    • A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus
    • Mori K, Ma W, Gething MJ, et al. A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell 1993; 74:743-756.
    • (1993) Cell , vol.74 , pp. 743-756
    • Mori, K.1    Ma, W.2    Gething, M.J.3
  • 16
    • 0032525990 scopus 로고    scopus 로고
    • A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
    • Tirasophon W, Welihinda AA, Kaufman RJ. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev 1998; 12:1812-1824.
    • (1998) Genes Dev , vol.12 , pp. 1812-1824
    • Tirasophon, W.1    Welihinda, A.A.2    Kaufman, R.J.3
  • 17
    • 0032190546 scopus 로고    scopus 로고
    • Cloning of mammalian Ire1 reveals diversity in the ER stress responses
    • Wang XZ, Harding HP, Zhang Y, et al. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. Embo J 1998; 17:5708-5717.
    • (1998) Embo J , vol.17 , pp. 5708-5717
    • Wang, X.Z.1    Harding, H.P.2    Zhang, Y.3
  • 18
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • Urano F. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000; 287:664-666.
    • (2000) Science , vol.287 , pp. 664-666
    • Urano, F.1
  • 19
    • 1442321303 scopus 로고    scopus 로고
    • Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2
    • Kaneko M, Niinuma Y, Nomura Y. Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2. Biol Pharm Bull 2003; 26:931-935.
    • (2003) Biol Pharm Bull , vol.26 , pp. 931-935
    • Kaneko, M.1    Niinuma, Y.2    Nomura, Y.3
  • 20
    • 50249116184 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress response in immunity and autoimmunity
    • Todd DJ, Lee AH, Glimcher LH. The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol 2008; 8:663-674.
    • (2008) Nat Rev Immunol , vol.8 , pp. 663-674
    • Todd, D.J.1    Lee, A.H.2    Glimcher, L.H.3
  • 21
    • 33745893809 scopus 로고    scopus 로고
    • Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
    • Hollien J, Weissman JS. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science 2006; 313:104-107.
    • (2006) Science , vol.313 , pp. 104-107
    • Hollien, J.1    Weissman, J.S.2
  • 22
    • 1842843855 scopus 로고    scopus 로고
    • Roles of CHOP/GADD153 in endoplasmic reticulum stress
    • Oyadomari S, Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 2004; 11:381-389.
    • (2004) Cell Death Differ , vol.11 , pp. 381-389
    • Oyadomari, S.1    Mori, M.2
  • 23
    • 84887620237 scopus 로고    scopus 로고
    • ER stress-induced cell death mechanisms
    • Sano R, Reed JC. ER stress-induced cell death mechanisms. Biochim Biophys Acta 2013; 1833:3460-3470.
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 3460-3470
    • Sano, R.1    Reed, J.C.2
  • 24
    • 0035094262 scopus 로고    scopus 로고
    • Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice
    • Bertolotti A, Wang X, Novoa I, et al. Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest 2001; 107:585-593.
    • (2001) J Clin Invest , vol.107 , pp. 585-593
    • Bertolotti, A.1    Wang, X.2    Novoa, I.3
  • 25
    • 84874251933 scopus 로고    scopus 로고
    • Negative feedback by IRE1beta optimizes mucin production in goblet cells
    • Tsuru A, Fujimoto N, Takahashi S, et al. Negative feedback by IRE1beta optimizes mucin production in goblet cells. Proc Natl Acad Sci U S A 2013; 110:2864-2869.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 2864-2869
    • Tsuru, A.1    Fujimoto, N.2    Takahashi, S.3
  • 26
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi KS, Chamaillard M, Ogura Y, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005; 307:731-734.
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1    Chamaillard, M.2    Ogura, Y.3
  • 27
    • 84887621906 scopus 로고    scopus 로고
    • Paneth cells as a site of origin for intestinal inflammation
    • Adolph TE, Tomczak MF, Niederreiter L, et al. Paneth cells as a site of origin for intestinal inflammation. Nature 2013; 503:272-276.
    • (2013) Nature , vol.503 , pp. 272-276
    • Adolph, T.E.1    Tomczak, M.F.2    Niederreiter, L.3
  • 28
    • 0031595210 scopus 로고    scopus 로고
    • Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa
    • Rogler G, Brand K, Vogl D, et al. Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology 1998; 115:357-369.
    • (1998) Gastroenterology , vol.115 , pp. 357-369
    • Rogler, G.1    Brand, K.2    Vogl, D.3
  • 30
    • 67649240439 scopus 로고    scopus 로고
    • OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells
    • van der Flier LG, Haegebarth A, Stange DE, et al. OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology 2009; 137:15-17.
    • (2009) Gastroenterology , vol.137 , pp. 15-17
    • Van Der Flier, L.G.1    Haegebarth, A.2    Stange, D.E.3
  • 31
    • 84885437087 scopus 로고    scopus 로고
    • ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells
    • Niederreiter L, Fritz TMJ, Adolph TE, et al. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells. J Exp Med 2013; 210:2041-2056.
    • (2013) J Exp Med , vol.210 , pp. 2041-2056
    • Niederreiter, L.1    Fritz, T.M.J.2    Adolph, T.E.3
  • 32
    • 84876486995 scopus 로고    scopus 로고
    • The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice
    • Cao SS, Zimmermann EM, Chuang BM, et al. The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology 2013; 144:989-1000.
    • (2013) Gastroenterology , vol.144 , pp. 989-1000
    • Cao, S.S.1    Zimmermann, E.M.2    Chuang, B.M.3
  • 33
    • 84898720437 scopus 로고    scopus 로고
    • Phosphorylation of eIF2alpha is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice
    • Cao SS, Wang M, Harrington JC, et al. Phosphorylation of eIF2alpha is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice. Inflamm Bowel Dis 2014; 20:712-722.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 712-722
    • Cao, S.S.1    Wang, M.2    Harrington, J.C.3
  • 34
    • 39049141776 scopus 로고    scopus 로고
    • The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation
    • Wang Z, Hao Y, Lowe AW. The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation. Cancer Res 2008; 68:492-497.
    • (2008) Cancer Res , vol.68 , pp. 492-497
    • Wang, Z.1    Hao, Y.2    Lowe, A.W.3
  • 35
    • 0033583231 scopus 로고    scopus 로고
    • Cloning of the gene gob-4, which is expressed in intestinal goblet cells in mice
    • Komiya T, Tanigawa Y, Hirohashi S. Cloning of the gene gob-4, which is expressed in intestinal goblet cells in mice. Biochim Biophys Acta 1999; 1444:434-438.
    • (1999) Biochim Biophys Acta , vol.1444 , pp. 434-438
    • Komiya, T.1    Tanigawa, Y.2    Hirohashi, S.3
  • 36
    • 74749103667 scopus 로고    scopus 로고
    • Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice
    • Zhao F, Edwards R, Dizon D, et al. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev Biol 2010; 338:270-279.
    • (2010) Dev Biol , vol.338 , pp. 270-279
    • Zhao, F.1    Edwards, R.2    Dizon, D.3
  • 37
    • 0032054744 scopus 로고    scopus 로고
    • CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
    • Zinszner H, Kuroda M, Wang X, et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 1998; 12:982-995.
    • (1998) Genes Dev , vol.12 , pp. 982-995
    • Zinszner, H.1    Kuroda, M.2    Wang, X.3
  • 38
    • 65649084877 scopus 로고    scopus 로고
    • Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis
    • Namba T, Tanaka K, Ito Y, et al. Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis. Am J Pathol 2009; 174:1786-1798.
    • (2009) Am J Pathol , vol.174 , pp. 1786-1798
    • Namba, T.1    Tanaka, K.2    Ito, Y.3
  • 39
    • 41549092745 scopus 로고    scopus 로고
    • Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
    • Heazlewood CK, Cook MC, Eri R, et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med 2008; 5:e54.
    • (2008) PLoS Med , vol.5 , pp. e54
    • Heazlewood, C.K.1    Cook, M.C.2    Eri, R.3
  • 40
    • 79955106916 scopus 로고    scopus 로고
    • An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity
    • Eri RD, Adams RJ, Tran TV, et al. An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity. Mucosal Immunol 2011; 4:354-364.
    • (2011) Mucosal Immunol , vol.4 , pp. 354-364
    • Eri, R.D.1    Adams, R.J.2    Tran, T.V.3
  • 41
    • 62549129560 scopus 로고    scopus 로고
    • Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
    • Brandl K, Rutschmann S, Li X, et al. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A 2009; 106:3300-3305.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 3300-3305
    • Brandl, K.1    Rutschmann, S.2    Li, X.3
  • 42
    • 71849110923 scopus 로고    scopus 로고
    • Different mechanisms of recognition and ER retention by transmembrane transcription factors CREB-H and ATF6
    • Llarena M, Bailey D, Curtis H, et al. Different mechanisms of recognition and ER retention by transmembrane transcription factors CREB-H and ATF6. Traffic 2010; 11:48-69.
    • (2010) Traffic , vol.11 , pp. 48-69
    • Llarena, M.1    Bailey, D.2    Curtis, H.3
  • 43
    • 84858020459 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine
    • Asada R, Saito A, Kawasaki N, et al. The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine. J Biol Chem 2008; 287:8144-8153.
    • (2008) J Biol Chem , vol.287 , pp. 8144-8153
    • Asada, R.1    Saito, A.2    Kawasaki, N.3
  • 44
    • 84894628100 scopus 로고    scopus 로고
    • Increased susceptibility to dextran sulfate sodium-induced colitis in the endoplasmic reticulum stress transducer OASIS deficient mice
    • Hino K, Saito A, Asada R, et al. Increased susceptibility to dextran sulfate sodium-induced colitis in the endoplasmic reticulum stress transducer OASIS deficient mice. PLoS One 2014; 9:e88048.
    • (2014) PLoS One , vol.9 , pp. e88048
    • Hino, K.1    Saito, A.2    Asada, R.3
  • 45
    • 79251586725 scopus 로고    scopus 로고
    • Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion
    • e3
    • Grootjans J, Hodin CM, de Haan J-J, et al. Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion. Gastroenterology 2011; 140:529-539; e3.
    • (2011) Gastroenterology , vol.140 , pp. 529-539
    • Grootjans, J.1    Hodin, C.M.2    De Haan, J.-J.3
  • 46
    • 84870546460 scopus 로고    scopus 로고
    • ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth
    • Hart LS, Cunningham JT, Datta T, et al. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest 2012; 122:4621-4634.
    • (2012) J Clin Invest , vol.122 , pp. 4621-4634
    • Hart, L.S.1    Cunningham, J.T.2    Datta, T.3
  • 47
    • 80052342419 scopus 로고    scopus 로고
    • PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment
    • Avivar-valderas A, Salas E, Diehl JA, et al. PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol Cell Biol 2011; 31:3616-3629.
    • (2011) Mol Cell Biol , vol.31 , pp. 3616-3629
    • Avivar-Valderas, A.1    Salas, E.2    Diehl, J.A.3
  • 48
    • 80051813164 scopus 로고    scopus 로고
    • Eating the strangers within: Host control of intracellular bacteria via xenophagy
    • Knodler LA, Celli J. Eating the strangers within: host control of intracellular bacteria via xenophagy. Cell Microbiol 2011; 13:1319-1327.
    • (2011) Cell Microbiol , vol.13 , pp. 1319-1327
    • Knodler, L.A.1    Celli, J.2
  • 49
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe J, Franke A, Rosenstiel P, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 2007; 39:207-211.
    • (2007) Nat Genet , vol.39 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3
  • 50
    • 34347338690 scopus 로고    scopus 로고
    • Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    • Parkes M, Barrett JC, Prescott NJ, et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 2007; 39:830-832.
    • (2007) Nat Genet , vol.39 , pp. 830-832
    • Parkes, M.1    Barrett, J.C.2    Prescott, N.J.3
  • 51
    • 77953904042 scopus 로고    scopus 로고
    • Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
    • Cadwell K, Patel KK, Maloney NS, et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 2010; 141:1135-1145.
    • (2010) Cell , vol.141 , pp. 1135-1145
    • Cadwell, K.1    Patel, K.K.2    Maloney, N.S.3
  • 52
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008; 456:259-263.
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3
  • 53
    • 84896730900 scopus 로고    scopus 로고
    • A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3
    • Murthy A, Li Y, Peng I, et al. A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature 2014; 506:456-462.
    • (2014) Nature , vol.506 , pp. 456-462
    • Murthy, A.1    Li, Y.2    Peng, I.3
  • 54
    • 33845459165 scopus 로고    scopus 로고
    • Autophagy is activated for cell survival after endoplasmic reticulum stress
    • Ogata M, Hino S, Saito A, et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 2006; 26:9220-9231.
    • (2006) Mol Cell Biol , vol.26 , pp. 9220-9231
    • Ogata, M.1    Hino, S.2    Saito, A.3
  • 55
    • 84896065933 scopus 로고    scopus 로고
    • Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1alpha (IRE1alpha) in human colon cancer cells
    • Shimodaira Y, Takahashi S, Kinouchi Y, et al. Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1alpha (IRE1alpha) in human colon cancer cells. Biochem Biophys Res Commun 2014; 445:524-533.
    • (2014) Biochem Biophys Res Commun , vol.445 , pp. 524-533
    • Shimodaira, Y.1    Takahashi, S.2    Kinouchi, Y.3
  • 56
    • 49949105827 scopus 로고    scopus 로고
    • The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells
    • Li J, Ni M, Lee B, et al. The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ 2008; 15:1460-1471.
    • (2008) Cell Death Differ , vol.15 , pp. 1460-1471
    • Li, J.1    Ni, M.2    Lee, B.3
  • 57
    • 84902211251 scopus 로고    scopus 로고
    • Genomic ATG16L1 risk allelerestricted Paneth cell ER stress in quiescent Crohn's disease
    • Deuring JJ, Fuhler GM, Konstantinov SR, et al. Genomic ATG16L1 risk allelerestricted Paneth cell ER stress in quiescent Crohn's disease. Gut 2013; 63:1081-1091.
    • (2013) Gut , vol.63 , pp. 1081-1091
    • Deuring, J.J.1    Fuhler, G.M.2    Konstantinov, S.R.3
  • 58
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40:955-962.
    • (2008) Nat Genet , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3
  • 59
    • 77950298959 scopus 로고    scopus 로고
    • Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    • McGovern DP, Gardet A, Torkvist L, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet 2010; 42:332-337.
    • (2010) Nat Genet , vol.42 , pp. 332-337
    • McGovern, D.P.1    Gardet, A.2    Torkvist, L.3
  • 60
    • 33846234333 scopus 로고    scopus 로고
    • Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: Impact on chronic inflammation
    • Shkoda A, Ruiz Pa, Daniel H, et al. Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation. Gastroenterology 2007; 132:190-207.
    • (2007) Gastroenterology , vol.132 , pp. 190-207
    • Shkoda, A.1    Pa, R.2    Daniel, H.3
  • 61
    • 84055223938 scopus 로고    scopus 로고
    • Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding
    • Deuring JJ, de Haar C, Koelewijn CL, et al. Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding. Biochem J 2012; 441:87-93.
    • (2012) Biochem J , vol.441 , pp. 87-93
    • Deuring, J.J.1    De Haar, C.2    Koelewijn, C.L.3
  • 62
    • 80052110662 scopus 로고    scopus 로고
    • Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis
    • Treton X, Pedruzzi E, Cazals-Hatem D, et al. Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis. Gastroenterology 2011; 141:1024-1035.
    • (2011) Gastroenterology , vol.141 , pp. 1024-1035
    • Treton, X.1    Pedruzzi, E.2    Cazals-Hatem, D.3
  • 63
    • 36549058329 scopus 로고    scopus 로고
    • Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation
    • Hu S, Ciancio MJ, Lahav M, et al. Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation. Gastroenterology 2007; 133:1893-1904.
    • (2007) Gastroenterology , vol.133 , pp. 1893-1904
    • Hu, S.1    Ciancio, M.J.2    Lahav, M.3
  • 64
    • 84885673740 scopus 로고    scopus 로고
    • Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation
    • Liu B, Gulati AS, Cantillana V, et al. Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 2014; 305:G573-G584.
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.305 , pp. G573-G584
    • Liu, B.1    Gulati, A.S.2    Cantillana, V.3
  • 65
    • 79851513757 scopus 로고    scopus 로고
    • Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis
    • Werner T, Wagner SJ, Martinez I, et al. Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis. Gut 2011; 60:325-333.
    • (2011) Gut , vol.60 , pp. 325-333
    • Werner, T.1    Wagner, S.J.2    Martinez, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.