-
1
-
-
70949107842
-
Inflammatory bowel disease
-
Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med 361: 2066-2078, 2009.
-
(2009)
N Engl J Med
, vol.361
, pp. 2066-2078
-
-
Abraham, C.1
Cho, J.H.2
-
2
-
-
0034252293
-
Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria
-
Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ. Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 1: 113-118, 2000.
-
(2000)
Nat Immunol
, vol.1
, pp. 113-118
-
-
Ayabe, T.1
Satchell, D.P.2
Wilson, C.L.3
Parks, W.C.4
Selsted, M.E.5
Ouellette, A.J.6
-
3
-
-
38449097465
-
The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia
-
Bafica A, Feng CG, Santiago HC, Aliberti J, Cheever A, Thomas KE, Taylor GA, Vogel SN, Sher A. The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. J Immunol 179: 5514-5522, 2007.
-
(2007)
J Immunol
, vol.179
, pp. 5514-5522
-
-
Bafica, A.1
Feng, C.G.2
Santiago, H.C.3
Aliberti, J.4
Cheever, A.5
Thomas, K.E.6
Taylor, G.A.7
Vogel, S.N.8
Sher, A.9
-
4
-
-
33744509713
-
The interferon-inducible p47 (IRG) GTPases in vertebrates: Loss of the cell autonomous resistance mechanism in the human lineage
-
Bekpen C, Hunn JP, Rohde C, Parvanova I, Guethlein L, Dunn DM, Glowalla E, Leptin M, Howard JC. The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol 6: R92, 2005.
-
(2005)
Genome Biol
, vol.6
-
-
Bekpen, C.1
Hunn, J.P.2
Rohde, C.3
Parvanova, I.4
Guethlein, L.5
Dunn, D.M.6
Glowalla, E.7
Leptin, M.8
Howard, J.C.9
-
5
-
-
79954915318
-
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
-
Bevins CL, Salzman NH. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 9: 356-368, 2011.
-
(2011)
Nat Rev Microbiol
, vol.9
, pp. 356-368
-
-
Bevins, C.L.1
Salzman, N.H.2
-
6
-
-
77957047689
-
Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum
-
Biswas A, Liu YJ, Hao L, Mizoguchi A, Salzman NH, Bevins CL, Kobayashi KS. Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum. Proc Natl Acad Sci USA 107: 14739-14744, 2010.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 14739-14744
-
-
Biswas, A.1
Liu, Y.J.2
Hao, L.3
Mizoguchi, A.4
Salzman, N.H.5
Bevins, C.L.6
Kobayashi, K.S.7
-
7
-
-
34547762705
-
MyD88- mediated signals induce the bactericidal lectin RegIIIα and protect mice against intestinal Listeria monocytogenes infection
-
Brandl K, Plitas G, Schnabl B, DeMatteo RP, Pamer EG. MyD88- mediated signals induce the bactericidal lectin RegIIIα and protect mice against intestinal Listeria monocytogenes infection. J Exp Med 204: 1891-1900, 2007.
-
(2007)
J Exp Med
, vol.204
, pp. 1891-1900
-
-
Brandl, K.1
Plitas, G.2
Schnabl, B.3
Dematteo, R.P.4
Pamer, E.G.5
-
8
-
-
19744378057
-
GTPases regulate Toxoplasma gondii survival in activated macrophages
-
Butcher BA, Greene RI, Henry SC, Annecharico KL, Weinberg JB, Denkers EY, Sher A, Taylor GA. p47 GTPases regulate Toxoplasma gondii survival in activated macrophages. Infect Immun 73: 3278-3286, 2005.
-
(2005)
Infect Immun
, vol.73
, pp. 3278-3286
-
-
Butcher, B.A.1
Greene, R.I.2
Henry, S.C.3
Annecharico, K.L.4
Weinberg, J.B.5
Denkers, E.Y.6
Sher, A.7
Taylor, G.A.8
-
9
-
-
56249135538
-
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
-
Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456: 259-263, 2008.
-
(2008)
Nature
, vol.456
, pp. 259-263
-
-
Cadwell, K.1
Liu, J.Y.2
Brown, S.L.3
Miyoshi, H.4
Loh, J.5
Lennerz, J.K.6
Kishi, C.7
Kc, W.8
Carrero, J.A.9
Hunt, S.10
Stone, C.D.11
Brunt, E.M.12
Xavier, R.J.13
Sleckman, B.P.14
Li, E.15
Mizushima, N.16
Stappenbeck, T.S.17
Virgin, H.W.18
-
10
-
-
77953904042
-
Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
-
Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 141: 1135-1145, 2010.
-
(2010)
Cell
, vol.141
, pp. 1135-1145
-
-
Cadwell, K.1
Patel, K.K.2
Maloney, N.S.3
Liu, T.C.4
Ng, A.C.5
Storer, C.E.6
Head, R.D.7
Xavier, R.8
Stappenbeck, T.S.9
Virgin, H.W.10
-
11
-
-
84869030015
-
Fusion and fission: Interlinked processes critical for mitochondrial health
-
Chan DC. Fusion and fission: interlinked processes critical for mitochondrial health. Annu Rev Genet 46: 265-287, 2012.
-
(2012)
Annu Rev Genet
, vol.46
, pp. 265-287
-
-
Chan, D.C.1
-
12
-
-
82655189171
-
Concanavalin A/IFN-α triggers autophagy- related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption
-
e28323
-
Chang CP, Yang MC, Lei HY. Concanavalin A/IFN-α triggers autophagy- related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption. PLos One 6: e28323, 2011.
-
(2011)
PLos One
, pp. 6
-
-
Chang, C.P.1
Yang, M.C.2
Lei, H.Y.3
-
13
-
-
0035898464
-
Inactivation of LRG-47 and IRG-47 reveals a family of interferon-α-inducible genes with essential, pathogenspecific roles in resistance to infection
-
Collazo CM, Yap GS, Sempowski GD, Lusby KC, Tessarollo L, Woude GF, Sher A, Taylor GA. Inactivation of LRG-47 and IRG-47 reveals a family of interferon-α-inducible genes with essential, pathogenspecific roles in resistance to infection. J Exp Med 194: 181-188, 2001.
-
(2001)
J Exp Med
, vol.194
, pp. 181-188
-
-
Collazo, C.M.1
Yap, G.S.2
Sempowski, G.D.3
Lusby, K.C.4
Tessarollo, L.5
Woude, G.F.6
Sher, A.7
Taylor, G.A.8
-
14
-
-
84871941976
-
Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication
-
Degrandi D, Kravets E, Konermann C, Beuter-Gunia C, Klumpers V, Lahme S, Wischmann E, Mausberg AK, Beer-Hammer S, Pfeffer K. Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication. Proc Natl Acad Sci USA 110: 294-299, 2013.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 294-299
-
-
Degrandi, D.1
Kravets, E.2
Konermann, C.3
Beuter-Gunia, C.4
Klumpers, V.5
Lahme, S.6
Wischmann, E.7
Mausberg, A.K.8
Beer-Hammer, S.9
Pfeffer, K.10
-
15
-
-
37549048915
-
The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation
-
Feng CG, Weksberg DC, Taylor GA, Sher A, Goodell MA. The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell 2: 83-89, 2008.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 83-89
-
-
Feng, C.G.1
Weksberg, D.C.2
Taylor, G.A.3
Sher, A.4
Goodell, M.A.5
-
16
-
-
54549089752
-
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4α T cell populations by preventing interferon-α-induced cell death
-
Feng CG, Zheng L, Jankovic D, Bafica A, Cannons JL, Watford WT, Chaussabel D, Hieny S, Caspar P, Schwartzberg PL, Lenardo MJ, Sher A. The immunity-related GTPase Irgm1 promotes the expansion of activated CD4α T cell populations by preventing interferon-α-induced cell death. Nat Immunol 9: 1279-1287, 2008.
-
(2008)
Nat Immunol
, vol.9
, pp. 1279-1287
-
-
Feng, C.G.1
Zheng, L.2
Jankovic, D.3
Bafica, A.4
Cannons, J.L.5
Watford, W.T.6
Chaussabel, D.7
Hieny, S.8
Caspar, P.9
Schwartzberg, P.L.10
Lenardo, M.J.11
Sher, A.12
-
17
-
-
80052641505
-
Crohn's disease: NOD2, autophagy and ER stress converge
-
Fritz T, Niederreiter L, Adolph T, Blumberg RS, Kaser A. Crohn's disease: NOD2, autophagy and ER stress converge. Gut 60: 1580-1588, 2011.
-
(2011)
Gut
, vol.60
, pp. 1580-1588
-
-
Fritz, T.1
Niederreiter, L.2
Adolph, T.3
Blumberg, R.S.4
Kaser, A.5
-
18
-
-
84857530417
-
Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition
-
Gulati AS, Shanahan MT, Arthur JC, Grossniklaus E, von Furstenberg RJ, Kreuk L, Henning SJ, Jobin C, Sartor RB. Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition. PLos One 7: e32403, 2012.
-
(2012)
PLos One
, vol.7
-
-
Gulati, A.S.1
Shanahan, M.T.2
Arthur, J.C.3
Grossniklaus, E.4
von Furstenberg, R.J.5
Kreuk, L.6
Henning, S.J.7
Jobin, C.8
Sartor, R.B.9
-
19
-
-
10944253145
-
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
-
Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119: 753-766, 2004.
-
(2004)
Cell
, vol.119
, pp. 753-766
-
-
Gutierrez, M.G.1
Master, S.S.2
Singh, S.B.3
Taylor, G.A.4
Colombo, M.I.5
Deretic, V.6
-
20
-
-
33846627302
-
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
-
Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Gunther S, Prescott NJ, Onnie CM, Hasler R, Sipos B, Folsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39: 207-211, 2007.
-
(2007)
Nat Genet
, vol.39
, pp. 207-211
-
-
Hampe, J.1
Franke, A.2
Rosenstiel, P.3
Till, A.4
Teuber, M.5
Huse, K.6
Albrecht, M.7
Mayr, G.8
De La Vega, F.M.9
Briggs, J.10
Gunther, S.11
Prescott, N.J.12
Onnie, C.M.13
Hasler, R.14
Sipos, B.15
Folsch, U.R.16
Lengauer, T.17
Platzer, M.18
Mathew, C.G.19
Krawczak, M.20
Schreiber, S.21
more..
-
21
-
-
76149089546
-
Regulation of macrophage motility by Irgm1
-
Henry SC, Traver M, Daniell X, Indaram M, Oliver T, Taylor GA. Regulation of macrophage motility by Irgm1. J Leukoc Biol 87: 333-343, 2010.
-
(2010)
J Leukoc Biol
, vol.87
, pp. 333-343
-
-
Henry, S.C.1
Traver, M.2
Daniell, X.3
Indaram, M.4
Oliver, T.5
Taylor, G.A.6
-
22
-
-
0036739724
-
Paneth and intermediate cell hyperplasia induced in mice by helminth infections
-
Kamal M, Dehlawi MS, Brunet LR, Wakelin D. Paneth and intermediate cell hyperplasia induced in mice by helminth infections. Parasitology 125: 275-281, 2002.
-
(2002)
Parasitology
, vol.125
, pp. 275-281
-
-
Kamal, M.1
Dehlawi, M.S.2
Brunet, L.R.3
Wakelin, D.4
-
23
-
-
0034776894
-
Mucosal T cells regulate Paneth and intermediate cell numbers in the small intestine of T. spiralis-infected mice
-
Kamal M, Wakelin D, Ouellette AJ, Smith A, Podolsky DK, Mahida YR. Mucosal T cells regulate Paneth and intermediate cell numbers in the small intestine of T. spiralis-infected mice. Clin Exp Immunol 126: 117-125, 2001.
-
(2001)
Clin Exp Immunol
, vol.126
, pp. 117-125
-
-
Kamal, M.1
Wakelin, D.2
Ouellette, A.J.3
Smith, A.4
Podolsky, D.K.5
Mahida, Y.R.6
-
24
-
-
50249086073
-
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134: 743-756, 2008.
-
(2008)
Cell
, vol.134
, pp. 743-756
-
-
Kaser, A.1
Lee, A.H.2
Franke, A.3
Glickman, J.N.4
Zeissig, S.5
Tilg, H.6
Nieuwenhuis, E.E.7
Higgins, D.E.8
Schreiber, S.9
Glimcher, L.H.10
Blumberg, R.S.11
-
25
-
-
33751549487
-
Paneth cells: Leukocyte-like mediators of innate immunity in the intestine
-
Keshav S. Paneth cells: leukocyte-like mediators of innate immunity in the intestine. J Leukoc Biol 80: 500-508, 2006.
-
(2006)
J Leukoc Biol
, vol.80
, pp. 500-508
-
-
Keshav, S.1
-
26
-
-
79959216005
-
Genetics and pathogenesis of inflammatory bowel disease
-
Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature 474: 307-317, 2011.
-
(2011)
Nature
, vol.474
, pp. 307-317
-
-
Khor, B.1
Gardet, A.2
Xavier, R.J.3
-
27
-
-
79954479289
-
Genome-wide association studies and Crohn's disease
-
Lee JC, Parkes M. Genome-wide association studies and Crohn's disease. Brief Funct Genomics 10: 71-76, 2011.
-
(2011)
Brief Funct Genomics
, vol.10
, pp. 71-76
-
-
Lee, J.C.1
Parkes, M.2
-
28
-
-
33748444233
-
Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages
-
Ling YM, Shaw MH, Ayala C, Coppens I, Taylor GA, Ferguson DJ, Yap GS. Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J Exp Med 203: 2063-2071, 2006.
-
(2006)
J Exp Med
, vol.203
, pp. 2063-2071
-
-
Ling, Y.M.1
Shaw, M.H.2
Ayala, C.3
Coppens, I.4
Taylor, G.A.5
Ferguson, D.J.6
Yap, G.S.7
-
29
-
-
0035188740
-
Behaviour of Crohn's disease according to the Vienna classification: Changing pattern over the course of the disease
-
Louis E, Collard A, Oger AF, Degroote E, Aboul Nasr El Yafi FA, Belaiche J. Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease. Gut 49: 777-782, 2001.
-
(2001)
Gut
, vol.49
, pp. 777-782
-
-
Louis, E.1
Collard, A.2
Oger, A.F.3
Degroote, E.4
Aboul, N.E.L.5
Yafi, F.A.6
Belaiche, J.7
-
30
-
-
0142240338
-
Immune control of tuberculosis by IFN-α-inducible LRG-47
-
MacMicking JD, Taylor GA, McKinney JD. Immune control of tuberculosis by IFN-α-inducible LRG-47. Science 302: 654-659, 2003.
-
(2003)
Science
, vol.302
, pp. 654-659
-
-
Macmicking, J.D.1
Taylor, G.A.2
McKinney, J.D.3
-
31
-
-
0031945843
-
Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis
-
Mahler M, Bristol IJ, Leiter EH, Workman AE, Birkenmeier EH, Elson CO, Sundberg JP. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol Gastrointest Liver Physiol 274: G544-G551, 1998.
-
(1998)
Am J Physiol Gastrointest Liver Physiol
, vol.274
-
-
Mahler, M.1
Bristol, I.J.2
Leiter, E.H.3
Workman, A.E.4
Birkenmeier, E.H.5
Elson, C.O.6
Sundberg, J.P.7
-
33
-
-
49649126253
-
Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases
-
Martens S, Parvanova I, Zerrahn J, Griffiths G, Schell G, Reichmann G, Howard JC. Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases. PLoS Pathog 1: e24, 2005.
-
(2005)
PLoS Pathog
, vol.1
-
-
Martens, S.1
Parvanova, I.2
Zerrahn, J.3
Griffiths, G.4
Schell, G.5
Reichmann, G.6
Howard, J.C.7
-
34
-
-
0030818051
-
Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice
-
Neurath MF, Fuss I, Pasparakis M, Alexopoulou L, Haralambous S, Meyer Zum, Buschenfelde KH, Strober W, Kollias G. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. Eur J Immunol 27: 1743-1750, 1997.
-
(1997)
Eur J Immunol
, vol.27
, pp. 1743-1750
-
-
Neurath, M.F.1
Fuss, I.2
Pasparakis, M.3
Alexopoulou, L.4
Haralambous, S.5
Zum, M.6
Buschenfelde, K.H.7
Strober, W.8
Kollias, G.9
-
35
-
-
0025181580
-
A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
-
Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98: 694-702, 1990.
-
(1990)
Gastroenterology
, vol.98
, pp. 694-702
-
-
Okayasu, I.1
Hatakeyama, S.2
Yamada, M.3
Ohkusa, T.4
Inagaki, Y.5
Nakaya, R.6
-
36
-
-
79960940581
-
Paneth cell α-defensins in enteric innate immunity
-
Ouellette AJ. Paneth cell α-defensins in enteric innate immunity. Cell Mol Life Sci 68: 2215-2229, 2011.
-
(2011)
Cell Mol Life Sci
, vol.68
, pp. 2215-2229
-
-
Ouellette, A.J.1
-
37
-
-
34347338690
-
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
-
Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, Nimmo ER, Cummings FR, Soars D, Drummond H, Lees CW, Khawaja SA, Bagnall R, Burke DA, Todhunter CE, Ahmad T, Onnie CM, McArdle W, Strachan D, Bethel G, Bryan C, Lewis CM, Deloukas P, Forbes A, Sanderson J, Jewell DP, Satsangi J, Mansfield JC, Cardon L, Mathew CG. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 39: 830-832, 2007.
-
(2007)
Nat Genet
, vol.39
, pp. 830-832
-
-
Parkes, M.1
Barrett, J.C.2
Prescott, N.J.3
Tremelling, M.4
Anderson, C.A.5
Fisher, S.A.6
Roberts, R.G.7
Nimmo, E.R.8
Cummings, F.R.9
Soars, D.10
Drummond, H.11
Lees, C.W.12
Khawaja, S.A.13
Bagnall, R.14
Burke, D.A.15
Todhunter, C.E.16
Ahmad, T.17
Onnie, C.M.18
McArdle, W.19
Strachan, D.20
Bethel, G.21
Bryan, C.22
Lewis, C.M.23
Deloukas, P.24
Forbes, A.25
Sanderson, J.26
Jewell, D.P.27
Satsangi, J.28
Mansfield, J.C.29
Cardon, L.30
Mathew, C.G.31
more..
-
38
-
-
0036161792
-
The multifaceted Paneth cell
-
Porter EM, Bevins CL, Ghosh D, Ganz T. The multifaceted Paneth cell. Cell Mol Life Sci 59: 156-170, 2002.
-
(2002)
Cell Mol Life Sci
, vol.59
, pp. 156-170
-
-
Porter, E.M.1
Bevins, C.L.2
Ghosh, D.3
Ganz, T.4
-
39
-
-
51249103405
-
Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort
-
Roberts RL, Hollis-Moffatt JE, Gearry RB, Kennedy MA, Barclay ML, Merriman TR. Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort. Genes Immun 9: 561-565, 2008.
-
(2008)
Genes Immun
, vol.9
, pp. 561-565
-
-
Roberts, R.L.1
Hollis-Moffatt, J.E.2
Gearry, R.B.3
Kennedy, M.A.4
Barclay, M.L.5
Merriman, T.R.6
-
40
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1 production
-
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1 production. Nature 456: 264-268, 2008.
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
Uematsu, S.4
Yang, B.G.5
Satoh, T.6
Omori, H.7
Noda, T.8
Yamamoto, N.9
Komatsu, M.10
Tanaka, K.11
Kawai, T.12
Tsujimura, T.13
Takeuchi, O.14
Yoshimori, T.15
Akira, S.16
-
41
-
-
74049122536
-
Enteric defensins are essential regulators of intestinal microbial ecology
-
Salzman NH, Hung K, Haribhai D, Chu H, Karlsson-Sjoberg J, Amir E, Teggatz P, Barman M, Hayward M, Eastwood D, Stoel M, Zhou Y, Sodergren E, Weinstock GM, Bevins CL, Williams CB, Bos NA. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 11: 76-83, 2010.
-
(2010)
Nat Immunol
, vol.11
, pp. 76-83
-
-
Salzman, N.H.1
Hung, K.2
Haribhai, D.3
Chu, H.4
Karlsson-Sjoberg, J.5
Amir, E.6
Teggatz, P.7
Barman, M.8
Hayward, M.9
Eastwood, D.10
Stoel, M.11
Zhou, Y.12
Sodergren, E.13
Weinstock, G.M.14
Bevins, C.L.15
Williams, C.B.16
Bos, N.A.17
-
42
-
-
38649115342
-
Microbial influences in inflammatory bowel diseases
-
Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology 134: 577-594, 2008.
-
(2008)
Gastroenterology
, vol.134
, pp. 577-594
-
-
Sartor, R.B.1
-
43
-
-
44949231424
-
Analyzing real-time PCR data by the comparative CT method
-
Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative CT method. Nat Protoc 3: 1101-1108, 2008.
-
(2008)
Nat Protoc
, vol.3
, pp. 1101-1108
-
-
Schmittgen, T.D.1
Livak, K.J.2
-
44
-
-
84876857964
-
Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii
-
Selleck EM, Fentress SJ, Beatty WL, Degrandi D, Pfeffer K, Virgin HW, Macmicking JD, Sibley LD. Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii. PLoS Pathog 9: e1003320, 2013.
-
(2013)
PLoS Pathog
, vol.9
-
-
Selleck, E.M.1
Fentress, S.J.2
Beatty, W.L.3
Degrandi, D.4
Pfeffer, K.5
Virgin, H.W.6
Macmicking, J.D.7
Sibley, L.D.8
-
45
-
-
37049020693
-
Emerging themes in IFN-α-induced macrophage immunity by the p47 and p65 GTPase families
-
Shenoy AR, Kim BH, Choi HP, Matsuzawa T, Tiwari S, MacMicking JD. Emerging themes in IFN-α-induced macrophage immunity by the p47 and p65 GTPase families. Immunobiology 212: 771-784, 2007.
-
(2007)
Immunobiology
, vol.212
, pp. 771-784
-
-
Shenoy, A.R.1
Kim, B.H.2
Choi, H.P.3
Matsuzawa, T.4
Tiwari, S.5
Macmicking, J.D.6
-
46
-
-
33748506089
-
induces autophagy to eliminate intracellular mycobacteria
-
Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313: 1438-1441, 2006.
-
(2006)
Science
, vol.313
, pp. 1438-1441
-
-
Singh, S.B.1
Davis, A.S.2
Taylor, G.A.3
Deretic, V.4
Human, I.R.G.M.5
-
47
-
-
78649833818
-
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
-
Singh SB, Ornatowski W, Vergne I, Naylor J, Delgado M, Roberts E, Ponpuak M, Master S, Pilli M, White E, Komatsu M, Deretic V. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol 12: 1154-1165, 2010.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 1154-1165
-
-
Singh, S.B.1
Ornatowski, W.2
Vergne, I.3
Naylor, J.4
Delgado, M.5
Roberts, E.6
Ponpuak, M.7
Master, S.8
Pilli, M.9
White, E.10
Komatsu, M.11
Deretic, V.12
-
48
-
-
34047256441
-
IRG proteins: Key mediators of interferon-regulated host resistance to intracellular pathogens
-
Taylor GA. IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens. Cell Microbiol 9: 1099-1107, 2007.
-
(2007)
Cell Microbiol
, vol.9
, pp. 1099-1107
-
-
Taylor, G.A.1
-
49
-
-
0034681123
-
Pathogen-specific loss of host resistance in mice lacking the IFN-α-inducible gene IGTP
-
Taylor GA, Collazo CM, Yap GS, Nguyen K, Gregorio TA, Taylor LS, Eagleson B, Secrest L, Southon EA, Reid SW, Tessarollo L, Bray M, McVicar DW, Komschlies KL, Young HA, Biron CA, Sher A, Vande Woude GF. Pathogen-specific loss of host resistance in mice lacking the IFN-α-inducible gene IGTP. Proc Natl Acad Sci USA 97: 751-755, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 751-755
-
-
Taylor, G.A.1
Collazo, C.M.2
Yap, G.S.3
Nguyen, K.4
Gregorio, T.A.5
Taylor, L.S.6
Eagleson, B.7
Secrest, L.8
Southon, E.A.9
Reid, S.W.10
Tessarollo, L.11
Bray, M.12
McVicar, D.W.13
Komschlies, K.L.14
Young, H.A.15
Biron, C.A.16
Sher, A.17
Vande Woude, G.F.18
-
50
-
-
84860136921
-
Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease
-
Thachil E, Hugot JP, Arbeille B, Paris R, Grodet A, Peuchmaur M, Codogno P, Barreau F, Ogier-Denis E, Berrebi D, Viala J. Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease. Gastroenterology 142: 1097-1099, 2012.
-
(2012)
Gastroenterology
, vol.142
, pp. 1097-1099
-
-
Thachil, E.1
Hugot, J.P.2
Arbeille, B.3
Paris, R.4
Grodet, A.5
Peuchmaur, M.6
Codogno, P.7
Barreau, F.8
Ogier-Denis, E.9
Berrebi, D.10
Viala, J.11
-
51
-
-
67651174262
-
Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria
-
Tiwari S, Choi HP, Matsuzawa T, Pypaert M, MacMicking JD. Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. Nat Immunol 10: 907-917, 2009.
-
(2009)
Nat Immunol
, vol.10
, pp. 907-917
-
-
Tiwari, S.1
Choi, H.P.2
Matsuzawa, T.3
Pypaert, M.4
Macmicking, J.D.5
-
52
-
-
84883840386
-
Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines
-
Todaro GJ, Green H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol 17: 299-313, 1963.
-
(1963)
J Cell Biol
, vol.17
, pp. 299-313
-
-
Todaro, G.J.1
Green, H.2
-
53
-
-
80052235117
-
(IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy
-
Traver MK, Henry SC, Cantillana V, Oliver T, Hunn JP, Howard JC, Beer S, Pfeffer K, Coers J, Taylor GA. Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. J Biol Chem 286: 30471-30480, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 30471-30480
-
-
Traver, M.K.1
Henry, S.C.2
Cantillana, V.3
Oliver, T.4
Hunn, J.P.5
Howard, J.C.6
Beer, S.7
Pfeffer, K.8
Coers, J.9
Taylor, G.A.10
Immunity-Related, G.M.11
-
54
-
-
17144402633
-
Altered epithelial cell lineage allocation and global expansion of the crypt epithelial stem cell population are associated with ileitis in SAMP1/YitFc mice
-
Vidrich A, Buzan JM, Barnes S, Reuter BK, Skaar K, Ilo C, Cominelli F, Pizarro T, Cohn SM. Altered epithelial cell lineage allocation and global expansion of the crypt epithelial stem cell population are associated with ileitis in SAMP1/YitFc mice. Am J Pathol 166: 1055-1067, 2005.
-
(2005)
Am J Pathol
, vol.166
, pp. 1055-1067
-
-
Vidrich, A.1
Buzan, J.M.2
Barnes, S.3
Reuter, B.K.4
Skaar, K.5
Ilo, C.6
Cominelli, F.7
Pizarro, T.8
Cohn, S.M.9
-
55
-
-
80053462850
-
Metagenomics and personalized medicine
-
Virgin HW, Todd JA. Metagenomics and personalized medicine. Cell 147: 44-56, 2011.
-
(2011)
Cell
, vol.147
, pp. 44-56
-
-
Virgin, H.W.1
Todd, J.A.2
-
56
-
-
79952319773
-
Mitochondria removal by autophagy
-
Wang K, Klionsky DJ. Mitochondria removal by autophagy. Autophagy 7: 297-300, 2011.
-
(2011)
Autophagy
, vol.7
, pp. 297-300
-
-
Wang, K.1
Klionsky, D.J.2
-
57
-
-
7244257312
-
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression
-
Wehkamp J, Harder J, Weichenthal M, Schwab M, Schaffeler E, Schlee M, Herrlinger KR, Stallmach A, Noack F, Fritz P, Schroder JM, Bevins CL, Fellermann K, Stange EF. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression. Gut 53: 1658-1664, 2004.
-
(2004)
Gut
, vol.53
, pp. 1658-1664
-
-
Wehkamp, J.1
Harder, J.2
Weichenthal, M.3
Schwab, M.4
Schaffeler, E.5
Schlee, M.6
Herrlinger, K.R.7
Stallmach, A.8
Noack, F.9
Fritz, P.10
Schroder, J.M.11
Bevins, C.L.12
Fellermann, K.13
Stange, E.F.14
-
58
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Consortium
-
Wellcome Trust Case Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678, 2007.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
59
-
-
0033214433
-
Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense
-
Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, Lopez-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC. Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286: 113-117, 1999.
-
(1999)
Science
, vol.286
, pp. 113-117
-
-
Wilson, C.L.1
Ouellette, A.J.2
Satchell, D.P.3
Ayabe, T.4
Lopez-Boado, Y.S.5
Stratman, J.L.6
Hultgren, S.J.7
Matrisian, L.M.8
Parks, W.C.9
-
60
-
-
34347262689
-
Chemically induced mouse models of intestinal inflammation
-
Wirtz S, Neufert C, Weigmann B, Neurath MF. Chemically induced mouse models of intestinal inflammation. Nat Protoc 2: 541-546, 2007.
-
(2007)
Nat Protoc
, vol.2
, pp. 541-546
-
-
Wirtz, S.1
Neufert, C.2
Weigmann, B.3
Neurath, M.F.4
-
61
-
-
61449117883
-
Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNα-inducible immunityrelated GTPases (IRG proteins) triggers necrotic cell death
-
Zhao YO, Khaminets A, Hunn JP, Howard JC. Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNα-inducible immunityrelated GTPases (IRG proteins) triggers necrotic cell death. PLoS Pathog 5: e1000288, 2009.
-
(2009)
PLoS Pathog
, vol.5
-
-
Zhao, Y.O.1
Khaminets, A.2
Hunn, J.P.3
Howard, J.C.4
|