Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis

Gut

Volumn 60, Issue 3, 2011, Pages 325-333

  Werner, Tanja ^a   Wagner, Stefan J ^a   Martínez, Inés ^b   Walter, Jens ^b   Chang, Jung Su ^a   Clavel, Thomas ^a   Kisling, Sigrid ^a   Schuemann, Klaus ^a   Haller, Dirk ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERROUS SULFATE; RNA 16S; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELLULAR STRESS RESPONSE; CROHN DISEASE; CYTOTOXICITY; DIET SUPPLEMENTATION; ENDOPLASMIC RETICULUM; EPITHELIUM CELL; HETEROZYGOSITY; ILEITIS; INTESTINE FLORA; MICROBIAL DIVERSITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PYROSEQUENCING; SMALL INTESTINE; T LYMPHOCYTE; WILD TYPE;

ANIMALS; APOPTOSIS; CECUM; CELL LINE; CHRONIC DISEASE; COCULTURE TECHNIQUES; CROHN DISEASE; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; ILEITIS; ILEUM; INTESTINAL MUCOSA; IRON; IRON, DIETARY; MICE; MICE, INBRED C57BL; STRESS, PHYSIOLOGICAL; T-LYMPHOCYTES, CYTOTOXIC;

EID: 79851513757     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2010.216929     Document Type: Article

References (26)

1. Perl DP, Fogarty U, Harpaz N, et al. Bacterial - metal interactions: the potential role of aluminum and other trace elements in the etiology of Crohn's disease. Inflamm Bowel Dis 2004;10:881-3. (Pubitemid 39545232)
2. Liguori L. Iron protein succinylate in the treatment of iron deficiency: controlled, double-blind, multicenter clinical trial on over 1,000 patients. Int J Clin Pharmacol Ther Toxicol 1993;31:103-23.
3. Coplin M, Schuette S, Leichtmann G, et al. Tolerability of iron: a comparison of bis-glycino iron II and ferrous sulfate. Clin Ther 1991;13:606-12.
4. Clavel T, Haller D. Bacteria- and host-derived mechanisms to control intestinal epithelial cell homeostasis: implications for chronic inflammation. Inflamm Bowel Dis 2007;13:1153-64. (Pubitemid 47402601)
5. Heazlewood CK, Cook MC, Eri R, et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med 2008;5:e54.
6. Kaser A, Lee AH, Franke A, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 2008;134:743-56.
7. Shkoda A, Ruiz PA, Daniel H, et al. Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation. Gastroenterology 2007;132:190-207. (Pubitemid 46108743)
8. Brandl K, Rutschmann S, Li X, et al. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A 2009;106:3300-5.
9. Apostolaki M, Manoloukos M, Roulis M, et al. Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease. Gastroenterology 2008;134:2025-35. (Pubitemid 351790742)
10. Werner T, Hoermannsperger G, Schuemann K, et al. Intestinal epithelial cell proteome from wild-type and TNFΔARE/WT mice: effect of iron on the development of chronic ileitis. J Proteome Res 2009;7:3252-64.
11. Rath HC, Herfarth HH, Ikeda JS, et al. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest 1996;98:945-53. (Pubitemid 26293312)
12. Ruiz PA, Shkoda A, Kim SC, et al. IL-10 gene-deficient mice lack TGF-beta/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis. J Immunol 2005;174:2990-9. (Pubitemid 40279719)
13. Kontoyiannis D, Boulougouris G, Manoloukos M, et al. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 2002;196:1563-74. (Pubitemid 36026468)
14. Kaser A, Blumberg RS. Endoplasmic reticulum stress and intestinal inflammation. Mucosal Immunol 2010;3:11-16.
15. Kaser A, Blumberg RS. Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease. Semin Immunol 2009;21:156-63.
16. Buffinton GD, Doe WF. Depleted mucosal antioxidant defences in inflammatory bowel disease. Free Radic Biol Med 1995;19:911-18.
17. Lih-Brody L, Powell SR, Collier KP, et al. Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Dig Dis Sci 1996;41:2078-86. (Pubitemid 26366811)
18. Simmonds NJ, Allen RE, Stevens TR, et al. Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease. Gastroenterology 1992;103:186-96.
19. Millar AD, Rampton DS, Blake DR. Effects of iron and iron chelation in vitro on mucosal oxidant activity in ulcerative colitis. Aliment Pharmacol Ther 2000;14:1163-8.
20. Erichsen K, Hausken T, Ulvik RJ, et al. Ferrous fumarate deteriorated plasma antioxidant status in patients with Crohn disease. Scand J Gastroenterol 2003;38:543-8. (Pubitemid 36609862)
21. Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010;464:59-65.
22. Ryan P, Kelly RG, Lee G, et al. Bacterial DNA within granulomas of patients with Crohn's disease - detection by laser capture microdissection and PCR. Am J Gastroenterol 2004;99:1539-43. (Pubitemid 39180104)
23. Darfeuille-Michaud A, Boudeau J, Bulois P, et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 2004;127:412-21. (Pubitemid 39091889)
24. Florin TH. A role for sulfate-reducing bacteria in ulcerative colitis. Gastroenterology 1990;98:A170.
25. Kleessen B, Kroesen AJ, Buhr HJ, et al. Mucosal and invading bacteria in patients with inflammatory bowel disease compared with controls. Scand J Gastroenterol 2002;37:1034-41.
26. Sartor RB. Probiotic therapy of intestinal inflammation and infections. Curr Opin Gastroenterol 2005;21:44-50. (Pubitemid 40189223)