Modifiable Lifestyle Factors in Dementia: A Systematic Review of Longitudinal Observational Cohort Studies

Journal of Alzheimer's Disease

Volumn 42, Issue 1, 2014, Pages 119-135

  Di Marco, Luigi Yuri ^a   Marzo, Alberto ^a   Muñoz Ruiz, Miguel ^b   Ikram, M Arfan ^c   Kivipelto, Miia ^b   Ruefenacht, Daniel ^d   Venneri, Annalena ^a   Soininen, Hilkka ^b   Wanke, Isabel ^d   Ventikos, Yiannis A ^e   Frangi, Alejandro F ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d KLINIK HIRSLANDEN   (Switzerland)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer's disease; dementia; longitudinal observational cohort studies; modifiable lifestyle factors

Indexed keywords

ALCOHOL; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CYANOCOBALAMIN; FLAVONOID; FOLIC ACID; MAGNESIUM; MINERAL; MONOUNSATURATED FATTY ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POTASSIUM; SATURATED FATTY ACID; VEGETABLE OIL; VITAMIN; VITAMIN B GROUP; VITAMIN D;

ALCOHOL CONSUMPTION; ALCOHOLIC BEVERAGE; CALORIC INTAKE; COFFEE; DAIRY PRODUCT; DEMENTIA; DIET SUPPLEMENTATION; EATING HABIT; ENERGY EXPENDITURE; FAT INTAKE; FOOD FREQUENCY QUESTIONNAIRE; FRUIT; FRUIT JUICE; HUMAN; LEISURE; LIFESTYLE MODIFICATION; MAGNESIUM INTAKE; MARRIAGE; MEDITERRANEAN DIET; MENTAL PERFORMANCE; MILK; MINERAL INTAKE; PHYSICAL ACTIVITY; POTASSIUM INTAKE; POULTRY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SEA FOOD; SMOKING HABIT; SOCIAL BEHAVIOR; SOCIAL INTERACTION; SOCIAL NETWORK; SODIUM INTAKE; SYSTEMATIC REVIEW; TEA; VEGETABLE; VITAMIN INTAKE; WINE; DIET; LIFESTYLE; MOTOR ACTIVITY; OBSERVATIONAL STUDY;

DEMENTIA; DIET; HUMANS; LIFE STYLE; MOTOR ACTIVITY; OBSERVATIONAL STUDY AS TOPIC;

EID: 84916933519     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-132225     Document Type: Review

References (115)

1. Justin BN, Turek M, Hakim AM (2013) Heart disease as a risk factor for dementia. Clin Epidemiol 5, 135-145.
2. Blumenthal JA, Smith PJ, Welsh-Bohmer K, Babyak MA, Browndyke J, Lin PH, Doraiswamy PM, Burke J, Kraus W, Hinderliter A, Sherwood A (2013) Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial. Contemp Clin Trials 34, 60-69.
3. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M, Alzheimer's Disease, International (2005) Global prevalence of dementia: A Delphi consensus study. Lancet 366, 2112-2117.
4. Matthews FE, Arthur A, Barnes LE, Bond J, Jagger C, Robinson L, Brayne C; on behalf of the Medical Research Council Cognitive Function and Ageing Collaboration (2013) A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the Cognitive Function and Ageing Study I and II. Lancet 382, 1405-1412.
5. Schrijvers EM, Verhaaren BF, Koudstaal PJ, Hofman A, Ikram MA, Breteler MM (2012) Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study. Neurology 78, 1456-1463.
6. Qiu C, von Strauss E, Bäckman L, Winblad B, Fratiglioni L (2013) Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden. Neurology 80, 1888-1894.
7. Wilson RS, Weir DR, Leurgans SE, Evans DA, Hebert LE, Langa KM, Plassman BL, Small BJ, Bennett DA (2011) Sources of variability in estimates of the prevalence of Alzheimer's disease in the United States. Alzheimers Dement 7, 74-79.
8. Whitehouse PJ, Sciulli CG, Mason RM (1997) Dementia drug development: Use of information systems to harmonize global drug development. Psychopharmacol Bull 33, 129-133.
9. Plassman BL, Langa KM, Fisher GG, Heeringa SG, Weir DR, Ofstedal MB, Burke JR, Hurd MD, Potter GG, Rodgers WL, Steffens DC, Willis RJ, Wallace RB (2007) Prevalence of dementia in the United States: The aging, demographics, and memory study. Neuroepidemiology 29, 125-132.
10. Alonso A, Mosley TH, Jr., Gottesman RF, Catellier D, Sharrett AR, Coresh J (2009) Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: The Atherosclerosis Risk in Communities (ARIC) study. J Neurol Neurosurg Psychiatry 80, 1194-1201.
11. Elias MF, Goodell AL, Waldstein SR (2012) Obesity, cognitive functioning and dementia: Back to the future. J Alzheimers Dis 30, S113-S125.
12. Reitz C, den Heijer T, van Duijn C, Hofman A, Breteler MM(2007) Relation between smoking and risk of dementia and Alzheimer disease: The Rotterdam Study. Neurology 69, 998-1005.
13. Tolppanen AM, Solomon A, Soininen H, Kivipelto M (2012) Midlife vascular risk factors and Alzheimer's disease: Evidence from epidemiological studies. J Alzheimers Dis 32, 531-540.
14. Katzman R, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, Renbing X, Peck A (1988) Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 23, 138-144.
15. Fratiglioni L, Wang HX (2007) Brain reserve hypothesis in dementia. J Alzheimers Dis 12, 11-22.
16. Liu Y, Julkunen V, Paajanen T, Westman E, Wahlund LO, Aitken A, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Spenger C, Lovestone S, Simmons A, Soininen H; AddNeuroMed Consortium (2012) Education increases reserve against Alzheimer's disease-evidence from structural MRI analysis. Neuroradiology 54, 929-938.
17. Anstey KJ, Bahar-Fuchs A, Herath P, Rebok GW, Cherbuin N(2013)A12-week multidomain intervention versus active control to reduce risk of Alzheimer's disease: Study protocol for a randomized controlled trial. Trial 14, 60.
18. Gillette-Guyonnet S, Andrieu S, Dantoine T, Dartigues JF, Touchon J, Vellas B; MAPT Study Group (2009) Commentary on "A roadmap for the prevention of dementia II. Leon Thal Symposium 2008." The Multidomain Alzheimer Preventive Trial (MAPT): A new approach to the prevention of Alzheimer's disease. Alzheimers Dement 5, 114-121.
19. Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Nissinen A, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter- Neely A, Strandberg T, Tuomilehto J, Soininen H (2013) The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress. Alzheimers Dement 9, 657-665.
20. Richard E, Van den Heuvel E, Moll van Charante EP, Achthoven L, Vermeulen M, Bindels PJ, Van Gool WA (2009) Prevention of dementia by intensive vascular care (PreDIVA): A cluster-randomized trial in progress. Alzheimer Dis Assoc Disord 23, 198-204.
21. Fratiglioni L, Paillard-Borg S, Winblad B (2004) An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol 3, 343-353.
22. Center for Reviews and Dissemination (2009) Systematic Reviews CRD's Guidance for Undertaking Reviews in Health Care. University of York, York, United Kingdom.
23. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, Wilson RS, Scherr PA (2002) Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 287, 3230-3237.
24. Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, Witteman JC, Breteler MM (2002) Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 287, 3223-3229.
25. Devore EE, Grodstein F, van Rooij FJ, Hofman A, Stampfer MJ, Witteman JC, Breteler MM(2010) Dietary antioxidants and long-term risk of dementia. Arch Neurol 67, 819-825.
26. Commenges D, Scotet V, Renaud S, Jacqmin-Gadda H, Barberger-Gateau P, Dartigues JF (2000) Intake of flavonoids and risk of dementia. Eur J Epidemiol 16, 357-363.
27. Morris MC, Evans DA, Bienias JL, Scherr PA, Tangney CC, Hebert LE, Bennett DA, Wilson RS, Aggarwal N (2004) Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline. J Neurol Neurosurg Psychiatry 75, 1093-1099.
28. Luchsinger JA, Tang MX, Miller J, Green R, Mayeux R (2007) Relation of higher folate intake to lower risk of Alzheimer disease in the elderly. Arch Neurol 64, 86-92.
29. Annweiler C, Rolland Y, Schott AM, Blain H, Vellas B, Herrmann FR, Beauchet O (2012) Higher vitamin D dietary intake is associated with lower risk of Alzheimer's disease: A 7-year follow-up. J Gerontol A Biol Sci Med Sci 67, 1205-1211.
30. Gu Y, Nieves JW, Stern Y, Luchsinger JA, Scarmeas N (2010) Food combination and Alzheimer disease risk: A protective diet. Arch Neurol 67, 699-706.
31. Luchsinger JA, Tang MX, Shea S, MayeuxR(2003) Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol 60, 203-208.
32. Laurin D, Masaki KH, Foley DJ, White LR, Launer LJ (2004) Midlife dietary intake of antioxidants and risk of latelife incident dementia: The Honolulu-Asia Aging Study. Am J Epidemiol 159, 959-967.
33. Morris MC, Evans DA, Schneider JA, Tangney CC, Bienias JL, Aggarwal NT (2006) Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer's disease. J Alzheimers Dis 9, 435-443.
34. Nelson C, Wengreen HJ, Munger RG, Corcoran CD (2009) Dietary folate, vitamin B-12, vitamin B-6 and incident Alzheimer's disease: The cache county memory, health and aging study. J Nutr Health Aging 13, 899-905.
35. Devore EE, Feskens E, Ikram MA, den Heijer T, Vernooij M, van der Lijn F, Hofman A, Niessen WJ, Breteler MM(2013) Total antioxidant capacity of the diet and major neurologic outcomes in older adults. Neurology 80, 904-910.
36. Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM (1997) Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol 42, 776-782.
37. Engelhart MJ, Geerlings MI, Ruitenberg A, Van Swieten JC, Hofman A, Witteman JC, Breteler MM(2002) Diet and risk of dementia: Does fat matter?: The Rotterdam Study. Neurology 59, 1915-1921.
38. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, Schneider J, Wilson RS (2003) Dietary fats and the risk of incident Alzheimer disease. Arch Neurol 60, 194-200.
39. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS, Aggarwal N, Schneider J (2003) Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 60, 940-946.
40. Larrieu S, Letenneur L, Helmer C, Dartigues JF, Barberger- Gateau P (2004) Nutritional factors and risk of incident dementia in the PAQUID longitudinal cohort. J Nutr Health Aging 8, 150-154.
41. Devore EE, Grodstein F, van Rooij FJ, Hofman A, Rosner B, Stampfer MJ, Witteman JC, Breteler MM(2009) Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. Am J Clin Nutr 90, 170-176.
42. Laitinen MH, Ngandu T, Rovio S, Helkala EL, Uusitalo U, Viitanen M, Nissinen A, Tuomilehto J, Soininen H, KivipeltoM(2006) Fat intake at midlife and risk of dementia and Alzheimer's disease:Apopulation-based study. Dement Geriatr Cogn Disord 22, 99-107.
43. Ozawa M, Ninomiya T, Ohara T, Hirakawa Y, Doi Y, Hata J, Uchida K, Shirota T, Kitazono T, Kiyohara Y (2012) Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: The Hisayama Study. J Am Geriatr Soc 60, 1515-1520.
44. Scarmeas N, Stern Y, Tang MX, Mayeux R, Luchsinger JA (2006) Mediterranean diet and risk for Alzheimer's disease. Ann Neurol 59, 912-921.
45. Gu Y, Luchsinger JA, Stern Y, Scarmeas N (2010) Mediterranean diet, inflammatory and metabolic biomarkers, and risk of Alzheimer's disease. J Alzheimers Dis 22, 483-492.
46. Féart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues JF, Scarmeas N, Barberger-Gateau P (2009) Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA 302, 638-648.
47. Barberger-Gateau P, Raffaitin C, Letenneur L, Berr C, Tzourio C, Dartigues JF, Alpérovitch A (2007) Dietary patterns and risk of dementia: The Three-City cohort study. Neurology 69, 1921-1930.
48. Luchsinger JA, Tang MX, Shea S, Mayeux R (2002) Caloric intake and the risk of Alzheimer disease. Arch Neurol 59, 1258-1263.
49. Verghese J, Lipton RB, Katz MJ, Hall CB, Derby CA, Kuslansky G, Ambrose AF, Sliwinski M, Buschke H (2003) Leisure activities and the risk of dementia in the elderly. N Engl J Med 348, 2508-2516.
50. Akbaraly TN, Portet F, Fustinoni S, Dartigues JF, Artero S, Rouaud O, Touchon J, Ritchie K, Berr C (2009) Leisure activities and the risk of dementia in the elderly: Results from the Three-City Study. Neurology 73, 854-861.
51. Dartigues JF, Foubert-Samier A, Le Goff M, Viltard M, Amieva H, Orgogozo JM, Barberger-Gateau P, Helmer C (2013) Playing board games, cognitive decline and dementia: A French population-based cohort study. BMJ Open 3, e002998.
52. Hughes TF, Chang CC, Vander Bilt J, Ganguli M (2010) Engagement in reading and hobbies and risk of incident dementia: The MoVIES project. Am J Alzheimers Dis Other Demen 25, 432-438.
53. Luck T, Riedel-Heller SG, Luppa M, Wiese B, Köhler M, Jessen F, Bickel H, Weyerer S, Pentzek M, König HH, Prokein J, Ernst A, Wagner M, Mösch E, Werle J, Fuchs A, Brettschneider C, Scherer M, Maier W (2013) Apolipoprotein E epsilon 4 genotype and a physically active lifestyle in late life: Analysis of gene-environment interaction for the risk of dementia and Alzheimer's disease dementia. Psychol Med 44, 1319-1329.
54. Simons LA, Simons J, McCallum J, Friedlander Y (2006) Lifestyle factors and risk of dementia: Dubbo Study of the elderly. Med J Aust 184, 68-70.
55. de Bruijn RF, Schrijvers EM, de Groot KA, Witteman JC, Hofman A, Franco OH, Koudstaal PJ, Ikram MA(2013) The association between physical activity and dementia in an elderly population: The Rotterdam Study. Eur J Epidemiol 28, 277-283.
56. Paillard-Borg S, Fratiglioni L, Winblad B, Wang HX (2009) Leisure activities in late life in relation to dementia risk: Principal component analysis. Dement Geriatr Cogn Disord 28, 136-144.
57. Taaffe DR, Irie F, Masaki KH, Abbott RD, Petrovitch H, Ross GW, White LR (2008) Physical activity, physical function, and incident dementia in elderly men: The Honolulu-Asia Aging Study. J Gerontol A Biol Sci Med Sci 63, 529-535.
58. Kivipelto M, Rovio S, Ngandu T, K°areholt I, Eskelinen M, Winblad B, Hachinski V, Cedazo-Minguez A, Soininen H, Tuomilehto J, Nissinen A (2008) Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: A population-based study. J Cell Mol Med 12, 2762-2771.
59. Ravaglia G, Forti P, Lucicesare A, Pisacane N, Rietti E, Bianchin M, Dalmonte E (2008) Physical activity and dementia risk in the elderly: Findings from a prospective Italian study. Neurology 70, 1786-1794.
60. Larson EB, Wang L, Bowen JD, McCormick WC, Teri L, Crane P, Kukull W (2006) Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med 144, 73-81.
61. Rovio S, Kareholt I, Helkala EL, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A, Kivipelto M (2005) Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol 4, 705-711.
62. Podewils LJ, Guallar E, Kuller LH, Fried LP, Lopez OL, Carlson M, Lyketsos CG (2005) Physical activity, APOE genotype, and dementia risk: Findings from the Cardiovascular Health Cognition Study.AmJ Epidemiol 161, 639-651.
63. Abbott RD, White LR, Ross GW, Masaki KH, Curb JD, Petrovitch H (2004) Walking and dementia in physically capable elderly men. JAMA 292, 1447-1453.
64. Lindsay J, Laurin D, Verreault R, Hébert R, Helliwell B, Hill GB, McDowell I (2002) Risk factors for Alzheimer's disease: A prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol 156, 445-453.
65. Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K (2001) Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol 58, 498-504.
66. Eriksson Sörman D, Sundström A, Rönnlund M, Adolfsson R, Nilsson LG (2013) Leisure activity in old age and risk of dementia:A15-year prospective study. J Gerontol BPsychol Sci Soc Sci. doi: 10.1093/geronb/gbt056
67. Karp A, Paillard-Borg S, Wang HX, Silverstein M, Winblad B, Fratiglioni L (2006) Mental, physical and social components in leisure activities equally contribute to decrease dementia risk. Dement Geriatr Cogn Disord 21, 65-73.
68. Scarmeas N, Levy G, Tang MX, Manly J, Stern Y (2001) Influence of leisure activity on the incidence of Alzheimer's disease. Neurology 57, 2236-2242.
69. Fabrigoule C, Letenneur L, Dartigues JF, Zarrouk M, Commenges D, Barberger-Gateau P (1995) Social and leisure activities and risk of dementia: A prospective longitudinal study. J Am Geriatr Soc 43, 485-490.
70. Buchman AS, Boyle PA, Yu L, Shah RC, Wilson RS, Bennett DA (2012) Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology 78, 1323-1329.
71. Tranah GJ, Blackwell T, Stone KL, Ancoli-Israel S, Paudel ML, Ensrud KE, Cauley JA, Redline S, Hillier TA, Cummings SR, Yaffe K, Research SO F, Group (2011) Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women. Ann Neurol 70, 722-732.
72. Hebert LE, Scherr PA, Beckett LA, Funkenstein HH, Albert MS, Chown MJ, Evans DA (1992) Relation of smoking and alcohol consumption to incident Alzheimer's disease. Am J Epidemiol 135, 347-355.
73. Peters R, Beckett N, Geneva M, Tzekova M, Lu FH, Poulter R, Gainsborough N, Williams B, de Vernejoul MC, Fletcher A, Bulpitt C (2009) Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET. Age Ageing 38, 521-527.
74. Ruitenberg A, van Swieten JC, Witteman JC, Mehta KM, van Duijn CM, Hofman A, Breteler MM (2002) Alcohol consumption and risk of dementia: The Rotterdam Study. Lancet 359, 281-286.
75. Mehlig K, Skoog I, Guo X, Schütze M, Gustafson D, Waern M, Ostling S, Björkelund C, Lissner L (2008) Alcoholic beverages and incidence of dementia: 34-year follow-up of the prospective population study of women in Goteborg. Am J Epidemiol 167, 684-691.
76. Deng J, Zhou DH, Li J, Wang YJ, Gao C, Chen M (2006) A 2-year follow-up study of alcohol consumption and risk of dementia. Clin Neurol Neurosurg 108, 378-383.
77. Luchsinger JA, Tang MX, Siddiqui M, Shea S, Mayeux R (2004) Alcohol intake and risk of dementia. J Am Geriatr Soc 52, 540-546.
78. Huang W, Qiu C, Winblad B, Fratiglioni L (2002) Alcohol consumption and incidence of dementia in a community sample aged 75 years and older. J Clin Epidemiol 55, 959-964.
79. Orgogozo JM, Dartigues JF, Lafont S, Letenneur L, Commenges D, Salamon R, Renaud S, Breteler MB(1997)Wine consumption and dementia in the elderly: A prospective community study in the Bordeaux area. Rev Neurol (Paris) 153, 185-192.
80. Anttila T, Helkala EL, Viitanen M, Kareholt I, Fratiglioni L, Winblad B, Soininen H, Tuomilehto J, Nissinen A, Kivipelto M (2004) Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: A prospective population based study. BMJ 329, 539.
81. Dai Q, Borenstein AR, Wu Y, Jackson JC, Larson EB (2006) Fruit and vegetable juices and Alzheimer's disease: The Kame Project. Am J Med 119, 751-759.
82. Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M (2009) Midlife coffee and tea drinking and the risk of late-life dementia:Apopulation-based CAIDE study. J Alzheimers Dis 16, 85-91.
83. Chen R, Hu Z, Wei L, Ma Y, Liu Z, Copeland JR (2011) Incident dementia in a defined older Chinese population. PLoS One 6, e24817.
84. Rusanen M, Kivipelto M, Quesenberry CP Jr, Zhou J, Whitmer RA( 2011) Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia. Arch Intern Med 171, 333-339.
85. Alonso A, Jacobs DR Jr, Menotti A, Nissinen A, Dontas A, Kafatos A, Kromhout D (2009) Cardiovascular risk factors and dementia mortality: 40 years of follow-up in the Seven Countries Study. J Neurol Sci 280, 79-83.
86. Aggarwal NT, Bienias JL, Bennett DA, Wilson RS, Morris MC, Schneider JA, Shah RC, Evans DA (2006) The relation of cigarette smoking to incident Alzheimer's disease in a biracial urban community population. Neuroepidemiology 26, 140-146.
87. Juan D, Zhou DH, Li J, Wang JY, Gao C, Chen M (2004) A 2-year follow-up study of cigarette smoking and risk of dementia. Eur J Neurol 11, 277-282.
88. Tyas SL, White LR, Petrovitch H, Webster Ross G, Foley DJ, Heimovitz HK, Launer LJ (2003) Mid-life smoking and latelife dementia: The Honolulu-Asia Aging Study. Neurobiol Aging 24, 589-596.
89. Ott A, Slooter AJ, Hofman A, van Harskamp F, Witteman JC, Van Broeckhoven C, van Duijn CM, Breteler MM(1998) Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: The Rotterdam Study. Lancet 351, 1840-1843.
90. Rusanen M, Rovio S, Ngandu T, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M (2010) Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: A population-based cardiovascular risk factors, aging and dementia study. Dement Geriatr Cogn Disord 30, 277-284.
91. Crooks VC, Lubben J, Petitti DB, Little D, Chiu V (2008) Social network, cognitive function, and dementia incidence among elderly women. Am J Public Health 98, 1221-1227.
92. Fratiglioni L, Wang HX, Ericsson K, Maytan M, Winblad B (2000) Influence of social network on occurrence of dementia: A community-based longitudinal study. Lancet 355, 1315-1319.
93. Helmer C, Damon D, Letenneur L, Fabrigoule C, Barberger- Gateau P, Lafont S, Fuhrer R, Antonucci T, Commenges D, Orgogozo JM, Dartigues JF (1999) Marital status and risk of Alzheimer's disease: A French population-based cohort study. Neurology 53, 1953-1958.
94. Norton MC, Dew J, Smith H, Fauth E, Piercy KW, Breitner JC, Tschanz J, Wengreen H, Welsh-Bohmer K; Cache County Investigators (2012) Lifestyle behavior pattern is associated with different levels of risk for incident dementia and Alzheimer's disease: The Cache County study. J Am Geriatr Soc 60, 405-412.
95. Scarmeas N, Luchsinger JA, Schupf N, Brickman AM, Cosentino S, Tang MX, Stern Y (2009) Physical activity, diet, and risk of Alzheimer disease. JAMA 302, 627-637.
96. Marshall RS (2012) Effects of altered cerebral hemodynamics on cognitive function. J Alzheimers Dis 32, 633-642.
97. Mazza M, Marano G, Traversi G, Bria P, Mazza S (2011) Primary cerebral blood flowdeficiency and Alzheimer's disease: Shadows and lights. J Alzheimers Dis 23, 375-389.
98. Dhaliwal SS, Welborn TA, Howat PA (2013) Recreational physical activity as an independent predictor of multivariable cardiovascular disease risk. PLoS One 8, e83435.
99. de la Torre JC (2004) Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. Lancet Neurol 3, 184-190.
100. Thosar SS, Johnson BD, Johnston JD, Wallace JP (2012) Sitting and endothelial dysfunction: The role of shear stress. Med Sci Monit 18, RA173-RA180.
101. Pan S (2009) Molecular mechanisms responsible for the atheroprotective effects of laminar shear stress. Antioxid Redox Signal 11, 1669-1682.
102. Davis ME, Grumbach IM, Fukai T, Cutchins A, Harrison DG (2004) Shear stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor kappaB binding. J Biol Chem 279, 163-168.
103. Yaffe K, Hoang T (2013) Nonpharmacologic treatment and prevention strategies for dementia. Continuum (Minneap Minn) 19, 372-381.
104. Bilbul M, Schipper HM (2011) Risk profiles of Alzheimer disease. Can J Neurol Sci 38, 580-592.
105. Xu WL, Atti AR, Gatz M, Pedersen NL, Johansson B, FratiglioniL(2011) Midlife overweight and obesity increase late-life dementia risk: A population-based twin study. Neurology 76, 1568-1574.
106. Petrovitch H, White LR, Izmirilian G, Ross GW, Havlik RJ, Markesbery W, Nelson J, Davis DG, Hardman J, Foley DJ, Launer LJ (2000) Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: The HAAS. Honolulu-Asia aging Study. Neurobiol Aging 21, 57-62.
107. Toda N, Okamura T (2012) Cerebral blood flow regulation by nitric oxide in Alzheimer's disease. J Alzheimers Dis 32, 569-578.
108. Tousoulis D, Papageorgiou N, Androulakis E, Siasos G, Latsios G, Tentolouris K, Stefanadis C (2013) Diabetes mellitus-associated vascular impairment: Novel circulating biomarkers and therapeutic approaches. J Am Coll Cardiol 62, 667-676.
109. Lourida I, Soni M, Thompson-Coon J, Purandare N, Lang IA, Ukoumunne OC, Llewellyn DJ (2013) Mediterranean diet, cognitive function, and dementia: A systematic review. Epidemiology 24, 479-489.
110. Denis I, Potier B, Vancassel S, Heberden C, Lavialle M (2013) Omega-3 fatty acids and brain resistance to ageing and stress: Body of evidence and possible mechanisms. Ageing Res Rev 12, 579-594.
111. Bourre JM (2006) Effects of nutrients (in food) on the structure and function of the nervous system: Update on dietary requirements for brain. Part 2: Macronutrients. J Nutr Health Aging 10, 386-399.
112. Collins MA, Neafsey EJ, Wang K, Achille NJ, Mitchell RM, Sivaswamy S (2010) Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: Possible signaling mechanisms. Mol Neurobiol 41, 420-425.
113. Anstey KJ, von Sanden C, Salim A, O'Kearney R (2007) Smoking as a risk factor for dementia and cognitive decline: Ameta-analysis of prospective studies.AmJ Epidemiol 166, 367-378.
114. Amieva H, Stoykova R, Matharan F, Helmer C, Antonucci TC, Dartigues JF (2010) What aspects of social network are protective for dementia? Not the quantity but the quality of social interactions is protective up to 15 years later. Psychosom Med 72, 905-911.
115. Cadar D, Pikhart H, Mishra G, Stephen A, Kuh D, Richards M(2012) The role of lifestyle behaviors on 20-year cognitive decline. J Aging Res 2012, 304014.