-
1
-
-
0034241796
-
Positron emission tomography provides molecular imaging of biological processes
-
Phelps, M. E. Positron emission tomography provides molecular imaging of biological processes Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 9226-9233
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 9226-9233
-
-
Phelps, M.E.1
-
2
-
-
41849104653
-
PET versus SPECT: Strengths, limitations and challenges
-
Rahmim, A.; Zaidi, H. PET versus SPECT: strengths, limitations and challenges Nucl. Med. Commun. 2008, 29, 193-207
-
(2008)
Nucl. Med. Commun.
, vol.29
, pp. 193-207
-
-
Rahmim, A.1
Zaidi, H.2
-
3
-
-
4344644532
-
Cyclotron production of medical radionuclides
-
2 nd ed. Vértes, A. Nagy, S. Klencsár, Z. Lovas, R. G. Rösch, F. Springer: Dordrecht, The Netherlands
-
Qaim, S. M. Cyclotron production of medical radionuclides. In Handbook of Nuclear Chemistry, 2 nd ed.; Vértes, A.; Nagy, S.; Klencsár, Z.; Lovas, R. G.; Rösch, F., Eds.; Springer: Dordrecht, The Netherlands, 2011; pp 1903-1933.
-
(2011)
Handbook of Nuclear Chemistry
, pp. 1903-1933
-
-
Qaim, S.M.1
-
4
-
-
84873258911
-
-
U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research: Silver Spring, MD
-
PET Drugs-Current Good Manufacturing Practice (CGMP); U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research: Silver Spring, MD, 2011; http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM266640.pdf.
-
(2011)
PET Drugs-Current Good Manufacturing Practice (CGMP)
-
-
-
5
-
-
79960071142
-
FDA cGMP requirements for PET drugs
-
Norenberg, J. P.; Schwarz, S.; VanBrocklin, H. FDA cGMP requirements for PET drugs J. Nucl. Med. 2011, 52, 16N
-
(2011)
J. Nucl. Med.
, vol.52
, pp. 16N
-
-
Norenberg, J.P.1
Schwarz, S.2
Vanbrocklin, H.3
-
6
-
-
84981922420
-
Chemistry of the positron and of positronium
-
Ache, H. J. Chemistry of the positron and of positronium Angew. Chem., Int. Ed. 1972, 11, 179-199
-
(1972)
Angew. Chem., Int. Ed.
, vol.11
, pp. 179-199
-
-
Ache, H.J.1
-
7
-
-
33745239255
-
Performance of list mode data acquisition with ECAT EXACT HR and ECAT EXACT HR positron emission scanners
-
Watabe, H.; Matsumoto, K.; Senda, M.; Iida, H. Performance of list mode data acquisition with ECAT EXACT HR and ECAT EXACT HR positron emission scanners Ann. Nucl. Med. 2006, 20, 189-194
-
(2006)
Ann. Nucl. Med.
, vol.20
, pp. 189-194
-
-
Watabe, H.1
Matsumoto, K.2
Senda, M.3
Iida, H.4
-
8
-
-
0018166544
-
18F] 2-Deoxy-2-Fluoro- D -Glucose
-
18F] 2-deoxy-2-fluoro- d -glucose J. Nucl. Med. 1978, 19, 1154-1161
-
(1978)
J. Nucl. Med.
, vol.19
, pp. 1154-1161
-
-
Gallagher, B.M.1
Fowler, J.S.2
Gutterson, N.I.3
Macgregor, R.R.4
Wan, C.W.5
Wolf, A.P.6
-
9
-
-
33947252746
-
Impact of ventricular enlargement on the measurement of metabolic activity in spatially normalized PET
-
Reig, S.; Penedo, M.; Gispert, J. D.; Pascau, J.; Sanchez-Gonzalez, J.; Garcia-Barreno, P.; Desco, M. Impact of ventricular enlargement on the measurement of metabolic activity in spatially normalized PET NeuroImage 2007, 35, 748-758
-
(2007)
NeuroImage
, vol.35
, pp. 748-758
-
-
Reig, S.1
Penedo, M.2
Gispert, J.D.3
Pascau, J.4
Sanchez-Gonzalez, J.5
Garcia-Barreno, P.6
Desco, M.7
-
10
-
-
0021047386
-
Striatal dopamine metabolism in living monkeys examined by positron emission tomography
-
Garnett, E. S.; Firnau, G.; Nahmias, C.; Chirakal, R. Striatal dopamine metabolism in living monkeys examined by positron emission tomography Brain Res. 1983, 280, 169-171
-
(1983)
Brain Res.
, vol.280
, pp. 169-171
-
-
Garnett, E.S.1
Firnau, G.2
Nahmias, C.3
Chirakal, R.4
-
11
-
-
71949123177
-
PET studies of cerebral levodopa metabolism: A review of clinical findings and modeling approaches
-
Kumakura, Y.; Cumming, P. PET studies of cerebral levodopa metabolism: a review of clinical findings and modeling approaches Neuroscientist 2009, 15, 635-650
-
(2009)
Neuroscientist
, vol.15
, pp. 635-650
-
-
Kumakura, Y.1
Cumming, P.2
-
12
-
-
34547846251
-
Consensus nomenclature for in vivo imaging of reversibly binding radioligands
-
Innis, R. B.; Cunningham, V. J.; Delforge, J.; Fujita, M.; Gjedde, A.; Gunn, R. N.; Holden, J.; Houle, S.; Huang, S. C.; Ichise, M.; Iida, H.; Ito, H.; Kimura, Y.; Koeppe, R. A.; Knudsen, G. M.; Knuuti, J.; Lammertsma, A. A.; Laruelle, M.; Logan, J.; Maguire, R. P.; Mintun, M. A.; Morris, E. D.; Parsey, R.; Price, J. C.; Slifstein, M.; Sossi, V.; Suhara, T.; Votaw, J. R.; Wong, D. F.; Carson, R. E. Consensus nomenclature for in vivo imaging of reversibly binding radioligands J. Cereb. Blood Flow Metab. 2009, 27, 1533-1539
-
(2009)
J. Cereb. Blood Flow Metab.
, vol.27
, pp. 1533-1539
-
-
Innis, R.B.1
Cunningham, V.J.2
Delforge, J.3
Fujita, M.4
Gjedde, A.5
Gunn, R.N.6
Holden, J.7
Houle, S.8
Huang, S.C.9
Ichise, M.10
Iida, H.11
Ito, H.12
Kimura, Y.13
Koeppe, R.A.14
Knudsen, G.M.15
Knuuti, J.16
Lammertsma, A.A.17
Laruelle, M.18
Logan, J.19
Maguire, R.P.20
Mintun, M.A.21
Morris, E.D.22
Parsey, R.23
Price, J.C.24
Slifstein, M.25
Sossi, V.26
Suhara, T.27
Votaw, J.R.28
Wong, D.F.29
Carson, R.E.30
more..
-
13
-
-
33646701318
-
Use of PET/CT scanning in cancer patients: Technical and practical considerations
-
Griffeth, L. K. Use of PET/CT scanning in cancer patients: technical and practical considerations Proc. (Bayl. Univ. Med. Cent.) 2005, 18, 321-330
-
(2005)
Proc. (Bayl. Univ. Med. Cent.)
, vol.18
, pp. 321-330
-
-
Griffeth, L.K.1
-
14
-
-
84870380368
-
PET/MRI for neurologic applications
-
Catana, C.; Drzezga, A.; Heiss, W.-D.; Rosen, B. R. PET/MRI for neurologic applications J. Nucl. Med. 2012, 53, 1916-1925
-
(2012)
J. Nucl. Med.
, vol.53
, pp. 1916-1925
-
-
Catana, C.1
Drzezga, A.2
Heiss, W.-D.3
Rosen, B.R.4
-
15
-
-
33751206346
-
Radiochemistry and radiopharmaceutical chemistry in life sciences
-
2 nd ed. Vértes, A. Nagy, S. Klencsár, Z. Lovas, R. G. Rösch, F. Springer, Dordrecht, The Netherlands
-
Rösch, F. Radiochemistry and radiopharmaceutical chemistry in life sciences. In Handbook of Nuclear Chemistry, 2 nd ed.; Vértes, A.; Nagy, S.; Klencsár, Z.; Lovas, R. G.; Rösch, F., Eds.; Springer, Dordrecht, The Netherlands, 2011.
-
(2011)
Handbook of Nuclear Chemistry
-
-
Rösch, F.1
-
17
-
-
84857279469
-
Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders
-
Virdee, K.; Cumming, P.; Caprioli, D.; Jupp, B.; Rominger, A.; Aigbirhio, F. I.; Fryer, T. D.; Riss, P. J.; Dalley, J. W. Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders Neurosci. Biobehav. Rev. 2012, 36, 1188-1216
-
(2012)
Neurosci. Biobehav. Rev.
, vol.36
, pp. 1188-1216
-
-
Virdee, K.1
Cumming, P.2
Caprioli, D.3
Jupp, B.4
Rominger, A.5
Aigbirhio, F.I.6
Fryer, T.D.7
Riss, P.J.8
Dalley, J.W.9
-
18
-
-
33646105868
-
Neuroreceptor imaging in psychiatry: Theory and applications
-
Frankle, W. G.; Slifstein, M.; Talbot, P. S.; Laruelle, M. Neuroreceptor imaging in psychiatry: theory and applications Neuroimaging, Part B 2005, 67, 385-440
-
(2005)
Neuroimaging, Part B
, vol.67
, pp. 385-440
-
-
Frankle, W.G.1
Slifstein, M.2
Talbot, P.S.3
Laruelle, M.4
-
20
-
-
79960308066
-
Noninvasive nuclear imaging enables the in vivo quantification of striatal dopamine receptor expression and raclopride affinity in mice
-
Fischer, K.; Sossi, V.; Schmid, A.; Thunemann, M.; Maier, F. C.; Judenhofer, M. S.; Mannheim, J. G.; Reischl, G.; Pichler, B. J. Noninvasive nuclear imaging enables the in vivo quantification of striatal dopamine receptor expression and raclopride affinity in mice J. Nucl. Med. 2011, 52, 1133-1141
-
(2011)
J. Nucl. Med.
, vol.52
, pp. 1133-1141
-
-
Fischer, K.1
Sossi, V.2
Schmid, A.3
Thunemann, M.4
Maier, F.C.5
Judenhofer, M.S.6
Mannheim, J.G.7
Reischl, G.8
Pichler, B.J.9
-
21
-
-
0031951911
-
Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals
-
Hume, S. P.; Gunn, R. N.; Jones, T. Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals Eur. J. Nucl. Med. 1998, 25, 173-176
-
(1998)
Eur. J. Nucl. Med.
, vol.25
, pp. 173-176
-
-
Hume, S.P.1
Gunn, R.N.2
Jones, T.3
-
22
-
-
79955419410
-
Synopsis of some recent tactical application of bioisoteres in drug design
-
Meanwell, N. A. Synopsis of some recent tactical application of bioisoteres in drug design J. Med. Chem. 2011, 54, 2529-2591
-
(2011)
J. Med. Chem.
, vol.54
, pp. 2529-2591
-
-
Meanwell, N.A.1
-
23
-
-
84886254229
-
Fluorine-for-hydrogen: A strategy for radiolabeling, not a replacement
-
Kilbourn, M. R. Fluorine-for-hydrogen: a strategy for radiolabeling, not a replacement Nucl. Med. Biol. 2013, 40, 956-958
-
(2013)
Nucl. Med. Biol.
, vol.40
, pp. 956-958
-
-
Kilbourn, M.R.1
-
24
-
-
0023146627
-
11C-N-methyl-spiperone
-
11C-N-methyl-spiperone Acta Neurol. Scand. 1987, 75, 87-94
-
(1987)
Acta Neurol. Scand.
, vol.75
, pp. 87-94
-
-
Hagglund, J.1
Aquilonius, S.M.2
Eckernas, S.A.3
Hartvig, P.4
Lundquist, H.5
Gullberg, P.6
Langström, B.7
-
25
-
-
45549111342
-
18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor
-
18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor Nucl. Med. Biol. 1998, 15, 83-97
-
(1998)
Nucl. Med. Biol.
, vol.15
, pp. 83-97
-
-
Welch, M.J.1
Katzenellenbogen, J.A.2
Mathias, C.J.3
Brodack, J.W.4
Carlson, K.E.5
Chi, D.Y.6
Dence, C.S.7
Kilboum, M.R.8
Perlmutter, J.S.9
Raichle, M.E.10
Terpogossian, M.M.11
-
26
-
-
0025187686
-
Synthesis of fluorine-18 labeled GABA uptake inhibitors
-
Kilbourn, M. R.; Pavia, M. R.; Gregor, V. E. Synthesis of fluorine-18 labeled GABA uptake inhibitors Int. J. Radiat. Appl. Instrum., Part A 1990, 41, 823-828
-
(1990)
Int. J. Radiat. Appl. Instrum., Part A
, vol.41
, pp. 823-828
-
-
Kilbourn, M.R.1
Pavia, M.R.2
Gregor, V.E.3
-
27
-
-
0034745413
-
18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide], a marker for PET detection of hypoxia
-
18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide], a marker for PET detection of hypoxia Bioorg. Med. Chem. 2001, 9, 665-675
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 665-675
-
-
Josse, O.1
Labar, D.2
Georges, B.3
Grégoire, V.4
Marchand-Brynaert, J.5
-
28
-
-
0035503276
-
18F]-EF5, a marker for PET detection of hypoxia: Synthesis of precursor and a new fluorination procedure
-
18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure Appl. Radiat. Isot. 2001, 54, 73-80
-
(2001)
Appl. Radiat. Isot.
, vol.54
, pp. 73-80
-
-
Dolbier, W.R.1
Li, A.R.2
Koch, C.J.3
Shiue, C.Y.4
Kachur, A.V.5
-
30
-
-
84886250423
-
18F]trifluoromethylation of aryl and heteroaryl iodides for PET imaging
-
18F]trifluoromethylation of aryl and heteroaryl iodides for PET imaging Nat. Chem. 2013, 5, 941-944
-
(2013)
Nat. Chem.
, vol.5
, pp. 941-944
-
-
Huiban, M.1
Tredwell, M.2
Mizuta, S.3
Wan, Z.4
Zhang, X.5
Collier, T.L.6
Gouverneur, V.7
Passchier, J.8
-
31
-
-
84861654947
-
18F]DMFP infusions
-
18F]DMFP infusions Synapse 2012, 66, 705-713
-
(2012)
Synapse
, vol.66
, pp. 705-713
-
-
Mille, E.1
Cumming, P.2
Rominger, A.3
La Fougère, C.4
Tatsch, K.5
Wängler, B.6
Bartenstein, P.7
Böning, G.8
-
32
-
-
0029869731
-
2A receptors with positron emission tomography
-
2A receptors with positron emission tomography Life Sci. 1996, 58, 187-192
-
(1996)
Life Sci.
, vol.58
, pp. 187-192
-
-
Lundkvist, C.1
Halldin, C.2
Ginovart, N.3
Nyberg, S.4
Swahn, C.G.5
Carr, A.A.6
Brunner, F.7
Farde, F.8
-
33
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feeney, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Delivery Rev. 2001, 46, 3-26
-
(2001)
Adv. Drug Delivery Rev.
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
34
-
-
84879040833
-
Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand
-
Zhang, L.; Villalobos, A.; Beck, E. M.; Bocan, T.; Chappie, T. A.; Chen, L.; Grimwood, S.; Heck, S. D.; Helal, C. J.; Hou, X.; Humphrey, J. M.; Lu, J.; Skaddan, M. B.; McCarthy, T. J.; Verhoest, P. R.; Wager, T. T.; Zasadny, K. Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand J. Med. Chem. 2013, 56, 4568-4579
-
(2013)
J. Med. Chem.
, vol.56
, pp. 4568-4579
-
-
Zhang, L.1
Villalobos, A.2
Beck, E.M.3
Bocan, T.4
Chappie, T.A.5
Chen, L.6
Grimwood, S.7
Heck, S.D.8
Helal, C.J.9
Hou, X.10
Humphrey, J.M.11
Lu, J.12
Skaddan, M.B.13
McCarthy, T.J.14
Verhoest, P.R.15
Wager, T.T.16
Zasadny, K.17
-
35
-
-
67649392372
-
Xenobiotic-metabolizing enzymes and transporters in the normal human brain: Regional and cellular mapping as a basis for putative roles in cerebral function
-
Dutheil, F.; Dauchy, S.; Diry, M.; Sazdovitch, V.; Cloarec, O.; Mellottée, L.; Bièche, I.; Ingelman-Sundberg, M.; Flinois, J. P.; de Waziers, I.; Beaune, P.; Declèves, X.; Duyckaerts, C.; Loriot, M. A. Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function Drug Metab. Dispos. 2009, 37, 165-174
-
(2009)
Drug Metab. Dispos.
, vol.37
, pp. 165-174
-
-
Dutheil, F.1
Dauchy, S.2
Diry, M.3
Sazdovitch, V.4
Cloarec, O.5
Mellottée, L.6
Bièche, I.7
Ingelman-Sundberg, M.8
Flinois, J.P.9
De Waziers, I.10
Beaune, P.11
Declèves, X.12
Duyckaerts, C.13
Loriot, M.A.14
-
36
-
-
77956316385
-
Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: Proof-of-concept in a chronic rat model of temporal lobe epilepsy
-
Bartmann, H.; Fuest, C.; la Fougere, C.; Xiong, G.; Just, T.; Schlichtiger, J.; Winter, P.; Boning, G.; Wängler, B.; Pekcec, A.; Soerensen, J.; Bartenstein, P.; Cumming, P.; Potschka, H. Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy Epilepsia 2010, 51, 1780-1790
-
(2010)
Epilepsia
, vol.51
, pp. 1780-1790
-
-
Bartmann, H.1
Fuest, C.2
La Fougere, C.3
Xiong, G.4
Just, T.5
Schlichtiger, J.6
Winter, P.7
Boning, G.8
Wängler, B.9
Pekcec, A.10
Soerensen, J.11
Bartenstein, P.12
Cumming, P.13
Potschka, H.14
-
37
-
-
79952799894
-
Transport of selected PET radiotracers by human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2): An in vitro screening
-
Tournier, N.; Valette, H.; Peyronneau, M. A.; Saba, W.; Goutal, S.; Kuhnast, B.; Dollé, F.; Scherrmann, J. M.; Cisternino, S.; Bottlaender, M. Transport of selected PET radiotracers by human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2): an in vitro screening J. Nucl. Med. 2011, 52, 415-423
-
(2011)
J. Nucl. Med.
, vol.52
, pp. 415-423
-
-
Tournier, N.1
Valette, H.2
Peyronneau, M.A.3
Saba, W.4
Goutal, S.5
Kuhnast, B.6
Dollé, F.7
Scherrmann, J.M.8
Cisternino, S.9
Bottlaender, M.10
-
38
-
-
0038792263
-
11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
-
11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents J. Med. Chem. 2003, 46, 2740-2754
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2740-2754
-
-
Mathis, C.A.1
Wang, Y.2
Holt, D.P.3
Huang, G.-F.4
Debnath, M.L.5
Klunk, W.E.6
-
39
-
-
10744232413
-
Imaging brain amyloid in Alzheimer's disease with Pittsburg Compound-B
-
Klunk, W. E.; Engler, H.; Nordberg, A.; Wang, Y.; Blomqvist, G.; Holt, D. P.; Bergström, M.; Savitcheva, I.; Huang, G. F.; Estrada, S.; Ausén, B.; Debnath, M. L.; Barletta, J.; Price, J. C.; Sandell, J.; Lopresti, B. J.; Wall, A.; Koivisto, P.; Antoni, G.; Mathis, C. A.; Longström, B. Imaging brain amyloid in Alzheimer's disease with Pittsburg Compound-B Ann. Neurol. 2004, 55, 306-319
-
(2004)
Ann. Neurol.
, vol.55
, pp. 306-319
-
-
Klunk, W.E.1
Engler, H.2
Nordberg, A.3
Wang, Y.4
Blomqvist, G.5
Holt, D.P.6
Bergström, M.7
Savitcheva, I.8
Huang, G.F.9
Estrada, S.10
Ausén, B.11
Debnath, M.L.12
Barletta, J.13
Price, J.C.14
Sandell, J.15
Lopresti, B.J.16
Wall, A.17
Koivisto, P.18
Antoni, G.19
Mathis, C.A.20
Longström, B.21
more..
-
40
-
-
84885000918
-
-
Patent WO2004083195 A1
-
Klunk, W. E.; Mathis, C. A., Jr.; Wang, Y. Benzothiazole Derivative Compounds, Compositions and Uses. Patent WO2004083195 A1, 2004; p 134.
-
(2004)
Benzothiazole Derivative Compounds, Compositions and Uses
, pp. 134
-
-
Klunk, W.E.1
Mathis, C.A.2
Wang, Y.3
-
41
-
-
84897911084
-
11C]PIB across the spectrum of Alzheimer's disease
-
11C]PIB across the spectrum of Alzheimer's disease Eur. J. Nucl. Med. Mol. Imaging 2014, 41, 290-300
-
(2014)
Eur. J. Nucl. Med. Mol. Imaging
, vol.41
, pp. 290-300
-
-
Hatashita, S.1
Yamasaki, H.2
Suzuki, Y.3
Tanaka, K.4
Wakebe, D.5
Hayakawa, H.6
-
42
-
-
84869021291
-
Development of positron emission tomography beta-amyloid plaque imaging agents
-
Mathis, C. A.; Mason, N. S.; Lopresti, B. J.; Klunk, W. E. Development of positron emission tomography beta-amyloid plaque imaging agents Semin. Nucl. Med. 2012, 42, 423-432
-
(2012)
Semin. Nucl. Med.
, vol.42
, pp. 423-432
-
-
Mathis, C.A.1
Mason, N.S.2
Lopresti, B.J.3
Klunk, W.E.4
-
43
-
-
80055040100
-
Florbetaben to trance amyloid-β in the Alzheimer brain by means of PET
-
Barthel, H.; Sabri, O. Florbetaben to trance amyloid-β in the Alzheimer brain by means of PET J. Alzheimer's Dis. 2011, 26, 117-121
-
(2011)
J. Alzheimer's Dis.
, vol.26
, pp. 117-121
-
-
Barthel, H.1
Sabri, O.2
-
44
-
-
77953937194
-
18F-AV-45 (flobetapir F-18)
-
18F-AV-45 (flobetapir F-18) J. Nucl. Med. 2010, 51, 913-920
-
(2010)
J. Nucl. Med.
, vol.51
, pp. 913-920
-
-
Wong, D.F.1
Rosenberg, P.B.2
Zhou, Y.3
Kumar, A.4
Vanessa Raymont, V.5
Ravert, H.T.6
Dannals, R.F.7
Nandi, A.8
Brašić, J.R.9
Ye, W.10
Hilton, J.11
Lyketsos, C.12
Kung, H.F.13
Joshi, A.D.14
Skovronsky, D.M.15
Pontecorvo, M.J.16
-
45
-
-
62649174043
-
The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice
-
Lopéz-Muñoz, F.; Alamos, C. The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice Brain Res. Bull. 2009, 79, 130-141
-
(2009)
Brain Res. Bull.
, vol.79
, pp. 130-141
-
-
Lopéz-Muñoz, F.1
Alamos, C.2
-
46
-
-
84913593562
-
Importance and hurdles to drug discovery for neurological disease
-
Berger, J. R.; Choi, D.; Kaminski, H. J.; Gordon, M. F.; Hurko, O.; D'Cruz, O. N.; Pleasure, S. J.; Feldman, E. L. Importance and hurdles to drug discovery for neurological disease Ann. Neurol. 2013, 74, 441-446
-
(2013)
Ann. Neurol.
, vol.74
, pp. 441-446
-
-
Berger, J.R.1
Choi, D.2
Kaminski, H.J.3
Gordon, M.F.4
Hurko, O.5
D'Cruz, O.N.6
Pleasure, S.J.7
Feldman, E.L.8
-
48
-
-
0003734820
-
-
European Federation of Pharmaceutica Industries and Associations: Brussels, Belgium
-
The Pharmaceutical Industry in Figures; European Federation of Pharmaceutica Industries and Associations: Brussels, Belgium, 2013; http://www.efpia.eu/uploads/Modules/Documents/figures-key-data-2013.pdf.
-
(2013)
The Pharmaceutical Industry in Figures
-
-
-
49
-
-
39649084919
-
The FDA critical path initiative and its influence on new drug development
-
Woodcock, J.; Woosley, R. The FDA critical path initiative and its influence on new drug development Annu. Rev. Med. 2008, 59, 1-12
-
(2008)
Annu. Rev. Med.
, vol.59
, pp. 1-12
-
-
Woodcock, J.1
Woosley, R.2
-
51
-
-
0030947805
-
FK960 [N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate], a novel potential antidementia drug, improves visual recognition memory in rhesus monkeys: Comparison with physostigmine
-
Matsuoka, N.; Ainer, T. G. FK960 [N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate], a novel potential antidementia drug, improves visual recognition memory in rhesus monkeys: comparison with physostigmine J. Pharmacol. Exp. Ther. 1997, 280, 1201-1209
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.280
, pp. 1201-1209
-
-
Matsuoka, N.1
Ainer, T.G.2
-
52
-
-
0037228438
-
Measurement of brain concentration of FK960 for development of a novel antidementia drug: A PET study in conscious rhesus monkeys
-
Noda, A.; Takamatsu, H.; Murakami, Y.; Yajima, K.; Tatsumi, M.; Ichise, R.; Nishimura, S. Measurement of brain concentration of FK960 for development of a novel antidementia drug: a PET study in conscious rhesus monkeys J. Nucl. Med. 2003, 44, 105-108
-
(2003)
J. Nucl. Med.
, vol.44
, pp. 105-108
-
-
Noda, A.1
Takamatsu, H.2
Murakami, Y.3
Yajima, K.4
Tatsumi, M.5
Ichise, R.6
Nishimura, S.7
-
53
-
-
10644243586
-
2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia
-
2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia Int. J. Neuropsychopharmacol. 2004, 7, 421-430
-
(2004)
Int. J. Neuropsychopharmacol.
, vol.7
, pp. 421-430
-
-
Vernaleken, I.1
Siessmeier, T.2
Buchholz, H.G.3
Härtter, S.4
Hiemke, C.5
Stoeter, P.6
Rösch, F.7
Bartenstein, P.8
Gründer, G.9
-
54
-
-
36949036673
-
11C]-(+)-PHNO positron emission tomography study
-
11C]-(+)-PHNO positron emission tomography study Neuropsychopharmacology 2008, 33, 279-289
-
(2008)
Neuropsychopharmacology
, vol.33
, pp. 279-289
-
-
Willeit, M.1
Ginovart, N.2
Graff, A.3
Rusjan, P.4
Vitcu, I.5
Houle, S.6
Seeman, P.7
Wilson, A.A.8
Kapur, S.9
-
55
-
-
0025294009
-
Cocaine-induced reduction of glucose utilization in human brain
-
London, E. D.; Cascella, N. G.; Wong, D. F.; Philips, R. L.; Dannals, R. F.; Links, J. M.; Herning, R.; Grayson, R.; Jaffe, J. H.; Wagner, H. N. Cocaine-induced reduction of glucose utilization in human brain Arch. Gen. Psychiatry 1990, 47, 567-574
-
(1990)
Arch. Gen. Psychiatry
, vol.47
, pp. 567-574
-
-
London, E.D.1
Cascella, N.G.2
Wong, D.F.3
Philips, R.L.4
Dannals, R.F.5
Links, J.M.6
Herning, R.7
Grayson, R.8
Jaffe, J.H.9
Wagner, H.N.10
-
56
-
-
0033151283
-
Selegiline effects on cocaine-induced changes in medial temporal lobe metabolism and subjective ratings of euphoria
-
Bartzokis, G.; Beckson, M.; Newton, T.; Mandelkern, M.; Mintz, J.; Foster, J. A.; Ling, W.; Bridge, T. P. Selegiline effects on cocaine-induced changes in medial temporal lobe metabolism and subjective ratings of euphoria Neuropsychopharmacology 1999, 20, 583-590
-
(1999)
Neuropsychopharmacology
, vol.20
, pp. 583-590
-
-
Bartzokis, G.1
Beckson, M.2
Newton, T.3
Mandelkern, M.4
Mintz, J.5
Foster, J.A.6
Ling, W.7
Bridge, T.P.8
-
57
-
-
84884274090
-
11C]MK-4232: The first positron emission tomography tracer for the calcitonin gene-related peptide receptor
-
11C]MK-4232: the first positron emission tomography tracer for the calcitonin gene-related peptide receptor ACS Med. Chem. Lett. 2013, 4, 863-868
-
(2013)
ACS Med. Chem. Lett.
, vol.4
, pp. 863-868
-
-
Bell, I.M.1
Gallicchio, S.N.2
Stump, C.A.3
Bruno, J.G.4
Fan, H.5
Gantert, L.T.6
Hostetler, E.D.7
Kemmerer, A.L.8
McWherter, M.9
Moore, E.L.10
Mosser, S.D.11
Purcell, M.L.12
Riffel, K.13
Salvatore, C.A.14
Sanabria-Bohórquez, S.15
Staas, D.D.16
White, R.B.17
Williams, M.18
Zartman, C.B.19
Cook, J.J.20
Hargreaves, R.J.21
Kane, S.A.22
Graham, S.L.23
Selnick, H.G.24
more..
-
58
-
-
84886024087
-
11C]MK-4232
-
11C]MK-4232 J. Pharmacol. Exp. Ther. 2013, 347, 478-486
-
(2013)
J. Pharmacol. Exp. Ther.
, vol.347
, pp. 478-486
-
-
Hostetler, E.D.1
Joshi, A.D.2
Sanabria-Bohórquez, S.3
Fan, H.4
Zeng, Z.5
Purcell, M.6
Gantert, L.7
Riffel, K.8
Williams, M.9
O'Malley, S.10
Miller, P.11
Selnick, H.G.12
Gallicchio, S.N.13
Bell, I.M.14
Salvatore, C.A.15
Kane, S.A.16
Li, C.C.17
Hargreaves, R.J.18
De Groot, T.19
Bormans, G.20
Van Hecken, A.21
Derdelinckx, I.22
De Hoon, J.23
Reynders, T.24
Declercq, R.25
De Lepeleire, I.26
Kennedy, W.P.27
Blanchard, R.28
Marcantonio, E.E.29
Sur, C.30
Cook, J.J.31
Van Laere, K.32
Evelhoch, J.L.33
more..
-
59
-
-
15444380798
-
11C: Labeling chemistry and labeled compounds
-
2 nd ed. Vértes, A. Nagy, S. Klencsár, Z. Lovas, R. G. Rösch, F. Springer: Dordrecht, The Netherlands
-
11C: Labeling chemistry and labeled compounds. In Handbook of Nuclear Chemistry, 2 nd ed.; Vértes, A.; Nagy, S.; Klencsár, Z.; Lovas, R. G.; Rösch, F., Eds.; Springer: Dordrecht, The Netherlands, 2011; pp 1977-2019.
-
(2011)
Handbook of Nuclear Chemistry
, pp. 1977-2019
-
-
Antoni, G.1
Kihlberg, T.2
Langström, B.3
-
60
-
-
34848848499
-
Fluorine in pharmaceuticals: Looking beyond intuition
-
Müller, K.; Faeh, C.; Diederich, F. Fluorine in pharmaceuticals: looking beyond intuition Science 2007, 317, 1881-1886
-
(2007)
Science
, vol.317
, pp. 1881-1886
-
-
Müller, K.1
Faeh, C.2
Diederich, F.3
-
61
-
-
84879336508
-
18F: Labeling chemistry and labeled compounds
-
2 nd ed. Vértes, A. Nagy, S. Klencsár, Z. Lovas, R. G. Rösch, F. Springer: Dordrecht, The Netherlands
-
18F: labeling chemistry and labeled compounds. In Handbook of Nuclear Chemistry, 2 nd ed.; Vértes, A.; Nagy, S.; Klencsár, Z.; Lovas, R. G.; Rösch, F., Eds.; Springer: Dordrecht, The Netherlands, 2011; pp 2021-2071.
-
(2011)
Handbook of Nuclear Chemistry
, pp. 2021-2071
-
-
Ross, T.L.1
Wester, H.J.2
-
62
-
-
4043075234
-
Chemistry of fluorine-18 radiopharmaceuticals
-
Welch, M. J. Redvanly, C. S. Wiley & Sons Ltd, New York
-
Snyder, S. E.; Kilbourn, M. R. Chemistry of fluorine-18 radiopharmaceuticals. In Handbook of Radiopharmaceuticals, Radiochemistry and Applications; Welch, M. J.; Redvanly, C. S., Eds.; Wiley & Sons Ltd, New York, 2003; pp 195-228.
-
(2003)
Handbook of Radiopharmaceuticals, Radiochemistry and Applications
, pp. 195-228
-
-
Snyder, S.E.1
Kilbourn, M.R.2
-
63
-
-
0029562223
-
The pharmacology of GR203040, a novel, potent and selective non-peptide tachykinin NK1 receptor antagonist
-
Beattie, D. T.; Beresford, I. J.; Connor, H. E.; Marshall, F.; Hancock, A. B.; Hagan, R. M.; Bowers, J.; Birch, P. J.; Ward, P. The pharmacology of GR203040, a novel, potent and selective non-peptide tachykinin NK1 receptor antagonist Br. J. Pharmacol. 1995, 116, 3149-3157
-
(1995)
Br. J. Pharmacol.
, vol.116
, pp. 3149-3157
-
-
Beattie, D.T.1
Beresford, I.J.2
Connor, H.E.3
Marshall, F.4
Hancock, A.B.5
Hagan, R.M.6
Bowers, J.7
Birch, P.J.8
Ward, P.9
-
64
-
-
0030603866
-
GR 205171: A novel antagonist with high affinity for the tachykinin NK-1 receptor and potent broad-spectrum anti-emetic activity
-
Gardner, C. J.; Armour, D. R.; Beattie, D. T.; Gale, J. D.; Hawcock, A. B.; Kilpatrick, G. J.; Twissell, D. J.; Ward, P. GR 205171: A novel antagonist with high affinity for the tachykinin NK-1 receptor and potent broad-spectrum anti-emetic activity Regul. Pept. 1996, 65, 45-53
-
(1996)
Regul. Pept.
, vol.65
, pp. 45-53
-
-
Gardner, C.J.1
Armour, D.R.2
Beattie, D.T.3
Gale, J.D.4
Hawcock, A.B.5
Kilpatrick, G.J.6
Twissell, D.J.7
Ward, P.8
-
65
-
-
79955680163
-
NK-1 receptor antagonists: A new paradigm in pharmacological therapy
-
Muñoz, M.; Coveñaz, R. NK-1 receptor antagonists: a new paradigm in pharmacological therapy Curr. Med. Chem. 2011, 18, 1820-1831
-
(2011)
Curr. Med. Chem.
, vol.18
, pp. 1820-1831
-
-
Muñoz, M.1
Coveñaz, R.2
-
66
-
-
0033983766
-
11C]labelled selective high affinity NK1-antagonists, GR203040 and GR205171 - PET studies in rhesus monkey
-
11C]labelled selective high affinity NK1-antagonists, GR203040 and GR205171-PET studies in rhesus monkey Neuropharmacology 2000, 39, 664-670
-
(2000)
Neuropharmacology
, vol.39
, pp. 664-670
-
-
Bergström, M.1
Fasth, K.J.2
Kilpatrick, G.3
Ward, P.4
Cable, K.M.5
Wipperman, M.D.6
Sutherland, D.R.7
Langström, B.8
-
67
-
-
33747193244
-
Tachykinin receptors antagonists: From research to clinic
-
Quartara, L.; Altamura, M. Tachykinin receptors antagonists: from research to clinic Curr. Drug Targets 2006, 7, 975-992
-
(2006)
Curr. Drug Targets
, vol.7
, pp. 975-992
-
-
Quartara, L.1
Altamura, M.2
-
68
-
-
25844469581
-
Translational research in central nervous system drug discovery
-
Hurko, O.; Ryan, J. L. Translational research in central nervous system drug discovery NeuroRx 2005, 2, 671-682
-
(2005)
NeuroRx
, vol.2
, pp. 671-682
-
-
Hurko, O.1
Ryan, J.L.2
-
69
-
-
0036386982
-
Measuring drug-related receptor occupancy with positron emission tomography
-
Passchier, J.; Gee, A.; Willemsen, A.; Vaalburg, W.; van Waarde, A. Measuring drug-related receptor occupancy with positron emission tomography Methods 2002, 27, 278-286
-
(2002)
Methods
, vol.27
, pp. 278-286
-
-
Passchier, J.1
Gee, A.2
Willemsen, A.3
Vaalburg, W.4
Van Waarde, A.5
-
70
-
-
84858688208
-
2 receptor occupancy for the atypical antipsychotics risperidone and paliperidone
-
2 receptor occupancy for the atypical antipsychotics risperidone and paliperidone J. Pharmacol. Exp. Ther. 2012, 341, 81-89
-
(2012)
J. Pharmacol. Exp. Ther.
, vol.341
, pp. 81-89
-
-
Muly, E.C.1
Votaw, J.R.2
Howell, L.L.3
-
71
-
-
33751304147
-
2C receptor antagonists EMD 281014 and SB- 243213, respectively, on sleep and waking in the rat
-
2C receptor antagonists EMD 281014 and SB- 243213, respectively, on sleep and waking in the rat Eur. J. Pharmacol. 2006, 553, 163-167
-
(2006)
Eur. J. Pharmacol.
, vol.553
, pp. 163-167
-
-
Monti, J.M.1
Jantos, H.2
-
72
-
-
6944227845
-
Prophylactic and therapeutic effects of acute systemic injections of EMD 281014, a selective serotonin 2A receptor antagonist on anxiety induced by predator stress in rats
-
Adamec, R.; Creamer, K.; Bartoszyk, G. D.; Burton, P. Prophylactic and therapeutic effects of acute systemic injections of EMD 281014, a selective serotonin 2A receptor antagonist on anxiety induced by predator stress in rats Eur. J. Pharmacol. 2004, 504, 79-96
-
(2004)
Eur. J. Pharmacol.
, vol.504
, pp. 79-96
-
-
Adamec, R.1
Creamer, K.2
Bartoszyk, G.D.3
Burton, P.4
-
73
-
-
5444227614
-
2 antagonist in humans: A dose-finding PET study
-
2 antagonist in humans: a dose-finding PET study Psychopharmacology 2004, 175, 382-388
-
(2004)
Psychopharmacology
, vol.175
, pp. 382-388
-
-
Mamo, D.1
Sedman, E.2
Tillner, J.3
Sellers, E.M.4
Romach, M.K.5
Kapur, S.6
-
74
-
-
0343580507
-
2A receptor occupancy in the human brain after a single oral dose of the putative antipsychotic drug MDL 100,907 measured by positron emission tomography
-
2A receptor occupancy in the human brain after a single oral dose of the putative antipsychotic drug MDL 100,907 measured by positron emission tomography Neuropsychopharmacology 1997, 17, 175-185
-
(1997)
Neuropsychopharmacology
, vol.17
, pp. 175-185
-
-
Gründer, G.1
Yokoi, F.2
Offord, S.J.3
Ravert, H.T.4
Dannals, R.F.5
Salzmann, J.K.6
Szymanski, S.7
Wilson, P.D.8
Howard, D.R.9
Wong, D.F.10
-
75
-
-
80053575167
-
18F]fallypride positron emission tomography study
-
18F]fallypride positron emission tomography study Biol. Psychiatry 2011, 70, 770-776
-
(2011)
Biol. Psychiatry
, vol.70
, pp. 770-776
-
-
Spreckelmeyer, K.N.1
Paulzen, M.2
Raptis, M.3
Baltus, T.4
Schaffrath, S.5
Van Waesberghe, J.6
Zalewski, M.M.7
Rösch, F.8
Vernaleken, I.9
Schäfer, W.M.10
Gründer, G.11
-
77
-
-
0028981528
-
11C]WAY-100,635
-
11C]WAY-100,635 Eur. J. Pharmacol. 1995, 283, R1-3
-
(1995)
Eur. J. Pharmacol.
, vol.283
, pp. 1-3
-
-
Pike, V.W.1
McCarron, J.A.2
Lammertsma, A.A.3
Hume, S.P.4
Poole, K.5
Grasby, P.M.6
Malizia, A.7
Cliffe, I.A.8
Fletcher, A.9
Bench, C.J.10
-
78
-
-
0345108066
-
11C]WAY-100635, in monkey and human plasma by HPLC: Comparison of the behaviour of an identified radioactive metabolite with parent radioligand in monkey using PET
-
11C]WAY-100635, in monkey and human plasma by HPLC: comparison of the behaviour of an identified radioactive metabolite with parent radioligand in monkey using PET Nucl. Med. Biol. 1996, 23, 627-634
-
(1996)
Nucl. Med. Biol.
, vol.23
, pp. 627-634
-
-
Osman, S.1
Lundkvist, C.2
Pike, V.W.3
Halldin, C.4
McCarron, J.A.5
Swahn, C.G.6
Ginovart, N.7
Lutshra, S.K.8
Bench, C.J.9
Grasby, P.M.10
Wikström, H.11
Barf, T.12
Cliffe, I.A.13
Fletcher, A.14
Farde, L.15
-
79
-
-
17544367164
-
11C]WAY-100635 in humans: Comparison of arterial and reference tissue input functions
-
11C]WAY-100635 in humans: comparison of arterial and reference tissue input functions J. Cereb. Blood Flow Metab. 2000, 20, 1111-1133
-
(2000)
J. Cereb. Blood Flow Metab.
, vol.20
, pp. 1111-1133
-
-
Parsey, R.V.1
Slifstein, M.2
Hwang, D.R.3
Abi-Dargham, A.4
Simpson, N.5
Mawlawi, O.6
Guo, N.N.7
Van, H.R.8
Mann, J.J.9
Laruelle, M.10
-
80
-
-
0029971954
-
11C]WAY-100635
-
11C]WAY-100635 Eur. J. Pharmacol. 1996, 301, R5-7
-
(1996)
Eur. J. Pharmacol.
, vol.301
, pp. 5-7
-
-
Pike, V.W.1
McCarron, J.A.2
Lammertsma, A.A.3
Osman, S.4
Hume, S.P.5
Sargent, P.A.6
Bench, C.J.7
Cliffe, I.A.8
Fletcher, A.9
Grasby, P.M.10
-
81
-
-
0001989283
-
Evidence for the existence of monoamine-containing neurons in the central nervous system
-
Dahlström, A.; Fuxe, F. Evidence for the existence of monoamine-containing neurons in the central nervous system Acta Physiol. Scand. 1964, 62, 1-55
-
(1964)
Acta Physiol. Scand.
, vol.62
, pp. 1-55
-
-
Dahlström, A.1
Fuxe, F.2
-
82
-
-
0742304657
-
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
-
Seamans, J. K.; Yang, C. R. The principal features and mechanisms of dopamine modulation in the prefrontal cortex Prog. Neurobiol. 2004, 74, 1-58
-
(2004)
Prog. Neurobiol.
, vol.74
, pp. 1-58
-
-
Seamans, J.K.1
Yang, C.R.2
-
83
-
-
0034016318
-
Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex
-
Durstewitz, D.; Seamans, J. K.; Sejnowski, T. J. Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex J. Neurophysiol. 2000, 83, 1733-1750
-
(2000)
J. Neurophysiol.
, vol.83
, pp. 1733-1750
-
-
Durstewitz, D.1
Seamans, J.K.2
Sejnowski, T.J.3
-
84
-
-
78651116398
-
Effect of chlorpromazine and haloperidol on formation of 3-methoxytyramine and normetanephrine on mouse brain
-
Carlsson, A.; Lindqvist, M. Effect of chlorpromazine and haloperidol on formation of 3-methoxytyramine and normetanephrine on mouse brain Acta Pharmacol. Toxicol. 1963, 20, 140-144
-
(1963)
Acta Pharmacol. Toxicol.
, vol.20
, pp. 140-144
-
-
Carlsson, A.1
Lindqvist, M.2
-
85
-
-
0016594390
-
Detection of the neuroleptic properties of clozapine, sulpiride and thioridazine
-
Costall, B.; Naylor, R. J. Detection of the neuroleptic properties of clozapine, sulpiride and thioridazine Psychopharmacology 1975, 43, 69-74
-
(1975)
Psychopharmacology
, vol.43
, pp. 69-74
-
-
Costall, B.1
Naylor, R.J.2
-
86
-
-
0002447720
-
Das klinische Wirkungsbild von Clozapin
-
Angst, J.; Bente, D.; Berner, P.; Heimann, H.; Helmchen, H.; Hippius, H. Das klinische Wirkungsbild von Clozapin Pharmakopsychiatrie 1971, 4, 201-221
-
(1971)
Pharmakopsychiatrie
, vol.4
, pp. 201-221
-
-
Angst, J.1
Bente, D.2
Berner, P.3
Heimann, H.4
Helmchen, H.5
Hippius, H.6
-
89
-
-
0027491943
-
18F]fluorodopamine: Initial findings in humans
-
18F]fluorodopamine: initial findings in humans J. Am. Coll. Cardiol. 1993, 22, 1961-71
-
(1993)
J. Am. Coll. Cardiol.
, vol.22
, pp. 1961-1971
-
-
Goldstein, D.S.1
Eisenhofer, G.2
Dunn, B.B.3
Armando, I.4
Lenders, J.5
Grossman, E.6
Holmes, C.7
Kirk, K.L.8
Bacharach, S.9
Adams, R.10
Hersecovitch, P.11
Kopin, I.J.12
-
90
-
-
0031979045
-
Compartmental analysis of dopa decarboxylation in living brain from dynamic positron emission tomograms
-
Cumming, P.; Gjedde, A. Compartmental analysis of dopa decarboxylation in living brain from dynamic positron emission tomograms Synapse 1998, 29, 37-61
-
(1998)
Synapse
, vol.29
, pp. 37-61
-
-
Cumming, P.1
Gjedde, A.2
-
91
-
-
0028586026
-
Positron emission tomography and central neurotransmitter systems in movement disorders
-
Weeks, R. A.; Brooks, D. J. Positron emission tomography and central neurotransmitter systems in movement disorders Fundam. Clin. Pharmacol. 1994, 8, 503-517
-
(1994)
Fundam. Clin. Pharmacol.
, vol.8
, pp. 503-517
-
-
Weeks, R.A.1
Brooks, D.J.2
-
92
-
-
0027437033
-
Positron emission tomographic studies of dopa-responsive dystonia and early-onset idiopathic parkinsonism
-
Snow, B. J.; Nygaard, T. G.; Takahashi, H.; Calne, D. B. Positron emission tomographic studies of dopa-responsive dystonia and early-onset idiopathic parkinsonism Ann. Neurol. 1993, 34, 733-738
-
(1993)
Ann. Neurol.
, vol.34
, pp. 733-738
-
-
Snow, B.J.1
Nygaard, T.G.2
Takahashi, H.3
Calne, D.B.4
-
93
-
-
35048900928
-
Neuroreceptor imaging studies in schizophrenia
-
Frankle, W. G. Neuroreceptor imaging studies in schizophrenia Harv. Rev. Psychiatry 2007, 15, 212-232
-
(2007)
Harv. Rev. Psychiatry
, vol.15
, pp. 212-232
-
-
Frankle, W.G.1
-
94
-
-
0035053443
-
A reversible tracer analysis approach to the study of effective dopamine turnover
-
Sossi, V.; Doudet, D. J.; Holden, J. E. A reversible tracer analysis approach to the study of effective dopamine turnover J. Cereb. Blood Flow Metab. 2001, 21, 469-476
-
(2001)
J. Cereb. Blood Flow Metab.
, vol.21
, pp. 469-476
-
-
Sossi, V.1
Doudet, D.J.2
Holden, J.E.3
-
95
-
-
0035452463
-
Loss of metabolites from monkey striatum during PET with FDOPA
-
Cumming, P.; Munk, O. L.; Doudet, D. Loss of metabolites from monkey striatum during PET with FDOPA Synapse 2001, 41, 212-218
-
(2001)
Synapse
, vol.41
, pp. 212-218
-
-
Cumming, P.1
Munk, O.L.2
Doudet, D.3
-
96
-
-
21344464929
-
18F]fluorodopamine storage capacity
-
18F]fluorodopamine storage capacity J. Cereb. Blood Flow Metab. 2005, 25, 807-819
-
(2005)
J. Cereb. Blood Flow Metab.
, vol.25
, pp. 807-819
-
-
Kumakura, Y.1
Vernaleken, I.2
Grunder, G.3
Bartenstein, P.4
Gjedde, A.5
Cumming, P.6
-
97
-
-
34547486316
-
18F]fluorodopa/positron emission tomography study
-
18F]fluorodopa/positron emission tomography study J. Neurosci. 2007, 27, 8080-8087
-
(2007)
J. Neurosci.
, vol.27
, pp. 8080-8087
-
-
Kumakura, Y.1
Cumming, P.2
Vernaleken, I.3
Buchholz, H.G.4
Siessmeier, T.5
Heinz, A.6
Kienast, T.7
Bartenstein, P.8
Grunder, G.9
-
98
-
-
0038388945
-
Subchronic haloperidol downregulates dopamine synthesis capacity in the brain of schizophrenic patients in vivo
-
Gründer, G.; Vernaleken, I.; Muller, M. J.; Davids, E.; Heydari, N.; Buchholz, H. G.; Bartenstein, P.; Munk, O. L.; Stoeter, P.; Wong, D. F.; Gjedde, A.; Cumming, P. Subchronic haloperidol downregulates dopamine synthesis capacity in the brain of schizophrenic patients in vivo Neuropsychopharmacology 2003, 28, 787-794
-
(2003)
Neuropsychopharmacology
, vol.28
, pp. 787-794
-
-
Gründer, G.1
Vernaleken, I.2
Muller, M.J.3
Davids, E.4
Heydari, N.5
Buchholz, H.G.6
Bartenstein, P.7
Munk, O.L.8
Stoeter, P.9
Wong, D.F.10
Gjedde, A.11
Cumming, P.12
-
99
-
-
40849096177
-
18F]-FDOPA kinetics are predictive of haloperidol-induced changes in dopamine turnover and cognitive performance: A positron emission tomography study in healthy subjects
-
18F]-FDOPA kinetics are predictive of haloperidol-induced changes in dopamine turnover and cognitive performance: a positron emission tomography study in healthy subjects Neuroimage 2008, 40, 1222-1231
-
(2008)
Neuroimage
, vol.40
, pp. 1222-1231
-
-
Vernaleken, I.1
Kumakura, Y.2
Buchholz, H.G.3
Siessmeier, T.4
Hilgers, R.D.5
Bartenstein, P.6
Cumming, P.7
Grunder, G.8
-
100
-
-
33646129666
-
18F]fluorodopa (FDOPA) kinetics in the brain of healthy volunteers after acute haloperidol challenge
-
18F]fluorodopa (FDOPA) kinetics in the brain of healthy volunteers after acute haloperidol challenge NeuroImage 2006, 30, 1332-1339
-
(2006)
NeuroImage
, vol.30
, pp. 1332-1339
-
-
Vernaleken, I.1
Kumakura, Y.2
Cumming, P.3
Buchholz, H.G.4
Siessmeier, T.5
Stoeter, P.6
Muller, M.J.7
Bartenstein, P.8
Grunder, G.9
-
101
-
-
0034965097
-
Acute neuroleptic stimulates DOPA decarboxylase in porcine brain in vivo
-
Danielsen, E. H.; Smith, D.; Hermansen, F.; Gjedde, A.; Cumming, P. Acute neuroleptic stimulates DOPA decarboxylase in porcine brain in vivo Synapse 2001, 41, 172-175
-
(2001)
Synapse
, vol.41
, pp. 172-175
-
-
Danielsen, E.H.1
Smith, D.2
Hermansen, F.3
Gjedde, A.4
Cumming, P.5
-
102
-
-
0027236992
-
Homovanillic acid in the cerebrospinal fluid: Patterns of response after four weeks of neuroleptic treatment
-
Sharma, R. P.; Javaid, J. I.; Janicak, P. G.; Davis, J. M.; Faull, K. Homovanillic acid in the cerebrospinal fluid: patterns of response after four weeks of neuroleptic treatment Biol. Psychiatry 1993, 34, 128-134
-
(1993)
Biol. Psychiatry
, vol.34
, pp. 128-134
-
-
Sharma, R.P.1
Javaid, J.I.2
Janicak, P.G.3
Davis, J.M.4
Faull, K.5
-
103
-
-
84879507260
-
Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: Findings in a second cohort
-
Egerton, A.; Chaddock, C. A.; Winton-Brown, T. T.; Bloomfield, M. A.; Bhattacharyya, S.; Allen, P.; McGuire, P. K.; Howes, O. D. Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: findings in a second cohort Biol. Psychiatry 2013, 74, 106-112
-
(2013)
Biol. Psychiatry
, vol.74
, pp. 106-112
-
-
Egerton, A.1
Chaddock, C.A.2
Winton-Brown, T.T.3
Bloomfield, M.A.4
Bhattacharyya, S.5
Allen, P.6
McGuire, P.K.7
Howes, O.D.8
-
104
-
-
58149489347
-
Elevated striatal dopamine function linked to prodromal signs of schizophrenia
-
Howes, O. D.; Montgomery, A. J.; Asselin, M. C.; Murray, R. M.; Valli, I.; Tabraham, P.; Bramon-Bosch, E.; Valmaggia, L.; Johns, L.; Broome, M.; McGuire, P. K.; Grasby, P. M. Elevated striatal dopamine function linked to prodromal signs of schizophrenia Arch. Gen. Psychiatry 2009, 66, 13-20
-
(2009)
Arch. Gen. Psychiatry
, vol.66
, pp. 13-20
-
-
Howes, O.D.1
Montgomery, A.J.2
Asselin, M.C.3
Murray, R.M.4
Valli, I.5
Tabraham, P.6
Bramon-Bosch, E.7
Valmaggia, L.8
Johns, L.9
Broome, M.10
McGuire, P.K.11
Grasby, P.M.12
-
105
-
-
84869010512
-
Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals
-
Allen, P.; Luigjes, J.; Howes, O. D.; Egerton, A.; Hirao, K.; Valli, I.; Kambeitz, J.; Fusar-Poli, P.; Broome, M.; McGuire, P. Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals Schizophr. Bull. 2012, 38, 1268-1276
-
(2012)
Schizophr. Bull.
, vol.38
, pp. 1268-1276
-
-
Allen, P.1
Luigjes, J.2
Howes, O.D.3
Egerton, A.4
Hirao, K.5
Valli, I.6
Kambeitz, J.7
Fusar-Poli, P.8
Broome, M.9
McGuire, P.10
-
106
-
-
0012144684
-
Neurochemical and neuropharmacological imaging in schizophrenia
-
Davis, K. L. Charney, D. S. Coyle, J. T. Nemeroff, C. Lippincott, Williams, & Wilkins: Philadelphia, PA
-
Weinberger, D. R.; Laruelle, M. Neurochemical and neuropharmacological imaging in schizophrenia. In Neuropharmacology: The Fifth Generation of Progress; Davis, K. L.; Charney, D. S.; Coyle, J. T.; Nemeroff, C., Eds.; Lippincott, Williams, & Wilkins: Philadelphia, PA, 2001.
-
(2001)
Neuropharmacology: The Fifth Generation of Progress
-
-
Weinberger, D.R.1
Laruelle, M.2
-
107
-
-
0036006950
-
2 receptor binding in the anterior cingulate cortex in schizophrenia
-
2 receptor binding in the anterior cingulate cortex in schizophrenia Arch. Gen. Psychiatry 2002, 59, 25-30
-
(2002)
Arch. Gen. Psychiatry
, vol.59
, pp. 25-30
-
-
Suhara, T.1
Okubo, Y.2
Yasuno, F.3
Sudo, Y.4
Inoue, M.5
Ichimiya, T.6
Nakashima, Y.7
Nakayama, K.8
Tanada, S.9
Suzuki, K.10
Halldin, C.11
Farde, L.12
-
108
-
-
2942615018
-
2 receptor binding in subregions of the thalamus in schizophrenia
-
2 receptor binding in subregions of the thalamus in schizophrenia Am. J. Psychiatry 2004, 161, 1016-1022
-
(2004)
Am. J. Psychiatry
, vol.161
, pp. 1016-1022
-
-
Yasuno, F.1
Suhara, T.2
Okubo, Y.3
Sudo, Y.4
Inoue, M.5
Ichimiya, T.6
Takano, A.7
Nakayama, K.8
Halldin, C.9
Farde, L.10
-
109
-
-
33745375661
-
3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia
-
3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia Schizophr. Res. 2006, 85, 232-244
-
(2006)
Schizophr. Res.
, vol.85
, pp. 232-244
-
-
Buchsbaum, M.S.1
Christian, B.T.2
Lehrer, D.S.3
Narayanan, T.K.4
Shi, B.5
Mantil, J.6
Kemether, E.7
Oakes, T.R.8
Mukherjee, J.9
-
110
-
-
84891634592
-
2/3-receptor availability in schizophrenia decreases with progression of psychosis
-
2/3-receptor availability in schizophrenia decreases with progression of psychosis J. Nucl. Med. 2009, 50, 80
-
(2009)
J. Nucl. Med.
, vol.50
, pp. 80
-
-
Vernaleken, I.1
Raptis, M.2
Bartenstein, P.3
Wong, D.F.4
Schaefer, W.M.5
Roesch, F.6
Grunder, G.7
-
111
-
-
3142564337
-
Die Dosierung der Neuroleptika unter feinmotorischer Kontrolle als konstruktiver Beitrag zum Thema der "pharmakeule".
-
Haase, H.-J. Perimed: Erlangen
-
Haase, H.-J. Die Dosierung der Neuroleptika unter feinmotorischer Kontrolle als konstruktiver Beitrag zum Thema der "Pharmakeule". In Psychopharmakotherapie. Optimale Dosierung der Neuroleptika; Haase, H.-J., Ed.; Perimed: Erlangen, 1982.
-
(1982)
Psychopharmakotherapie. Optimale Dosierung der Neuroleptika
-
-
Haase, H.-J.1
-
112
-
-
0022560086
-
76Br]bromospiperone binding sites demonstrated by positron emission tomography in progressive supranuclear palsy
-
76Br]bromospiperone binding sites demonstrated by positron emission tomography in progressive supranuclear palsy J. Cereb. Blood Flow Metab. 1986, 6, 131-136
-
(1986)
J. Cereb. Blood Flow Metab.
, vol.6
, pp. 131-136
-
-
Baron, J.C.1
Mazière, B.2
Loc'H, C.3
Cambon, H.4
Sgouropoulos, P.5
Bonnet, A.M.6
Agid, Y.7
-
113
-
-
0023465626
-
In vivo assay for neuroleptic receptor binding in the striatum. Positron tomography in humans
-
Cambon, H.; Baron, J. C.; Boulenger, J. P.; Loc'h, C.; Zarifian, E.; Maziere, B. In vivo assay for neuroleptic receptor binding in the striatum. Positron tomography in humans Br. J. Psychiatry 1987, 151, 824-830
-
(1987)
Br. J. Psychiatry
, vol.151
, pp. 824-830
-
-
Cambon, H.1
Baron, J.C.2
Boulenger, J.P.3
Loc'H, C.4
Zarifian, E.5
Maziere, B.6
-
115
-
-
0024426716
-
Striatal dopamine receptor occupancy during and following withdrawal from neuroleptic treatment: Correlative evaluation by positron emission tomography and plasma prolactin levels
-
Baron, J. C.; Martinot, J. L.; Cambon, H.; Boulenger, J. P.; Poirier, M. F.; Caillard, V.; Blin, J.; Huret, J. D.; Loc'h, C.; Maziere, B. Striatal dopamine receptor occupancy during and following withdrawal from neuroleptic treatment: correlative evaluation by positron emission tomography and plasma prolactin levels Psychopharmacology 1989, 99, 463-472
-
(1989)
Psychopharmacology
, vol.99
, pp. 463-472
-
-
Baron, J.C.1
Martinot, J.L.2
Cambon, H.3
Boulenger, J.P.4
Poirier, M.F.5
Caillard, V.6
Blin, J.7
Huret, J.D.8
Loc'H, C.9
Maziere, B.10
-
116
-
-
0021892405
-
11C-labelled raclopride, a new potent dopamine receptor antagonist: Preliminary PET studies of cerebral dopamine receptors in the monkey
-
11C-labelled raclopride, a new potent dopamine receptor antagonist: preliminary PET studies of cerebral dopamine receptors in the monkey Int. J. Appl. Radiat. Isot. 1985, 36, 269-273
-
(1985)
Int. J. Appl. Radiat. Isot.
, vol.36
, pp. 269-273
-
-
Ehrin, E.1
Farde, L.2
De Paulis, T.3
Eriksson, L.4
Greitz, T.5
Johnstrom, P.6
Litton, J.E.7
Nilsson, J.L.8
Sedvall, G.9
Stone-Elander, S.10
Ögren, S.11
-
118
-
-
0027520871
-
2-dopamine receptor occupancy in relation to antipsychotic drug effects: A double-blind PET study of schizophrenic patients
-
2-dopamine receptor occupancy in relation to antipsychotic drug effects: a double-blind PET study of schizophrenic patients Biol. Psychiatry 1993, 33, 227-235
-
(1993)
Biol. Psychiatry
, vol.33
, pp. 227-235
-
-
Nordström, A.L.1
Farde, L.2
Wiesel, F.A.3
Forslund, K.4
Pauli, S.5
Halldin, C.6
Uppfeldt, G.7
-
119
-
-
0027487422
-
2 dopamine receptor occupancy in relation to extrapyramidal syndromes in patients being treated with neuroleptic drugs
-
2 dopamine receptor occupancy in relation to extrapyramidal syndromes in patients being treated with neuroleptic drugs Psychopharmacol. Ser. 1993, 10, 94-100
-
(1993)
Psychopharmacol. Ser.
, vol.10
, pp. 94-100
-
-
Farde, L.1
Nordstrom, A.L.2
-
120
-
-
0026718710
-
2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects
-
2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects Arch. Gen. Psychiatry 1992, 49, 538-544
-
(1992)
Arch. Gen. Psychiatry
, vol.49
, pp. 538-544
-
-
Farde, L.1
Nordstrom, A.L.2
Wiesel, F.A.3
Pauli, S.4
Halldin, C.5
Sedvall, G.6
-
121
-
-
0015655656
-
Letter: Effects of antiparkinsonian drugs on neuroleptic-induced extrapyramidal signs in monkeys
-
Shintomi, K.; Yamamura, M. Letter: Effects of antiparkinsonian drugs on neuroleptic-induced extrapyramidal signs in monkeys J. Pharm. Pharmacol. 1973, 25, 666-667
-
(1973)
J. Pharm. Pharmacol.
, vol.25
, pp. 666-667
-
-
Shintomi, K.1
Yamamura, M.2
-
122
-
-
0024854809
-
The ratios of serotonin and dopamine affinities differentiate atypical and typical antipsychotic drugs
-
Meltzer, H. Y.; Matsubara, S.; Lee, J. C. The ratios of serotonin and dopamine affinities differentiate atypical and typical antipsychotic drugs Psychopharmacol. Bull. 1989, 25, 390-392
-
(1989)
Psychopharmacol. Bull.
, vol.25
, pp. 390-392
-
-
Meltzer, H.Y.1
Matsubara, S.2
Lee, J.C.3
-
123
-
-
2442457725
-
2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone
-
2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone Am. J. Psychiatry 2004, 161, 818-825
-
(2004)
Am. J. Psychiatry
, vol.161
, pp. 818-825
-
-
Mamo, D.1
Kapur, S.2
Shammi, C.M.3
Papatheodorou, G.4
Mann, S.5
Therrien, F.6
Remington, G.7
-
125
-
-
0032982714
-
2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia
-
2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia Am. J. Psychiatry 1999, 156, 286-293
-
(1999)
Am. J. Psychiatry
, vol.156
, pp. 286-293
-
-
Kapur, S.1
Zipursky, R.B.2
Remington, G.3
-
126
-
-
84872331092
-
2A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography
-
2A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography Psychopharmacology 2013, 225, 329-339
-
(2013)
Psychopharmacology
, vol.225
, pp. 329-339
-
-
Nakazawa, S.1
Yokoyama, C.2
Nishimura, N.3
Horisawa, T.4
Kawasaki, A.5
Mizuma, H.6
Doi, H.7
Onoe, H.8
-
127
-
-
84883456045
-
2 receptor occupancy by lurasidone using positron emission tomography in healthy male subjects
-
2 receptor occupancy by lurasidone using positron emission tomography in healthy male subjects Psychopharmacology 2013, 229, 245-252
-
(2013)
Psychopharmacology
, vol.229
, pp. 245-252
-
-
Wong, D.F.1
Kuwabara, H.2
Brasic, J.R.3
Stock, T.4
Maini, A.5
Gean, E.G.6
Loebel, A.7
-
128
-
-
85067744904
-
D2 receptor occupancy following lurasidone treatment in patients with schizophrenia or schizoaffective disorder
-
Potkin, S. G.; Keator, D. B.; Kesler-West, M. L.; Nguyen, D. D.; van Erp, T. G.; Mukherjee, J.; Shah, N.; Preda, A. D2 receptor occupancy following lurasidone treatment in patients with schizophrenia or schizoaffective disorder CNS Spectr. 2013, 1-6
-
(2013)
CNS Spectr.
, pp. 1-6
-
-
Potkin, S.G.1
Keator, D.B.2
Kesler-West, M.L.3
Nguyen, D.D.4
Van Erp, T.G.5
Mukherjee, J.6
Shah, N.7
Preda, A.8
-
129
-
-
33947681636
-
Therapeutic drug monitoring for optimizing amisulpride therapy in patients with schizophrenia
-
Muller, M. J.; Regenbogen, B.; Hartter, S.; Eich, F. X.; Hiemke, C. Therapeutic drug monitoring for optimizing amisulpride therapy in patients with schizophrenia J. Psychiatr. Res. 2007, 41, 673-679
-
(2007)
J. Psychiatr. Res.
, vol.41
, pp. 673-679
-
-
Muller, M.J.1
Regenbogen, B.2
Hartter, S.3
Eich, F.X.4
Hiemke, C.5
-
130
-
-
49349105633
-
2 receptor occupancy induced by atypical antipsychotics in stabilized schizophrenic patients
-
2 receptor occupancy induced by atypical antipsychotics in stabilized schizophrenic patients J. Psychopharmacol. 2008, 22, 8828-8894
-
(2008)
J. Psychopharmacol.
, vol.22
, pp. 8828-8894
-
-
Catafau, A.M.1
Penengo, M.M.2
Nucci, G.3
Bullich, S.4
Corripio, I.5
Parellada, E.6
Garcia-Ribera, C.7
Gomeni, R.8
Merlo-Pich, E.9
-
131
-
-
77957234962
-
2/3 receptor occupancy by quetiapine in striatal and extrastriatal areas
-
2/3 receptor occupancy by quetiapine in striatal and extrastriatal areas Int. J. Neuropsychopharmacol. 2010, 13, 951-960
-
(2010)
Int. J. Neuropsychopharmacol.
, vol.13
, pp. 951-960
-
-
Vernaleken, I.1
Janouschek, H.2
Raptis, M.3
Hellmann, S.4
Veselinovic, T.5
Brocheler, A.6
Boy, C.7
Cumming, P.8
Hiemke, C.9
Rosch, F.10
Schafer, W.M.11
Grunder, G.12
-
132
-
-
84881370595
-
7 receptor in the rat brain
-
7 receptor in the rat brain Bioorg. Med. Chem. 2013, 21, 5316-5322
-
(2013)
Bioorg. Med. Chem.
, vol.21
, pp. 5316-5322
-
-
Shimoda, Y.1
Yui, J.2
Xie, L.3
Fujinaga, M.4
Yamasaki, T.5
Ogawa, M.6
Nengaki, N.7
Kumata, K.8
Hatori, A.9
Kawamura, K.10
Zhang, M.R.11
-
134
-
-
0017202410
-
A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems
-
Costall, B.; Naylor, R. J. A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems Eur. J. Pharmacol. 1976, 40, 9-19
-
(1976)
Eur. J. Pharmacol.
, vol.40
, pp. 9-19
-
-
Costall, B.1
Naylor, R.J.2
-
135
-
-
0041880367
-
123I]epidepride SPET study of amisulpride-treated patients
-
123I]epidepride SPET study of amisulpride-treated patients Am. J. Psychiatry 2003, 160, 1413-1420
-
(2003)
Am. J. Psychiatry
, vol.160
, pp. 1413-1420
-
-
Bressan, R.A.1
Erlandsson, K.2
Jones, H.M.3
Mulligan, R.4
Flanagan, R.J.5
Ell, P.J.6
Pilowsky, L.S.7
-
136
-
-
10644243586
-
2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia
-
2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia Int. J. Neuropsychopharmacol. 2004, 7, 421-430
-
(2004)
Int. J. Neuropsychopharmacol.
, vol.7
, pp. 421-430
-
-
Vernaleken, I.1
Siessmeier, T.2
Buchholz, H.G.3
Hartter, S.4
Hiemke, C.5
Stoeter, P.6
Rosch, F.7
Bartenstein, P.8
Grunder, G.9
-
137
-
-
67649452096
-
7 antagonist: Relevance for antidepressant actions in vivo
-
7 antagonist: relevance for antidepressant actions in vivo Psychopharmacol. 2009, 205, 119-128
-
(2009)
Psychopharmacol.
, vol.205
, pp. 119-128
-
-
Abbas, A.I.1
Hedlund, P.B.2
Huang, X.P.3
Tran, T.B.4
Meltzer, H.Y.5
Roth, B.L.6
-
138
-
-
0030859144
-
Limbic selectivity of clozapine
-
Pilowsky, L. S.; Mulligan, R. S.; Acton, P. D.; Ell, P. J.; Costa, D. C.; Kerwin, R. W. Limbic selectivity of clozapine Lancet 1997, 350, 490-491
-
(1997)
Lancet
, vol.350
, pp. 490-491
-
-
Pilowsky, L.S.1
Mulligan, R.S.2
Acton, P.D.3
Ell, P.J.4
Costa, D.C.5
Kerwin, R.W.6
-
139
-
-
12244284609
-
123I]-epidepride SPET study
-
123I]-epidepride SPET study J. Clin. Psychopharmacol. 2003, 23, 5-14
-
(2003)
J. Clin. Psychopharmacol.
, vol.23
, pp. 5-14
-
-
Bressan, R.A.1
Erlandsson, K.2
Jones, H.M.3
Mulligan, R.S.4
Ell, P.J.5
Pilowsky, L.S.6
-
140
-
-
33646137570
-
3 receptor-binding profile of clozapine in patients with schizophrenia
-
3 receptor-binding profile of clozapine in patients with schizophrenia Neuropsychopharmacology 2006, 31, 1027-1035
-
(2006)
Neuropsychopharmacology
, vol.31
, pp. 1027-1035
-
-
Gründer, G.1
Landvogt, C.2
Vernaleken, I.3
Buchholz, H.G.4
Ondracek, J.5
Siessmeier, T.6
Hartter, S.7
Schreckenberger, M.8
Stoeter, P.9
Hiemke, C.10
Rosch, F.11
Wong, D.F.12
Bartenstein, P.13
-
141
-
-
0028964653
-
18F]fluoropropyl)-2,3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer
-
18F]fluoropropyl)-2,3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer Nucl. Med. Biol. 1995, 22, 283-296
-
(1995)
Nucl. Med. Biol.
, vol.22
, pp. 283-296
-
-
Mukherjee, J.1
Yang, Z.Y.2
Das, M.K.3
Brown, T.4
-
142
-
-
48949098297
-
18F]fallypride PET study
-
18F]fallypride PET study Am. J. Psychiatry 2008, 165, 988-995
-
(2008)
Am. J. Psychiatry
, vol.165
, pp. 988-995
-
-
Gründer, G.1
Fellows, C.2
Janouschek, H.3
Veselinovic, T.4
Boy, C.5
Brocheler, A.6
Kirschbaum, K.M.7
Hellmann, S.8
Spreckelmeyer, K.M.9
Hiemke, C.10
Rosch, F.11
Schaefer, W.M.12
Vernaleken, I.13
-
143
-
-
0033151286
-
Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes
-
Lawler, C. P.; Prioleau, C.; Lewis, M. M.; Mak, C.; Jiang, D.; Schetz, J. A.; Gonzalez, A. M.; Sibley, D. R.; Mailman, R. B. Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes Neuropsychopharmacology 1999, 20, 612-627
-
(1999)
Neuropsychopharmacology
, vol.20
, pp. 612-627
-
-
Lawler, C.P.1
Prioleau, C.2
Lewis, M.M.3
Mak, C.4
Jiang, D.5
Schetz, J.A.6
Gonzalez, A.M.7
Sibley, D.R.8
Mailman, R.B.9
-
144
-
-
4344714861
-
Aripiprazole: A review of its use in schizophrenia and schizoaffective disorder
-
Swainston Harrison, T.; Perry, C. M. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder Drugs 2004, 64, 1715-1736
-
(2004)
Drugs
, vol.64
, pp. 1715-1736
-
-
Swainston Harrison, T.1
Perry, C.M.2
-
145
-
-
34249085382
-
2 receptors in antipsychotic response - A double-blind PET study in schizophrenia
-
2 receptors in antipsychotic response - a double-blind PET study in schizophrenia Neuropsychopharmacology 2007, 32, 1209-1215
-
(2007)
Neuropsychopharmacology
, vol.32
, pp. 1209-1215
-
-
Agid, O.1
Mamo, D.2
Ginovart, N.3
Vitcu, I.4
Wilson, A.A.5
Zipursky, R.B.6
Kapur, S.7
-
146
-
-
0032988563
-
A glutamatergic deficiency model of schizophrenia
-
Carlsson, A.; Hansson, L. O.; Waters, N.; Carlsson, M. L. A glutamatergic deficiency model of schizophrenia Br. J. Psychiatry Suppl. 1999, 2-6
-
(1999)
Br. J. Psychiatry Suppl.
, pp. 2-6
-
-
Carlsson, A.1
Hansson, L.O.2
Waters, N.3
Carlsson, M.L.4
-
147
-
-
0030941817
-
Hypofrontality in schizophrenia: Distributed dysfunctional circuits in neuroleptic-naive patients
-
Andreasen, N. C.; O'Leary, D. S.; Flaum, M.; Nopoulos, P.; Watkins, G. L.; Boles Ponto, L. L.; Hichwa, R. D. Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naive patients Lancet 1997, 349, 1730-1734
-
(1997)
Lancet
, vol.349
, pp. 1730-1734
-
-
Andreasen, N.C.1
O'Leary, D.S.2
Flaum, M.3
Nopoulos, P.4
Watkins, G.L.5
Boles Ponto, L.L.6
Hichwa, R.D.7
-
148
-
-
0023082787
-
Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia
-
Javitt, D. C. Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia Hillside J. Clin. Psychiatry 1987, 9, 12-35
-
(1987)
Hillside J. Clin. Psychiatry
, vol.9
, pp. 12-35
-
-
Javitt, D.C.1
-
149
-
-
0032809337
-
Interactive effects of subanesthetic ketamine and haloperidol in healthy humans
-
Krystal, J. H.; D'Souza, D. C.; Karper, L. P.; Bennett, A.; Abi-Dargham, A.; Abi-Saab, D.; Cassello, K.; Bowers, M. B., Jr.; Vegso, S.; Heninger, G. R.; Charney, D. S. Interactive effects of subanesthetic ketamine and haloperidol in healthy humans Psychopharmacology 1999, 145, 193-204
-
(1999)
Psychopharmacology
, vol.145
, pp. 193-204
-
-
Krystal, J.H.1
D'Souza, D.C.2
Karper, L.P.3
Bennett, A.4
Abi-Dargham, A.5
Abi-Saab, D.6
Cassello, K.7
Bowers, M.B.8
Vegso, S.9
Heninger, G.R.10
Charney, D.S.11
-
150
-
-
0029658545
-
Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia
-
Heresco-Levy, U.; Javitt, D. C.; Ermilov, M.; Mordel, C.; Horowitz, A.; Kelly, D. Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia Br. J. Psychiatry 1996, 169, 610-617
-
(1996)
Br. J. Psychiatry
, vol.169
, pp. 610-617
-
-
Heresco-Levy, U.1
Javitt, D.C.2
Ermilov, M.3
Mordel, C.4
Horowitz, A.5
Kelly, D.6
-
151
-
-
77951295370
-
11C]GSK931145 as a novel ligand for imaging the type 1 glycine transporter with positron emission tomography
-
11C]GSK931145 as a novel ligand for imaging the type 1 glycine transporter with positron emission tomography Synapse 2010, 64, 542-549
-
(2010)
Synapse
, vol.64
, pp. 542-549
-
-
Passchier, J.1
Gentile, G.2
Porter, R.3
Herdon, H.4
Salinas, C.5
Jakobsen, S.6
Audrain, H.7
Laruelle, M.8
Gunn, R.N.9
-
152
-
-
79251534703
-
11C]CMPyPB, glycine transporter 1 (GlyT1) PET radiotracers
-
11C]CMPyPB, glycine transporter 1 (GlyT1) PET radiotracers Synapse 2011, 65, 261-270
-
(2011)
Synapse
, vol.65
, pp. 261-270
-
-
Hamill, T.G.1
Eng, W.2
Jennings, A.3
Lewis, R.4
Thomas, S.5
Wood, S.6
Street, L.7
Wisnoski, D.8
Wolkenberg, S.9
Lindsley, C.10
Sanabria-Bohorquez, S.11
Patel, S.12
Riffel, K.13
Ryan, C.14
Cook, J.15
Sur, C.16
Burns, D.17
Hargreaves, R.18
-
153
-
-
84855979108
-
Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia
-
Alberati, D.; Moreau, J. L.; Lengyel, J.; Hauser, N.; Mory, R.; Borroni, E.; Pinard, E.; Knoflach, F.; Schlotterbeck, G.; Hainzl, D.; Wettstein, J. G. Glycine reuptake inhibitor RG1678: a pharmacologic characterization of an investigational agent for the treatment of schizophrenia Neuropharmacology 2012, 62, 1152-1161
-
(2012)
Neuropharmacology
, vol.62
, pp. 1152-1161
-
-
Alberati, D.1
Moreau, J.L.2
Lengyel, J.3
Hauser, N.4
Mory, R.5
Borroni, E.6
Pinard, E.7
Knoflach, F.8
Schlotterbeck, G.9
Hainzl, D.10
Wettstein, J.G.11
-
154
-
-
84892748327
-
The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey
-
Eddins, D.; Hamill, T. G.; Puri, V.; Cannon, C. E.; Vivian, J. A.; Sanabria-Bohorquez, S. M.; Cook, J. J.; Morrow, J. A.; Thomson, F.; Uslaner, J. M. The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey Psychopharmacology 2014, 231, 511-519
-
(2014)
Psychopharmacology
, vol.231
, pp. 511-519
-
-
Eddins, D.1
Hamill, T.G.2
Puri, V.3
Cannon, C.E.4
Vivian, J.A.5
Sanabria-Bohorquez, S.M.6
Cook, J.J.7
Morrow, J.A.8
Thomson, F.9
Uslaner, J.M.10
-
155
-
-
84872495665
-
Glycine transporter type 1 occupancy by bitopertin: A positron emission tomography study in healthy volunteers
-
Martin-Facklam, M.; Pizzagalli, F.; Zhou, Y.; Ostrowitzki, S.; Raymont, V.; Brasic, J. R.; Parkar, N.; Umbricht, D.; Dannals, R. F.; Goldwater, R.; Wong, D. F. Glycine transporter type 1 occupancy by bitopertin: a positron emission tomography study in healthy volunteers Neuropsychopharmacology 2013, 38, 504-512
-
(2013)
Neuropsychopharmacology
, vol.38
, pp. 504-512
-
-
Martin-Facklam, M.1
Pizzagalli, F.2
Zhou, Y.3
Ostrowitzki, S.4
Raymont, V.5
Brasic, J.R.6
Parkar, N.7
Umbricht, D.8
Dannals, R.F.9
Goldwater, R.10
Wong, D.F.11
-
156
-
-
55949132109
-
The role of phosphodiesterases in schizophrenia: Therapeutic implications
-
Siuciak, J. A. The role of phosphodiesterases in schizophrenia: therapeutic implications CNS Drugs 2008, 22, 983-993
-
(2008)
CNS Drugs
, vol.22
, pp. 983-993
-
-
Siuciak, J.A.1
-
157
-
-
84904961034
-
In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: Potential relevance to cognitive deficits in schizophrenia
-
Redrobe, J. P.; Jørgensen, M.; Christoffersen, C. T.; Montezinho, L. P.; Bastlund, J. F.; Carnerup, M.; Bundgaard, C.; Lerdrup, L.; Plath, N. In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: potential relevance to cognitive deficits in schizophrenia Psychopharmacology 2014, 231, 3151-3167
-
(2014)
Psychopharmacology
, vol.231
, pp. 3151-3167
-
-
Redrobe, J.P.1
Jørgensen, M.2
Christoffersen, C.T.3
Montezinho, L.P.4
Bastlund, J.F.5
Carnerup, M.6
Bundgaard, C.7
Lerdrup, L.8
Plath, N.9
-
158
-
-
80051897157
-
Synthesis, in vivo occupancy and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging
-
Andrés, J.-I.; De Angelis, M.; Alcazar, J.; Iturrino, L.; Langlois, X.; Dedeurwaerdere, S.; Lenaerts, I.; Vanhoof, G.; Celen, S.; Bormans, G. Synthesis, in vivo occupancy and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging J. Med. Chem. 2011, 54, 5820-5835
-
(2011)
J. Med. Chem.
, vol.54
, pp. 5820-5835
-
-
Andrés, J.-I.1
De Angelis, M.2
Alcazar, J.3
Iturrino, L.4
Langlois, X.5
Dedeurwaerdere, S.6
Lenaerts, I.7
Vanhoof, G.8
Celen, S.9
Bormans, G.10
-
159
-
-
79851490485
-
18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain
-
18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain J. Nucl. Med. 2010, 51, 1584-1591
-
(2010)
J. Nucl. Med.
, vol.51
, pp. 1584-1591
-
-
Celen, S.1
Koole, M.2
De Angelis, M.3
Sannen, I.4
Chitneni, S.K.5
Alcazar, J.6
Schmidt, M.7
Verbruggen, A.8
Langlois, X.9
Van Laere, K.10
Andrés, J.I.11
Bormans, G.12
-
161
-
-
80555125102
-
A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging
-
Lee, E.; Kamlet, A. S.; Powers, D. C.; Neumann, C. N.; Boursalian, G. B.; Furuya, T.; Choi, D. C.; Hooker, J. M.; Ritter, T. A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging Science 2011, 334, 639-642
-
(2011)
Science
, vol.334
, pp. 639-642
-
-
Lee, E.1
Kamlet, A.S.2
Powers, D.C.3
Neumann, C.N.4
Boursalian, G.B.5
Furuya, T.6
Choi, D.C.7
Hooker, J.M.8
Ritter, T.9
|