GR205171: A novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity

Regulatory Peptides

Volumn 65, Issue 1, 1996, Pages 45-53

  Gardner, C J ^a   Armour, D R ^a   Beattie, D T ^a   Gale, J D ^b   Hawcock, A B ^a   Kilpatrick, G J ^a,c   Twissell, D J ^a   Ward, P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Antagonist; Anti emetic; Emesis; GR205171; NK1 binding affinity; Tachykinin NK1

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; CISPLATIN; COPPER SULFATE; CYCLOPHOSPHAMIDE; IPECAC; MORPHINE; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; VOFOPITANT; [2 METHOXY 5 (1 TETRAZOLYL)BENZYL](2 PHENYL 3 PIPERIDINYL)AMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG SYNTHESIS; FEMALE; FERRET; HAMSTER; HUMAN; INSECTIVORE; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; VOMITING;

ANIMALIA; CANIS FAMILIARIS; CEPHAELIS IPECACUANHA; CRICETINAE; EMESIS; MUSTELA PUTORIUS FURO; SUNCUS; SUNCUS MURINUS;

EID: 0030603866     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/0167-0115(96)00071-7     Document Type: Article

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