Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging

Journal of Medicinal Chemistry

Volumn 54, Issue 16, 2011, Pages 5820-5835

  Andrés, José Ignacio ^a   De Angelis, Meri ^a   Alcázar, Jesús ^a   Iturrino, Laura ^a   Langlois, Xavier ^a   Dedeurwaerdere, Stefanie ^a   Lenaerts, Ilse ^a   Vanhoof, Greet ^a   Celen, Sofie ^b   Bormans, Guy ^b  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [1 (2 FLUOROETHYL) 4 PYRIDIN 4 YL 1H PYRAZOL 3 YL]PHENOXYMETHYL]QUINOLINE F 18; 2 [[4 [1 (2 FLUOROETHYL) 4 (4 PYRIDINYL) 1H PYRAZOL 3 YL]PHENOXY]METHYL] 3,5 DIMETHYLPYRIDINE F 18; 2 [[4 [1 (2 FLUOROETHYL) 4 (4 PYRIDINYL) 1H PYRAZOL 3 YL]PHENOXY]METHYL] 5 METHOXYPYRIDINE C 11; 2 [[4 [1 (2 FLUOROETHYL) 4 (4 PYRIDINYL) 1H PYRAZOL 3 YL]PHENOXY]METHYL] 5 METHOXYPYRIDINE F 18; LIGAND; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10A; PHOSPHODIESTERASE 10A INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG DISTRIBUTION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG UPTAKE; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; LIPOPHILICITY; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RAT;

ANIMALS; BIOCATALYSIS; BRAIN; CELL LINE; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; MALE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; SPODOPTERA; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 80051897157     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200536d     Document Type: Article

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