메뉴 건너뛰기




Volumn 18, Issue 12, 2011, Pages 1820-1831

NK-1 receptor antagonists: A new paradigm in pharmacological therapy

Author keywords

Analgesic; Antialcohol addiction; Antidepressant; Antiinflammatory; Antitumour; Antivirus proliferation; Anxyolitic; Substance P

Indexed keywords

17ALPHA ETHYNYL 17BETA HYDROXY 5ALPHA ANDROSTANO[3,2 B]PYRIMIDO[1,2 A]BENZIMIDAZOLE; 2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; 2 [3,5 BIS(TRIFLUOROMETHYL)BENZYLOXY] 4 (3 OXO 1,2,4 TRIAZOL 5 YLMETHYL) 3 PHENYLMORPHOLINE; 2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; 3 (2 METHOXY 5 TRIFLUOROMETHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 3 [3,5 BIS(TRIFLUOROMETHYL)BENZYLOXY] 2 PHENYLPIPERIDINE; 4 (2 METHOXYPHENYL) 2 [2 (2 METHOXYPHENYL)PROPIONYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 OL; [2 METHOXY 5 (1 TETRAZOLYL)BENZYL](2 PHENYL 3 PIPERIDINYL)AMINE; APREPITANT; DAPITANT; DEXAMETHASONE; EZLOPITANT; FOSAPREPITANT; L 709210; L 737488; LANEPITANT; LY 686017; N ACETYLTRYPTOPHAN 3,5 BIS(TRIFLUOROMETHYL)BENZYL ESTER; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NOLPITANTIUM; OVERPITANT; PLACEBO; SEROTONIN 3 ANTAGONIST; SSR 240600; SUBSTANCE P; UNCLASSIFIED DRUG; VESTIPITANT; VINBLASTINE; VOFOPITANT;

EID: 79955680163     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986711795496746     Document Type: Article
Times cited : (49)

References (136)
  • 3
    • 0018102058 scopus 로고
    • The distribution of substance P immunoreactive fibres in the rat central nervous system
    • Cuello, A.C.; Kanazawa, I. The distribution of substance P immunoreactive fibres in the rat central nervous system. J. Comp. Neurol., 1978, 178, 129-156.
    • (1978) J. Comp. Neurol , vol.178 , pp. 129-156
    • Cuello, A.C.1    Kanazawa, I.2
  • 5
    • 0022588287 scopus 로고
    • Substance P in the human brain
    • DOI 10.1016/0306-4522(86)90041-2
    • Mai, J.K.; Stephens, P.H.; Hopf, A.; Cuello, A.C. Substance P in the human brain. Neuroscience, 1986, 17, 709-739. (Pubitemid 16131267)
    • (1986) Neuroscience , vol.17 , Issue.3 , pp. 709-739
    • Mai, J.K.1    Stephens, P.H.2    Hopf, A.3    Cuello, A.C.4
  • 6
    • 0024203060 scopus 로고
    • Immunocytochemical study of substance P-like fibres and cell bodies in cat diencephalon
    • Burgos, C.; Aguirre, J.A.; Alonso, J.R.; Coveñas, R. Immunocytochemical study of substance P-like fibres and cell bodies in the cat diencephalon. J. Hirnforsch., 1988, 29, 651-657. (Pubitemid 19046442)
    • (1988) Journal fur Hirnforschung , vol.29 , Issue.6 , pp. 651-657
    • Burgos, C.1    Aguirre, J.A.2    Alonso, J.R.3    Covenas, R.4
  • 7
    • 0021957091 scopus 로고
    • 125I]physalaemin
    • DOI 10.1016/0006-8993(85)90598-0
    • Wolf, S.S.; Moody, T.W.; Quirion, R.; O'Donohue, T.L. Biochemical characterization and autoradiographic localization of central SP receptor using [125I] physalaemin. Brain Res., 1985, 332, 299-307. (Pubitemid 15108000)
    • (1985) Brain Research , vol.332 , Issue.2 , pp. 299-307
    • Wolf, S.S.1    Moody, T.W.2    Quirion, R.3    O'Donohue, T.L.4
  • 8
    • 0023018025 scopus 로고
    • Pharmacological characterization and autoradiographic localization of substance P receptors in guinea pig brain
    • DOI 10.1016/0196-9781(86)90106-3
    • Dam, T.V.; Quirion, R. Pharmacological characterization and autoradiographic characterization of substance P receptors in guinea-pig brain. Peptides, 1986, 7, 855-864. (Pubitemid 17182354)
    • (1986) Peptides , vol.7 , Issue.5 , pp. 855-864
    • Dam, T.-V.1    Quirion, R.2
  • 9
    • 0022480480 scopus 로고
    • A comparative autoradiographic study of the distributions of substance P and eledoisin binding sites in rat brain
    • DOI 10.1016/0006-8993(86)91073-5
    • Danks, J.A.; Rothman, R.B.; Cascieri, M.A.; Chicchi, G.G.; Liang, T.; Herkenham, M. A comparative autoradiographic study of the distributions of substance P and eledoisin binding sites in rat brain. Brain Res., 1986, 385, 273-281. (Pubitemid 16006841)
    • (1986) Brain Research , vol.385 , Issue.2 , pp. 273-281
    • Danks, J.A.1    Rothman, R.B.2    Cascieri, M.A.3
  • 10
  • 11
    • 0027466839 scopus 로고
    • Distribution of the substance P (NK1) receptor in the central nervous system
    • Maeno, H.; Kiyama, H.; Tohyama, M. Distribution of the substance P (NK1) receptor in the central nervous system. Mol. Brain Res., 1993, 18, 43-58.
    • (1993) Mol. Brain Res , vol.18 , pp. 43-58
    • Maeno, H.1    Kiyama, H.2    Tohyama, M.3
  • 12
    • 0028070434 scopus 로고
    • Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat
    • Nakaya, Y.; Kaneko, T.; Shigemoto, R.; Nakanishi, S.; Mizuno, N. Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J. Comp. Neurol., 1994, 347, 249-274. (Pubitemid 24273427)
    • (1994) Journal of Comparative Neurology , vol.347 , Issue.2 , pp. 249-274
    • Nakaya, Y.1    Kaneko, T.2    Shigemoto, R.3    Nakanishi, S.4    Mizuno, N.5
  • 13
    • 0028814683 scopus 로고
    • Quantitation, cellular localization and regulation of neurokinin receptor gene expression whithin the rat substantia nigra
    • Whitty, C.J.; Walker, P.D.; Goebel, D.J.; Poosch, M.S.; Bannon, M.J. Quantitation, cellular localization and regulation of neurokinin receptor gene expression whithin the rat substantia nigra. Neuroscience, 1995, 64, 419-425.
    • (1995) Neuroscience , vol.64 , pp. 419-425
    • Whitty, C.J.1    Walker, P.D.2    Goebel, D.J.3    Poosch, M.S.4    Bannon, M.J.5
  • 14
    • 3242753679 scopus 로고    scopus 로고
    • Tachykinins and tachykinin receptor: Structure and activity relationships
    • Almeida, T.; Rojo, J.; Nieto, P.M. Tachykinins and tachykinin receptor: structure and activity relationships. Curr. Med. Chem., 2004, 11, 763-771.
    • (2004) Curr. Med. Chem , vol.11 , pp. 763-771
    • Almeida, T.1    Rojo, J.2    Nieto, P.M.3
  • 15
    • 0019520093 scopus 로고
    • Central blood pressure effects of substance P and angiotensin II: Role of the sympathetic nervous system and vasopressin
    • DOI 10.1016/0014-2999(81)90384-8
    • Unger, T.; Rascher, W.; Schuster, C.; Pavlovitch, R.; Schömig, A.; Dietz, R.; Ganten, D. Central blood pressure effects of substance P and angiotensin II: role of the sympathetic nervous system and vasopressin. Eur. J. Pharmacol., 1981, 71, 33-42. (Pubitemid 11112563)
    • (1981) European Journal of Pharmacology , vol.71 , Issue.1 , pp. 33-42
    • Unger, T.1    Rascher, W.2    Schuster, C.3
  • 16
    • 0030246919 scopus 로고    scopus 로고
    • 1 receptor antagonist L-733,060 in gerbils
    • DOI 10.1016/0304-3959(96)03109-0
    • Rupniak, N.M.; Carlson, E.; Boyce, S.; Webb, J.K.; Hill, R.G. Enantioselective inhibition of the formalin paw late phase by the NK1 receptor antagonist L- 733,060 in gerbils. Pain, 1996, 67, 189-195. (Pubitemid 26319652)
    • (1996) Pain , vol.67 , Issue.1 , pp. 189-195
    • Rupniak, N.M.J.1    Carlson, E.2    Boyce, S.3    Webb, J.K.4    Hill, R.G.5
  • 17
    • 0031594899 scopus 로고    scopus 로고
    • The tachykinin receptor. Part II: Distribution and pathophysiological roles
    • DOI 10.1016/S0143-4179(98)90015-4
    • Quartara, L.; Maggi, C.A. The tachykinin NK1 receptor. Part II: distribution and pathophysiological roles. Neuropeptides, 1998, 32, 1-49. (Pubitemid 28167857)
    • (1998) Neuropeptides , vol.32 , Issue.1 , pp. 1-49
    • Quartara, L.1    Maggi, C.A.2
  • 19
    • 0343820002 scopus 로고    scopus 로고
    • Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion
    • DOI 10.1016/S0304-3959(99)00240-7, PII S0304395999002407
    • Samsam, M.; Coveñas, R.; Ahangari, R.; Yajeya, J.; Narváez, J.A.; Tramu, G. Simultaneous depletion of neurokinin A, substance P and calcitonin generelated peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion. Pain, 2000, 84, 389-395. (Pubitemid 30074242)
    • (2000) Pain , vol.84 , Issue.2-3 , pp. 389-395
    • Samsam, M.1    Covenas, R.2    Ahangari, R.3    Yajeya, J.4    Narvaez, J.A.5    Tramu, G.6
  • 23
    • 0022346134 scopus 로고
    • Substance P receptor-mediated chemotaxis of human monocytes
    • Ruff, M.R.; Wahl, S.M.; Pert, C.B. Substance P receptor-mediated chemotaxis of human monocytes Peptides, 1985, 6, 107-111. (Pubitemid 16211115)
    • (1985) Peptides , vol.6 , Issue.SUPPL. 2 , pp. 107-111
    • Ruff, M.R.1    Wahl, S.M.2    Pert, C.B.3
  • 26
    • 66149137995 scopus 로고    scopus 로고
    • Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinase-dependent mechanism
    • Meshki, J.; Douglas, S.D.; Lai, J.P.; Schwartz, L.; Kilpatrick, L.E.; Tuluc, F. Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinase-dependent mechanism. J. Biol. Chem., 2009, 284, 9280-9289.
    • (2009) J. Biol. Chem , vol.284 , pp. 9280-9289
    • Meshki, J.1    Douglas, S.D.2    Lai, J.P.3    Schwartz, L.4    Kilpatrick, L.E.5    Tuluc, F.6
  • 27
    • 45349096499 scopus 로고    scopus 로고
    • Cell motility through plasma membrane blebbing
    • DOI 10.1083/jcb.200802081
    • Fackler, O.T.; Grosse, R. Cell motility through plasma membrane blebbing. J. Cell Biol., 2008, 181, 879-884. (Pubitemid 351846821)
    • (2008) Journal of Cell Biology , vol.181 , Issue.6 , pp. 879-884
    • Fackler, O.T.1    Grosse, R.2
  • 28
    • 63849298539 scopus 로고    scopus 로고
    • Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity
    • Janelsins, B.M.; Mathers, A.R.; Tkacheva, O.A.; Erdos, G.; Shufesky, W.J.; Morelli, A.E.; Larregina, A.T. Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity. Blood, 2009, 113, 3017-3026.
    • (2009) Blood , vol.113 , pp. 3017-3026
    • Janelsins, B.M.1    Mathers, A.R.2    Tkacheva, O.A.3    Erdos, G.4    Shufesky, W.J.5    Morelli, A.E.6    Larregina, A.T.7
  • 30
    • 15544363087 scopus 로고    scopus 로고
    • Neurons derived from human mesenchymal stem cells show synaptic transmission and can be induced to produce the neurotransmitter substance P by interleukin-1α
    • DOI 10.1634/stemcells.2004-0251
    • Cho, K.J.; Trzaska, K.A., Greco, S.J.; McArdle, J.; Wang, F.S.; Ye, J.H.; Rameshwar, P. Neurons derived from human mesenchymal stem cells show synaptic transmission and can be induced to produce the neurotransmitter substance P by interleukin-1 alpha. Stem Cells, 2005, 23, 383-391. (Pubitemid 40404457)
    • (2005) Stem Cells , vol.23 , Issue.3 , pp. 383-391
    • Cho, K.J.1    Trzaska, K.A.2    Greco, S.J.3    McArdle, J.4    Wang, F.S.5    Ye, J.-H.6    Rameshwar, P.7
  • 31
    • 33644866842 scopus 로고    scopus 로고
    • Administration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow-derived neuronal cells
    • Kawada, H.; Takizawa, S.; Takanashi, T.; Morita, Y.; Fujita, J.; Fukuda, K.; Takagi, S.; Okano, H.; Ando, K.; Hotta, T. Administration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow-derived neuronal cells. Circulation, 2006, 113, 701-710.
    • (2006) Circulation , vol.113 , pp. 701-710
    • Kawada, H.1    Takizawa, S.2    Takanashi, T.3    Morita, Y.4    Fujita, J.5    Fukuda, K.6    Takagi, S.7    Okano, H.8    Ando, K.9    Hotta, T.10
  • 32
    • 34548833893 scopus 로고    scopus 로고
    • Substance P is a promoter of adult neural progenitor cell proliferation under normal and ischemic conditions
    • DOI 10.3171/JNS-07/09/0593
    • Park, S.W.; Yan, Y.P.; Satriotomo, I.; Vemuganti, R.; Dempsey, R.J. Substance P is a promoter of adult neural progenitor cell proliferation under normal and ischemic conditions. J. Neurosurg., 2007, 107, 593-599. (Pubitemid 47451044)
    • (2007) Journal of Neurosurgery , vol.107 , Issue.3 , pp. 593-599
    • Park, S.-W.1    Yan, Y.-P.2    Satriotomo, I.3    Vemuganti, R.4    Dempsey, R.J.5
  • 34
    • 0031283503 scopus 로고    scopus 로고
    • 1 receptor. Part I: Ligands and mechanisms of cellular activation
    • DOI 10.1016/S0143-4179(97)90001-9
    • Quartara, L.; Maggi, C.A. The tachykinin NK1 receptor. Part I: ligands and mechanisms of cellular activation. Neuropeptides, 1997, 31, 537-563. (Pubitemid 28037471)
    • (1997) Neuropeptides , vol.31 , Issue.6 , pp. 537-563
    • Quartara, L.1    Maggi, C.A.2
  • 35
    • 3042799978 scopus 로고    scopus 로고
    • Antitumoral action of the neurokinin-1 receptor antagonist L-733 060 on human melanoma cell lines
    • DOI 10.1097/01.cmr.0000129376.22141.a3
    • Muñoz, M.; Pérez, A.; Rosso, M.; Zamarriego, C.; Rosso, R. Antitumoural action of NK1 receptor antagonist L-733,060 on human melanoma cell lines. Melanoma Res., 2004, 14, 183-188. (Pubitemid 38879579)
    • (2004) Melanoma Research , vol.14 , Issue.3 , pp. 183-188
    • Munoz, M.1    Perez, A.2    Rosso, M.3    Zamarriego, C.4    Rosso, R.5
  • 36
    • 23044450652 scopus 로고    scopus 로고
    • The NK1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on neuroblastoma and glioma cell lines
    • DOI 10.1016/j.npep.2005.03.004, PII S014341790500034X
    • Muñoz, M.; Rosso, M.; Pérez, A.; Coveñas, R.; Rosso, R.; Zamarriego, C.; Piruat, J.I. The NK1 receptor is involved in the antitumoural action of L- 733,060 and in the mitogenic action of substance P on neuroblastoma and glioma cell lines. Neuropeptides, 2005, 39, 427-432. (Pubitemid 41073623)
    • (2005) Neuropeptides , vol.39 , Issue.4 , pp. 427-432
    • Munoz, M.1    Rosso, M.2    Perez, A.3    Covenas, R.4    Rosso, R.5    Zamarriego, C.6    Piruat, J.I.7
  • 37
    • 23244463917 scopus 로고    scopus 로고
    • Antitumoral action of the neurokinin-1-receptor antagonist L-733,060 and mitogenic action of substance P on human retinoblastoma cell lines
    • DOI 10.1167/iovs.04-1530
    • Muñoz, M.; Rosso, M.; Pérez, A.; Coveñas, R.; Rosso, R.; Zamarriego, C.; Soult, J.A.; Montero, I. Antitumoural action of the neurokinin-1- receptor antagonist L-733,060 and mitogenic action of substance P on human retinoblastoma cell lines. Invest. Ophthalmol. Vis. Sci., 2005, 46, 2567-2570. (Pubitemid 43119507)
    • (2005) Investigative Ophthalmology and Visual Science , vol.46 , Issue.7 , pp. 2567-2570
    • Munoz, M.1    Rosso, M.2    Perez, A.3    Covenas, R.4    Rosso, R.5    Zamarriego, C.6    Soult, J.A.7    Montero, I.8
  • 38
    • 33745590666 scopus 로고    scopus 로고
    • The NK-1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on human pancreatic cancer cell lines
    • DOI 10.2174/157018006777574168
    • Muñoz, M.; Rosso, M.; Coveñas, R. The NK-1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on human pancreatic cancer cell lines. Lett. Drug Des. Discovery, 2006, 3, 323-329. (Pubitemid 43988115)
    • (2006) Letters in Drug Design and Discovery , vol.3 , Issue.5 , pp. 323-329
    • Munoz, M.1    Rosso, M.2    Covenas, R.3
  • 39
    • 51049102605 scopus 로고    scopus 로고
    • The NK-1 receptor is involved in the antitumor action of L-733,060 and in the mitogenic action of substance P on human gastrointestinal cancer cell lines
    • Rosso, M.; Robles-Frias, M.J.; Coveñas, R.; Salinas-Martín, M.V.; Muñoz, M. The NK-1 receptor is involved in the antitumor action of L-733,060 and in the mitogenic action of substance P on human gastrointestinal cancer cell lines. Tumor Biol., 2008, 29, 245-254.
    • (2008) Tumor Biol , vol.29 , pp. 245-254
    • Rosso, M.1    Robles-Frias, M.J.2    Coveñas, R.3    Salinas-Martín, M.V.4    Muñoz, M.5
  • 41
    • 0036160387 scopus 로고    scopus 로고
    • Attenuation of hyperalgesia in a rat model of neuropathic pain after intrathecal pre- or post-treatment with a neurokinin-1 antagonist
    • DOI 10.1016/S0304-3959(01)00410-9, PII S0304395901004109
    • Cahill, C.M.; Coderre, T.J. Attenuation of hyperalgesia in a rat model of neuropathic pain after intrathecal pre- or post-treatment with a neurokinin-1 antagonist. Pain, 2002, 95, 277-285. (Pubitemid 34142651)
    • (2002) Pain , vol.95 , Issue.3 , pp. 277-285
    • Cahill, C.M.1    Coderre, T.J.2
  • 42
  • 44
    • 40549118238 scopus 로고    scopus 로고
    • NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2
    • Muñoz, M.; Rosso, M.; Aguilar, F.J.; González-Moles, M.A.; Redondo, M.; Esteban, F. NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2. Investig. New Drugs, 2008, 26, 111-118.
    • (2008) Investig. New Drugs , vol.26 , pp. 111-118
    • Muñoz, M.1    Rosso, M.2    Aguilar, F.J.3    González-Moles, M.A.4    Redondo, M.5    Esteban, F.6
  • 45
    • 77955151651 scopus 로고    scopus 로고
    • The NK-1 receptor is expressed in human melanoma and is involved in the antitumor action of the NK-1 receptor antagonist aprepitant on melanoma cell lines
    • Muñoz, M.; Rosso, M.; Robles-Frías, M.J.; Salinas-Martín, M.V.; Rosso, R.; González, A.; Coveñas, R. The NK-1 receptor is expressed in human melanoma and is involved in the antitumor action of the NK-1 receptor antagonist aprepitant on melanoma cell lines. Lab. Invest., 2010, 90, 1259-1269.
    • (2010) Lab. Invest. , vol.90 , pp. 1259-1269
    • Muñoz, M.1    Rosso, M.2    Robles-Frías, M.J.3    Salinas-Martín, M.V.4    Rosso, R.5    González, A.6    Coveñas, R.7
  • 46
    • 0035137002 scopus 로고    scopus 로고
    • Substance P: A pioneer amongst neuropeptides
    • DOI 10.1046/j.0954-6820.2000.00773.x
    • Hökfelt, T.; Pernow, B.; Wahren, J. Substance P: a pioneer amongst neuropeptides. J. Intern. Med., 2001, 249, 27-40. (Pubitemid 32147090)
    • (2001) Journal of Internal Medicine , vol.249 , Issue.1 , pp. 27-40
    • Hokfelt, T.1    Pernow, B.2    Wahren, J.3
  • 48
    • 0029658238 scopus 로고    scopus 로고
    • 1 tachykinin receptor antagonist, CP 99,994, in antagonizing the acute and delayed emesis induced by cisplatin in the ferret
    • Rudd, J.A.; Jordan, C.C.; Naylor, R.J. The action of the NK1 tachykinin receptor antagonist CP-99,994 in antagonizing the acute and delayed emesis induced by cisplatin in the ferret. Br. J. Pharmacol., 1996, 119, 931-936. (Pubitemid 26366488)
    • (1996) British Journal of Pharmacology , vol.119 , Issue.5 , pp. 931-936
    • Rudd, J.A.1    Jordan, C.C.2    Naylor, R.J.3
  • 49
    • 0023804454 scopus 로고
    • Place aversion induced by the substance P analogue, dimetil-C7, is not state dependent: Implication of substance P in aversion
    • Elliott, P.J. Place aversion induced by the substance P analogue, dimetil-C7, is not state dependent: implication of substance P in aversion. Exp. Brain Res., 1988, 73, 354-356.
    • (1988) Exp. Brain Res , vol.73 , pp. 354-356
    • Elliott, P.J.1
  • 51
    • 45149100927 scopus 로고    scopus 로고
    • Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission
    • DOI 10.1038/sj.npp.1301594, PII 1301594
    • Ebner, K.; Singewald, G.M.; Whittle, N.; Ferraguti, F.; Singewald, N. Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission. Neuropsychopharmacology, 2008, 33, 1929-1941. (Pubitemid 351832607)
    • (2008) Neuropsychopharmacology , vol.33 , Issue.8 , pp. 1929-1941
    • Ebner, K.1    Singewald, G.M.2    Whittle, N.3    Ferraguti, F.4    Singewald, N.5
  • 52
    • 56649105314 scopus 로고    scopus 로고
    • Substance P in stress and anxiety: NK-1 receptor antagonism interacts with key brain areas of the stress circuitry
    • Ebner, K.; Muigg, P.; Singewald, G.; Singewald, N. Substance P in stress and anxiety: NK-1 receptor antagonism interacts with key brain areas of the stress circuitry. Ann. NY Acad. Sci., 2008, 1144, 61-73.
    • (2008) Ann. NY Acad. Sci , vol.1144 , pp. 61-73
    • Ebner, K.1    Muigg, P.2    Singewald, G.3    Singewald, N.4
  • 53
    • 38449098153 scopus 로고    scopus 로고
    • Stress-induced release of substance P in the locus coeruleus modulates cortical noradrenaline release
    • Ebner, K.; Singewald, N. Stress-induced release of substance P in the locus coeruleus modulates cortical noradrenaline release. Naunyn Schmiedebergs Arch. Pharmacol., 2007, 376, 73-78.
    • (2007) Naunyn Schmiedebergs Arch. Pharmacol , vol.376 , pp. 73-78
    • Ebner, K.1    Singewald, N.2
  • 54
    • 0030571026 scopus 로고    scopus 로고
    • Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice
    • DOI 10.1016/0014-2999(96)00390-1
    • Teixeira, R.M.; Santos, A.R.; Ribeiro, S.J.; Calixto, J.B.; Rae, G.A.; De Lima, T.C. Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice. Eur. J. Pharmacol., 1996, 311, 7-14. (Pubitemid 26298493)
    • (1996) European Journal of Pharmacology , vol.311 , Issue.1 , pp. 7-14
    • Teixeira, R.M.1    Santos, A.R.S.2    Ribeiro, S.J.3    Calixto, J.B.4    Rae, G.A.5    De Lima, T.C.M.6
  • 55
    • 0034057760 scopus 로고    scopus 로고
    • 1) receptors attenuates neonatal vocalisation in guinea-pigs and mice
    • DOI 10.1016/S0028-3908(00)00052-6, PII S0028390800000526
    • Rupniak, N.M.; Carlson, E.C.; Harrison, T.; Oates, B.; Seward, E.; Owen, S.; de Felipe, C.; Hunt, S.; Wheeldon, A. Pharmacological blockade or genetic deletion of substance P (NK1) receptors attenuates neonatal vocalisation in guinea-pigs and mice. Neuropharmacology, 2000, 39, 1413-1421. (Pubitemid 30249203)
    • (2000) Neuropharmacology , vol.39 , Issue.8 , pp. 1413-1421
    • Rupniak, N.M.J.1    Carlson, E.C.2    Harrison, T.3    Oates, B.4    Seward, E.5    Owen, S.6    De Felipe, C.7    Hunt, S.8    Wheeldon, A.9
  • 57
    • 0036711461 scopus 로고    scopus 로고
    • The gerbil elevated plus-maze I: Behavioral characterization and pharmacological validation
    • DOI 10.1016/S0893-133X(02)00312-3, PII S0893133X02003123
    • Varty, G.B.; Morgan, C.A.; Cohen-Williams, M.E.; Coffin, V.L.; Carey, G.J. The gerbil elevated plus-maze I: behavioral characterization and pharmacological validation. Neuropsychopharmacology, 2002, 27, 357-370. (Pubitemid 35253784)
    • (2002) Neuropsychopharmacology , vol.27 , Issue.3 , pp. 357-370
    • Varty, G.B.1    Morgan, C.A.2    Cohen-Williams, M.E.3    Coffin, V.L.4    Carey, G.J.5
  • 58
    • 45149083874 scopus 로고    scopus 로고
    • Behavioral and pharmacological validation of the gerbil forced-swim test: Effects of neurokinin-1 receptor antagonists
    • DOI 10.1038/sj.npp.1301586, PII 1301586
    • Wallace-Boone, T.L.; Newton, A.E.; Wright, R.N.; Lodge, N.J.; McElroy, J.F. Behavioral and pharmacological validation of the gerbil forced-swim test: effects of neurokinin-1 receptor antagonists. Neuropsychopharmacology, 2008, 33, 1919-1928. (Pubitemid 351832600)
    • (2008) Neuropsychopharmacology , vol.33 , Issue.8 , pp. 1919-1928
    • Wallace-Boone, T.L.1    Newton, A.E.2    Wright, R.N.3    Lodge, N.J.4    McElroy, J.F.5
  • 59
    • 0025090789 scopus 로고
    • Effects of haloperidol and clozapine on preprotachykinin-A messenger RNA, tachykinin tissue levels, release and neurokinin-1 receptors in the striato- nigral system
    • Humpel, C.; Knaus, G.A.; Auer, B.; Knaus, H.G.; Haring, C.; Theodorson, E.; Saria, A. Effects of haloperidol and clozapine on preprotachykinin-A messenger RNA, tachykinin tissue levels, release and neurokinin-1 receptors in the striato- nigral system. Synapse, 1990, 6, 1-9.
    • (1990) Synapse , vol.6 , pp. 1-9
    • Humpel, C.1    Knaus, G.A.2    Auer, B.3    Knaus, H.G.4    Haring, C.5    Theodorson, E.6    Saria, A.7
  • 61
    • 0030580383 scopus 로고    scopus 로고
    • Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat
    • DOI 10.1016/S0006-8993(96)00812-8, PII S0006899396008128
    • Shirayama, Y.; Mitsushio, H.; Takashima, M.; Ichinawa, H.; Takahashi, K. Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat. Brain Res., 1996, 739, 70-78. (Pubitemid 26387364)
    • (1996) Brain Research , vol.739 , Issue.1-2 , pp. 70-78
    • Shirayama, Y.1    Mitsushio, H.2    Takashima, M.3    Ichikawa, H.4    Takahashi, K.5
  • 62
    • 0037331104 scopus 로고    scopus 로고
    • The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test
    • Varty, G.B.; Cohen-Williams, M.E.; Hunter, J.C. The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test. Behav. Pharmacol., 2003, 14, 87-95. (Pubitemid 36279029)
    • (2003) Behavioural Pharmacology , vol.14 , Issue.1 , pp. 87-95
    • Varty, G.B.1    Cohen-Williams, M.E.2    Hunter, J.C.3
  • 64
    • 0023898089 scopus 로고
    • Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides
    • Holzer, P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience, 1988, 24, 739-768.
    • (1988) Neuroscience , vol.24 , pp. 739-768
    • Holzer, P.1
  • 65
    • 1842685406 scopus 로고    scopus 로고
    • Involvement of peripherally released substance P and calcitonin gene-related peptide in mediating mechanical hyperalgesia in a traumatic neuropathy model of the rat
    • DOI 10.1016/j.neulet.2004.02.043, PII S0304394004002368
    • Jang, J.H.; Nam, T.S.; Paik, K.S.; Leem, J.W. Involvement of peripherally released substance P and calcitonin gene-related peptide in mediating mechanical hyperalgesia in a traumatic neuropathy model of the rat. Neurosci. Lett., 2004, 360, 129-132. (Pubitemid 38479750)
    • (2004) Neuroscience Letters , vol.360 , Issue.3 , pp. 129-132
    • Jang, J.H.1    Nam, T.S.2    Paik, K.S.3    Leem, J.W.4
  • 66
    • 36448967916 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonists inhibit the recruitment of opioid-containing leukocytes and impair peripheral antinociception
    • DOI 10.1097/01.anes.0000291454.90754.de, PII 0000054220071200000021
    • Rittner, H.L.; Lux, C.; Labuz, D.; Mousa, S.A.; Achäfer, M.; Stein, C.; Brack, A. Neurokinin-1 receptor antagonists inhibit the recruitment of opioid-containing leukocytes and impair peripheral antinociception. Anesthesiology, 2007, 107, 1009-1017. (Pubitemid 350175684)
    • (2007) Anesthesiology , vol.107 , Issue.6 , pp. 1009-1017
    • Rittner, H.L.1    Lux, C.2    Labuz, D.3    Mousa, S.A.4    Schafer, M.5    Stein, C.6    Brack, A.7
  • 67
    • 0032568417 scopus 로고    scopus 로고
    • Primary afferent tachykinins are required to experience moderate to intense pain
    • DOI 10.1038/32897
    • Cao, Y.Q.; Mantyh, P.W.; Carlson, E.J.; Gillespie, A.M.; Epstein, C.J.; Basbaum, A.I. Primary afferent tachykinins are required to experience moderate to intense pain. Nature, 1998, 392, 390-394. (Pubitemid 28168735)
    • (1998) Nature , vol.392 , Issue.6674 , pp. 390-394
    • Cao, Y.Q.1    Mantyh, P.W.2    Carlson, E.J.3    Gillespie, A.-M.4    Epstein, C.J.5    Basbaum, A.I.6
  • 69
    • 0026570879 scopus 로고
    • The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation
    • Lembeck, F.; Donnerer, J.; Tsuchiya, M.; Nagahisa, A. The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br. J. Pharmacol., 1992, 105, 527-530.
    • (1992) Br. J. Pharmacol , vol.105 , pp. 527-530
    • Lembeck, F.1    Donnerer, J.2    Tsuchiya, M.3    Nagahisa, A.4
  • 70
    • 0025696326 scopus 로고
    • Evidence that endogenous nitric oxide modulates edema formation induced by substance P
    • Hughes, S.R.; Williams, T.J.; Brain, S.D. Evidence that endogenous nitric oxide modulates edema formation induced by substance P. Eur. J. Pharmacol., 1990, 191, 481-484.
    • (1990) Eur. J. Pharmacol , vol.191 , pp. 481-484
    • Hughes, S.R.1    Williams, T.J.2    Brain, S.D.3
  • 71
    • 0032476647 scopus 로고    scopus 로고
    • Identification of a δ isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes
    • DOI 10.1016/S0165-5728(98)00170-2, PII S0165572898001702
    • Lai, J.P.; Douglas, S.D.; Rappaport, E.; Wu, J.M.; Ho, W.Z. Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes. J. Neuroimmunol., 1998, 91, 121-128. (Pubitemid 28545252)
    • (1998) Journal of Neuroimmunology , vol.91 , Issue.1-2 , pp. 121-128
    • Lai, J.-P.1    Douglas, S.D.2    Rappaport, E.3    Wu, J.M.4    Ho, W.-Z.5
  • 73
    • 0023890991 scopus 로고
    • In vivo immunomodulation by the neuropeptide substance P
    • Scicchinato, R.; Biennenstock, J.; Stanisz, A.M. In vivo immunomodulation by the neuropeptide substance P. Immunology, 1988, 63, 733-735.
    • (1988) Immunology , vol.63 , pp. 733-735
    • Scicchinato, R.1    Biennenstock, J.2    Stanisz, A.M.3
  • 74
    • 0027195970 scopus 로고
    • Modulation of T lymphocyte function by neuropeptides: Evidence for their role as local immunoregulatory elements
    • Nio, D.A.; Moylan, R.N.; Roche, J.K. Modulation of T lymphocyte function by neuropeptides. Evidence for their role as local immunoregulatory elements. J. Immunol., 1993, 150, 5281-5288. (Pubitemid 23180641)
    • (1993) Journal of Immunology , vol.150 , Issue.12 , pp. 5281-5288
    • Nio, D.A.1    Moylan, R.N.2    Roche, J.K.3
  • 76
    • 0026533638 scopus 로고
    • Migraine: Theories of pathogenesis
    • Blau, J.N. Migraine: theories of pathogenesis. Lancet, 1992, 339, 1202-1207.
    • (1992) Lancet , vol.339 , pp. 1202-1207
    • Blau, J.N.1
  • 77
    • 0026027912 scopus 로고
    • The visceral organ grain: Implications for the pathophysiology of vascular head pain
    • Moskowitz, MA. The visceral organ grain: implications for the pathophysiology of vascular head pain. Neurology, 1991, 41, 182-186.
    • (1991) Neurology , vol.41 , pp. 182-186
    • Moskowitz, MA.1
  • 78
    • 0035057675 scopus 로고    scopus 로고
    • Depletion of substance P, neurokinin A and calcitonin gene-related peptide from the contralateral and ipsilateral caudal trigeminal nucleus following unilateral electrical stimulation of the trigeminal ganglion; a possible neurophysiological and neuroanatomical link to generalized head pain
    • DOI 10.1016/S0891-0618(01)00088-6, PII S0891061801000886
    • Samsam, M.; Coveñas, R.; Csillik, B.; Ahangari, R.; Yajeya, J.; Riquelme, R.; Narváez, J.A.; Tramu, G. Depletion of substance P, neurokinin A and calcitonin gene-related peptide from the contralateral and ipsilateral caudal trigeminal nucleus following unilateral electrical stimulation of the trigeminal ganglion: a possible neurophysiological and neuroanatomical link to generalized head pain. J. Chem. Neuroanat., 2001, 21, 161-169. (Pubitemid 32324239)
    • (2001) Journal of Chemical Neuroanatomy , vol.21 , Issue.2 , pp. 161-169
    • Samsam, M.1    Covenas, R.2    Csillik, B.3    Ahangari, R.4    Yajeya, J.5    Riquelme, R.6    Narvaez, J.A.7    Tramu, G.8
  • 79
    • 0036171973 scopus 로고    scopus 로고
    • Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
    • DOI 10.1038/nm0202-136
    • Bolay, H.; Reuter, U.; Dunn, A.K.; Huang, Z.; Boas, D.A.; Moskowitz, M.A. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat. Med., 2002, 8, 136-142. (Pubitemid 34155124)
    • (2002) Nature Medicine , vol.8 , Issue.2 , pp. 136-142
    • Bolay, H.1    Reuter, U.2    Dunn, A.K.3    Huang, Z.4    Boas, D.A.5    Moskowitz, M.A.6
  • 80
    • 0034636497 scopus 로고    scopus 로고
    • Rewarding effects of opiates are absent in mice lacking the receptor for substance P
    • DOI 10.1038/35012069
    • Murtra, P.; Sheasby, A.M.; Hunt, S.P.; de Felipe, C. Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Nature, 2000, 405, 180-3. (Pubitemid 30313535)
    • (2000) Nature , vol.405 , Issue.6783 , pp. 180-183
    • Murtra, P.1    Sheasby, A.M.2    Hunt, S.P.3    De Felipe, C.4
  • 81
    • 0028006409 scopus 로고
    • Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens
    • DOI 10.1016/0165-0173(94)90002-7
    • Angulo, J.A.; McEwen, B.S. Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens. Brain Res.Brain Res.Rev., 1994, 19, 1-28. (Pubitemid 24024082)
    • (1994) Brain Research Reviews , vol.19 , Issue.1 , pp. 1-28
    • Angulo, J.A.1    McEwen, B.S.2
  • 82
    • 0025647094 scopus 로고
    • Striatal dopamine and glutamate release: Effects of intranigral injections of substance P
    • Reid, M.S.; Herrera-Marschitz, M.; Kehr, J.; Ungerstedt, U. Striatal dopamine and glutamate release: effects of intranigral injections of substance P. Acta Physiol. Scand., 1990, 140, 527-537.
    • (1990) Acta Physiol. Scand , vol.140 , pp. 527-537
    • Reid, M.S.1    Herrera-Marschitz, M.2    Kehr, J.3    Ungerstedt, U.4
  • 83
    • 0025042666 scopus 로고
    • Effects of intranigral substance P and neurokinin A on striatal dopamine release - I. Interactions with substance P antagonists
    • DOI 10.1016/0306-4522(90)90007-Q
    • Reid, M.S.; Herrera-Marschitz, M.; Hökfelt, T.; Ohlin, M.; Valentino, K.L.; Ungerstedt, U. Effects of intranigral substance P and neurokinin A on striatal dopamine release - I. Interactions with substance P antagonists. Neuroscience, 1990, 36, 643-658. (Pubitemid 20282179)
    • (1990) Neuroscience , vol.36 , Issue.3 , pp. 643-658
    • Reid, M.S.1    Herrera-Marschitz, M.2    Hokfelt, T.3    Ohlin, M.4    Valentino, K.L.5    Ungerstedt, U.6
  • 84
    • 0036829194 scopus 로고    scopus 로고
    • Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain
    • DOI 10.1046/j.1471-4159.2002.01155.x
    • Yu, J.; Cadet, J.L.; Angulo, J.A. Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain. J. Neurochem., 2002, 83, 613-622. (Pubitemid 35231815)
    • (2002) Journal of Neurochemistry , vol.83 , Issue.3 , pp. 613-622
    • Yu, J.1    Cadet, J.L.2    Angulo, J.A.3
  • 86
    • 0032185613 scopus 로고    scopus 로고
    • 1 receptor antagonist, CP-122,721-1, attenuates kainic acid-induced seizure activity
    • DOI 10.1016/S0169-328X(98)00191-0, PII S0169328X98001910
    • Zachrisson, O.; Lindefor, N.; Brené, S. A tachykinin NK1 receptor antagonist, CP-122,721, attenuates kainic acid-induced seizure activity. Brain Res. Mol. Brain Res., 1998, 60, 291-295. (Pubitemid 28466593)
    • (1998) Molecular Brain Research , vol.60 , Issue.2 , pp. 291-295
    • Zachrisson, O.1    Lindefors, N.2    Brene, S.3
  • 87
    • 0030790069 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonist SR140333: A novel type of drug to treat cerebral ischemia
    • Yu, Z.; Cheng, G.; Huang, X.; Li, K.; Cao, X. Neurokinin-1 receptor antagonist SR-140,333: a novel type of drug to treat cerebral ischemia. Neuroreport, 1997, 8, 2117-2119. (Pubitemid 27319656)
    • (1997) NeuroReport , vol.8 , Issue.9-10 , pp. 2117-2119
    • Yu, Z.1    Cheng, G.2    Huang, X.3    Li, K.4    Cao, X.5
  • 89
    • 1342287208 scopus 로고    scopus 로고
    • Neurokinin-1 Receptor Antagonists Protect Mice from CD95- and Tumor Necrosis Factor-α-Mediated Apoptotic Liver Damage
    • DOI 10.1124/jpet.103.059329
    • Bang, R.; Biburger, M.; Neuhuber, W.L.; Tiegs, G. Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-alphamediated apoptotic liver damage. J. Pharmacol. Exp. Ther., 2004, 308, 1174-1180. (Pubitemid 38263995)
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.308 , Issue.3 , pp. 1174-1180
    • Bang, R.1    Biburger, M.2    Neuhuber, W.L.3    Tiegs, G.4
  • 90
    • 77956624273 scopus 로고    scopus 로고
    • Serum concentrations of substance P in cholestasis
    • Trivedi, M.; Bergasa, N.V. Serum concentrations of substance P in cholestasis. Ann. Hepatol., 2010, 9, 177-180.
    • (2010) Ann. Hepatol. , vol.9 , pp. 177-180
    • Trivedi, M.1    Bergasa, N.V.2
  • 91
    • 77956193969 scopus 로고    scopus 로고
    • Targeting the neurokinin receptor 1 with aprepitant: A novel antipruritic strategy
    • Ständer, S.; Siepmann, D.; Herrgott, I.; Sunderkötter, C.; Luger, T.A. Targeting the neurokinin receptor 1 with aprepitant: a novel antipruritic strategy. PLoS One, 2010, 5, e10968.
    • (2010) PLoS One , vol.5
    • Ständer, S.1    Siepmann, D.2    Herrgott, I.3    Sunderkötter, C.4    Luger, T.A.5
  • 92
    • 0033992327 scopus 로고    scopus 로고
    • Substance P activates NFkappaB independent of elevations in intracellular calcium in murine macrophages and dendritic cells
    • Marriott, I.; Mason, M.J.; Elhofy, A.; Bost, K.L. Substance P activates NFkappaB independent of elevations in intracellular calcium in murine macrophages and dendritic cells. J. Neuroimmunol., 2000, 102, 163-171.
    • (2000) J. Neuroimmunol , vol.102 , pp. 163-171
    • Marriott, I.1    Mason, M.J.2    Elhofy, A.3    Bost, K.L.4
  • 93
    • 0031573083 scopus 로고    scopus 로고
    • The Neuropeptide Substance P Activates Transcription Factor NF-κB and κB-Dependent Gene Expression in Human Astrocytoma Cells
    • Lieb, K.; Fiebich, B.L.; Berger, M.; Bauer, J.; Schulze-Osthoff, K. The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells. J. Immunol., 1997, 159, 4952-4958. (Pubitemid 127471032)
    • (1997) Journal of Immunology , vol.159 , Issue.10 , pp. 4952-4958
    • Lieb, K.1    Fiebich, B.L.2    Berger, M.3    Bauer, J.4    Schulze-Osthoff, K.5
  • 94
    • 0023753067 scopus 로고
    • Effect of neuropeptides on production of inflammatory cytokines by human monocytes
    • Lotz, M.; Vaughan, J.H.; Carson, D.A. Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science, 1988, 241, 1218-1221.
    • (1988) Science , vol.241 , pp. 1218-1221
    • Lotz, M.1    Vaughan, J.H.2    Carson, D.A.3
  • 95
    • 0025270459 scopus 로고
    • The neuropeptide substance P stimulates production of interleukin 1 in human blood monocytes: activated cells are preferentially influenced by the neuropeptide
    • Laurenzi, M.A.; Persson, M.A.; Dalsgaard, C.J.; Haegerstrand, A. The neuropeptide substance P stimulates production of interleukin 1 in human blood monocytes: activated cells are preferentially influenced by the neuropeptide. Scand. J. Immunol., 1990, 31, 529-533. (Pubitemid 20121231)
    • (1990) Scandinavian Journal of Immunology , vol.31 , Issue.4 , pp. 529-533
    • Laurenzi, M.A.1    Persson, M.A.A.2    Dalsgaard, C.-J.3    Haegerstrand, A.4
  • 96
    • 0031092708 scopus 로고    scopus 로고
    • Substance P-Induced IL-12 Production by Murine Macrophages
    • Kincy-Cain, T.; Bost, K.L. Substance P-induced IL-12 production by murine macrophages. J. Immunol., 1997, 158, 2334-2339. (Pubitemid 127470019)
    • (1997) Journal of Immunology , vol.158 , Issue.5 , pp. 2334-2339
    • Kincy-Cain, T.1    Bost, K.L.2
  • 97
    • 44949266148 scopus 로고
    • Immunopathogenic mechanisms of HIV infection: Cytokine induction of HIV expression
    • Rosenberg, Z.F.; Fauci, A.S. Immunopathogenic mechanisms of HIV infection: cytokine induction of HIV expression. Immunol. Today, 1990, 11, 176-180. (Pubitemid 20118082)
    • (1990) Immunology Today , vol.11 , Issue.5 , pp. 176-180
    • Rosenberg, Z.F.1    Fauci, A.S.2
  • 98
    • 0025887046 scopus 로고
    • Immunopathogenesis of HIV infection
    • Rosenberg, Z.F.; Fauci, A.S. Immunopathogenesis of HIV infection. FASEB J., 1991, 5, 2382-2390. (Pubitemid 21905785)
    • (1991) FASEB Journal , vol.5 , Issue.10 , pp. 2382-2390
    • Rosenberg, Z.F.1    Fauci, A.S.2
  • 99
    • 0024987339 scopus 로고
    • Substance P production by P388D1 macrophages: A possible autocrine function for this neuropeptide
    • Pascual, D.W.; Bost, K.L. Substance P production by P388D1 macrophages: a possible autocrine function for this neuropeptide. Immunology, 1990, 71, 52-56. (Pubitemid 20296071)
    • (1990) Immunology , vol.71 , Issue.1 , pp. 52-56
    • Pascual, D.W.1    Bost, K.L.2
  • 101
    • 0031301905 scopus 로고    scopus 로고
    • Human Monocytes and Macrophages Express Substance P and Neurokinin-1 Receptor
    • Ho, W.Z.; Lai, J.P.; Zhu, X.H.; Uvaydova, M.; Douglas, S.D. Human monocytes and macrophages express substance P and neurokinin-1 receptor. J. Immunol., 1997, 159, 5654-5660. (Pubitemid 127470097)
    • (1997) Journal of Immunology , vol.159 , Issue.11 , pp. 5654-5660
    • Ho, W.-Z.1    Lai, J.-P.2    Zhu, X.-H.3    Uvaydova, M.4    Douglas, S.D.5
  • 102
    • 0026725160 scopus 로고
    • Modulation of the mRNAs encoding substance P and its receptor in rat macrophages by LPS
    • Bost, K.L.; Breeding, S.A.; Pascual, D.W. Modulation of the mRNAs encoding substance P and its receptor in rat macrophages by LPS. Reg. Immunol., 1992, 4, 105-112.
    • (1992) Reg. Immunol , vol.4 , pp. 105-112
    • Bost, K.L.1    Breeding, S.A.2    Pascual, D.W.3
  • 105
    • 0032564521 scopus 로고    scopus 로고
    • HIV-1 gp120 increases the permeability of rat brain endothelium cultures by a mechanism involving substance P
    • Annunziata, P.; Cioni, C.; Toneatto, S.; Paccagnini, E. HIV-1 gp120 increases the permeability of rat brain endothelium cultures by a mechanism involving substance P. AIDS, 1998, 12, 2377-2385. (Pubitemid 28558595)
    • (1998) AIDS , vol.12 , Issue.18 , pp. 2377-2385
    • Annunziata, P.1    Cioni, C.2    Toneatto, S.3    Paccagnini, E.4
  • 106
    • 0032761967 scopus 로고    scopus 로고
    • Evidence of blood-brain barrier alteration and activation in HIV-1 gp120 transgenic mice
    • Toneatto, S.; Finco, O.; van der Putten, H.; Abrignani, S.; Annunziata, P. Evidence of blood-brain barrier alteration and activation in HIV-1 gp120 transgenic mice. AIDS, 1999, 13, 2343-2348.
    • (1999) AIDS , vol.13 , pp. 2343-2348
    • Toneatto, S.1    Finco, O.2    Van Der Putten, H.3    Abrignani, S.4    Annunziata, P.5
  • 107
    • 0030040791 scopus 로고    scopus 로고
    • Substance P modulates human immunodeficiency virus replication in human peripheral blood monocyte-derived macrophages
    • Ho, W.Z.; Cnaan, A.; Li, Y.H.; Zhao, H.; Lee, H.R.; Song, L.; Douglas, S.D. Substance P modulates human immunodeficiency virus replication in human peripheral blood monocyte-derived macrophages. AIDS Res. Hum. Retroviruses, 1996, 12, 195-198. (Pubitemid 26054163)
    • (1996) AIDS Research and Human Retroviruses , vol.12 , Issue.3 , pp. 195-198
    • Wen-Zhe, H.1    Cnaan, A.2    Li, Y.-H.3    Zhao, H.4    Lee, H.-R.5    Song, L.6    Douglas, S.D.7
  • 109
    • 85047690901 scopus 로고    scopus 로고
    • Aprepitant a novel NK1-receptor antagonist
    • Patel, L.; Lindley, C. Aprepitant, a novel NK1-receptor antagonist. Expert. Opin. Pharmacother., 2003, 4, 2279-2296.
    • (2003) Expert. Opin. Pharmacother , vol.4 , pp. 2279-2296
    • Patel, L.1    Lindley, C.2
  • 110
    • 33846822055 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonist (aprepitant) inhibits drug-resistant HIV-1 infection of macrophages in vitro
    • Wang, X.; Douglas, S.D.; Lai, J.P.; Tuluc, F.; Tebas, P.; Ho, W.Z. Neurokinin-1 receptor antagonist (aprepitant) inhibits drug-resistant HIV-1 infection of macrophages in vitro. J. Neuroimmune Pharmacol., 2007, 2, 42-48.
    • (2007) J. Neuroimmune Pharmacol , vol.2 , pp. 42-48
    • Wang, X.1    Douglas, S.D.2    Lai, J.P.3    Tuluc, F.4    Tebas, P.5    Ho, W.Z.6
  • 115
    • 34247261574 scopus 로고    scopus 로고
    • Neurokinin-1 enables measles virus trans-synaptic spread in neurons
    • DOI 10.1016/j.virol.2007.02.033, PII S0042682207001328
    • Makhortova, N.R.; Askovich, P.; Patterson, C.E.; Gechman, L.A.; Gerard, N.P.; Rall, G.F. Neurokinin-1 enables measles virus trans-synaptic spread in neurons. Virology, 2007, 362, 235-244. (Pubitemid 46617700)
    • (2007) Virology , vol.362 , Issue.1 , pp. 235-244
    • Makhortova, N.R.1    Askovich, P.2    Patterson, C.E.3    Gechman, L.A.4    Gerard, N.P.5    Rall, G.F.6
  • 116
    • 77950639335 scopus 로고    scopus 로고
    • A new frontier in the treatment of cancer: NK-1 receptor antagonists
    • Muñoz, M.; Rosso, M.; Coveñas, R. A new frontier in the treatment of cancer: NK-1 receptor antagonists. Curr. Med. Chem., 2010, 17, 504-516.
    • (2010) Curr. Med. Chem. , vol.17 , pp. 504-516
    • Muñoz, M.1    Rosso, M.2    Coveñas, R.3
  • 117
    • 77952240278 scopus 로고    scopus 로고
    • The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug
    • Muñoz, M.; Rosso, M. The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug. Invest. New Drugs, 2010, 28, 187-193.
    • (2010) Invest. New Drugs , vol.28 , pp. 187-193
    • Muñoz, M.1    Rosso, M.2
  • 119
    • 0024163078 scopus 로고
    • 11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro
    • DOI 10.1073/pnas.85.6.1859
    • Woll, P.J.; Rozengurt E. [D-Arg1-D-Phe5, D-Trp7, 9, Leu11] Substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc. Natl. Acad. Sci. USA, 1988, 35, 1859-1863. (Pubitemid 24315783)
    • (1988) Proceedings of the National Academy of Sciences of the United States of America , vol.85 , Issue.6 , pp. 1859-1863
    • Woll, P.J.1    Rozengurt, E.2
  • 120
    • 27644463170 scopus 로고    scopus 로고
    • Role of NK-1 and NK-2 tachykinin receptor antagonism on the growth of human breast carcinoma cell line MDA-MB-231
    • DOI 10.1097/00001813-200511000-00007
    • Bigioni, M.; Benzo, A.; Irrissuto, C.; Maggi, C.A.; Goso, C. Role of NK-1 and NK-2 tachykinin receptor antagonism on the growth of human breast carcinoma cell line MDA-MB-231. Anticancer Drugs, 2005, 16, 1083-1089. (Pubitemid 41565774)
    • (2005) Anti-Cancer Drugs , vol.16 , Issue.10 , pp. 1083-1089
    • Bigioni, M.1    Benzo, A.2    Irrissuto, C.3    Maggi, C.A.4    Goso, C.5
  • 121
    • 33646558897 scopus 로고    scopus 로고
    • A role for substance P in cancer promotion and progression: A mechanism to counteract intracellular death signals following oncogene activation or DNA damage
    • DOI 10.1007/s10555-006-8161-9, Metalloproteinases and Cancer
    • Esteban, F.; Muñoz, M.; González-Moles, M.A.; Rosso, M. A role for substance P in cancer promotion and progression: a mechanism to counteract intracellular death signals following oncogene activation or DNA damage. Cancer Metast. Rev., 2006, 25, 137-145. (Pubitemid 43723988)
    • (2006) Cancer and Metastasis Reviews , vol.25 , Issue.1 , pp. 137-145
    • Esteban, F.1    Munoz, M.2    Gonzalez-Moles, M.A.3    Rosso, M.4
  • 122
    • 0028174947 scopus 로고
    • [D-Arg1-D-Phe5, D-Trp7, 9, Leu11] Substance P induces apoptosis in lung cancer cell lines in vitro
    • Reeve, J.G.; Bleehen, N.M. [D-Arg1-D-Phe5, D-Trp7, 9, Leu11] Substance P induces apoptosis in lung cancer cell lines in vitro. Biochem. Bioph. Res. Com., 1994, 199, 1313-1319.
    • (1994) Biochem. Bioph. Res. Com , vol.199 , pp. 1313-1319
    • Reeve, J.G.1    Bleehen, N.M.2
  • 123
    • 0032413398 scopus 로고    scopus 로고
    • Induction of apoptosis by a short-chain neuropeptide analog in small cell lung cancer-stimulation of multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo
    • Rosati, R.; Adil, M.R.; Ali, M.A.; Eliason, J.; Orosz, A.; Sebestye, N.F.; Kalemkerian, G.P. Induction of apoptosis by a short-chain neuropeptide analog in small cell lung cancer-stimulation of multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo. Peptides, 1998, 19, 1519-1523.
    • (1998) Peptides , vol.19 , pp. 1519-1523
    • Rosati, R.1    Adil, M.R.2    Ali, M.A.3    Eliason, J.4    Orosz, A.5    Sebestye, N.F.6    Kalemkerian, G.P.7
  • 124
    • 0029961467 scopus 로고    scopus 로고
    • Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway
    • Luo, W.; Sharif, T.R.; Sharif, M. Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway. Cancer Res., 1996, 56, 4983-4991. (Pubitemid 26374439)
    • (1996) Cancer Research , vol.56 , Issue.21 , pp. 4983-4991
    • Luo, W.1    Sharif, T.R.2    Sharif, M.3
  • 125
    • 0034718604 scopus 로고    scopus 로고
    • The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta-arrestin-dependent scaffolding complex
    • DeFea, K.A.; Vaughn, Z.D.; O'Bryan, E.M.; Nishijima, D.; Dery, O.; Bunnett, N.W: The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta-arrestin-dependent scaffolding complex. Proc. Natl. Acad. Sci. USA., 2000, 97, 11086-11091.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11086-11091
    • Defea, K.A.1    Vaughn, Z.D.2    O'Bryan, E.M.3    Nishijima, D.4    Dery, O.5    Bunnett, N.W.6
  • 126
    • 65649138814 scopus 로고    scopus 로고
    • A constiutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas
    • Akazawa, T.; Kwatra, S.G.; Goldsmith, L.E.; Richardson, M.D.; Cox. E.A.; Sampom, J.H.; Kwatra, M.M. A constiutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas. J. Neurochem., 2009, 109, 1079-1086.
    • (2009) J. Neurochem , vol.109 , pp. 1079-1086
    • Akazawa, T.1    Kwatra, S.G.2    Goldsmith, L.E.3    Richardson, M.D.4    Cox, E.A.5    Sampom, J.H.6    Kwatra, M.M.7
  • 128
    • 0025092876 scopus 로고
    • Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells
    • DOI 10.1016/0026-2862(90)90024-L
    • Ziche, M.; Morbidelli, L.; Pacini, M.; Geppetti, P.; Alessandri, G.; Maggi, C.A. Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells. Microvasc. Res., 1990, 40, 264-278. (Pubitemid 20327679)
    • (1990) Microvascular Research , vol.40 , Issue.2 , pp. 264-278
    • Ziche, M.1    Morbidelli, L.2    Pacini, M.3    Geppetti, P.4    Alessandri, G.5    Maggi, C.A.6
  • 129
    • 0029071971 scopus 로고
    • Substance-P receptors in human primary neoplasms: Tumoral and vascular localization
    • Hennig, I.M.; Laissue, J.A.; Horisberger, U.; Reubi, J.C. Substance-P receptors in human primary neoplasms: tumoral and vascular localization. Int. J. Cancer., 1995, 61, 786-792.
    • (1995) Int. J. Cancer , vol.61 , pp. 786-792
    • Hennig, I.M.1    Laissue, J.A.2    Horisberger, U.3    Reubi, J.C.4
  • 131
    • 16844365620 scopus 로고    scopus 로고
    • 11]SP: A dual inhibitor of growth and angiogenesis in pancreatic cancer
    • DOI 10.1158/0008-5472.CAN-04-3197
    • Guha, S.; Eibl, G.; Kisfalvi, K.; Fan, R.S.; Burdick, M.; Reber, H; Hines, O.J.; Strieter, R.; Rozengurt, E. Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,DTrp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res., 2005, 65, 2738-2745. (Pubitemid 40490075)
    • (2005) Cancer Research , vol.65 , Issue.7 , pp. 2738-2745
    • Guha, S.1    Eibl, G.2    Kisfalvi, K.3    Fan, R.S.4    Burdick, M.5    Reber, H.6    Hines, O.J.7    Strieter, R.8    Rozengurt, E.9
  • 133
    • 4544321026 scopus 로고    scopus 로고
    • Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs
    • DOI 10.1002/ijc.20410
    • Lang, K.; Drell, T.L.; Lindecke, A.; Niggemann, B.; Kaltschmidt, C.; Zaenker, K.S.; Entschladen, F. Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int. J. Cancer, 2004, 112, 231-238. (Pubitemid 39244363)
    • (2004) International Journal of Cancer , vol.112 , Issue.2 , pp. 231-238
    • Lang, K.1    Drell IV, T.L.2    Lindecke, A.3    Niggemann, B.4    Kaltschmidt, C.5    Zaenker, K.S.6    Entschladen, F.7
  • 134
    • 33749165919 scopus 로고    scopus 로고
    • Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis?
    • DOI 10.1097/00000542-200610000-00008, PII 0000054220061000000008
    • Exadaktylos, A.K.; Buggy, D.J.; Moriarty, D.C.; Mascha, E.; Sessler, D.I. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology, 2006, 105, 660-664. (Pubitemid 44477309)
    • (2006) Anesthesiology , vol.105 , Issue.4 , pp. 660-664
    • Exadaktylos, A.K.1    Buggy, D.J.2    Moriarty, D.C.3    Mascha, E.4    Sessler, D.I.5
  • 135
    • 77955653145 scopus 로고    scopus 로고
    • Paravertebral anesthesia: How substance P and the NK-1 receptor could be involved in regional block and breast cancer recurrence
    • Muñoz, M.; Rosso, M.; Casinello, F.; Coveñas, R. Paravertebral anesthesia: how substance P and the NK-1 receptor could be involved in regional block and breast cancer recurrence. Breast Cancer Res. Treat., 2010, 122, 601-603.
    • (2010) Breast Cancer Res. Treat. , vol.122 , pp. 601-603
    • Muñoz, M.1    Rosso, M.2    Casinello, F.3    Coveñas, R.4
  • 136
    • 79953669021 scopus 로고    scopus 로고
    • The NK-1 receptor: A new target in cancer therapy
    • in press
    • Muñoz, M.; Rosso, M.; Coveñas, R. The NK-1 receptor: a new target in cancer therapy. Curr. Drug Targets, 2011, 12, (in press).
    • (2011) Curr. Drug Targets , vol.12
    • Muñoz, M.1    Rosso, M.2    Coveñas, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.