Opiate-induced dopamine release is modulated by severity of alcohol dependence: An [ 18F]fallypride positron emission tomography study

Biological Psychiatry

Volumn 70, Issue 8, 2011, Pages 770-776

  Spreckelmeyer, Katja N ^a   Paulzen, Michael ^a   Raptis, Mardjan ^a   Baltus, Thomas ^a   Schaffrath, Sabrina ^a   Van Waesberghe, Julia ^a   Zalewski, Magdalena M ^a   Rösch, Frank ^b   Vernaleken, Ingo ^a   Schfer, Wolfgang M ^c   Grnder, Gerhard ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c Krankenhaus St Franziskus   (Germany)

Author keywords

opioid receptors; Alcohol dependence; dopamine receptor availability; opioid dopamine interaction; positron emission tomography; reward

Indexed keywords

ALCOHOL; BETA ENDORPHIN; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; FALLYPRIDE F 18; REMIFENTANIL; TRACER; UNCLASSIFIED DRUG;

ADULT; ALCOHOLISM; AMYGDALOID NUCLEUS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DETOXIFICATION; DISEASE SEVERITY; DOPAMINE RELEASE; HUMAN; MALE; MESOLIMBIC DOPAMINERGIC SYSTEM; PHARMACOLOGICAL STIMULATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; SINGLE DRUG DOSE;

ADULT; ALCOHOLISM; ANALGESICS, OPIOID; BEHAVIOR, ADDICTIVE; BENZAMIDES; DOPAMINE; FLUORINE RADIOISOTOPES; FUNCTIONAL NEUROIMAGING; HUMANS; LIMBIC SYSTEM; MALE; MIDDLE AGED; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; PYRROLIDINES; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; RECEPTORS, OPIOID, MU; SEVERITY OF ILLNESS INDEX;

EID: 80053575167     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.05.035     Document Type: Article

References (52)

1. G. Di Chiara, and A. Imperato Preferential stimulation of dopamine release in the nucleus accumbens by opiates, alcohol, and barbiturates: Studies with transcerebral dialysis in freely moving rats Ann N Y Acad Sci 473 1986 367 381 (Pubitemid 17005422)
2. G.L. Gessa, F. Muntoni, M. Collu, L. Vargiu, and G. Mereu Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area Brain Res 348 1985 201 203 (Pubitemid 16235764)
3. G. Di Chiara, and A. Imperato Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats Proc Natl Acad Sci U S A 85 1988 5274 5278
4. N.B. Urban, L.S. Kegeles, M. Slifstein, X. Xu, D. Martinez, and E. Sakr Sex differences in striatal dopamine release in young adults after oral alcohol challenge: A positron emission tomography imaging study with [(1)(1)C]raclopride Biol Psychiatry 68 2010 689 696
5. I. Boileau, J.M. Assaad, R.O. Pihl, C. Benkelfat, M. Leyton, and M. Diksic Alcohol promotes dopamine release in the human nucleus accumbens Synapse 49 2003 226 231 (Pubitemid 36927963)
6. K.K. Yoder, E.D. Morris, C.C. Constantinescu, T.E. Cheng, M.D. Normandin, and S.J. O'Connor When what you see isn't what you get: Alcohol cues, alcohol administration, prediction error, and human striatal dopamine Alcohol Clin Exp Res 33 2009 139 149
7. K.K. Yoder, C.C. Constantinescu, D.A. Kareken, M.D. Normandin, T.E. Cheng, and S.J. O'Connor Heterogeneous effects of alcohol on dopamine release in the striatum: A PET study Alcohol Clin Exp Res 31 2007 965 973 (Pubitemid 46776176)
8. I. Salonen, J. Hietala, A. Laihinen, P. Lehikoinen, L. Leino, and K. Nagren A PET study on the acute effect of ethanol on striatal D2 dopamine receptors with [11C]raclopride in healthy males Human Psychopharmacology: Clinical and Experimental 12 1997 145 152 (Pubitemid 27224226)
9. V. Vengeliene, A. Bilbao, A. Molander, and R. Spanagel Neuropharmacology of alcohol addiction Br J Pharmacol 154 2008 299 315 (Pubitemid 351670598)
10. A. Herz Endogenous opioid systems and alcohol addiction Psychopharmacology (Berl) 129 1997 99 111 (Pubitemid 27033665)
11. S.W. Johnson, and R.A. North Opioids excite dopamine neurons by hyperpolarization of local interneurons J Neurosci 12 1992 483 488
12. N. Hagelberg, J.K. Kajander, K. Nagren, S. Hinkka, J. Hietala, and H. Scheinin Mu-receptor agonism with alfentanil increases striatal dopamine D2 receptor binding in man Synapse 45 2002 25 30 (Pubitemid 34595060)
13. M.R. Daglish, T.M. Williams, S.J. Wilson, L.G. Taylor, C.B. Eap, and M. Augsburger Brain dopamine response in human opioid addiction Br J Psychiatry 193 2008 65 72 (Pubitemid 351946810)
14. J.P. De Waele, D.N. Papachristou, and C. Gianoulakis The alcohol-preferring C57BL/6 mice present an enhanced sensitivity of the hypothalamic beta-endorphin system to ethanol than the alcohol-avoiding DBA/2 mice J Pharmacol Exp Ther 261 1992 788 794
15. I.L. Petrakis, L. Trevisan, C. D'Souza, R. Gil, S. Krasnicki, and E. Webb CSF monoamine metabolite and beta endorphin levels in recently detoxified alcoholics and healthy controls: Prediction of alcohol cue-induced craving? Alcoholism Clin Exp Res 23 1999 1336 1341 (Pubitemid 29409347)
16. C. Gianoulakis, B. Krishnan, and J. Thavundayil Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects at high risk of alcoholism Arch Gen Psychiatry 53 1996 250 257 (Pubitemid 26085207)
17. A. Heinz, M. Reimold, J. Wrase, D. Hermann, B. Croissant, and G. Mundle Correlation of stable elevations in striatal mu-opioid receptor availability in detoxified alcoholic patients with alcohol craving: A positron emission tomography study using carbon 11-labeled carfentanil Arch Gen Psychiatry 62 2005 57 64 (Pubitemid 40096071)
18. N.D. Volkow, G.J. Wang, J.S. Fowler, J. Logan, R. Hitzemann, and Y.S. Ding Decreases in dopamine receptors but not in dopamine transporters in alcoholics Alcohol Clin Exp Res 20 1996 1594 1598 (Pubitemid 26428110)
19. A. Heinz, T. Siessmeier, J. Wrase, D. Hermann, S. Klein, and S.M. Grusser Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving Am J Psychiatry 161 2004 1783 1789 (Pubitemid 39314671)
20. J. Guardia, A.M. Catafau, F. Batlle, J.C. Martin, L. Segura, and B. Gonzalvo Striatal dopaminergic D(2) receptor density measured by [(123)I]iodobenzamide SPECT in the prediction of treatment outcome of alcohol-dependent patients Am J Psychiatry 157 2000 127 129 (Pubitemid 30027434)
21. D. Martinez, R. Gil, M. Slifstein, D.R. Hwang, Y. Huang, and A. Perez Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum Biol Psychiatry 58 2005 779 786 (Pubitemid 41677416)
22. N.D. Volkow, G.J. Wang, F. Telang, J.S. Fowler, J. Logan, and M. Jayne Profound decreases in dopamine release in striatum in detoxified alcoholics: Possible orbitofrontal involvement J Neurosci 27 2007 12700 12706 (Pubitemid 350127825)
23. C. Fehr, I. Yakushev, N. Hohmann, H.G. Buchholz, C. Landvogt, and H. Deckers Association of low striatal dopamine d2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse Am J Psychiatry 165 2008 507 514 (Pubitemid 351694294)
24. N.D. Volkow, J.S. Fowler, A.P. Wolf, D. Schlyer, C.Y. Shiue, and R. Alpert Effects of chronic cocaine abuse on postsynaptic dopamine receptors Am J Psychiatry 147 1990 719 724 (Pubitemid 20188509)
25. N.D. Volkow, G.J. Wang, F. Telang, J.S. Fowler, J. Logan, and A.R. Childress Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues Neuroimage 39 2008 1266 1273
26. A.D. Smith, and F. Weiss Ethanol exposure differentially alters central monoamine neurotransmission in alcohol-preferring versus -nonpreferring rats J Pharmacol Exp Ther 288 1999 1223 1228 (Pubitemid 29254162)
27. D. Bustamante, M.E. Quintanilla, L. Tampier, V. Gonzalez-Lira, Y. Israel, and M. Herrera-Marschitz Ethanol induces stronger dopamine release in nucleus accumbens (shell) of alcohol-preferring (bibulous) than in alcohol-avoiding (abstainer) rats Eur J Pharmacol 591 2008 153 158
28. R. Spanagel, A. Herz, and T.S. Shippenberg Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway Proc Natl Acad Sci U S A 89 1992 2046 2050
29. G. Grnder, T. Siessmeier, M. Piel, I. Vernaleken, H.G. Buchholz, and Y. Zhou Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride J Nucl Med 44 2003 109 116 (Pubitemid 36077721)
30. D. Stark, M. Piel, H. Hubner, P. Gmeiner, G. Grunder, and F. Rosch In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors Bioorg Med Chem 15 2007 6819 6829 (Pubitemid 47385236)
31. R.P. Woods, S.R. Cherry, and J.C. Mazziotta Rapid automated algorithm for aligning and reslicing PET images J Comput Assist Tomogr 16 1992 620 633
32. R.N. Gunn, A.A. Lammertsma, S.P. Hume, and V.J. Cunningham Parametric imaging of ligand-receptor binding in PET using a simplified reference region model Neuroimage 6 1997 279 287 (Pubitemid 28018717)
33. T. Siessmeier, Y. Zhou, H.G. Buchholz, C. Landvogt, I. Vernaleken, and M. Piel Parametric mapping of binding in human brain of D2 receptor ligands of different affinities J Nucl Med 46 2005 964 972 (Pubitemid 43733511)
34. O. Mawlawi, D. Martinez, M. Slifstein, A. Broft, R. Chatterjee, and D.R. Hwang Imaging human mesolimbic dopamine transmission with positron emission tomography: I Accuracy and precision of D(2) receptor parameter measurements in ventral striatum J Cereb Blood Flow Metab 21 2001 1034 1057 (Pubitemid 32823740)
35. C. Xiao, and J.H. Ye Ethanol dually modulates GABAergic synaptic transmission onto dopaminergic neurons in ventral tegmental area: Role of mu-opioid receptors Neuroscience 153 2008 240 248
36. N.D. Volkow Opioid-dopamine interactions: implications for substance use disorders and their treatment Biol Psychiatry 68 2010 685 686
37. R.F. Anton, G. Oroszi, S. O'Malley, D. Couper, R. Swift, and H. Pettinati An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: Results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study Arch Gen Psychiatry 65 2008 135 144 (Pubitemid 351222547)
38. S.S. O'Malley, S. Krishnan-Sarin, C. Farren, and P.G. O'Connor Naltrexone-induced nausea in patients treated for alcohol dependence: Clinical predictors and evidence for opioid-mediated effects J Clin Psychopharmacol 20 2000 69 76 (Pubitemid 30056356)
39. L.A. Ray, and K.E. Hutchison Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: A double-blind placebo-controlled study Arch Gen Psychiatry 64 2007 1069 1077 (Pubitemid 47360852)
40. C.S. Barr, M. Schwandt, S.G. Lindell, S.A. Chen, D. Goldman, and S.J. Suomi Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques Arch Gen Psychiatry 64 2007 369 376 (Pubitemid 46376788)
41. R.F. Kaplan, R.E. Meyer, and C.F. Stroebel Alcohol dependence and responsivity to an ethanol stimulus as predictors of alcohol consumption Br J Addict 78 1983 259 267 (Pubitemid 13049045)
42. V.A. Ramchandani, J. Umhau, F.J. Pavon, V. Ruiz-Velasco, W. Margas, and H. Sun A genetic determinant of the striatal dopamine response to alcohol in men [published online ahead of print May 18] Mol Psychiatry 2010
43. E. Lynd-Balta, and S.N. Haber The organization of midbrain projections to the striatum in the primate: Sensorimotor-related striatum versus ventral striatum Neuroscience 59 1994 625 640 (Pubitemid 24131517)
44. T.D. Egan, C.F. Minto, D.J. Hermann, J. Barr, K.T. Muir, and S.L. Shafer Remifentanil versus alfentanil: comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers Anesthesiology 84 1996 821 833 (Pubitemid 26105245)
45. S.R. Jones, R.R. Gainetdinov, R.M. Wightman, and M.G. Caron Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter J Neurosci 18 1998 1979 1986 (Pubitemid 28141404)
46. J.A. Crespo, K. Sturm, A. Saria, and G. Zernig Simultaneous intra-accumbens remifentanil and dopamine kinetics suggest that neither determines within-session operant responding Psychopharmacology (Berl) 183 2005 201 209 (Pubitemid 41609272)
47. M. Laruelle Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review J Cereb Blood Flow Metab 20 2000 423 451 (Pubitemid 30164887)
48. M. Laruelle, R.N. Iyer, M.S. al-Tikriti, Y. Zea-Ponce, R. Malison, and S.S. Zoghbi Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates Synapse 25 1997 1 14 (Pubitemid 27014356)
49. R. Narendran, M. Slifstein, D.R. Hwang, Y. Hwang, E. Scher, and S. Reeder Amphetamine-induced dopamine release: Duration of action as assessed with the D2/3 receptor agonist radiotracer (-)-N-[(11)C]propyl-norapomorphine ([11C]NPA) in an anesthetized nonhuman primate Synapse 61 2007 106 109 (Pubitemid 44927734)
50. N. Guo, W. Guo, M. Kralikova, M. Jiang, I. Schieren, and R. Narendran Impact of D2 receptor internalization on binding affinity of neuroimaging radiotracers Neuropsychopharmacology 35 2010 806 817
51. V.L. Cropley, R.B. Innis, P.J. Nathan, A.K. Brown, J.L. Sangare, and A. Lerner Small effect of dopamine release and no effect of dopamine depletion on [18F]fallypride binding in healthy humans Synapse 62 2008 399 408 (Pubitemid 351614765)
52. D.J. Scott, C.S. Stohler, C.M. Egnatuk, H. Wang, R.A. Koeppe, and J.K. Zubieta Individual differences in reward responding explain placebo-induced expectations and effects Neuron 55 2007 325 336 (Pubitemid 47048908)