The synthesis and preclinical evaluation in rhesus monkey of [ 18F]MK-6577 and [ 11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers

Synapse

Volumn 65, Issue 4, 2011, Pages 261-270

  Hamill, Terence G ^a   Eng, Waisi ^a   Jennings, Andrew ^a   Lewis, Richard ^a   Thomas, Steven ^a   Wood, Suzanne ^a   Street, Leslie ^a   Wisnoski, David ^a   Wolkenberg, Scott ^a   Lindsley, Craig ^a   Sanabria Bohórquez, Sandra M ^a   Patel, Shil ^a   Riffel, Kerry ^a   Ryan, Christine ^a   Cook, Jacquelynn ^a   Sur, Cyrille ^a   Burns, H Donald ^a   Hargreaves, Richard ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Autoradiography; Carbon 11; Fluorine 18; Glycine transporter type 1; GlyT1; Positron emission tomography (PET); Rhesus monkey

Indexed keywords

2,4 DICHLORO N [1 [4 (3 METHOXYPYRIDIN 2 YL) 1 (PROPYLSULFONYL)PIPERIDIN 4 YL]METHYL]BENZAMIDE C 11; 2,4 DICHLORO N [1 [4 (6 FLUOROPYRIDIN 2 YL) 1 (PROPYLSULFONYL)PIPERIDIN 4 YL]METHYL]BENZAMIDE F 18; AROMATIC COMPOUND; DRUG METABOLITE; GLYCINE TRANSPORTER 1; MK 6577; TRACER; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN SLICE; CEREBELLUM; CORPUS STRIATUM; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG SCREENING; DRUG SYNTHESIS; DRUG UPTAKE; FRONTAL CORTEX; GRAY MATTER; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; NONHUMAN; NUCLEOPHILICITY; PONS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RHESUS MONKEY; SIGNAL TRANSDUCTION; SUBSTITUTION REACTION; THALAMUS;

ANIMALS; CARBON RADIOISOTOPES; CELL LINE; DRUG EVALUATION, PRECLINICAL; FLUORINE RADIOISOTOPES; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; MACACA MULATTA; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES;

EID: 79251534703     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20842     Document Type: Article

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