메뉴 건너뛰기




Volumn 20, Issue 5, 2014, Pages 365-380

Three-dimensional aggregates of mesenchymal stem cells: Cellular mechanisms, biological properties, and applications

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATES; CELL ENGINEERING; CHEMICAL ACTIVATION; DISEASE CONTROL; FLOWCHARTING; MOLECULAR INTERACTIONS; STEM CELLS; TISSUE ENGINEERING;

EID: 84913541357     PISSN: 19373368     EISSN: 19373376     Source Type: Journal    
DOI: 10.1089/ten.teb.2013.0537     Document Type: Review
Times cited : (323)

References (148)
  • 2
    • 84857838864 scopus 로고    scopus 로고
    • Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease
    • Ranganath, S.H., Levy, O., Inamdar, M.S., and Karp, J.M. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell 10, 244, 2012.
    • (2012) Cell Stem Cell , vol.10 , pp. 244
    • Ranganath, S.H.1    Levy, O.2    Inamdar, M.S.3    Karp, J.M.4
  • 3
    • 84884903598 scopus 로고    scopus 로고
    • Mesenchymal stem cells secretome: A new paradigm for central nervous system regeneration?
    • Teixeira, F.G., Carvalho, M.M., Sousa, N., and Salgado, A.J. Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration? Cell Mol Life Sci 70, 3871, 2013.
    • (2013) Cell Mol Life Sci , vol.70 , pp. 3871
    • Teixeira, F.G.1    Carvalho, M.M.2    Sousa, N.3    Salgado, A.J.4
  • 6
    • 77955000681 scopus 로고    scopus 로고
    • Dynamic threedimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential
    • Frith, J.E., Thomson, B., and Genever, P.G. Dynamic threedimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential. Tissue Eng Part C Methods 16, 735, 2010.
    • (2010) Tissue Eng Part C Methods , vol.16 , pp. 735
    • Frith, J.E.1    Thomson, B.2    Genever, P.G.3
  • 7
    • 0014261390 scopus 로고
    • Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues
    • Friedenstein, A.J., Petrakova, K.V., Kurolesova, A.I., and Frolova, G.P. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 6, 230, 1968.
    • (1968) Transplantation , vol.6 , pp. 230
    • Friedenstein, A.J.1    Petrakova, K.V.2    Kurolesova, A.I.3    Frolova, G.P.4
  • 9
    • 33745503987 scopus 로고    scopus 로고
    • Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    • da Silva Meirelles, L., Chagastelles, P.C., and Nardi, N.B. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 119(Pt 11), 2204, 2006.
    • (2006) J Cell Sci , vol.119 , pp. 2204
    • Da Silva-Meirelles, L.1    Chagastelles, P.C.2    Nardi, N.B.3
  • 10
    • 85007385331 scopus 로고    scopus 로고
    • Sources of mesenchymal stem cells: Current and future clinical use
    • Pozzobon, M., Piccoli, M., and De Coppi, P. Sources of mesenchymal stem cells: current and future clinical use. Adv Biochem Eng Biotechnol 2012. DOI: 10.1007/10- 2012-161
    • (2012) Adv Biochem Eng Biotechnol
    • Pozzobon, M.1    Piccoli, M.2    De Coppi, P.3
  • 11
    • 60549096066 scopus 로고    scopus 로고
    • Ear mesenchymal stem cells: An efficient adult multipotent cell population fit for rapid and scalable expansion
    • Sart, S., Schneider, Y.J., and Agathos, S.N. Ear mesenchymal stem cells: an efficient adult multipotent cell population fit for rapid and scalable expansion. J Biotechnol 139, 291, 2009.
    • (2009) J Biotechnol , vol.139 , pp. 291
    • Sart, S.1    Schneider, Y.J.2    Agathos, S.N.3
  • 12
    • 84859392969 scopus 로고    scopus 로고
    • Three-dimensional spheroid culture of human gingiva-derived mesenchymal stem cells enhances mitigation of chemotherapy-induced oral mucositis
    • Zhang, Q., Nguyen, A.L., Shi, S., Hill, C., Wilder-Smith, P., Krasieva, T.B., and Le, A.D. Three-dimensional spheroid culture of human gingiva-derived mesenchymal stem cells enhances mitigation of chemotherapy-induced oral mucositis. Stem Cells Dev 21, 937, 2012.
    • (2012) Stem Cells Dev , vol.21 , pp. 937
    • Zhang, Q.1    Nguyen, A.L.2    Shi, S.3    Hill, C.4    Wilder-Smith, P.5    Krasieva, T.B.6    Le, A.D.7
  • 13
    • 84872088799 scopus 로고    scopus 로고
    • The meaning, the sense and the significance: Translating the science of mesenchymal stem cells into medicine
    • Bianco, P., Cao, X., Frenette, P.S., Mao, J.J., Robey, P.G., Simmons, P.J., and Wang, C.Y. The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nat Med 19, 35, 2013.
    • (2013) Nat Med , vol.19 , pp. 35
    • Bianco, P.1    Cao, X.2    Frenette, P.S.3    Mao, J.J.4    Robey, P.G.5    Simmons, P.J.6    Wang, C.Y.7
  • 14
    • 41549139755 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Revisiting history, concepts, and assays
    • Bianco, P., Robey, P.G., and Simmons, P.J. Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell 2, 313, 2008.
    • (2008) Cell Stem Cell , vol.2 , pp. 313
    • Bianco, P.1    Robey, P.G.2    Simmons, P.J.3
  • 15
    • 34848863384 scopus 로고    scopus 로고
    • Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
    • Caplan, A.I. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol 213, 341, 2007.
    • (2007) J Cell Physiol , vol.213 , pp. 341
    • Caplan, A.I.1
  • 16
    • 84875468183 scopus 로고    scopus 로고
    • The mesenchymal stromal cells dilemma-does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?
    • Galipeau, J. The mesenchymal stromal cells dilemma-does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road? Cytotherapy 15, 2, 2013.
    • (2013) Cytotherapy , vol.15 , pp. 2
    • Galipeau, J.1
  • 18
    • 84866636444 scopus 로고    scopus 로고
    • Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype
    • Ylostalo, J.H., Bartosh, T.J., Coble, K., and Prockop, D.J. Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype. Stem Cells 30, 2283, 2012.
    • (2012) Stem Cells , vol.30 , pp. 2283
    • Ylostalo, J.H.1    Bartosh, T.J.2    Coble, K.3    Prockop, D.J.4
  • 19
    • 84880964090 scopus 로고    scopus 로고
    • Shortterm spheroid formation enhances the regenerative capacity of adipose-derived stem cells by promoting stemness, angiogenesis, and chemotaxis
    • Cheng, N.C., Chen, S.Y., Li, J.R., and Young, T.H. Shortterm spheroid formation enhances the regenerative capacity of adipose-derived stem cells by promoting stemness, angiogenesis, and chemotaxis. Stem Cells Transl Med 2, 584, 2013.
    • (2013) Stem Cells Transl Med , vol.2 , pp. 584
    • Cheng, N.C.1    Chen, S.Y.2    Li, J.R.3    Young, T.H.4
  • 22
    • 84861871104 scopus 로고    scopus 로고
    • Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration
    • Suzuki, S., Muneta, T., Tsuji, K., Ichinose, S., Makino, H., Umezawa, A., and Sekiya, I. Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration. Arthritis Res Ther 14, R136, 2012.
    • (2012) Arthritis Res Ther , vol.14 , pp. R136
    • Suzuki, S.1    Muneta, T.2    Tsuji, K.3    Ichinose, S.4    Makino, H.5    Umezawa, A.6    Sekiya, I.7
  • 23
    • 84878978933 scopus 로고    scopus 로고
    • Transplantation of aggregates of synovial mesenchymal stem cells regenerates meniscus more effectively in a rat massive meniscal defect
    • Katagiri, H., Muneta, T., Tsuji, K., Horie, M., Koga, H., Ozeki, N., Kobayashi, E., and Sekiya, I. Transplantation of aggregates of synovial mesenchymal stem cells regenerates meniscus more effectively in a rat massive meniscal defect. Biochem Biophys Res Commun 435, 603, 2013.
    • (2013) Biochem Biophys Res Commun , vol.435 , pp. 603
    • Katagiri, H.1    Muneta, T.2    Tsuji, K.3    Horie, M.4    Koga, H.5    Ozeki, N.6    Kobayashi, E.7    Sekiya, I.8
  • 24
    • 58749093939 scopus 로고    scopus 로고
    • Recent advances in threedimensional multicellular spheroid culture for biomedical research
    • Lin, R.Z., and Chang, H.Y. Recent advances in threedimensional multicellular spheroid culture for biomedical research. Biotechnol J 3, 1172, 2008.
    • (2008) Biotechnol J , vol.3 , pp. 1172
    • Lin, R.Z.1    Chang, H.Y.2
  • 25
    • 0000273795 scopus 로고
    • The dissociation and aggregation of cells from organ rudiments of the early chick embryo
    • Moscona, A., and Moscona, H. The dissociation and aggregation of cells from organ rudiments of the early chick embryo. J Anat 86, 287, 1952.
    • (1952) J Anat , vol.86 , pp. 287
    • Moscona, A.1    Moscona, H.2
  • 26
    • 34250860104 scopus 로고    scopus 로고
    • Methods for inducing embryoid body formation: In vitro differentiation system of embryonic stem cells
    • Kurosawa, H. Methods for inducing embryoid body formation: in vitro differentiation system of embryonic stem cells. J Biosci Bioeng 103, 389, 2007.
    • (2007) J Biosci Bioeng , vol.103 , pp. 389
    • Kurosawa, H.1
  • 29
    • 79955679188 scopus 로고    scopus 로고
    • Eyes wide open: A critical review of sphere-formation as an assay for stem cells
    • Pastrana, E., Silva-Vargas, V., and Doetsch, F. Eyes wide open: a critical review of sphere-formation as an assay for stem cells. Cell Stem Cell 8, 486, 2011.
    • (2011) Cell Stem Cell , vol.8 , pp. 486
    • Pastrana, E.1    Silva-Vargas, V.2    Doetsch, F.3
  • 30
    • 77955714347 scopus 로고    scopus 로고
    • Chondrogenic differentiation of human mesenchymal stem cells: A comparison between micromass and pellet culture systems
    • Zhang, L., Su, P., Xu, C., Yang, J., Yu, W., and Huang, D. Chondrogenic differentiation of human mesenchymal stem cells: a comparison between micromass and pellet culture systems. Biotechnol Lett 32, 1339, 2010.
    • (2010) Biotechnol Lett , vol.32 , pp. 1339
    • Zhang, L.1    Su, P.2    Xu, C.3    Yang, J.4    Yu, W.5    Huang, D.6
  • 31
    • 0033835868 scopus 로고    scopus 로고
    • Cellular interactions and signaling in cartilage development
    • DeLise, A.M., Fischer, L., and Tuan, R.S. Cellular interactions and signaling in cartilage development. Osteoarthritis Cartilage 8, 309, 2000.
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 309
    • Delise, A.M.1    Fischer, L.2    Tuan, R.S.3
  • 32
    • 27944437070 scopus 로고    scopus 로고
    • Morphological examination during in vitro cartilage formation by human mesenchymal stem cells
    • Ichinose, S., Tagami, M., Muneta, T., and Sekiya, I. Morphological examination during in vitro cartilage formation by human mesenchymal stem cells. Cell Tissue Res 322, 217, 2005.
    • (2005) Cell Tissue Res , vol.322 , pp. 217
    • Ichinose, S.1    Tagami, M.2    Muneta, T.3    Sekiya, I.4
  • 33
    • 68549118666 scopus 로고    scopus 로고
    • The use of injectable spherically symmetric cell aggregates self-assembled in a thermo-responsive hydrogel for enhanced cell transplantation
    • Lee, W.Y., Chang, Y.H., Yeh, Y.C., Chen, C.H., Lin, K.M., Huang, C.C., Chang, Y., and Sung, H.W. The use of injectable spherically symmetric cell aggregates self-assembled in a thermo-responsive hydrogel for enhanced cell transplantation. Biomaterials 30, 5505, 2009.
    • (2009) Biomaterials , vol.30 , pp. 5505
    • Lee, W.Y.1    Chang, Y.H.2    Yeh, Y.C.3    Chen, C.H.4    Lin, K.M.5    Huang, C.C.6    Chang, Y.7    Sung, H.W.8
  • 34
    • 61549112193 scopus 로고    scopus 로고
    • 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells
    • Wang, W., Itaka, K., Ohba, S., Nishiyama, N., Chung, U.I., Yamasaki, Y., and Kataoka, K. 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials 30, 2705, 2009.
    • (2009) Biomaterials , vol.30 , pp. 2705
    • Wang, W.1    Itaka, K.2    Ohba, S.3    Nishiyama, N.4    Chung, U.I.5    Yamasaki, Y.6    Kataoka, K.7
  • 35
    • 84859427951 scopus 로고    scopus 로고
    • Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential
    • Baraniak, P.R., and McDevitt, T.C. Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential. Cell Tissue Res 347, 701, 2012.
    • (2012) Cell Tissue Res , vol.347 , pp. 701
    • Baraniak, P.R.1    McDevitt, T.C.2
  • 37
    • 45149091594 scopus 로고    scopus 로고
    • Culturing of human mesenchymal stem cells as threedimensional aggregates induces functional expression of CXCR4 that regulates adhesion to endothelial cells
    • Potapova, I.A., Brink, P.R., Cohen, I.S., and Doronin, S.V. Culturing of human mesenchymal stem cells as threedimensional aggregates induces functional expression of CXCR4 that regulates adhesion to endothelial cells. J Biol Chem 283, 13100, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 13100
    • Potapova, I.A.1    Brink, P.R.2    Cohen, I.S.3    Doronin, S.V.4
  • 38
    • 79951580027 scopus 로고    scopus 로고
    • Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells
    • Bhang, S.H., Cho, S.W., La, W.G., Lee, T.J., Yang, H.S., Sun, A.Y., Baek, S.H., Rhie, J.W., and Kim, B.S. Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells. Biomaterials 32, 2734, 2011.
    • (2011) Biomaterials , vol.32 , pp. 2734
    • Bhang, S.H.1    Cho, S.W.2    La, W.G.3    Lee, T.J.4    Yang, H.S.5    Sun, A.Y.6    Baek, S.H.7    Rhie, J.W.8    Kim, B.S.9
  • 40
    • 80052966768 scopus 로고    scopus 로고
    • Bottom-up tissue engineering
    • Elbert, D.L. Bottom-up tissue engineering. Curr Opin Biotechnol 22, 674, 2011.
    • (2011) Curr Opin Biotechnol , vol.22 , pp. 674
    • Elbert, D.L.1
  • 41
    • 36849044035 scopus 로고    scopus 로고
    • Rods, tori, and honeycombs: The directed self-assembly of microtissues with prescribed microscale geometries
    • Dean, D.M., Napolitano, A.P., Youssef, J., and Morgan, J.R. Rods, tori, and honeycombs: the directed self-assembly of microtissues with prescribed microscale geometries. FASEB J 21, 4005, 2007.
    • (2007) FASEB J , vol.21 , pp. 4005
    • Dean, D.M.1    Napolitano, A.P.2    Youssef, J.3    Morgan, J.R.4
  • 42
    • 84866251102 scopus 로고    scopus 로고
    • Advances in the formation, use and understanding of multi-cellular spheroids
    • Achilli, T.M., Meyer, J., and Morgan, J.R. Advances in the formation, use and understanding of multi-cellular spheroids. Expert Opin Biol Ther 12, 1347, 2012.
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 1347
    • Achilli, T.M.1    Meyer, J.2    Morgan, J.R.3
  • 43
    • 11844297415 scopus 로고    scopus 로고
    • The differential adhesion hypothesis: A direct evaluation
    • Foty, R.A., and Steinberg, M.S. The differential adhesion hypothesis: a direct evaluation. Dev Biol 278, 255, 2005.
    • (2005) Dev Biol , vol.278 , pp. 255
    • Foty, R.A.1    Steinberg, M.S.2
  • 44
    • 0000829359 scopus 로고
    • On the mechanism of tissue reconstruction by dissociated cells, III. Free energy relations and the reorganization of fused, heteronomic tissue fragments
    • Steinberg, M.S. On the mechanism of tissue reconstruction by dissociated cells, III. free energy relations and the reorganization of fused, heteronomic tissue fragments. Proc Natl Acad Sci USA 48, 1769, 1962.
    • (1962) Proc Natl Acad Sci USA , vol.48 , pp. 1769
    • Steinberg, M.S.1
  • 45
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg, H.M. Developmental regulation of the growth plate. Nature 423, 332, 2003.
    • (2003) Nature , vol.423 , pp. 332
    • Kronenberg, H.M.1
  • 46
    • 0033973655 scopus 로고    scopus 로고
    • All for one and one for all: Condensations and the initiation of skeletal development
    • Hall, B.K., and Miyake, T. All for one and one for all: condensations and the initiation of skeletal development. Bioessays 22, 138, 2000.
    • (2000) Bioessays , vol.22 , pp. 138
    • Hall, B.K.1    Miyake, T.2
  • 47
    • 84864094853 scopus 로고    scopus 로고
    • Recapitulation of mesenchymal condensation enhances in vitro chondrogenesis of human mesenchymal stem cells
    • Ghone, N.V., and Grayson, W.L. Recapitulation of mesenchymal condensation enhances in vitro chondrogenesis of human mesenchymal stem cells. J Cell Physiol 227, 3701, 2012.
    • (2012) J Cell Physiol , vol.227 , pp. 3701
    • Ghone, N.V.1    Grayson, W.L.2
  • 48
    • 65249111036 scopus 로고    scopus 로고
    • Spherically symmetric mesenchymal stromal cell bodies inherent with endogenous extracellular matrices for cellular cardiomyoplasty
    • Wang, C.C., Chen, C.H., Hwang, S.M., Lin, W.W., Huang, C.H., Lee, W.Y., Chang, Y., and Sung, H.W. Spherically symmetric mesenchymal stromal cell bodies inherent with endogenous extracellular matrices for cellular cardiomyoplasty. Stem Cells 27, 724, 2009.
    • (2009) Stem Cells , vol.27 , pp. 724
    • Wang, C.C.1    Chen, C.H.2    Hwang, S.M.3    Lin, W.W.4    Huang, C.H.5    Lee, W.Y.6    Chang, Y.7    Sung, H.W.8
  • 49
    • 84875947728 scopus 로고    scopus 로고
    • Endogenous extracellular matrices enhance human mesenchymal stem cell aggregate formation and survival
    • Kim, J., and Ma, T. Endogenous extracellular matrices enhance human mesenchymal stem cell aggregate formation and survival. Biotechnol Prog 29, 441, 2013.
    • (2013) Biotechnol Prog , vol.29 , pp. 441
    • Kim, J.1    Ma, T.2
  • 50
    • 79952359684 scopus 로고    scopus 로고
    • A scaffold-free in vitro model for osteogenesis of human mesenchymal stem cells
    • Hildebrandt, C., Buth, H., and Thielecke, H. A scaffold-free in vitro model for osteogenesis of human mesenchymal stem cells. Tissue Cell 43, 91, 2011.
    • (2011) Tissue Cell , vol.43 , pp. 91
    • Hildebrandt, C.1    Buth, H.2    Thielecke, H.3
  • 51
    • 0000829358 scopus 로고
    • On the mechanism of tissue reconstruction by dissociated cells. I. Population kinetics, differential adhesiveness, and the absence of directed migration
    • Steinberg, M.S. On the mechanism of tissue reconstruction by dissociated cells. I. Population kinetics, differential adhesiveness, and the absence of directed migration. Proc Natl Acad Sci USA 48, 1577, 1962.
    • (1962) Proc Natl Acad Sci USA , vol.48 , pp. 1577
    • Steinberg, M.S.1
  • 52
    • 0036107125 scopus 로고    scopus 로고
    • The differential interfacial tension hypothesis (DITH): A comprehensive theory for the selfrearrangement of embryonic cells and tissues
    • Brodland, G.W. The Differential Interfacial Tension Hypothesis (DITH): a comprehensive theory for the selfrearrangement of embryonic cells and tissues. J Biomech Eng 124, 188, 2002.
    • (2002) J Biomech Eng , vol.124 , pp. 188
    • Brodland, G.W.1
  • 53
    • 84867310804 scopus 로고    scopus 로고
    • Knowing the boundaries: Extending the differential adhesion hypothesis in embryonic cell sorting
    • Amack, J.D., and Manning, M.L. Knowing the boundaries: extending the differential adhesion hypothesis in embryonic cell sorting. Science 338, 212, 2012.
    • (2012) Science , vol.338 , pp. 212
    • Amack, J.D.1    Manning, M.L.2
  • 55
    • 0035983142 scopus 로고    scopus 로고
    • TGF-beta1-stimulated osteoblasts require intracellular calcium signaling for enhanced alpha5 integrin expression
    • Nesti, L.J., Caterson, E.J., Wang, M., Chang, R., Chapovsky, F., Hoek, J.B., and Tuan, R.S. TGF-beta1-stimulated osteoblasts require intracellular calcium signaling for enhanced alpha5 integrin expression. Ann N Y Acad Sci 961, 178, 2002.
    • (2002) Ann N y Acad Sci , vol.961 , pp. 178
    • Nesti, L.J.1    Caterson, E.J.2    Wang, M.3    Chang, R.4    Chapovsky, F.5    Hoek, J.B.6    Tuan, R.S.7
  • 56
    • 33646368912 scopus 로고    scopus 로고
    • Dynamic analysis of hepatoma spheroid formation: Roles of Ecadherin and beta1-integrin
    • Lin, R.Z., Chou, L.F., Chien, C.C., and Chang, H.Y. Dynamic analysis of hepatoma spheroid formation: roles of Ecadherin and beta1-integrin. Cell Tissue Res 324, 411, 2006.
    • (2006) Cell Tissue Res , vol.324 , pp. 411
    • Lin, R.Z.1    Chou, L.F.2    Chien, C.C.3    Chang, H.Y.4
  • 57
    • 38449101699 scopus 로고    scopus 로고
    • Diversity of cell-mediated adhesions in breast cancer spheroids
    • Ivascu, A., and Kubbies, M. Diversity of cell-mediated adhesions in breast cancer spheroids. Int J Oncol 31, 1403, 2007.
    • (2007) Int J Oncol , vol.31 , pp. 1403
    • Ivascu, A.1    Kubbies, M.2
  • 59
    • 84863464420 scopus 로고    scopus 로고
    • Spherical bullet formation via E-cadherin promotes therapeutic potency of mesenchymal stem cells derived from human umbilical cord blood for myocardial infarction
    • Lee, E.J., Park, S.J., Kang, S.K., Kim, G.H., Kang, H.J., Lee, S.W., Jeon, H.B., and Kim, H.S. Spherical bullet formation via E-cadherin promotes therapeutic potency of mesenchymal stem cells derived from human umbilical cord blood for myocardial infarction. Mol Ther 20, 1424, 2012.
    • (2012) Mol Ther , vol.20 , pp. 1424
    • Lee, E.J.1    Park, S.J.2    Kang, S.K.3    Kim, G.H.4    Kang, H.J.5    Lee, S.W.6    Jeon, H.B.7    Kim, H.S.8
  • 61
    • 84861559441 scopus 로고    scopus 로고
    • Human adipose stem cells maintain proliferative, synthetic and multipotential properties when suspension cultured as self-assembling spheroids
    • Kapur, S.K., Wang, X., Shang, H., Yun, S., Li, X., Feng, G., Khurgel, M., and Katz, A.J. Human adipose stem cells maintain proliferative, synthetic and multipotential properties when suspension cultured as self-assembling spheroids. Biofabrication 4, 025004, 2012.
    • (2012) Biofabrication , vol.4 , pp. 025004
    • Kapur, S.K.1    Wang, X.2    Shang, H.3    Yun, S.4    Li, X.5    Feng, G.6    Khurgel, M.7    Katz, A.J.8
  • 62
    • 84861697540 scopus 로고    scopus 로고
    • Stiffening of human mesenchymal stem cell spheroid microenvironments induced by incorporation of gelatin microparticles
    • Baraniak, P.R., Cooke, M.T., Saeed, R., Kinney, M.A., Fridley, K.M., and McDevitt, T.C. Stiffening of human mesenchymal stem cell spheroid microenvironments induced by incorporation of gelatin microparticles. J Mech Behav Biomed Mater 11, 63, 2012.
    • (2012) J Mech Behav Biomed Mater , vol.11 , pp. 63
    • Baraniak, P.R.1    Cooke, M.T.2    Saeed, R.3    Kinney, M.A.4    Fridley, K.M.5    McDevitt, T.C.6
  • 63
    • 77955643473 scopus 로고    scopus 로고
    • Alpha5beta1 integrin-fibronectin interactions specify liquid to solid phase transition of 3D cellular aggregates
    • Caicedo-Carvajal, C.E., Shinbrot, T., and Foty, R.A. Alpha5beta1 integrin-fibronectin interactions specify liquid to solid phase transition of 3D cellular aggregates. PLoS One 5, e11830, 2010.
    • (2010) PLoS One , vol.5 , pp. e11830
    • Caicedo-Carvajal, C.E.1    Shinbrot, T.2    Foty, R.A.3
  • 64
    • 33747152561 scopus 로고    scopus 로고
    • Matrix elasticity directs stem cell lineage specification
    • Engler, A.J., Sen, S., Sweeney, H.L., and Discher, D.E. Matrix elasticity directs stem cell lineage specification. Cell 126, 677, 2006.
    • (2006) Cell , vol.126 , pp. 677
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 65
    • 74249089196 scopus 로고    scopus 로고
    • Synthetic materials in the study of cell response to substrate rigidity
    • Nemir, S., and West, J.L. Synthetic materials in the study of cell response to substrate rigidity. Ann Biomed Eng 38, 2, 2010.
    • (2010) Ann Biomed Eng , vol.38 , pp. 2
    • Nemir, S.1    West, J.L.2
  • 66
    • 84861353004 scopus 로고    scopus 로고
    • Forcing stem cells to behave: A biophysical perspective of the cellular microenvironment
    • Sun, Y., Chen, C.S., and Fu, J. Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment. Annu Rev Biophys 41, 519, 2012.
    • (2012) Annu Rev Biophys , vol.41 , pp. 519
    • Sun, Y.1    Chen, C.S.2    Fu, J.3
  • 67
    • 84862837839 scopus 로고    scopus 로고
    • The effect of culture conditions on the adipogenic and osteogenic inductions of mesenchymal stem cells on micropatterned surfaces
    • Peng, R., Yao, X., Cao, B., Tang, J., and Ding, J. The effect of culture conditions on the adipogenic and osteogenic inductions of mesenchymal stem cells on micropatterned surfaces. Biomaterials 33, 6008, 2012.
    • (2012) Biomaterials , vol.33 , pp. 6008
    • Peng, R.1    Yao, X.2    Cao, B.3    Tang, J.4    Ding, J.5
  • 68
    • 77950427004 scopus 로고    scopus 로고
    • Geometric cues for directing the differentiation of mesenchymal stem cells
    • Kilian, K.A., Bugarija, B., Lahn, B.T., and Mrksich, M. Geometric cues for directing the differentiation of mesenchymal stem cells. Proc Natl Acad Sci USA 107, 4872, 2010.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4872
    • Kilian, K.A.1    Bugarija, B.2    Lahn, B.T.3    Mrksich, M.4
  • 70
    • 45349084219 scopus 로고    scopus 로고
    • Reproducible, ultra high-throughput formation of multicellular organization from single cell suspensionderived human embryonic stem cell aggregates
    • Ungrin, M.D., Joshi, C., Nica, A., Bauwens, C., and Zandstra, P.W. Reproducible, ultra high-throughput formation of multicellular organization from single cell suspensionderived human embryonic stem cell aggregates. PLoS One 3, e1565, 2008.
    • (2008) PLoS One , vol.3 , pp. e1565
    • Ungrin, M.D.1    Joshi, C.2    Nica, A.3    Bauwens, C.4    Zandstra, P.W.5
  • 71
    • 83555179053 scopus 로고    scopus 로고
    • The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities
    • Cheng, N.C., Wang, S., and Young, T.H. The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities. Biomaterials 33, 1748, 2012.
    • (2012) Biomaterials , vol.33 , pp. 1748
    • Cheng, N.C.1    Wang, S.2    Young, T.H.3
  • 72
    • 79960846930 scopus 로고    scopus 로고
    • Spheroid formation of mesenchymal stem cells on chitosan and chitosan-hyaluronan membranes
    • Huang, G.S., Dai, L.G., Yen, B.L., and Hsu, S.H. Spheroid formation of mesenchymal stem cells on chitosan and chitosan-hyaluronan membranes. Biomaterials 32, 6929, 2011.
    • (2011) Biomaterials , vol.32 , pp. 6929
    • Huang, G.S.1    Dai, L.G.2    Yen, B.L.3    Hsu, S.H.4
  • 74
    • 68749102068 scopus 로고    scopus 로고
    • Chondrocytes cultured in stirred suspension with serum-free medium containing pluronic-68 aggregate and proliferate while maintaining their differentiated phenotype
    • Gigout, A., Buschmann, M.D., and Jolicoeur, M. Chondrocytes cultured in stirred suspension with serum-free medium containing pluronic-68 aggregate and proliferate while maintaining their differentiated phenotype. Tissue Eng Part A 15, 2237, 2009.
    • (2009) Tissue Eng Part A , vol.15 , pp. 2237
    • Gigout, A.1    Buschmann, M.D.2    Jolicoeur, M.3
  • 75
    • 0031817577 scopus 로고    scopus 로고
    • In vitro chondrogenesis of bone marrowderived mesenchymal progenitor cells
    • Johnstone, B., Hering, T.M., Caplan, A.I., Goldberg, V.M., and Yoo, J.U. In vitro chondrogenesis of bone marrowderived mesenchymal progenitor cells. Exp Cell Res 238, 265, 1998.
    • (1998) Exp Cell Res , vol.238 , pp. 265
    • Johnstone, B.1    Hering, T.M.2    Caplan, A.I.3    Goldberg, V.M.4    Yoo, J.U.5
  • 76
    • 0037331189 scopus 로고    scopus 로고
    • Cartilagelike gene expression in differentiated human stem cell spheroids: A comparison of bone marrow-derived and adipose tissue-derived stromal cells
    • Winter, A., Breit, S., Parsch, D., Benz, K., Steck, E., Hauner, H., Weber, R.M., Ewerbeck, V., and Richter, W. Cartilagelike gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells. Arthritis Rheum 48, 418, 2003.
    • (2003) Arthritis Rheum , vol.48 , pp. 418
    • Winter, A.1    Breit, S.2    Parsch, D.3    Benz, K.4    Steck, E.5    Hauner, H.6    Weber, R.M.7    Ewerbeck, V.8    Richter, W.9
  • 77
    • 0042671274 scopus 로고    scopus 로고
    • Formation of a chondro-osseous rudiment in micromass cultures of human bone-marrow stromal cells
    • Muraglia, A., Corsi, A., Riminucci, M., Mastrogiacomo, M., Cancedda, R., Bianco, P., and Quarto, R. Formation of a chondro-osseous rudiment in micromass cultures of human bone-marrow stromal cells. J Cell Sci 116(Pt 14), 2949, 2003.
    • (2003) J Cell Sci , vol.116 , pp. 2949
    • Muraglia, A.1    Corsi, A.2    Riminucci, M.3    Mastrogiacomo, M.4    Cancedda, R.5    Bianco, P.6    Quarto, R.7
  • 78
    • 80255123421 scopus 로고    scopus 로고
    • 3-D spheroid culture of bone marrow mesenchymal stem cell of rhesus monkey with improved multi-differentiation potential to epithelial progenitors and neuron in vitro
    • Jing, Y., and Jian-Xiong, Y. 3-D spheroid culture of bone marrow mesenchymal stem cell of rhesus monkey with improved multi-differentiation potential to epithelial progenitors and neuron in vitro. Clin Exp Ophthalmol 39, 808, 2011.
    • (2011) Clin Exp Ophthalmol , vol.39 , pp. 808
    • Jing, Y.1    Jian-Xiong, Y.2
  • 81
    • 84867403469 scopus 로고    scopus 로고
    • Regulation of autocrine fibroblast growth factor-2 signaling by perfusion flow in 3D human mesenchymal stem cell constructs
    • Kim, J., and Ma, T. Regulation of autocrine fibroblast growth factor-2 signaling by perfusion flow in 3D human mesenchymal stem cell constructs. Biotechnol Prog 28, 1384, 2012.
    • (2012) Biotechnol Prog , vol.28 , pp. 1384
    • Kim, J.1    Ma, T.2
  • 82
    • 84872798232 scopus 로고    scopus 로고
    • Autocrine fibroblast growth factor 2-mediated interactions between human mesenchymal stem cells and the extracellular matrix under varying oxygen tension
    • Kim, J., and Ma, T. Autocrine fibroblast growth factor 2-mediated interactions between human mesenchymal stem cells and the extracellular matrix under varying oxygen tension. J Cell Biochem 114, 716, 2013.
    • (2013) J Cell Biochem , vol.114 , pp. 716
    • Kim, J.1    Ma, T.2
  • 83
    • 84864297082 scopus 로고    scopus 로고
    • Extracellular matrix protein mediated regulation of the osteoblast differentiation of bone marrow derived human mesenchymal stem cells
    • Mathews, S., Bhonde, R., Gupta, P.K., and Totey, S. Extracellular matrix protein mediated regulation of the osteoblast differentiation of bone marrow derived human mesenchymal stem cells. Differentiation 84, 185, 2012.
    • (2012) Differentiation , vol.84 , pp. 185
    • Mathews, S.1    Bhonde, R.2    Gupta, P.K.3    Totey, S.4
  • 84
  • 85
    • 1842426730 scopus 로고    scopus 로고
    • Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment
    • McBeath, R., Pirone, D.M., Nelson, C.M., Bhadriraju, K., and Chen, C.S. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 6, 483, 2004.
    • (2004) Dev Cell , vol.6 , pp. 483
    • McBeath, R.1    Pirone, D.M.2    Nelson, C.M.3    Bhadriraju, K.4    Chen, C.S.5
  • 86
    • 77950584190 scopus 로고    scopus 로고
    • Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin
    • Gao, L., McBeath, R., and Chen, C.S. Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin. Stem Cells 28, 564, 2010.
    • (2010) Stem Cells , vol.28 , pp. 564
    • Gao, L.1    McBeath, R.2    Chen, C.S.3
  • 87
    • 84860140464 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension
    • Wang, Y.K., Yu, X., Cohen, D.M., Wozniak, M.A., Yang, M.T., Gao, L., Eyckmans, J., and Chen, C.S. Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension. Stem Cells Dev 21, 1176, 2012.
    • (2012) Stem Cells Dev , vol.21 , pp. 1176
    • Wang, Y.K.1    Yu, X.2    Cohen, D.M.3    Wozniak, M.A.4    Yang, M.T.5    Gao, L.6    Eyckmans, J.7    Chen, C.S.8
  • 88
    • 56249113001 scopus 로고    scopus 로고
    • Emergence of patterned stem cell differentiation within multicellular structures
    • Ruiz, S.A., and Chen, C.S. Emergence of patterned stem cell differentiation within multicellular structures. Stem Cells 26, 2921, 2008.
    • (2008) Stem Cells , vol.26 , pp. 2921
    • Ruiz, S.A.1    Chen, C.S.2
  • 90
    • 74849111063 scopus 로고    scopus 로고
    • The regulation of stem cell differentiation by cell-cell contact on micropatterned material surfaces
    • Tang, J., Peng, R., and Ding, J. The regulation of stem cell differentiation by cell-cell contact on micropatterned material surfaces. Biomaterials 31, 2470, 2010.
    • (2010) Biomaterials , vol.31 , pp. 2470
    • Tang, J.1    Peng, R.2    Ding, J.3
  • 91
    • 74449093252 scopus 로고    scopus 로고
    • Notch signaling during chondrogenesis of human bone marrow stem cells
    • Oldershaw, R.A., and Hardingham, T.E. Notch signaling during chondrogenesis of human bone marrow stem cells. Bone 46, 286, 2010.
    • (2010) Bone , vol.46 , pp. 286
    • Oldershaw, R.A.1    Hardingham, T.E.2
  • 92
    • 0028107165 scopus 로고
    • Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis
    • Oberlender, S.A., and Tuan, R.S. Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis. Development 120, 177, 1994.
    • (1994) Development , vol.120 , pp. 177
    • Oberlender, S.A.1    Tuan, R.S.2
  • 93
    • 0033861575 scopus 로고    scopus 로고
    • Relative abundance of different cadherins defines differentiation of mesenchymal precursors into osteogenic, myogenic, or adipogenic pathways
    • Shin, C.S., Lecanda, F., Sheikh, S., Weitzmann, L., Cheng, S.L., and Civitelli, R. Relative abundance of different cadherins defines differentiation of mesenchymal precursors into osteogenic, myogenic, or adipogenic pathways. J Cell Biochem 78, 566, 2000.
    • (2000) J Cell Biochem , vol.78 , pp. 566
    • Shin, C.S.1    Lecanda, F.2    Sheikh, S.3    Weitzmann, L.4    Cheng, S.L.5    Civitelli, R.6
  • 94
    • 84867140065 scopus 로고    scopus 로고
    • The calcium-dependent regulation of spheroid formation and cardiomyogenic differentiation for MSCs on chitosan membranes
    • Yeh, H.Y., Liu, B.H., and Hsu, S.H. The calcium-dependent regulation of spheroid formation and cardiomyogenic differentiation for MSCs on chitosan membranes. Biomaterials 33, 8943, 2012.
    • (2012) Biomaterials , vol.33 , pp. 8943
    • Yeh, H.Y.1    Liu, B.H.2    Hsu, S.H.3
  • 95
    • 33845227116 scopus 로고    scopus 로고
    • Cell-cell adhesion and signaling through cadherins: Connecting bone cells in their microenvironment
    • Mbalaviele, G., Shin, C.S., and Civitelli, R. Cell-cell adhesion and signaling through cadherins: connecting bone cells in their microenvironment. J Bone Miner Res 21, 1821, 2006.
    • (2006) J Bone Miner Res , vol.21 , pp. 1821
    • Mbalaviele, G.1    Shin, C.S.2    Civitelli, R.3
  • 96
    • 84865258598 scopus 로고    scopus 로고
    • Integration of cellular adhesion and Wnt signaling: Interactions between N-cadherin and LRP5 and their role in regulating bone mass
    • Zhong, Z., and Williams, B.O. Integration of cellular adhesion and Wnt signaling: Interactions between N-cadherin and LRP5 and their role in regulating bone mass. J Bone Miner Res 27, 1849, 2012.
    • (2012) J Bone Miner Res , vol.27 , pp. 1849
    • Zhong, Z.1    Williams, B.O.2
  • 97
    • 84865243092 scopus 로고    scopus 로고
    • Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation
    • Hay, E., Buczkowski, T., Marty, C., Da Nascimento, S., Sonnet, P., and Marie, P.J. Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation. J Bone Miner Res 27, 1852, 2012.
    • (2012) J Bone Miner Res , vol.27 , pp. 1852
    • Hay, E.1    Buczkowski, T.2    Marty, C.3    Da Nascimento, S.4    Sonnet, P.5    Marie, P.J.6
  • 99
    • 0142103359 scopus 로고    scopus 로고
    • Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves Ncadherin and mitogen-activated protein kinase and Wnt signaling cross-talk
    • Tuli, R., Tuli, S., Nandi, S., Huang, X., Manner, P.A., Hozack, W.J., Danielson, K.G., Hall, D.J., and Tuan, R.S. Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves Ncadherin and mitogen-activated protein kinase and Wnt signaling cross-talk. J Biol Chem 278, 41227, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 41227
    • Tuli, R.1    Tuli, S.2    Nandi, S.3    Huang, X.4    Manner, P.A.5    Hozack, W.J.6    Danielson, K.G.7    Hall, D.J.8    Tuan, R.S.9
  • 100
    • 84876090357 scopus 로고    scopus 로고
    • Substrate-dependent Wnt signaling in MSC differentiation within biomaterial-derived 3D spheroids
    • Hsu, S.H., and Huang, G.S. Substrate-dependent Wnt signaling in MSC differentiation within biomaterial-derived 3D spheroids. Biomaterials 34, 4725, 2013.
    • (2013) Biomaterials , vol.34 , pp. 4725
    • Hsu, S.H.1    Huang, G.S.2
  • 102
    • 59649115836 scopus 로고    scopus 로고
    • The regulation of the gap junction of human mesenchymal stem cells through the internalization of quantum dots
    • Chang, J.C., Hsu, S.H., and Su, H.L. The regulation of the gap junction of human mesenchymal stem cells through the internalization of quantum dots. Biomaterials 30, 1937, 2009.
    • (2009) Biomaterials , vol.30 , pp. 1937
    • Chang, J.C.1    Hsu, S.H.2    Su, H.L.3
  • 103
    • 33846381723 scopus 로고    scopus 로고
    • The function of connexin 43 on the differentiation of rat bone marrow cells in culture
    • Kamijo, M., Haraguchi, T., Tonogi, M., and Yamane, G.Y. The function of connexin 43 on the differentiation of rat bone marrow cells in culture. Biomed Res 27, 289, 2006.
    • (2006) Biomed Res , vol.27 , pp. 289
    • Kamijo, M.1    Haraguchi, T.2    Tonogi, M.3    Yamane, G.Y.4
  • 105
    • 0035957918 scopus 로고    scopus 로고
    • Inhibition of gap-junctional communication induces the trans-differentiation of osteoblasts to an adipocytic phenotype in vitro
    • Schiller, P.C., D'Ippolito, G., Brambilla, R., Roos, B.A., and Howard, G.A. Inhibition of gap-junctional communication induces the trans-differentiation of osteoblasts to an adipocytic phenotype in vitro. J Biol Chem 276, 14133, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 14133
    • Schiller, P.C.1    D'Ippolito, G.2    Brambilla, R.3    Roos, B.A.4    Howard, G.A.5
  • 106
    • 0033816428 scopus 로고    scopus 로고
    • Association of enhanced expression of gap junctions with in vitro chondrogenic differentiation of rat nasal septal cartilagereleased cells following their dedifferentiation and redifferentiation
    • Loty, S., Foll, C., Forest, N., and Sautier, J.M. Association of enhanced expression of gap junctions with in vitro chondrogenic differentiation of rat nasal septal cartilagereleased cells following their dedifferentiation and redifferentiation. Arch Oral Biol 45, 843, 2000.
    • (2000) Arch Oral Biol , vol.45 , pp. 843
    • Loty, S.1    Foll, C.2    Forest, N.3    Sautier, J.M.4
  • 107
    • 84862333810 scopus 로고    scopus 로고
    • Mass transfer limitations in embryoid bodies during human embryonic stem cell differentiation
    • Van Winkle, A.P., Gates, I.D., and Kallos, M.S. Mass transfer limitations in embryoid bodies during human embryonic stem cell differentiation. Cells Tissues Organs 196, 34, 2012.
    • (2012) Cells Tissues Organs , vol.196 , pp. 34
    • Van Winkle, A.P.1    Gates, I.D.2    Kallos, M.S.3
  • 108
    • 76049100577 scopus 로고    scopus 로고
    • HIF-1: Upstream and downstream of cancer metabolism
    • Semenza, G.L. HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20, 51, 2010.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 51
    • Semenza, G.L.1
  • 110
    • 84887904476 scopus 로고    scopus 로고
    • Dynamic compaction of human mesenchymal stem/precursor cells (MSC) into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6 and STC1)
    • Bartosh, T.J., Ylostalo, J.H., Bazhanov, N., Kuhlman, J., and Prockop, D.J. Dynamic compaction of human mesenchymal stem/precursor cells (MSC) into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6 and STC1). Stem Cells 2013. DOI: 10.1002/stem.1499.
    • (2013) Stem Cells
    • Bartosh, T.J.1    Ylostalo, J.H.2    Bazhanov, N.3    Kuhlman, J.4    Prockop, D.J.5
  • 111
    • 79951866274 scopus 로고    scopus 로고
    • Good manufacturing practices production of mesenchymal stem/stromal cells
    • Sensebe, L., Bourin, P., and Tarte, K. Good manufacturing practices production of mesenchymal stem/stromal cells. Hum Gene Ther 22, 19, 2011.
    • (2011) Hum Gene Ther , vol.22 , pp. 19
    • Sensebe, L.1    Bourin, P.2    Tarte, K.3
  • 113
    • 84872493244 scopus 로고    scopus 로고
    • Bioreactors to influence stem cell fate: Augmentation of mesenchymal stem cell signaling pathways via dynamic culture systems
    • Yeatts, A.B., Choquette, D.T., and Fisher, J.P. Bioreactors to influence stem cell fate: augmentation of mesenchymal stem cell signaling pathways via dynamic culture systems. Biochim Biophys Acta 1830, 2470, 2013.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 2470
    • Yeatts, A.B.1    Choquette, D.T.2    Fisher, J.P.3
  • 116
    • 84873298496 scopus 로고    scopus 로고
    • Cryopreservation of pluripotent stem cell aggregates in defined protein-free formulation
    • Sart, S., Ma, T., and Li, Y. Cryopreservation of pluripotent stem cell aggregates in defined protein-free formulation. Biotechnol Prog 29, 143, 2013.
    • (2013) Biotechnol Prog , vol.29 , pp. 143
    • Sart, S.1    Ma, T.2    Li, Y.3
  • 117
  • 119
    • 2942553906 scopus 로고    scopus 로고
    • Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells
    • Huang, C.Y., Hagar, K.L., Frost, L.E., Sun, Y., and Cheung, H.S. Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells. Stem Cells 22, 313, 2004.
    • (2004) Stem Cells , vol.22 , pp. 313
    • Huang, C.Y.1    Hagar, K.L.2    Frost, L.E.3    Sun, Y.4    Cheung, H.S.5
  • 120
    • 80054842180 scopus 로고    scopus 로고
    • Simulated microgravity using a rotary cell culture system promotes chondrogenesis of human adipose-derived mesenchymal stem cells via the p38 MAPK pathway
    • Yu, B., Yu, D., Cao, L., Zhao, X., Long, T., Liu, G., Tang, T., and Zhu, Z. Simulated microgravity using a rotary cell culture system promotes chondrogenesis of human adipose-derived mesenchymal stem cells via the p38 MAPK pathway. Biochem Biophys Res Commun 414, 412, 2011.
    • (2011) Biochem Biophys Res Commun , vol.414 , pp. 412
    • Yu, B.1    Yu, D.2    Cao, L.3    Zhao, X.4    Long, T.5    Liu, G.6    Tang, T.7    Zhu, Z.8
  • 121
    • 33845274027 scopus 로고    scopus 로고
    • Cartilaginous tissue formation from bone marrow cells using rotating wall vessel (RWV) bioreactor
    • Ohyabu, Y., Kida, N., Kojima, H., Taguchi, T., Tanaka, J., and Uemura, T. Cartilaginous tissue formation from bone marrow cells using rotating wall vessel (RWV) bioreactor. Biotechnol Bioeng 95, 1003, 2006.
    • (2006) Biotechnol Bioeng , vol.95 , pp. 1003
    • Ohyabu, Y.1    Kida, N.2    Kojima, H.3    Taguchi, T.4    Tanaka, J.5    Uemura, T.6
  • 122
    • 25444492582 scopus 로고    scopus 로고
    • RhoA and cytoskeletal disruption mediate reduced osteoblastogenesis and enhanced adipogenesis of human mesenchymal stem cells in modeled microgravity
    • Meyers, V.E., Zayzafoon, M., Douglas, J.T., and McDonald, J.M. RhoA and cytoskeletal disruption mediate reduced osteoblastogenesis and enhanced adipogenesis of human mesenchymal stem cells in modeled microgravity. J Bone Miner Res 20, 1858, 2005.
    • (2005) J Bone Miner Res , vol.20 , pp. 1858
    • Meyers, V.E.1    Zayzafoon, M.2    Douglas, J.T.3    McDonald, J.M.4
  • 123
    • 64849094619 scopus 로고    scopus 로고
    • Mechanically induced osteogenic differentiation-The role of RhoA, ROCKII and cytoskeletal dynamics
    • Arnsdorf, E.J., Tummala, P., Kwon, R.Y., and Jacobs, C.R. Mechanically induced osteogenic differentiation-the role of RhoA, ROCKII and cytoskeletal dynamics. J Cell Sci 122(Pt 4), 546, 2009.
    • (2009) J Cell Sci , vol.122 , pp. 546
    • Arnsdorf, E.J.1    Tummala, P.2    Kwon, R.Y.3    Jacobs, C.R.4
  • 124
    • 73349136774 scopus 로고    scopus 로고
    • Effects of flow shear stress and mass transport on the construction of a largescale tissue-engineered bone in a perfusion bioreactor
    • Li, D., Tang, T., Lu, J., and Dai, K. Effects of flow shear stress and mass transport on the construction of a largescale tissue-engineered bone in a perfusion bioreactor. Tissue Eng Part A 15, 2773, 2009.
    • (2009) Tissue Eng Part A , vol.15 , pp. 2773
    • Li, D.1    Tang, T.2    Lu, J.3    Dai, K.4
  • 125
    • 81455154337 scopus 로고    scopus 로고
    • Perfusion regulation of hMSC microenvironment and osteogenic differentiation in 3D scaffold
    • Kim, J., and Ma, T. Perfusion regulation of hMSC microenvironment and osteogenic differentiation in 3D scaffold. Biotechnol Bioeng 109, 252, 2012.
    • (2012) Biotechnol Bioeng , vol.109 , pp. 252
    • Kim, J.1    Ma, T.2
  • 127
    • 84861097397 scopus 로고    scopus 로고
    • Different effects of intermittent and continuous fluid shear stresses on osteogenic differentiation of human mesenchymal stem cells
    • Liu, L., Yu, B., Chen, J., Tang, Z., Zong, C., Shen, D., Zheng, Q., Tong, X., Gao, C., and Wang, J. Different effects of intermittent and continuous fluid shear stresses on osteogenic differentiation of human mesenchymal stem cells. Biomech Model Mechanobiol 11, 391, 2012.
    • (2012) Biomech Model Mechanobiol , vol.11 , pp. 391
    • Liu, L.1    Yu, B.2    Chen, J.3    Tang, Z.4    Zong, C.5    Shen, D.6    Zheng, Q.7    Tong, X.8    Gao, C.9    Wang, J.10
  • 128
    • 77954972299 scopus 로고    scopus 로고
    • Finite element analyses of fluid flow conditions in cell culture
    • Salvi, J.D., Lim, J.Y., and Donahue, H.J. Finite element analyses of fluid flow conditions in cell culture. Tissue Eng Part C Methods 16, 661, 2010.
    • (2010) Tissue Eng Part C Methods , vol.16 , pp. 661
    • Salvi, J.D.1    Lim, J.Y.2    Donahue, H.J.3
  • 129
    • 40849112959 scopus 로고    scopus 로고
    • Computational fluid dynamics for improved bioreactor design and 3D culture
    • Hutmacher, D.W., and Singh, H. Computational fluid dynamics for improved bioreactor design and 3D culture. Trends Biotechnol 26, 166, 2008.
    • (2008) Trends Biotechnol , vol.26 , pp. 166
    • Hutmacher, D.W.1    Singh, H.2
  • 131
    • 0020078829 scopus 로고
    • Influence of convection in the growth medium on oxygen tensions in multicellular tumor spheroids
    • Mueller-Klieser, W.F., and Sutherland, R.M. Influence of convection in the growth medium on oxygen tensions in multicellular tumor spheroids. Cancer Res 42, 237, 1982.
    • (1982) Cancer Res , vol.42 , pp. 237
    • Mueller-Klieser, W.F.1    Sutherland, R.M.2
  • 132
    • 79960651723 scopus 로고    scopus 로고
    • The multiparametric effects of hydrodynamic environments on stem cell culture
    • Kinney, M.A., Sargent, C.Y., and McDevitt, T.C. The multiparametric effects of hydrodynamic environments on stem cell culture. Tissue Eng Part B Rev 17, 249, 2011.
    • (2011) Tissue Eng Part B Rev , vol.17 , pp. 249
    • Kinney, M.A.1    Sargent, C.Y.2    McDevitt, T.C.3
  • 133
    • 78649643876 scopus 로고    scopus 로고
    • Simple modular bioreactors for tissue engineering: A system for characterization of oxygen gradients, human mesenchymal stem cell differentiation, and prevascularization
    • Lovett, M., Rockwood, D., Baryshyan, A., and Kaplan, D.L. Simple modular bioreactors for tissue engineering: a system for characterization of oxygen gradients, human mesenchymal stem cell differentiation, and prevascularization. Tissue Eng Part C Methods 16, 1565, 2010.
    • (2010) Tissue Eng Part C Methods , vol.16 , pp. 1565
    • Lovett, M.1    Rockwood, D.2    Baryshyan, A.3    Kaplan, D.L.4
  • 134
    • 31744442047 scopus 로고    scopus 로고
    • Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs
    • Grayson, W.L., Zhao, F., Izadpanah, R., Bunnell, B., and Ma, T. Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs. J Cell Physiol 207, 331, 2006.
    • (2006) J Cell Physiol , vol.207 , pp. 331
    • Grayson, W.L.1    Zhao, F.2    Izadpanah, R.3    Bunnell, B.4    Ma, T.5
  • 135
    • 78751535908 scopus 로고    scopus 로고
    • Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST
    • Tsai, C.C., Chen, Y.J., Yew, T.L., Chen, L.L., Wang, J.Y., Chiu, C.H., and Hung, S.C. Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST. Blood 117, 459, 2011.
    • (2011) Blood , vol.117 , pp. 459
    • Tsai, C.C.1    Chen, Y.J.2    Yew, T.L.3    Chen, L.L.4    Wang, J.Y.5    Chiu, C.H.6    Hung, S.C.7
  • 136
    • 80052560423 scopus 로고    scopus 로고
    • Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST
    • Yang, D.C., Yang, M.H., Tsai, C.C., Huang, T.F., Chen, Y.H., and Hung, S.C. Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST. PLoS One 6, e23965, 2011.
    • (2011) PLoS One , vol.6 , pp. e23965
    • Yang, D.C.1    Yang, M.H.2    Tsai, C.C.3    Huang, T.F.4    Chen, Y.H.5    Hung, S.C.6
  • 137
    • 23844493183 scopus 로고    scopus 로고
    • Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9
    • Robins, J.C., Akeno, N., Mukherjee, A., Dalal, R.R., Aronow, B.J., Koopman, P., and Clemens, T.L. Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone 37, 313, 2005.
    • (2005) Bone , vol.37 , pp. 313
    • Robins, J.C.1    Akeno, N.2    Mukherjee, A.3    Dalal, R.R.4    Aronow, B.J.5    Koopman, P.6    Clemens, T.L.7
  • 138
    • 79951802302 scopus 로고    scopus 로고
    • Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition
    • Tamama, K., Kawasaki, H., Kerpedjieva, S.S., Guan, J., Ganju, R.K., and Sen, C.K. Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition. J Cell Biochem 112, 804, 2011.
    • (2011) J Cell Biochem , vol.112 , pp. 804
    • Tamama, K.1    Kawasaki, H.2    Kerpedjieva, S.S.3    Guan, J.4    Ganju, R.K.5    Sen, C.K.6
  • 140
    • 77953683856 scopus 로고    scopus 로고
    • Scaffold-free cell delivery for use in regenerative medicine
    • Kelm, J.M., and Fussenegger, M. Scaffold-free cell delivery for use in regenerative medicine. Adv Drug Deliv Rev 62, 753, 2010.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 753
    • Kelm, J.M.1    Fussenegger, M.2
  • 142
    • 77949835790 scopus 로고    scopus 로고
    • Engineering scaffold-free bone tissue using bone marrow stromal cell sheets
    • Ma, D., Ren, L., Liu, Y., Chen, F., Zhang, J., Xue, Z., and Mao, T. Engineering scaffold-free bone tissue using bone marrow stromal cell sheets. J Orthop Res 28, 697, 2010.
    • (2010) J Orthop Res , vol.28 , pp. 697
    • Ma, D.1    Ren, L.2    Liu, Y.3    Chen, F.4    Zhang, J.5    Xue, Z.6    Mao, T.7
  • 146
    • 0036251743 scopus 로고    scopus 로고
    • Three-dimensional cultures of normal human osteoblasts: Proliferation and differentiation potential in vitro and upon ectopic implantation in nude mice
    • Ferrera, D., Poggi, S., Biassoni, C., Dickson, G.R., Astigiano, S., Barbieri, O., Favre, A., Franzi, A.T., Strangio, A., Federici, A., and Manduca, P. Three-dimensional cultures of normal human osteoblasts: proliferation and differentiation potential in vitro and upon ectopic implantation in nude mice. Bone 30, 718, 2002.
    • (2002) Bone , vol.30 , pp. 718
    • Ferrera, D.1    Poggi, S.2    Biassoni, C.3    Dickson, G.R.4    Astigiano, S.5    Barbieri, O.6    Favre, A.7    Franzi, A.T.8    Strangio, A.9    Federici, A.10    Manduca, P.11
  • 147
    • 84863588802 scopus 로고    scopus 로고
    • Transplantatation of scaffold-free spheroids composed of synoviumderived cells and chondrocytes for the treatment of cartilage defects of the knee
    • discussion 290
    • Lee, J.I., Sato, M., Kim, H.W., and Mochida, J. Transplantatation of scaffold-free spheroids composed of synoviumderived cells and chondrocytes for the treatment of cartilage defects of the knee. Eur Cell Mater 22, 275, 2011; discussion 290.
    • (2011) Eur Cell Mater , vol.22 , pp. 275
    • Lee, J.I.1    Sato, M.2    Kim, H.W.3    Mochida, J.4
  • 148
    • 84867014008 scopus 로고    scopus 로고
    • Transplantation of cord blood mesenchymal stem cells as spheroids enhances vascularization
    • Bhang, S.H., Lee, S., Shin, J.Y., Lee, T.J., and Kim, B.S. Transplantation of cord blood mesenchymal stem cells as spheroids enhances vascularization. Tissue Eng Part A 18, 2138, 2012.
    • (2012) Tissue Eng Part A , vol.18 , pp. 2138
    • Bhang, S.H.1    Lee, S.2    Shin, J.Y.3    Lee, T.J.4    Kim, B.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.