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Volumn 17, Issue 4, 2011, Pages 249-262

The multiparametric effects of hydrodynamic environments on stem cell culture

Author keywords

[No Author keywords available]

Indexed keywords

BIOPROCESSING; CELL AGGREGATION; CELL SOURCES; DIRECT DIFFERENTIATION; ENVIRONMENTAL PERTURBATIONS; FLUID MIXING; HYDRODYNAMIC FORCES; MIXED CULTURES; REGENERATIVE MEDICINE; SCALABLE APPROACH; SCALE-UP; SOMATIC CELLS; STATIC CULTURE; STEM CELL EXPANSION; SUSPENSION CULTURES; TISSUE ENGINEERING APPLICATIONS;

EID: 79960651723     PISSN: 19373368     EISSN: 19373376     Source Type: Journal    
DOI: 10.1089/ten.teb.2011.0040     Document Type: Article
Times cited : (118)

References (147)
  • 1
    • 77649285139 scopus 로고    scopus 로고
    • Stem cell paracrine actions and tissue regeneration
    • Baraniak, P.R., and McDevitt, T.C. Stem cell paracrine actions and tissue regeneration. Regen Med 5, 121, 2010.
    • (2010) Regen Med , vol.5 , pp. 121
    • Baraniak, P.R.1    McDevitt, T.C.2
  • 2
    • 0347135824 scopus 로고    scopus 로고
    • Embryonic stem cells in drug discovery
    • McNeish, J. Embryonic stem cells in drug discovery. Nat Rev Drug Discov 3, 70, 2004.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 70
    • McNeish, J.1
  • 3
    • 0346634892 scopus 로고    scopus 로고
    • Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
    • Hove, J.R., Kö ster, R.W., Forouhar, A.S., Acevedo-Bolton, G., Fraser, S.E., and Gharib, M. Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature 421, 172, 2003.
    • (2003) Nature , vol.421 , pp. 172
    • Hove, J.R.1    Kö Ster, R.W.2    Forouhar, A.S.3    Acevedo-Bolton, G.4    Fraser, S.E.5    Gharib, M.6
  • 4
    • 0030911999 scopus 로고    scopus 로고
    • Unilateral vitelline vein ligation alters intracardiac blood flow patterns and morphogenesis in the chick embryo
    • Hogers, B., DeRuiter, M.C., Gittenberger-de Groot, A.C., and Poelmann, R.E. Unilateral vitelline vein ligation alters intracardiac blood flow patterns and morphogenesis in the chick embryo. Circ Res 80, 473, 1997.
    • (1997) Circ Res , vol.80 , pp. 473
    • Hogers, B.1    Deruiter, M.C.2    Gittenberger-De Groot, A.C.3    Poelmann, R.E.4
  • 5
    • 21844479549 scopus 로고    scopus 로고
    • Changes in shear stress-related gene expression after experimentally altered venous return in the chicken embryo
    • Groenendijk, B.C., Hierck, B.P., Vrolijk, J., Baiker, M., Pourquie, M.J., Gittenberger-de Groot, A.C., et al. Changes in shear stress-related gene expression after experimentally altered venous return in the chicken embryo. Circ Res 96, 1291, 2005.
    • (2005) Circ Res , vol.96 , pp. 1291
    • Groenendijk, B.C.1    Hierck, B.P.2    Vrolijk, J.3    Baiker, M.4    Pourquie, M.J.5    Gittenberger-De Groot, A.C.6
  • 6
    • 0033485806 scopus 로고    scopus 로고
    • Hemodynamic shear stress and its role in atherosclerosis
    • Malek, A.M., Alper, S.L., and Izumo, S. Hemodynamic shear stress and its role in atherosclerosis. JAMA 282, 2035, 1999.
    • (1999) JAMA , vol.282 , pp. 2035
    • Malek, A.M.1    Alper, S.L.2    Izumo, S.3
  • 7
    • 0029072762 scopus 로고
    • Flow-mediated endothelial mechanotransduction
    • Davies, P.F. Flow-mediated endothelial mechanotransduction. Physiol Rev 75, 519, 1995.
    • (1995) Physiol Rev , vol.75 , pp. 519
    • Davies, P.F.1
  • 8
    • 0022160653 scopus 로고
    • The elongation and orientation of cultured endothelial cells in response to shear stress
    • Levesque, M.J., and Nerem, R.M. The elongation and orientation of cultured endothelial cells in response to shear stress. J Biomech Eng 107, 341, 1985.
    • (1985) J Biomech Eng , vol.107 , pp. 341
    • Levesque, M.J.1    Nerem, R.M.2
  • 10
    • 0029790770 scopus 로고    scopus 로고
    • Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: Cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress
    • Topper, J.N., Cai, J., Falb, D., and Gimbrone, M.A. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci USA 93, 10417, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10417
    • Topper, J.N.1    Cai, J.2    Falb, D.3    Gimbrone, M.A.4
  • 11
    • 0029741925 scopus 로고    scopus 로고
    • Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of vcam-1
    • Tsao, P.S., Buitrago, R., Chan, J.R., and Cooke, J.P. Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of vcam-1. Circulation 94, 1682, 1996.
    • (1996) Circulation , vol.94 , pp. 1682
    • Tsao, P.S.1    Buitrago, R.2    Chan, J.R.3    Cooke, J.P.4
  • 13
    • 0142180220 scopus 로고    scopus 로고
    • Proliferation, differentiation, and tube formation by endothelial progenitor cells in response to shear stress
    • Yamamoto, K., Takahashi, T., Asahara, T., Ohura, N., Sokabe, T., Kamiya, A., et al. Proliferation, differentiation, and tube formation by endothelial progenitor cells in response to shear stress. J Appl Physiol 95, 2081, 2003.
    • (2003) J Appl Physiol , vol.95 , pp. 2081
    • Yamamoto, K.1    Takahashi, T.2    Asahara, T.3    Ohura, N.4    Sokabe, T.5    Kamiya, A.6
  • 14
    • 24144432913 scopus 로고    scopus 로고
    • Shear stress induces endothelial differentiation from a murine embryonic mesenchymal progenitor cell line
    • Wang, H., Riha, G.M., Yan, S., Li, M., Chai, H., Yang, H., et al. Shear stress induces endothelial differentiation from a murine embryonic mesenchymal progenitor cell line. Arterioscler Thromb Vasc Biol 25, 1817, 2005.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1817
    • Wang, H.1    Riha, G.M.2    Yan, S.3    Li, M.4    Chai, H.5    Yang, H.6
  • 15
    • 20144385079 scopus 로고    scopus 로고
    • Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro
    • Yamamoto, K., Sokabe, T., Watabe, T., Miyazono, K., Yamashita, J.K., Obi, S., et al. Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro. Am J Physiol Heart Circ Physiol 288, H1915, 2005.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Yamamoto, K.1    Sokabe, T.2    Watabe, T.3    Miyazono, K.4    Yamashita, J.K.5    Obi, S.6
  • 17
    • 78149265781 scopus 로고    scopus 로고
    • Fluid shear stress promotes an endothelial-like phenotype during the early differentiation of embryonic stem cells
    • Ahsan, T., and Nerem, R.M. Fluid shear stress promotes an endothelial-like phenotype during the early differentiation of embryonic stem cells. Tissue Eng Part A 16, 3547, 2010.
    • (2010) Tissue Eng Part A , vol.16 , pp. 3547
    • Ahsan, T.1    Nerem, R.M.2
  • 18
    • 0001007610 scopus 로고
    • Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
    • Martin, G.R. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78, 7634, 1981.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 7634
    • Martin, G.R.1
  • 19
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • Evans, M.J., and Kaufman, M.H. Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154, 1981.
    • (1981) Nature , vol.292 , pp. 154
    • Evans, M.J.1    Kaufman, M.H.2
  • 20
    • 0021891053 scopus 로고
    • The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands and myocardium
    • Doetschman, T., Eistetter, H., Katz, M., Schmidt, W., and Kemler, R. The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol 87, 27, 1985.
    • (1985) J Embryol Exp Morphol , vol.87 , pp. 27
    • Doetschman, T.1    Eistetter, H.2    Katz, M.3    Schmidt, W.4    Kemler, R.5
  • 22
  • 23
    • 0034101804 scopus 로고    scopus 로고
    • Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
    • Reubinoff, B.E., Pera, M.F., Fong, C.Y., Trounson, A., and Bongso, A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 18, 399, 2000.
    • (2000) Nat Biotechnol , vol.18 , pp. 399
    • Reubinoff, B.E.1    Pera, M.F.2    Fong, C.Y.3    Trounson, A.4    Bongso, A.5
  • 25
    • 0041560908 scopus 로고    scopus 로고
    • Molecular signature of human embryonic stem cells and its comparison with the mouse
    • Sato, N., Sanjuan, I.M., Heke, M., Uchida, M., Naef, F., and Brivanlou, A.H. Molecular signature of human embryonic stem cells and its comparison with the mouse. Dev Biol 260, 404, 2003.
    • (2003) Dev Biol , vol.260 , pp. 404
    • Sato, N.1    Sanjuan, I.M.2    Heke, M.3    Uchida, M.4    Naef, F.5    Brivanlou, A.H.6
  • 27
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., and Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663, 2006.
    • (2006) Cell , vol.126 , pp. 663
    • Takahashi, K.1    Yamanaka, S.2
  • 28
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861, 2007.
    • (2007) Cell , vol.131 , pp. 861
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6
  • 30
    • 34249908901 scopus 로고    scopus 로고
    • In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
    • Wernig, M., Meissner, A., Foreman, R., Brambrink, T., Ku, M., Hochedlinger, K., et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448, 318, 2007.
    • (2007) Nature , vol.448 , pp. 318
    • Wernig, M.1    Meissner, A.2    Foreman, R.3    Brambrink, T.4    Ku, M.5    Hochedlinger, K.6
  • 31
    • 67649222358 scopus 로고    scopus 로고
    • Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
    • Chin, M.H., Mason, M.J., Xie, W., Volinia, S., Singer, M., Peterson, C., et al. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell 5, 111, 2009.
    • (2009) Cell Stem Cell , vol.5 , pp. 111
    • Chin, M.H.1    Mason, M.J.2    Xie, W.3    Volinia, S.4    Singer, M.5    Peterson, C.6
  • 32
    • 70649095120 scopus 로고    scopus 로고
    • Differential methylation of tissue-and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
    • Doi, A., Park, I.H., Wen, B., Murakami, P., Aryee, M.J., Irizarry, R., et al. Differential methylation of tissue-and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet 41, 1350, 2009.
    • (2009) Nat Genet , vol.41 , pp. 1350
    • Doi, A.1    Park, I.H.2    Wen, B.3    Murakami, P.4    Aryee, M.J.5    Irizarry, R.6
  • 34
    • 0023922373 scopus 로고
    • Purification and characterization of mouse hematopoietic stem cells
    • Spangrude, G.J., Heimfeld, S., and Weissman, I.L. Purification and characterization of mouse hematopoietic stem cells. Science 241, 58, 1988.
    • (1988) Science , vol.241 , pp. 58
    • Spangrude, G.J.1    Heimfeld, S.2    Weissman, I.L.3
  • 36
    • 34547134956 scopus 로고    scopus 로고
    • Stem/progenitor cell sources of insulin-producing cells for the treatment of diabetes
    • Lock, L.T., and Tzanakakis, E.S. Stem/progenitor cell sources of insulin-producing cells for the treatment of diabetes. Tissue Eng 13, 1399, 2007.
    • (2007) Tissue Eng , vol.13 , pp. 1399
    • Lock, L.T.1    Tzanakakis, E.S.2
  • 39
    • 33747152561 scopus 로고    scopus 로고
    • Matrix elasticity directs stem cell lineage specification
    • Engler, A.J., Sen, S., Sweeney, H.L., and Discher, D.E. Matrix elasticity directs stem cell lineage specification. Cell 126, 677, 2006.
    • (2006) Cell , vol.126 , pp. 677
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 40
    • 59549095389 scopus 로고    scopus 로고
    • Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: Scarlike rigidity inhibits beating
    • Engler, A.J., Carag-Krieger, C., Johnson, C.P., Raab, M., Tang, H.Y., Speicher, D.W., et al. Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scarlike rigidity inhibits beating. J Cell Sci 121, 3794, 2008.
    • (2008) J Cell Sci , vol.121 , pp. 3794
    • Engler, A.J.1    Carag-Krieger, C.2    Johnson, C.P.3    Raab, M.4    Tang, H.Y.5    Speicher, D.W.6
  • 42
    • 64549117445 scopus 로고    scopus 로고
    • Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes
    • Chang, T.T., and Hughes-Fulford, M. Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes. Tissue Eng Part A 15, 559, 2009.
    • (2009) Tissue Eng Part A , vol.15 , pp. 559
    • Chang, T.T.1    Hughes-Fulford, M.2
  • 43
    • 27644455685 scopus 로고    scopus 로고
    • Novel hepatocyte culture system developed using microfabrication and collagen/polyethylene glycol microcontact printing
    • Fukuda, J., Sakai, Y., and Nakazawa, K. Novel hepatocyte culture system developed using microfabrication and collagen/polyethylene glycol microcontact printing. Biomaterials 27, 1061, 2006.
    • (2006) Biomaterials , vol.27 , pp. 1061
    • Fukuda, J.1    Sakai, Y.2    Nakazawa, K.3
  • 45
    • 33646421684 scopus 로고    scopus 로고
    • Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro
    • Kunz-Schughart, L.A., Schroeder, J.A., Wondrak, M., van Rey, F., Lehle, K., Hofstaedter, F., et al. Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro. Am J Physiol, Cell Physiol 290, C1385, 2006.
    • (2006) Am J Physiol, Cell Physiol , vol.290
    • Kunz-Schughart, L.A.1    Schroeder, J.A.2    Wondrak, M.3    Van Rey, F.4    Lehle, K.5    Hofstaedter, F.6
  • 47
    • 1642385430 scopus 로고    scopus 로고
    • Microscale tissue engineering using gravity-enforced cell assembly
    • Kelm, J.M., and Fussenegger, M. Microscale tissue engineering using gravity-enforced cell assembly. Trends Biotechnol 22, 195, 2004.
    • (2004) Trends Biotechnol , vol.22 , pp. 195
    • Kelm, J.M.1    Fussenegger, M.2
  • 48
    • 39349106325 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development
    • Murry, C.E., and Keller, G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 132, 661, 2008.
    • (2008) Cell , vol.132 , pp. 661
    • Murry, C.E.1    Keller, G.2
  • 49
    • 77949777103 scopus 로고    scopus 로고
    • Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation
    • Shukla, S., Nair, R., Rolle, M.W., Braun, K.R., Chan, C.K., Johnson, P.Y., et al. Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation. J Histochem Cytochem 58, 345, 2010.
    • (2010) J Histochem Cytochem , vol.58 , pp. 345
    • Shukla, S.1    Nair, R.2    Rolle, M.W.3    Braun, K.R.4    Chan, C.K.5    Johnson, P.Y.6
  • 50
    • 27744499693 scopus 로고    scopus 로고
    • E-cadherin synergistically induces hepatospecific phenotype and maturation of embryonic stem cells in conjunction with hepatotrophic factors
    • Dasgupta, A., Hughey, R., Lancin, P., Larue, L., and Moghe, P.V. E-cadherin synergistically induces hepatospecific phenotype and maturation of embryonic stem cells in conjunction with hepatotrophic factors. Biotechnol Bioeng 92, 257, 2005.
    • (2005) Biotechnol Bioeng , vol.92 , pp. 257
    • Dasgupta, A.1    Hughey, R.2    Lancin, P.3    Larue, L.4    Moghe, P.V.5
  • 52
    • 0028365627 scopus 로고
    • Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiacspecific genes and ionic currents
    • Maltsev, V.A., Wobus, A.M., Rohwedel, J., Bader, M., and Hescheler, J. Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiacspecific genes and ionic currents. Circ Res 75, 233, 1994.
    • (1994) Circ Res , vol.75 , pp. 233
    • Maltsev, V.A.1    Wobus, A.M.2    Rohwedel, J.3    Bader, M.4    Hescheler, J.5
  • 53
    • 33746569478 scopus 로고    scopus 로고
    • Pluripotency: Capacity for in vitro differentiation of undifferentiated embryonic stem cells
    • Wiese, C., Kania, G., Rolletschek, A., Blyszczuk, P., and Wobus, A.M. Pluripotency: capacity for in vitro differentiation of undifferentiated embryonic stem cells. Methods Mol Biol 325, 181, 2006.
    • (2006) Methods Mol Biol , vol.325 , pp. 181
    • Wiese, C.1    Kania, G.2    Rolletschek, A.3    Blyszczuk, P.4    Wobus, A.M.5
  • 54
    • 33646113360 scopus 로고    scopus 로고
    • Enhanced differentiation of human embryonic stemcells into cardiomyocytes by combining hanging drop culture and 5-azacytidine treatment
    • Yoon, B.S., Yoo, S.J., Lee, J.E., You, S., Lee, H.T., and Yoon, H.S. Enhanced differentiation of human embryonic stemcells into cardiomyocytes by combining hanging drop culture and 5-azacytidine treatment. Differentiation 74, 149, 2006.
    • (2006) Differentiation , vol.74 , pp. 149
    • Yoon, B.S.1    Yoo, S.J.2    Lee, J.E.3    You, S.4    Lee, H.T.5    Yoon, H.S.6
  • 55
    • 78751560396 scopus 로고    scopus 로고
    • High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
    • Tung, Y.C., Hsiao, A.Y., Allen, S.G., Torisawa, Y.S., Ho, M., and Takayama, S. High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array. Analyst 136, 473, 2011.
    • (2011) Analyst , vol.136 , pp. 473
    • Tung, Y.C.1    Hsiao, A.Y.2    Allen, S.G.3    Torisawa, Y.S.4    Ho, M.5    Takayama, S.6
  • 56
    • 34250860104 scopus 로고    scopus 로고
    • Methods for inducing embryoid body formation: In vitro differentiation system of embryonic stem cells
    • Kurosawa, H. Methods for inducing embryoid body formation: in vitro differentiation system of embryonic stem cells. J Biosci Bioeng 103, 389, 2007.
    • (2007) J Biosci Bioeng , vol.103 , pp. 389
    • Kurosawa, H.1
  • 57
    • 0033586981 scopus 로고    scopus 로고
    • Inoculation and growth conditions for high-cell-density expansion of mammalian neural stem cells in suspension bioreactors
    • Kallos, M.S., and Behie, L.A. Inoculation and growth conditions for high-cell-density expansion of mammalian neural stem cells in suspension bioreactors. Biotechnol Bioeng 63, 473, 1999.
    • (1999) Biotechnol Bioeng , vol.63 , pp. 473
    • Kallos, M.S.1    Behie, L.A.2
  • 58
    • 0034136393 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers
    • Itskovitz-Eldor, J., Schuldiner, M., Karsenti, D., Eden, A., Yanuka, O., Amit, M., et al. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Mol Med 6, 88, 2000.
    • (2000) Mol Med , vol.6 , pp. 88
    • Itskovitz-Eldor, J.1    Schuldiner, M.2    Karsenti, D.3    Eden, A.4    Yanuka, O.5    Amit, M.6
  • 59
    • 16644365884 scopus 로고    scopus 로고
    • Increased rate of chondrocyte aggregation in a wavy-walled bioreactor
    • Bueno, E.M., Bilgen, B., Carrier, R.L., and Barabino, G.A. Increased rate of chondrocyte aggregation in a wavy-walled bioreactor. Biotechnol Bioeng 88, 767, 2004.
    • (2004) Biotechnol Bioeng , vol.88 , pp. 767
    • Bueno, E.M.1    Bilgen, B.2    Carrier, R.L.3    Barabino, G.A.4
  • 60
    • 0027105562 scopus 로고
    • Cell culture for three-dimensional modeling in rotating-wall vessels: An application of simulated microgravity
    • Schwarz, R.P., Goodwin, T.J., and Wolf, D.A. Cell culture for three-dimensional modeling in rotating-wall vessels: an application of simulated microgravity. J Tissue Cult Methods 14, 51, 1992.
    • (1992) J Tissue Cult Methods , vol.14 , pp. 51
    • Schwarz, R.P.1    Goodwin, T.J.2    Wolf, D.A.3
  • 61
    • 84951608143 scopus 로고
    • Threedimensional modeling of T-24 human bladder carcinoma cell line: A new simulated microgravity culture vessel
    • Prewett, T., Goodwin, T., and Spaulding, G. Threedimensional modeling of T-24 human bladder carcinoma cell line: a new simulated microgravity culture vessel. Methods Cell Sci 15, 29, 1993.
    • (1993) Methods Cell Sci , vol.15 , pp. 29
    • Prewett, T.1    Goodwin, T.2    Spaulding, G.3
  • 62
    • 33644821694 scopus 로고    scopus 로고
    • Characterization of mixing in a novel wavy-walled bioreactor for tissue engineering
    • Bilgen, B., Chang-Mateu, I.M., and Barabino, G.A. Characterization of mixing in a novel wavy-walled bioreactor for tissue engineering. Biotechnol Bioeng 92, 907, 2005.
    • (2005) Biotechnol Bioeng , vol.92 , pp. 907
    • Bilgen, B.1    Chang-Mateu, I.M.2    Barabino, G.A.3
  • 63
    • 0034693458 scopus 로고    scopus 로고
    • Computational and experimental investigation of flow and fluid mixing in the roller bottle bioreactor
    • Unger, D., Muzzio, F., and Aunins, J. Computational and experimental investigation of flow and fluid mixing in the roller bottle bioreactor. Biotechnol Bioeng 70, 117, 2000.
    • (2000) Biotechnol Bioeng , vol.70 , pp. 117
    • Unger, D.1    Muzzio, F.2    Aunins, J.3
  • 64
    • 33845462911 scopus 로고    scopus 로고
    • Flow characterization of a wavy-walled bioreactor for cartilage tissue engineering
    • Bilgen, B., Sucosky, P., Neitzel, G.P., and Barabino, G.A. Flow characterization of a wavy-walled bioreactor for cartilage tissue engineering. Biotechnol Bioeng 95, 1009, 2006.
    • (2006) Biotechnol Bioeng , vol.95 , pp. 1009
    • Bilgen, B.1    Sucosky, P.2    Neitzel, G.P.3    Barabino, G.A.4
  • 65
    • 74849140306 scopus 로고    scopus 로고
    • Hydrodynamic modulation of embryonic stem cell differentiation by rotary orbital suspension culture
    • Sargent, C.Y., Berguig, G.Y., Kinney, M.A., Hiatt, L.A., Carpenedo, R.L., Berson, R.E., et al. Hydrodynamic modulation of embryonic stem cell differentiation by rotary orbital suspension culture. Biotechnol Bioeng 105, 611, 2010.
    • (2010) Biotechnol Bioeng , vol.105 , pp. 611
    • Sargent, C.Y.1    Berguig, G.Y.2    Kinney, M.A.3    Hiatt, L.A.4    Carpenedo, R.L.5    Berson, R.E.6
  • 67
    • 34748921666 scopus 로고    scopus 로고
    • Rotary suspension culture enhances the efficiency, yield, and homogeneity of embryoid body differentiation
    • Carpenedo, R.L., Sargent, C.Y., and McDevitt, T.C. Rotary suspension culture enhances the efficiency, yield, and homogeneity of embryoid body differentiation. Stem Cells 25, 2224, 2007.
    • (2007) Stem Cells , vol.25 , pp. 2224
    • Carpenedo, R.L.1    Sargent, C.Y.2    McDevitt, T.C.3
  • 68
    • 65349162225 scopus 로고    scopus 로고
    • Cardiomyogenic differentiation of embryoid bodies is promoted by rotary orbital suspension culture
    • Sargent, C., Berguig, G., and McDevitt, T. Cardiomyogenic differentiation of embryoid bodies is promoted by rotary orbital suspension culture. Tissue Eng Part A 15, 331, 2009.
    • (2009) Tissue Eng Part A , vol.15 , pp. 331
    • Sargent, C.1    Berguig, G.2    McDevitt, T.3
  • 70
    • 79960648654 scopus 로고    scopus 로고
    • Agitation speed and interfacial mass transfer coefficients in mass transfer dominated reactions
    • Fernando, W.J.N., Othman, M.R., and Karunaratne, D.G.G.P. Agitation speed and interfacial mass transfer coefficients in mass transfer dominated reactions. IJET 11, 95, 2010.
    • (2010) IJET , vol.11 , pp. 95
    • Fernando, W.J.N.1    Othman, M.R.2    Karunaratne, D.G.G.P.3
  • 71
    • 33745035647 scopus 로고    scopus 로고
    • Scalable producing embryoid bodies by rotary cell culture system and constructing engineered cardiac tissue with ESderived cardiomyocytes in vitro
    • Wang, X., Wei, G., Yu, W., Zhao, Y., Yu, X., and Ma, X. Scalable producing embryoid bodies by rotary cell culture system and constructing engineered cardiac tissue with ESderived cardiomyocytes in vitro. Biotechnol Prog 22, 811, 2006.
    • (2006) Biotechnol Prog , vol.22 , pp. 811
    • Wang, X.1    Wei, G.2    Yu, W.3    Zhao, Y.4    Yu, X.5    Ma, X.6
  • 72
    • 2442451432 scopus 로고    scopus 로고
    • Bioreactor cultivation enhances the efficiency of human embryoid body (hEB) formation and differentiation
    • Gerecht-Nir, S., Cohen, S., and Itskovitz-Eldor, J. Bioreactor cultivation enhances the efficiency of human embryoid body (hEB) formation and differentiation. Biotechnol Bioeng 86, 493, 2004.
    • (2004) Biotechnol Bioeng , vol.86 , pp. 493
    • Gerecht-Nir, S.1    Cohen, S.2    Itskovitz-Eldor, J.3
  • 73
    • 61949475114 scopus 로고    scopus 로고
    • Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function
    • Brophy, C.M., Luebke-Wheeler, J.L., Amiot, B.P., Khan, H., Remmel, R.P., Rinaldo, P., et al. Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function. Hepatology 49, 578, 2009.
    • (2009) Hepatology , vol.49 , pp. 578
    • Brophy, C.M.1    Luebke-Wheeler, J.L.2    Amiot, B.P.3    Khan, H.4    Remmel, R.P.5    Rinaldo, P.6
  • 74
    • 0037013927 scopus 로고    scopus 로고
    • Fast dissociation kinetics between individual E-cadherin fragments revealed by flow chamber analysis
    • Perret, E., Benoliel, A.M., Nassoy, P., Pierres, A., Delmas, V., Thiery, J.P., et al. Fast dissociation kinetics between individual E-cadherin fragments revealed by flow chamber analysis. EMBO J 21, 2537, 2002.
    • (2002) EMBO J , vol.21 , pp. 2537
    • Perret, E.1    Benoliel, A.M.2    Nassoy, P.3    Pierres, A.4    Delmas, V.5    Thiery, J.P.6
  • 75
    • 33746866782 scopus 로고    scopus 로고
    • Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivation
    • Cameron, C.M., Hu, W.-S., and Kaufman, D.S. Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivation. Biotechnol Bioeng 94, 938, 2006.
    • (2006) Biotechnol Bioeng , vol.94 , pp. 938
    • Cameron, C.M.1    Hu, W.-S.2    Kaufman, D.S.3
  • 76
    • 33751563297 scopus 로고    scopus 로고
    • Expansion of undifferentiated murine embryonic stem cells as aggregates in suspension culture bioreactors
    • Cormier, J.T., zur Nieden, N.I., Rancourt, D.E., and Kallos, M.S. Expansion of undifferentiated murine embryonic stem cells as aggregates in suspension culture bioreactors. Tissue Eng 12, 3233, 2006.
    • (2006) Tissue Eng , vol.12 , pp. 3233
    • Cormier, J.T.1    Zur Nieden, N.I.2    Rancourt, D.E.3    Kallos, M.S.4
  • 77
    • 0032941232 scopus 로고    scopus 로고
    • Alginate hydrogels as synthetic extracellular matrix materials
    • Rowley, J.A., Madlambayan, G., and Mooney, D.J. Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials 20, 45, 1999.
    • (1999) Biomaterials , vol.20 , pp. 45
    • Rowley, J.A.1    Madlambayan, G.2    Mooney, D.J.3
  • 78
    • 56449090986 scopus 로고    scopus 로고
    • The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering
    • Hwang, Y.S., Cho, J., Tay, F., Heng JYY, Ho, R., Kazarian, S.G., et al. The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering. Biomaterials 30, 499, 2009.
    • (2009) Biomaterials , vol.30 , pp. 499
    • Hwang, Y.S.1    Cho, J.2    Tay, F.3    Jyy, H.4    Ho, R.5    Kazarian, S.G.6
  • 79
    • 52549116234 scopus 로고    scopus 로고
    • Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells
    • Benoit DSW, Schwartz, M.P., Durney, A.R., and Anseth, K.S. Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells. Nat Mater 7, 816, 2008.
    • (2008) Nat Mater , vol.7 , pp. 816
    • Benoit, D.S.W.1    Schwartz, M.P.2    Durney, A.R.3    Anseth, K.S.4
  • 80
    • 78651513849 scopus 로고    scopus 로고
    • Cardiac cell generation from encapsulated embryonic stem cells in static and scalable culture systems
    • Jing, D., Parikh, A., and Tzanakakis, E.S. Cardiac cell generation from encapsulated embryonic stem cells in static and scalable culture systems. Cell Transplant 19, 1397, 2010.
    • (2010) Cell Transplant , vol.19 , pp. 1397
    • Jing, D.1    Parikh, A.2    Tzanakakis, E.S.3
  • 81
    • 36849019026 scopus 로고    scopus 로고
    • Integrated 3-dimensional expansion and osteogenic differentiation of murine embryonic stem cells
    • Randle, W.L., Cha, J.M., Hwang Y-S, Chan KLA, Kazarian, S.G., Polak, J.M., et al. Integrated 3-dimensional expansion and osteogenic differentiation of murine embryonic stem cells. Tissue Eng 13, 2957, 2007.
    • (2007) Tissue Eng , vol.13 , pp. 2957
    • Randle, W.L.1    Cha, J.M.2    Hwang, Y.-S.3    Chan, K.L.A.4    Kazarian, S.G.5    Polak, J.M.6
  • 83
    • 16644366111 scopus 로고    scopus 로고
    • Scalable production of embryonic stem cell-derived cells
    • Dang, S.M., and Zandstra, P.W. Scalable production of embryonic stem cell-derived cells. Methods Mol Biol 290, 353, 2005.
    • (2005) Methods Mol Biol , vol.290 , pp. 353
    • Dang, S.M.1    Zandstra, P.W.2
  • 84
    • 0242468552 scopus 로고    scopus 로고
    • Generation of confluent cardiomyocyte monolayers derived from embryonic stem cells in suspension: A cell source for new therapies and screening strategies
    • Zweigerdt, R., Burg, M., Willbold, E., Abts, H., and Ruediger, M. Generation of confluent cardiomyocyte monolayers derived from embryonic stem cells in suspension: a cell source for new therapies and screening strategies. Cytotherapy 5, 399, 2003.
    • (2003) Cytotherapy , vol.5 , pp. 399
    • Zweigerdt, R.1    Burg, M.2    Willbold, E.3    Abts, H.4    Ruediger, M.5
  • 85
    • 35848931232 scopus 로고    scopus 로고
    • Stirred vessel cultures of rat brain cells aggregates: Characterization of major metabolic pathways and cell population dynamics
    • Santos, S.S., Leite, S.B., Sonnewald, U., Carrondo MJT, and Alves, P.M. Stirred vessel cultures of rat brain cells aggregates: characterization of major metabolic pathways and cell population dynamics. J Neurosci Res 85, 3386, 2007.
    • (2007) J Neurosci Res , vol.85 , pp. 3386
    • Santos, S.S.1    Leite, S.B.2    Sonnewald, U.3    Mjt, C.4    Alves, P.M.5
  • 86
    • 57449091705 scopus 로고    scopus 로고
    • Establishing a dynamic process for the formation, propagation, and differentiation of human embryoid bodies
    • Yirme, G., Amit, M., Laevsky, I., Osenberg, S., and Itskovitz-Eldor, J. Establishing a dynamic process for the formation, propagation, and differentiation of human embryoid bodies. Stem Cells Dev 17, 1227, 2008.
    • (2008) Stem Cells Dev , vol.17 , pp. 1227
    • Yirme, G.1    Amit, M.2    Laevsky, I.3    Osenberg, S.4    Itskovitz-Eldor, J.5
  • 87
    • 0029360524 scopus 로고
    • Effect of viscosity upon hydrodynamically controlled natural aggregates of animal cells grown in stirred vessels
    • Moreira, J.L., Santana, P.C., Feliciano, A.S., Cruz, P.E., Racher, A.J., Griffiths, J.B., et al. Effect of viscosity upon hydrodynamically controlled natural aggregates of animal cells grown in stirred vessels. Biotechnol Prog 11, 575, 1995.
    • (1995) Biotechnol Prog , vol.11 , pp. 575
    • Moreira, J.L.1    Santana, P.C.2    Feliciano, A.S.3    Cruz, P.E.4    Racher, A.J.5    Griffiths, J.B.6
  • 88
    • 0035195704 scopus 로고    scopus 로고
    • Effects of hydrodynamics on cultures of mammalian neural stem cell aggregates in suspension bioreactors
    • Sen, A., Kallos, M., and Behie, L. Effects of hydrodynamics on cultures of mammalian neural stem cell aggregates in suspension bioreactors. Ind Eng Chem Res 40, 5350, 2001.
    • (2001) Ind Eng Chem Res , vol.40 , pp. 5350
    • Sen, A.1    Kallos, M.2    Behie, L.3
  • 89
    • 51849126825 scopus 로고    scopus 로고
    • Expansion of human neural precursor cells in large-scale bioreactors for the treatment of neurodegenerative disorders
    • Baghbaderani, B.A., Behie, L.A., Sen, A., Mukhida, K., Hong, M., and Mendez, I. Expansion of human neural precursor cells in large-scale bioreactors for the treatment of neurodegenerative disorders. Biotechnol Prog 24, 859, 2008.
    • (2008) Biotechnol Prog , vol.24 , pp. 859
    • Baghbaderani, B.A.1    Behie, L.A.2    Sen, A.3    Mukhida, K.4    Hong, M.5    Mendez, I.6
  • 90
    • 33644821605 scopus 로고    scopus 로고
    • Differentiation and lineage selection of mouse embryonic stem cells in a stirred bench scale bioreactor with automated process control
    • Schroeder, M., Niebruegge, S., Werner, A., Willbold, E., Burg, M., Ruediger, M., et al. Differentiation and lineage selection of mouse embryonic stem cells in a stirred bench scale bioreactor with automated process control. Biotechnol Bioeng 92, 920, 2005.
    • (2005) Biotechnol Bioeng , vol.92 , pp. 920
    • Schroeder, M.1    Niebruegge, S.2    Werner, A.3    Willbold, E.4    Burg, M.5    Ruediger, M.6
  • 91
    • 0026036718 scopus 로고
    • Regulation of animal cell metabolism in bioreactors
    • Miller, W.M., and Blanch, H.W. Regulation of animal cell metabolism in bioreactors. Biotechnology 17, 119, 1991.
    • (1991) Biotechnology , vol.17 , pp. 119
    • Miller, W.M.1    Blanch, H.W.2
  • 92
    • 0030152222 scopus 로고    scopus 로고
    • Determination of specific oxygen uptake rates in human hematopoietic cultures and implications for bioreactor design
    • Peng, C.A., and Palsson, B.O. Determination of specific oxygen uptake rates in human hematopoietic cultures and implications for bioreactor design. Ann Biomed Eng 24, 373, 1996.
    • (1996) Ann Biomed Eng , vol.24 , pp. 373
    • Peng, C.A.1    Palsson, B.O.2
  • 93
    • 57649134966 scopus 로고    scopus 로고
    • Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells
    • Schieke, S.M., Ma, M., Cao, L., McCoy, J.P., Liu, C., Hensel, N.F., et al. Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells. J Biol Chem 283, 28506, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 28506
    • Schieke, S.M.1    Ma, M.2    Cao, L.3    McCoy, J.P.4    Liu, C.5    Hensel, N.F.6
  • 96
    • 16444378525 scopus 로고    scopus 로고
    • Role of nutrient supply on cell growth in bioreactor design for tissue engineering of hematopoietic cells
    • Pathi, P., Ma, T., and Locke, B.R. Role of nutrient supply on cell growth in bioreactor design for tissue engineering of hematopoietic cells. Biotechnol Bioeng 89, 743, 2005.
    • (2005) Biotechnol Bioeng , vol.89 , pp. 743
    • Pathi, P.1    Ma, T.2    Locke, B.R.3
  • 97
    • 0032487131 scopus 로고    scopus 로고
    • Stirred culture of peripheral and cord blood hematopoietic cells offers advantages over traditional static systems for clinically relevant applications
    • Collins, P.C., Miller, W.M., and Papoutsakis, E.T. Stirred culture of peripheral and cord blood hematopoietic cells offers advantages over traditional static systems for clinically relevant applications. Biotechnol Bioeng 59, 534, 1998.
    • (1998) Biotechnol Bioeng , vol.59 , pp. 534
    • Collins, P.C.1    Miller, W.M.2    Papoutsakis, E.T.3
  • 98
    • 0032078316 scopus 로고    scopus 로고
    • Characterization of hematopoietic cell expansion, oxygen uptake, and glycolysis in a controlled, stirred-tank bioreactor system
    • Collins, P.C., Nielsen, L.K., Patel, S.D., Papoutsakis, E.T., and Miller, W.M. Characterization of hematopoietic cell expansion, oxygen uptake, and glycolysis in a controlled, stirred-tank bioreactor system. Biotechnol Prog 14, 466, 1998.
    • (1998) Biotechnol Prog , vol.14 , pp. 466
    • Collins, P.C.1    Nielsen, L.K.2    Patel, S.D.3    Papoutsakis, E.T.4    Miller, W.M.5
  • 99
    • 33745484771 scopus 로고    scopus 로고
    • Ex vivo expansion of hematopoietic stem cells derived from umbilical cord blood in rotating wall vessel
    • Liu, Y., Liu, T., Fan, X., Ma, X., and Cui, Z. Ex vivo expansion of hematopoietic stem cells derived from umbilical cord blood in rotating wall vessel. J Biotechnol 124, 592, 2006.
    • (2006) J Biotechnol , vol.124 , pp. 592
    • Liu, Y.1    Liu, T.2    Fan, X.3    Ma, X.4    Cui, Z.5
  • 100
    • 34248146418 scopus 로고    scopus 로고
    • A comparative geneexpression analysis of CD34 + hematopoietic stem and progenitor cells grown in static and stirred culture systems
    • Li, Q., Liu, Q., Cai, H., and Tan, W.S. A comparative geneexpression analysis of CD34 + hematopoietic stem and progenitor cells grown in static and stirred culture systems. Cell Mol Biol Lett 11, 475, 2006.
    • (2006) Cell Mol Biol Lett , vol.11 , pp. 475
    • Li, Q.1    Liu, Q.2    Cai, H.3    Tan, W.S.4
  • 102
    • 77953808008 scopus 로고    scopus 로고
    • Interwoven four-compartment capillary membrane technology for three-dimensional perfusion with decentralized mass exchange to scale up embryonic stem cell culture
    • Gerlach, J.C., Lü bberstedt, M., Edsbagge, J., Ring, A., Hout, M., Baun, M., et al. Interwoven four-compartment capillary membrane technology for three-dimensional perfusion with decentralized mass exchange to scale up embryonic stem cell culture. Cells Tissues Organs (Print) 192, 39, 2010.
    • (2010) Cells Tissues Organs (Print) , vol.192 , pp. 39
    • Gerlach, J.C.1    Lü Bberstedt, M.2    Edsbagge, J.3    Ring, A.4    Hout, M.5    Baun, M.6
  • 103
    • 52049119029 scopus 로고    scopus 로고
    • Embryoid body morphology influences diffusive transport of inductive biochemicals: A strategy for stem cell differentiation
    • Sachlos, E., and Auguste, D.T. Embryoid body morphology influences diffusive transport of inductive biochemicals: a strategy for stem cell differentiation. Biomaterials 29, 4471, 2008.
    • (2008) Biomaterials , vol.29 , pp. 4471
    • Sachlos, E.1    Auguste, D.T.2
  • 104
    • 60849103067 scopus 로고    scopus 로고
    • Homogeneous and organized differentiation within embryoid bodies induced by microsphere-mediated delivery of small molecules
    • Carpenedo, R.L., Bratt-Leal, A.M., Marklein, R.A., Seaman, S.A., Bowen, N.J., McDonald, J.F., et al. Homogeneous and organized differentiation within embryoid bodies induced by microsphere-mediated delivery of small molecules. Biomaterials 30, 2507, 2009.
    • (2009) Biomaterials , vol.30 , pp. 2507
    • Carpenedo, R.L.1    Bratt-Leal, A.M.2    Marklein, R.A.3    Seaman, S.A.4    Bowen, N.J.5    McDonald, J.F.6
  • 105
    • 68749115159 scopus 로고    scopus 로고
    • Expansion and differentiation of human embryonic stem cells to endoderm progeny in a microcarrier stirred-suspension culture
    • Lock, L.T., and Tzanakakis, E.S. Expansion and differentiation of human embryonic stem cells to endoderm progeny in a microcarrier stirred-suspension culture. Tissue Eng Part A 15, 2051, 2009.
    • (2009) Tissue Eng Part A , vol.15 , pp. 2051
    • Lock, L.T.1    Tzanakakis, E.S.2
  • 106
    • 78049366735 scopus 로고    scopus 로고
    • Investigations into the metabolism of two-dimensional colony and suspended microcarrier cultures of human embryonic stem cells in serum-free media
    • Chen, X., Chen, A., Woo, T.L., Choo ABH, Reuveny, S., and Oh SKW. Investigations into the metabolism of two-dimensional colony and suspended microcarrier cultures of human embryonic stem cells in serum-free media. Stem Cells Dev 19, 1781, 2010.
    • (2010) Stem Cells Dev , vol.19 , pp. 1781
    • Chen, X.1    Chen, A.2    Woo, T.L.3    Choo, A.B.H.4    Reuveny, S.5    Oh, S.K.W.6
  • 107
    • 33845952788 scopus 로고    scopus 로고
    • Effects of glutamine, glucose, and oxygen concentration on the metabolism and proliferation of rabbit adipose-derived stem cells
    • Follmar, K.E., Decroos, F.C., Prichard, H.L., Wang, H.T., Erdmann, D., and Olbrich, K.C. Effects of glutamine, glucose, and oxygen concentration on the metabolism and proliferation of rabbit adipose-derived stem cells. Tissue Eng 12, 3525, 2006.
    • (2006) Tissue Eng , vol.12 , pp. 3525
    • Follmar, K.E.1    Decroos, F.C.2    Prichard, H.L.3    Wang, H.T.4    Erdmann, D.5    Olbrich, K.C.6
  • 108
    • 20344382984 scopus 로고    scopus 로고
    • Development of a perfusion fed bioreactor for embryonic stem cell-derived cardiomyocyte generation: Oxygen-mediated enhancement of cardiomyocyte output
    • Bauwens, C., Yin, T., Dang, S., Peerani, R., and Zandstra, P.W. Development of a perfusion fed bioreactor for embryonic stem cell-derived cardiomyocyte generation: oxygen-mediated enhancement of cardiomyocyte output. Biotechnol Bioeng 90, 452, 2005.
    • (2005) Biotechnol Bioeng , vol.90 , pp. 452
    • Bauwens, C.1    Yin, T.2    Dang, S.3    Peerani, R.4    Zandstra, P.W.5
  • 109
    • 77955057824 scopus 로고    scopus 로고
    • Improving expansion of pluripotent human embryonic stem cells in perfused bioreactors through oxygen control
    • Serra, M., Brito, C., Sousa MFQ, Jensen, J., Tostõ es, R., Clemente, J., et al. Improving expansion of pluripotent human embryonic stem cells in perfused bioreactors through oxygen control. J Biotechnol 148, 208, 2010.
    • (2010) J Biotechnol , vol.148 , pp. 208
    • Serra, M.1    Brito, C.2    Sousa, M.F.Q.3    Jensen, J.4    Tostõ Es, R.5    Clemente, J.6
  • 110
    • 34247124010 scopus 로고    scopus 로고
    • A combined fluid dynamics, mass transport and cell growth model for a three-dimensional perfused biorector for tissue engineering of haematopoietic cells
    • Ma, C., Kumar, R., Xu, X., and Mantalaris, A. A combined fluid dynamics, mass transport and cell growth model for a three-dimensional perfused biorector for tissue engineering of haematopoietic cells. Biochem Eng J 35, 1, 2007.
    • (2007) Biochem Eng J , vol.35 , pp. 1
    • Ma, C.1    Kumar, R.2    Xu, X.3    Mantalaris, A.4
  • 111
    • 56749161150 scopus 로고    scopus 로고
    • Propagation of embryonic stem cells in stirred suspension without serum
    • Kehoe, D.E., Lock, L.T., Parikh, A., and Tzanakakis, E.S. Propagation of embryonic stem cells in stirred suspension without serum. Biotechnol Prog 24, 1342, 2008.
    • (2008) Biotechnol Prog , vol.24 , pp. 1342
    • Kehoe, D.E.1    Lock, L.T.2    Parikh, A.3    Tzanakakis, E.S.4
  • 112
    • 34147145008 scopus 로고    scopus 로고
    • Embryonic stem cells remain highly pluripotent following long term expansion as aggregates in suspension bioreactors
    • zur Nieden, N.I., Cormier, J.T., Rancourt, D.E., and Kallos, M.S. Embryonic stem cells remain highly pluripotent following long term expansion as aggregates in suspension bioreactors. J Biotechnol 129, 421, 2007.
    • (2007) J Biotechnol , vol.129 , pp. 421
    • Zur Nieden, N.I.1    Cormier, J.T.2    Rancourt, D.E.3    Kallos, M.S.4
  • 114
    • 77955004097 scopus 로고    scopus 로고
    • Large-scale expansion of pluripotent human embryonic stem cells in stirred suspension bioreactors
    • Krawetz, R., Taiani, J., Liu, S., Meng, G., Li, X., Kallos, M., et al. Large-scale expansion of pluripotent human embryonic stem cells in stirred suspension bioreactors. Tissue Eng Part C Methods 16, 573, 2010.
    • (2010) Tissue Eng Part C Methods , vol.16 , pp. 573
    • Krawetz, R.1    Taiani, J.2    Liu, S.3    Meng, G.4    Li, X.5    Kallos, M.6
  • 115
    • 77952429809 scopus 로고    scopus 로고
    • Up-scaling single cell-inoculated suspension culture of human embryonic stem cells
    • Singh, H., Mok, P., Balakrishnan, T., Rahmat, S.N.B., and Zweigerdt, R. Up-scaling single cell-inoculated suspension culture of human embryonic stem cells. Stem Cell Res 4, 165, 2010.
    • (2010) Stem Cell Res , vol.4 , pp. 165
    • Singh, H.1    Mok, P.2    Balakrishnan, T.3    Rahmat, S.N.B.4    Zweigerdt, R.5
  • 116
    • 33749188522 scopus 로고    scopus 로고
    • Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells
    • Chen, X., Xu, H., Wan, C., McCaigue, M., and Li, G. Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells. Stem Cells 24, 2052, 2006.
    • (2006) Stem Cells , vol.24 , pp. 2052
    • Chen, X.1    Xu, H.2    Wan, C.3    McCaigue, M.4    Li, G.5
  • 117
    • 33745742869 scopus 로고    scopus 로고
    • Scaled-up production of mammalian neural precursor cell aggregates in computer-controlled suspension bioreactors
    • Gilbertson, J.A., Sen, A., Behie, L.A., and Kallos, M.S. Scaled-up production of mammalian neural precursor cell aggregates in computer-controlled suspension bioreactors. Biotechnol Bioeng 94, 783, 2006.
    • (2006) Biotechnol Bioeng , vol.94 , pp. 783
    • Gilbertson, J.A.1    Sen, A.2    Behie, L.A.3    Kallos, M.S.4
  • 118
    • 70350726541 scopus 로고    scopus 로고
    • Integrating human stem cell expansion and neuronal differentiation in bioreactors
    • Serra, M., Brito, C., Costa, E.M., Sousa, M.F.Q., and Alves, P.M. Integrating human stem cell expansion and neuronal differentiation in bioreactors. BMC Biotechnol 9, 82, 2009.
    • (2009) BMC Biotechnol , vol.9 , pp. 82
    • Serra, M.1    Brito, C.2    Costa, E.M.3    Sousa, M.F.Q.4    Alves, P.M.5
  • 119
    • 27144526161 scopus 로고    scopus 로고
    • Shear-controlled single-step mouse embryonic stem cell expansion and embryoid bodybased differentiation
    • Fok, E.Y., and Zandstra, P.W. Shear-controlled single-step mouse embryonic stem cell expansion and embryoid bodybased differentiation. Stem Cells 23, 1333, 2005.
    • (2005) Stem Cells , vol.23 , pp. 1333
    • Fok, E.Y.1    Zandstra, P.W.2
  • 120
    • 77954937162 scopus 로고    scopus 로고
    • Reduced differentiation efficiency of murine embryonic stem cells in stirred suspension bioreactors
    • Taiani, J., Krawetz, R.J., Nieden, N.Z., Wu, Y.E., Kallos, M.S., Matyas, J.R., et al. Reduced differentiation efficiency of murine embryonic stem cells in stirred suspension bioreactors. Stem Cells Dev 19, 989, 2010.
    • (2010) Stem Cells Dev , vol.19 , pp. 989
    • Taiani, J.1    Krawetz, R.J.2    Nieden, N.Z.3    Wu, Y.E.4    Kallos, M.S.5    Matyas, J.R.6
  • 121
    • 77955000681 scopus 로고    scopus 로고
    • Dynamic three-dimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential
    • Frith, J., Thomson, B., and Genever, P. Dynamic three-dimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential. Tissue Eng Part C Methods 16, 735, 2010.
    • (2010) Tissue Eng Part C Methods , vol.16 , pp. 735
    • Frith, J.1    Thomson, B.2    Genever, P.3
  • 122
    • 33748758179 scopus 로고    scopus 로고
    • Effect of 3D scaffold and dynamic culture condition on the global gene expression profile of mouse embryonic stem cells
    • Liu, H., Lin, J., and Roy, K. Effect of 3D scaffold and dynamic culture condition on the global gene expression profile of mouse embryonic stem cells. Biomaterials 27, 5978, 2006.
    • (2006) Biomaterials , vol.27 , pp. 5978
    • Liu, H.1    Lin, J.2    Roy, K.3
  • 123
    • 2042548006 scopus 로고    scopus 로고
    • Modeled microgravity inhibits osteogenic differentiation of human mesenchymal stem cells and increases adipogenesis
    • Zayzafoon, M., Gathings, W.E., and McDonald, J.M. Modeled microgravity inhibits osteogenic differentiation of human mesenchymal stem cells and increases adipogenesis. Endocrinology 145, 2421, 2004.
    • (2004) Endocrinology , vol.145 , pp. 2421
    • Zayzafoon, M.1    Gathings, W.E.2    McDonald, J.M.3
  • 124
    • 78149236761 scopus 로고    scopus 로고
    • Unique differentiation profile of mouse embryonic stem cells in rotary and stirred tank bioreactors
    • Fridley, K.M., Fernandez, I., Li M-T, Kettlewell, R.B., and Roy, K. Unique differentiation profile of mouse embryonic stem cells in rotary and stirred tank bioreactors. Tissue Eng Part A 16, 3285, 2010.
    • (2010) Tissue Eng Part A , vol.16 , pp. 3285
    • Fridley, K.M.1    Fernandez, I.2    Li, M.-T.3    Kettlewell, R.B.4    Roy, K.5
  • 125
    • 58249090413 scopus 로고    scopus 로고
    • Generation of human embryonic stem cell-derived mesoderm and cardiac cells using size-specified aggregates in an oxygen-controlled bioreactor
    • Niebruegge, S., Bauwens, C.L., Peerani, R., Thavandiran, N., Masse, S., Sevaptisidis, E., et al. Generation of human embryonic stem cell-derived mesoderm and cardiac cells using size-specified aggregates in an oxygen-controlled bioreactor. Biotechnol Bioeng 102, 493, 2009.
    • (2009) Biotechnol Bioeng , vol.102 , pp. 493
    • Niebruegge, S.1    Bauwens, C.L.2    Peerani, R.3    Thavandiran, N.4    Masse, S.5    Sevaptisidis, E.6
  • 126
    • 50649085287 scopus 로고    scopus 로고
    • Activation of hypoxic response in human embryonic stem cell-derived embryoid bodies
    • Cameron, C.M., Harding, F., Hu, W.S., and Kaufman, D.S. Activation of hypoxic response in human embryonic stem cell-derived embryoid bodies. Exp Biol Med 233, 1044, 2008.
    • (2008) Exp Biol Med , vol.233 , pp. 1044
    • Cameron, C.M.1    Harding, F.2    Hu, W.S.3    Kaufman, D.S.4
  • 129
    • 0033667481 scopus 로고    scopus 로고
    • Lactate elicits vascular endothelial growth factor from macrophages: A possible alternative to hypoxia
    • Constant, J.S., Feng, J.J., Zabel, D.D., Yuan, H., Suh, D.Y., Scheuenstuhl, H., et al. Lactate elicits vascular endothelial growth factor from macrophages: a possible alternative to hypoxia. Wound Repair Regen 8, 353, 2000.
    • (2000) Wound Repair Regen , vol.8 , pp. 353
    • Constant, J.S.1    Feng, J.J.2    Zabel, D.D.3    Yuan, H.4    Suh, D.Y.5    Scheuenstuhl, H.6
  • 131
    • 34547108569 scopus 로고    scopus 로고
    • Microfabrication-based modulation of embryonic stem cell differentiation
    • Park, J., Cho, C.H., Parashurama, N., Li, Y., Berthiaume, F., Toner, M., et al. Microfabrication-based modulation of embryonic stem cell differentiation. Lab Chip 7, 1018, 2007.
    • (2007) Lab Chip , vol.7 , pp. 1018
    • Park, J.1    Cho, C.H.2    Parashurama, N.3    Li, Y.4    Berthiaume, F.5    Toner, M.6
  • 132
    • 55049120510 scopus 로고    scopus 로고
    • Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories
    • Bauwens, C.L., Peerani, R., Niebruegge, S., Woodhouse, K.A., Kumacheva, E., Husain, M., et al. Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories. Stem Cells 26, 2300, 2008.
    • (2008) Stem Cells , vol.26 , pp. 2300
    • Bauwens, C.L.1    Peerani, R.2    Niebruegge, S.3    Woodhouse, K.A.4    Kumacheva, E.5    Husain, M.6
  • 133
    • 33748792541 scopus 로고    scopus 로고
    • 3-D microwell culture of human embryonic stem cells
    • Mohr, J.C., De Pablo, J.J., and Palecek, S.P. 3-D microwell culture of human embryonic stem cells. Biomaterials 27, 6032, 2006.
    • (2006) Biomaterials , vol.27 , pp. 6032
    • Mohr, J.C.1    De Pablo, J.J.2    Palecek, S.P.3
  • 134
    • 70350126572 scopus 로고    scopus 로고
    • Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11
    • Hwang, Y.S., Chung, B.G., Ortmann, D., Hattori, N., Moeller, H.C., and Khademhosseini, A. Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11. Proc Natl Acad Sci USA 106, 16978, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 16978
    • Hwang, Y.S.1    Chung, B.G.2    Ortmann, D.3    Hattori, N.4    Moeller, H.C.5    Khademhosseini, A.6
  • 135
    • 45349084219 scopus 로고    scopus 로고
    • Reproducible, ultra high-throughput formation of multicellular organization from single cell suspensionderived human embryonic stem cell aggregates
    • Ungrin MD, Joshi, C., Nica, A., Bauwens, C., and Zandstra, P.W. Reproducible, ultra high-throughput formation of multicellular organization from single cell suspensionderived human embryonic stem cell aggregates. PLoS ONE 3, e1565, 2008.
    • (2008) PLoS ONE , vol.3
    • Ungrin, M.D.1    Joshi, C.2    Nica, A.3    Bauwens, C.4    Zandstra, P.W.5
  • 136
    • 35648945318 scopus 로고    scopus 로고
    • Scaffold-free three-dimensional cell culture utilizing micromolded nonadhesive hydrogels
    • Napolitano, A.P., Dean, D.M., Man, A.J., Youssef, J., Ho, D.N., Rago, A.P., et al. Scaffold-free three-dimensional cell culture utilizing micromolded nonadhesive hydrogels. Biotechniques 43, 494, 496, 2007.
    • (2007) Biotechniques , vol.43 , pp. 494-496
    • Napolitano, A.P.1    Dean, D.M.2    Man, A.J.3    Youssef, J.4    Ho, D.N.5    Rago, A.P.6
  • 137
    • 79952512252 scopus 로고    scopus 로고
    • Bioengineering anembryonic human trophoblast vesicles
    • Robins JC, Morgan, J.R., Krueger, P., and Carson, S.A. Bioengineering anembryonic human trophoblast vesicles. Reprod Sci 18, 128, 2011.
    • (2011) Reprod Sci , vol.18 , pp. 128
    • Robins, J.C.1    Morgan, J.R.2    Krueger, P.3    Carson, S.A.4
  • 138
    • 56249113001 scopus 로고    scopus 로고
    • Emergence of patterned stem cell differentiation within multicellular structures
    • Ruiz SA, and Chen, C.S. Emergence of patterned stem cell differentiation within multicellular structures. Stem Cells 26, 2921, 2008.
    • (2008) Stem Cells , vol.26 , pp. 2921
    • Ruiz, S.A.1    Chen, C.S.2
  • 139
    • 36849044035 scopus 로고    scopus 로고
    • Rods, tori, and honeycombs: The directed self-assembly of microtissues with prescribed microscale geometries
    • Dean, D.M., Napolitano AP, Youssef, J., and Morgan, J.R. Rods, tori, and honeycombs: the directed self-assembly of microtissues with prescribed microscale geometries. FASEB J 21, 4005, 2007.
    • (2007) FASEB J , vol.21 , pp. 4005
    • Dean, D.M.1    Napolitano, A.P.2    Youssef, J.3    Morgan, J.R.4
  • 141
    • 77953827366 scopus 로고    scopus 로고
    • Microsphere size effects on embryoid body incorporation and embryonic stem cell differentiation
    • Carpenedo, R.L., Seaman, S.A., and McDevitt, T.C. Microsphere size effects on embryoid body incorporation and embryonic stem cell differentiation. J Biomed Mater Res A 94, 466, 2010.
    • (2010) J Biomed Mater Res A , vol.94 , pp. 466
    • Carpenedo, R.L.1    Seaman, S.A.2    McDevitt, T.C.3
  • 142
    • 78349304764 scopus 로고    scopus 로고
    • Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation
    • Bratt-Leal AM, Carpenedo, R.L., Ungrin, M.D., Zandstra PW, and McDevitt, T.C. Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation. Biomaterials 32, 48, 2011.
    • (2011) Biomaterials , vol.32 , pp. 48
    • Bratt-Leal, A.M.1    Carpenedo, R.L.2    Ungrin, M.D.3    Zandstra, P.W.4    McDevitt, T.C.5
  • 143
    • 75749158166 scopus 로고    scopus 로고
    • Chondrogenic differentiation of human mesenchymal stem cell aggregates via controlled release of TGF-b1 from incorporated polymer microspheres
    • Solorio, L.D., Fu AS, Hernández-Irizarry, R., and Alsberg, E. Chondrogenic differentiation of human mesenchymal stem cell aggregates via controlled release of TGF-b1 from incorporated polymer microspheres. J Biomed Mater Res A 92, 1139, 2010.
    • (2010) J Biomed Mater Res A , vol.92 , pp. 1139
    • Solorio, L.D.1    Fu, A.S.2    Hernández-Irizarry, R.3    Alsberg, E.4
  • 144
    • 0034789414 scopus 로고    scopus 로고
    • Transplantation of brain cells assembled around a programmable synthetic microenvironment
    • Mahoney, M.J., and Saltzman, W.M. Transplantation of brain cells assembled around a programmable synthetic microenvironment. Nat Biotechnol 19, 934, 2001.
    • (2001) Nat Biotechnol , vol.19 , pp. 934
    • Mahoney, M.J.1    Saltzman, W.M.2
  • 145
    • 48349136691 scopus 로고    scopus 로고
    • Human embryoid bodies containing nano-and microparticulate delivery vehicles
    • Ferreira, L., Squier, T., Park, H., Choe, H., Kohane, D., and Langer, R. Human embryoid bodies containing nano-and microparticulate delivery vehicles. AdvMater 20, 2285, 2008.
    • (2008) AdvMater , vol.20 , pp. 2285
    • Ferreira, L.1    Squier, T.2    Park, H.3    Choe, H.4    Kohane, D.5    Langer, R.6
  • 146
    • 53049090197 scopus 로고    scopus 로고
    • Cardiomyocyte production in mass suspension culture: Embryonic stem cells as a source for great amounts of functional cardiomyocytes
    • Niebruegge, S., Nehring, A., Bä r, H., Schroeder, M., Zweigerdt, R., and Lehmann, J. Cardiomyocyte production in mass suspension culture: embryonic stem cells as a source for great amounts of functional cardiomyocytes. Tissue Eng Part A 14, 1591, 2008.
    • (2008) Tissue Eng Part A , vol.14 , pp. 1591
    • Niebruegge, S.1    Nehring, A.2    Bä, R.H.3    Schroeder, M.4    Zweigerdt, R.5    Lehmann, J.6
  • 147
    • 57349132610 scopus 로고    scopus 로고
    • Improvement of culture conditions of human embryoid bodies using a controlled perfused and dialyzed bioreactor system
    • Côme, J., Nissan, X., Aubry, L., Tournois, J., Girard, M., Perrier AL, et al. Improvement of culture conditions of human embryoid bodies using a controlled perfused and dialyzed bioreactor system. Tissue Eng Part C 14, 289, 2008.
    • (2008) Tissue Eng Part C , vol.14 , pp. 289
    • Côme, J.1    Nissan, X.2    Aubry, L.3    Tournois, J.4    Girard, M.5    Perrier, A.L.6


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