Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype

Stem Cells

Volumn 30, Issue 10, 2012, Pages 2283-2296

  Ylöstalo, Joni H ^a   Bartosh, Thomas J ^a   Coble, Katie ^a   Prockop, Darwin J ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Caspase; COX2; LPS; Macrophage; MSC; Sphere

Indexed keywords

CASPASE; CD206 ANTIGEN; CELL ANTIGEN; CXCL2 CHEMOKINE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 23; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E2; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVATION; CELL STIMULATION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MACROPHAGE; MESENCHYMAL STEM CELL; MESENCHYMAL STROMA CELL; MICROARRAY ANALYSIS; MOLECULAR WEIGHT; PROSTAGLANDIN SYNTHESIS; SKIN FIBROBLAST; TRANSCRIPTION INITIATION;

ANTIBODIES; CASPASES; CELL CULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYTOKINES; DINOPROSTONE; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; LECTINS, C-TYPE; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MANNOSE-BINDING LECTINS; MESENCHYMAL STROMAL CELLS; NF-KAPPA B; RECEPTORS, CELL SURFACE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR;

EID: 84866636444     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1191     Document Type: Article

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