RhoA and cytoskeletal disruption mediate reduced osteoblastogenesis and enhanced adipogenesis of human mesenchymal stem cells in modeled microgravity

Journal of Bone and Mineral Research

Volumn 20, Issue 10, 2005, Pages 1858-1866

  Meyers, Valerie E ^a   Zayzafoon, Majd ^a   Douglas, Joanne T ^a   McDonald, Jay M ^a,b  

^a University of Alabama at Birmingham   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

Actin; Cytoskeleton; Microgravity; Osteoblast; RhoA

Indexed keywords

ACTIN; ADENOVIRUS VECTOR; ALKALINE PHOSPHATASE; ASCORBIC ACID 2 PHOSPHATE; CELL PROTEIN; COFILIN; COLLAGEN TYPE 1; DEXAMETHASONE; F ACTIN; FAT DROPLET; G ACTIN; GLUCOSE TRANSPORTER 4; GLYCEROL 2 PHOSPHATE; GUANOSINE TRIPHOSPHATASE; LEPTIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSCRIPTION FACTOR RUNX2;

ACTIN FILAMENT; ADIPOCYTE; ADIPOSE TISSUE; ADULT; AGING; ARTICLE; BONE DENSITY; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIPID STORAGE; MALE; MESENCHYMAL STEM CELL; MICROGRAVITY; OSSIFICATION; OSTEOBLAST; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPACE FLIGHT; STRESS FIBER; WESTERN BLOTTING;

ADIPOGENESIS; AGING; BONE DENSITY; CELL DIFFERENTIATION; CELLS, CULTURED; HUMANS; MESENCHYMAL STEM CELLS; OSTEOBLASTS; OSTEOGENESIS; RHOA GTP-BINDING PROTEIN; SPACE FLIGHT; STRESS FIBERS; WEIGHTLESSNESS;

EID: 25444492582     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.050611     Document Type: Article

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