Spherical bullet formation via E-cadherin promotes therapeutic potency of mesenchymal stem cells derived from human umbilical cord blood for myocardial infarction

Molecular Therapy

Volumn 20, Issue 7, 2012, Pages 1424-1433

  Lee, Eun Ju ^a   Park, Sung Jung ^a,b   Kang, Soo Kyoung ^a   Kim, Gi Hwan ^a   Kang, Hyun Jae ^a,b   Lee, Sae Won ^a   Jeon, Hong Bae ^c   Kim, Hyo Soo ^a,b  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c MEDIPOST Co Ltd   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; COMPLEMENTARY DNA; MITOGEN ACTIVATED PROTEIN KINASE; NEUTRALIZING ANTIBODY; PROTEIN KINASE B; UVOMORULIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL ADHESION; CELL CULTURE; CELL INTERACTION; CELL PROLIFERATION; CELL SURVIVAL; CELL SUSPENSION; CONFERENCE PAPER; CONTROLLED STUDY; ENGRAFTMENT; FLUORESCENCE ACTIVATED CELL SORTING; GENE DELIVERY SYSTEM; GENE OVEREXPRESSION; HEART CONTRACTION; HEART DILATATION; HEART INFARCTION; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART VENTRICLE SIZE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROARRAY ANALYSIS; MONOLAYER CULTURE; NONHUMAN; PARACRINE SIGNALING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; SPHEROID THREE DIMENSIONAL BULLET DELIVERY SYSTEM; UMBILICAL CORD BLOOD;

MURINAE; RATTUS;

EID: 84863464420     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2012.58     Document Type: Conference Paper

References (32)

1. Lee, ST, White, AJ, Matsushita, S, Malliaras, K, Steenbergen, C, Zhang, Y et al. (2011). Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction. J Am Coll Cardiol 57: 455-465.
2. Penn, MS and Mangi, AA (2008). Genetic enhancement of stem cell engraftment, survival, and efficacy. Circ Res 102: 1471-1482.
3. Chang, SA, Lee, EJ, Kang, HJ, Zhang, SY, Kim, JH, Li, L et al. (2008). Impact of myocardial infarct proteins and oscillating pressure on the differentiation of mesenchymal stem cells: effect of acute myocardial infarction on stem cell differentiation. Stem Cells 26: 1901-1912.
4. Orlic, D, Kajstura, J, Chimenti, S, Jakoniuk, I, Anderson, SM, Li, B et al. (2001). Bone marrow cells regenerate infarcted myocardium. Nature 410: 701-705. (Pubitemid 32290358)
5. Tomita, S, Li, RK, Weisel, RD, Mickle, DA, Kim, EJ, Sakai, T et al. (1999). Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 100(19 Suppl): II247-II256. (Pubitemid 29523543)
6. Ḱler, G, Sensken, S, Airey, JA, Trapp, T, mchen, M, Feldhahn, N et al. (2004). A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 200: 123-135. (Pubitemid 38982172)
7. Yang, SE, Ha, CW, Jung, M, Jin, HJ, Lee, M, Song, H et al. (2004). Mesenchymal stem/progenitor cells developed in cultures from UC blood. Cytotherapy 6: 476-486. (Pubitemid 39433582)
8. Pittenger, MF, Mackay, AM, Beck, SC, Jaiswal, RK, Douglas, R, Mosca, JD et al. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147. (Pubitemid 29282067)
9. Rasmusson, I (2006). Immune modulation by mesenchymal stem cells. Exp Cell Res 312: 2169-2179.
10. Meyer, GP, Wollert, KC, Lotz, J, Steffens, J, Lippolt, P, Fichtner, S et al. (2006). Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation 113: 1287-1294. (Pubitemid 43739450)
11. Janssens, S, Dubois, C, Bogaert, J, Theunissen, K, Deroose, C, Desmet, W et al. (2006). Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 367: 113-121. (Pubitemid 43077127)
12. Terrovitis, JV, Smith, RR and Marb, E (2010). Assessment and optimization of cell engraftment after transplantation into the heart. Circ Res 106: 479-494.
13. Li, W, Ma, N, Ong, LL, Nesselmann, C, Klopsch, C, Ladilov, Y et al. (2007). Bcl-2 engineered MSCs inhibited apoptosis and improved heart function. Stem Cells 25: 2118-2127. (Pubitemid 47258191)
14. Noiseux, N, Gnecchi, M, Lopez-Ilasaca, M, Zhang, L, Solomon, SD, Deb, A et al. (2006). Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Mol Ther 14: 840-850. (Pubitemid 44752717)
15. Hahn, JY, Cho, HJ, Kang, HJ, Kim, TS, Kim, MH, Chung, JH et al. (2008). Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction. J Am Coll Cardiol 51: 933-943.
16. Rosov̈ I, Dao, M, Capoccia, B, Link, D and Nolta, JA (2008). Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells 26: 2173-2182.
17. Grossmann, J (2002). Molecular mechanisms of "detachment-induced apoptosis-Anoikis". Apoptosis 7: 247-260.
18. Zvibel, I, Smets, F and Soriano, H (2002). Anoikis: roadblock to cell transplantation Cell Transplant 11: 621-630.
19. Frith, JE, Thomson, B and Genever, PG (2010). Dynamic three-dimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential. Tissue Eng Part C Methods 16: 735-749.
20. Qihao, Z, Xigu, C, Guanghui, C and Weiwei, Z (2007). Spheroid formation and differentiation into hepatocyte-like cells of rat mesenchymal stem cell induced by coculture with liver cells. DNA Cell Biol 26: 497-503. (Pubitemid 47105612)
21. Potapova, IA, Brink, PR, Cohen, IS and Doronin, SV (2008). Culturing of human mesenchymal stem cells as three-dimensional aggregates induces functional expression of CXCR4 that regulates adhesion to endothelial cells. J Biol Chem 283: 13100-13107.
22. Nagaya, N, Kangawa, K, Itoh, T, Iwase, T, Murakami, S, Miyahara, Y et al. (2005). Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 112: 1128-1135. (Pubitemid 41216119)
23. Scheubel, RJ, Zorn, H, Silber, RE, Kuss, O, Morawietz, H, Holtz, J et al. (2003). Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. J Am Coll Cardiol 42: 2073-2080. (Pubitemid 37549887)
24. Tepper, OM, Galiano, RD, Capla, JM, Kalka, C, Gagne, PJ, Jacobowitz, GR et al. (2002). Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 106: 2781-2786. (Pubitemid 35396976)
25. Zhang, M, Methot, D, Poppa, V, Fujio, Y, Walsh, K and Murry, CE (2001). Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies. J Mol Cell Cardiol 33: 907-921. (Pubitemid 32545326)
26. Georgopoulos, NT, Kirkwood, LA, Walker, DC and Southgate, J (2010). Differential regulation of growth-promoting signalling pathways by E-cadherin. PLoS ONE 5: e13621.
27. Kantak, SS and Kramer, RH (1998). E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells. J Biol Chem 273: 16953-16961. (Pubitemid 28311727)
28. Onder, TT, Gupta, PB, Mani, SA, Yang, J, Lander, ES and Weinberg, RA (2008). Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 68: 3645-3654.
29. Fadare, O, Reddy, H, Wang, J, Hileeto, D, Schwartz, PE and Zheng, W (2005). E-Cadherin and beta-Catenin expression in early stage cervical carcinoma: a tissue microarray study of 147 cases. World J Surg Oncol 3: 38.
30. St Croix, B, Sheehan, C, Rak, JW, Flenes, VA, Slingerland, JM and Kerbel, RS (1998). E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1). J Cell Biol 142: 557-571. (Pubitemid 28361560)
31. Youn, TJ, Kim, HS, Kang, HJ, Kim, DW, Cho, MC, Kim, CH et al. (2001). Inhibition of nitric oxide synthesis increases apoptotic cardiomyocyte death and myocardial angiotensin-converting enzyme gene expression in ischemia/reperfusion-injured myocardium of rats. Heart Vessels 16: 12-19.
32. Livak, KJ and Schmittgen, TD (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. (Pubitemid 34164012)