Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent il1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1)

Stem Cells

Volumn 31, Issue 11, 2013, Pages 2443-2456

  Bartosh, Thomas J ^a   Ylöstalo, Joni H ^a   Bazhanov, Nikolay ^a   Kuhlman, Jessica ^a   Prockop, Darwin J ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Caspase; Interleukin 1; Mesenchymal stem cell; Notch; Prostaglandin E2; Sphere

Indexed keywords

CASPASE; CYCLOOXYGENASE 2; HYPOCALCIN; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; PROSTAGLANDIN E2; STANNIOCALCIN 1 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INDUCED PROTEIN 6; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL AGGREGATION; CELL STRUCTURE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME ACTIVATION; HANGING DROP VAPOR DIFFUSION METHOD; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PERITONEUM; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALIA; MUS;

CASPASE; INTERLEUKIN 1; MESENCHYMAL STEM CELL; NOTCH; PROSTAGLANDIN E2; SPHERE;

ANIMALS; CASPASES; CELL ADHESION MOLECULES; CELLS, CULTURED; DINOPROSTONE; FIBROBLASTS; GLYCOPROTEINS; HUMANS; INFLAMMATION; INTERLEUKIN-1; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84887904476     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1499     Document Type: Article

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