Cellular interactions and signaling in cartilage development

Osteoarthritis and Cartilage

Volumn 8, Issue 5, 2000, Pages 309-334

  DeLise, A M ^a   Fischer, L ^a   Tuan, R S ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Cartilage; Cell adhesion; Condensation; Endochondral ossification; Growth factors; Signaling

Indexed keywords

COLLAGEN; CYCLIC AMP; FIBROBLAST GROWTH FACTOR; FIBRONECTIN; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; NERVE CELL ADHESION MOLECULE; PROTEIN KINASE C; PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CARTILAGE; CELL DIFFERENTIATION; CELL INTERACTION; CHONDROGENESIS; ENCHONDRAL OSSIFICATION; EXTRACELLULAR MATRIX; HUMAN; LIMB DEVELOPMENT; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033835868     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1999.0306     Document Type: Article

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268. Signal transduction through β-catenin and specification of cell fate during embryogenesis
269. Phosphorylation of the Drosophila adherens junction protein armadillo: Roles for wingless signal and zeste-white 3 kinase
270. Binding of GSK-3β to the APC-β-catenin complex and regulation of complex assembly
271. Wnt signaling: A common theme in animal development
272. Wnt genes
273. A new member of the frizzled family from Drosophila functions as a wingless receptor
274. Conservation of dishevelled structure and function between flies and mice: Isolation and characterization of dvl-2
275. Wingless signaling acts through zeste-white 3, the Drosophila homologue of glycogen synthase kinase 3 to regulate engrailed and establish cell fate
276. Linking frizzled and Wnt signaling in Drosophila
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284. Armadillo coactivates transcription driven by the product of the drosophila segment polarity gene dTCF
285. Two members of the TCF family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse
286. Beta-catenin localization during Xenopus embryogenesis: Accumulation at tissue and somite boundaries
287. Drosophila CBP represses the transcription factor TCF to antagonize wingless signaling
288. Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis
289. LEF1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development
290. Expression of Wnt-1 in PC12 cells results in modulation of plako-globin and E-cadherin and increased cellular adhesion
291. Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing β-catenin binding to the cell adhesion protein cadherin
292. Correlation of expression of Wnt-1 in developing limbs with abonormalities in growth and skeletal patterning
293. Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development
294. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4
295. Expression of two members of the Wnt family during mouse development - Restricted temporal and spatial patterns in the developing neural tube
296. Growth factors influencing bone development
297. Bone and cartilage differentiation
298. Transforming growth factor β gene family members and bone
299. Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGF beta family member
300. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from dorsal ectoderm
301. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
302. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
303. BMP-7 is required for nephrogenesis, eye development and skeletal patterning
304. Bmpr encodes a type 1 bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
305. Evidence from normal expression and targeted misexpression that bone morphogenetic protein-4 (BMP-4) plays a role in mouse embyronic lung morphogenesis
306. A role for bone morphogenetic proteins in the induction of cardiac myogenesis
307. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
308. Transforming growth factor-β
309. The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms
310. Control of transforming growth factor-β activity: Latency vs. activation
311. Expression, cloning and characterization of the TGF-β type III receptor
312. Cloning of the TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor
313. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase
314. TGFβ signals through a heteromeric protein kinase receptor complex
315. The transforming growth factor-β family
316. Bone morphogenetic protein receptors
317. Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
318. Caenorhabdans elegans genes sma-2, sma-3 and sma-4 define a conserved family of transforming growth factor β pathway components
319. Cloning and characterization of a novel member of the human Mad gene family (MADH6)
320. TGF-β signaling: Receptors, transducers and Mad proteins
321. SMADs: Mediators and regulators of TGF-β signaling
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333. BMP-4 responsive regulation of dorsal-ventral patterning by the homeobox protein Mix. 1
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335. Identification of transforming growth factor-βb members present in bone inductive protein purified from bovine bone
336. Isolation of growth factors from adult bovine bone
337. Purification and characterization of other distinct bone-inducing factors
338. Cell differentiation in response to partially purified osteosarcoma-derived bone morphogenetic protein in vivo and in vitro
339. Recombinant human bone morphogenetic protein induces bone formation
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341. Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals
342. Establishment of bone morphogenetic protein 2 responsive chondrogenic cell line
343. Bone morphogenetic protein 2b stimulation of growth and osteogenic phenotypes in rat osteoblast-like cells: Comparison with TGF-β1
344. The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2
345. Bone morphogenetic protein-2 converts the differentiation pathway of C212 myoblasts into the osteoblast lineage
346. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2
347. Transforming growth factor-β and bone morphogenetic protein-2 act by distinct mechanisms to promote chick limb cartilage differentiation in vitro
348. Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes
349. Formation of cartilage-like spheroids by micromass culture of murine C3H10T1/2 cells upon treatment with transforming growth factor-β1
350. Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells
351. Recombinant human BMP-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
352. BMP-2 stimulation of chondrogenesis in multipotential cells: Modulation of N-cadherin expression and function
353. BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice
354. The mouse short ear skeletal morphogenesis locus is associated with defects in bone morphogenetic member of the TGF-β superfamily
355. Ckyr61, product of growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells
356. Cyclic nucleotides during-chondrogenesis. Concentration and distribution in vivo and in vitro
357. Increase in levels of cyclic AMP during avian limb chondrogenesis in vitro
358. Studies on the possible role of cyclic AMP in limb morphogenesis and differentiation
359. Cyclic AMP derivatives stimulate the chondorgenic differentiation of the mesoderm subjacent to the apical ectodermal ridge of the chick limb bud
360. The influence of insulin, cAMP and calcium ionophore X537 A on the growth of the cartilage anlagen of limb buds in vitro
361. In vitro histogenic capacitites of limb mesenchyme from various stage mouse embryos
362. Stage and position related changes in chondrogenic response of chick embryonic wing mesenchyme to treatment with dibutyryl cyclic AMR
363. Chondrogenesis in mouse limb buds in vitro: Effects of dibutyryl cyclic AMP treatment
364. The cAMP-dependent protein kinases and cAMP signal transduction
365. Activation of protein kinase A is a pivotal step involved in both BMP-2- and cyclic AMP-induced chondrogenesis
366. Promotion of embryonic limb cartilage differentiation in vitro by staurosporinem, a protein kinase C inhibitor
367. Staurosporine, a protein kinase inhibitor, stimulates cartilage differentiation by embryonic facial mesenchyme
368. Activity of protein kinase C during the differentiation of chick limb bud mesenchymal cells
369. Expression of protein kinase C isozymes that are required for chondrogenesis of chick limb bud mesenchymal cells
370. Protein Kinase C regulates chondrogenesis of mesenchymes via mitogen-activated protein kinase signaling
371. The role of protein kinase C isoenzymes in the regulation of cell proliferation and differentiation
372. The establishment of murine Hox-1 expression domains during patterning of the limb
373. Hox genes and mammalian development
374. Analysis of Hox gene expression in the chick limb bud
375. Vertebrate limb development
376. Homeobox genes and pattern formation in the vertebrate limb
377. Altered expression of the chicken homeobox-containing genes GHox-7 and GHox-8 in the limb buds of limbless mutant chick embryos
378. Expression of the chicken homeobox-containing gene GHox-8 during embryonic chick limb development
379. Roles of the chicken homeobox-containing genes GHox-8, GHox-7, and GHox-4.6 in pattern formation during limb development
380. Apical ridge dependent and independent mesodermal domains of GHox-7 and GHox-8 expression in chick limb buds
381. Expression of Hox-7.1 in myoblasts inhibits terminal differentiation and induces cell transformation
382. Ectopic expression of Msx-2 in posterior limb bud mesoderm impairs limb morphogenesis while inducing BMP-4 expression, inhibiting cell proliferation, and promoting apoptosis
383. The apical ectodermal ridge regulates Hox7 and Hox8 gene expression in developing chick limb buds
384. A role for BMP-4 in the development of subcutaneous cartilage
385. Sexually dimorphic sterility phenotypes in Hoxa 10-deficient mice
386. Homeotic transformations and limb defects in Hoxa11 mutant mice
387. Hoxa11 structure, extensive antisense transcription and function in male and female fertility
388. Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes
389. The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning
390. A mutational analysis of the 5' HoxD genes: Dissection of genetic interactions during limb development in the mouse
391. Genomic structure of HOXD13 gene: A nine polyalanine duplication causes synpolydactyly in two unrelated families
392. Altered growth and branchin patterns in synpolydactyly caused by mutation in HOXD13
393. Synpolydactyly phenotypes correlate with size of expansions in HOXD13 polyalanine tract
394. Targeted disruption of Hoxd-10 affects mouse hindlimb development
395. Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice
396. Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11
397. Vertebrate Hox genes and proliferation: An alternative pathway to homeosis?
398. Function of homeobox genes in skeletal development
399. Genetic interactions of Hox genes in limb development: Learning from compound mutants
400. Synpolydactyly in mice with a targeted deficiency in the HoxD complex
401. Analysis of Hoxd13 and Hoxd11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth
402. Targeted misexpression of hox-4.6 in the avian limb bud causes apparent homeotic transformation
403. Misexpression of HoxA-13 induces cartilage homeotic transformation and changes in cell adhesiveness in chick limb buds
404. Sox genes find their feet
405. Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix
406. Architectural transcription factors: Proteins that remodel DNA
407. Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9
408. Mutations in SOX9 cause both autosomal sex reversal and campomelic dysplasia
409. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos
410. Toward understanding SOX9 function in chondrocyte differentiation
411. Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis
412. SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse
413. An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes
414. SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene
415. SOX9 directly regulates the type-II collagen gene
416. A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice
417. A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene
418. Sox9 is required for cartilage formation
419. The ets gene family
420. Mesodermal expression of the chicken erg gene associated with precartilaginous condensation and cartilage differentiation
421. Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes
422. The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development