Normalization of the tumor vasculature through oncogenic inhibition: An emerging paradigm in tumor biology

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 20, 2012, Pages

  Goel, Shom ^a   Fukumura, Dai ^a   Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN; TRASTUZUMAB;

ANGIOGENESIS; ANTIANGIOGENIC THERAPY; BREAST CANCER; CELL PROLIFERATION; CELL SURVIVAL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; GENE CONTROL; GENE MUTATION; HUMAN; LETTER; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTO ONCOGENE; SIGNAL TRANSDUCTION; TISSUE OXYGENATION; TISSUE PERFUSION; TREATMENT RESPONSE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION;

ANIMALS; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS B-RAF;

EID: 84861215641     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203794109     Document Type: Letter

References (5)

1. Bottos A, et al. (2012) Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia. Proc Natl Acad Sci USA 109: E353-E359.
2. Jain RK (2005) Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 307:58-62.
3. Goel S, et al. (2011) Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 91:1071-1121.
4. Jain RK, et al. (1998) Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor. Proc Natl Acad Sci USA 95:10820-10825. (Pubitemid 28413152)
5. Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK (2002) Tumour biology: Herceptin acts as an anti-angiogenic cocktail. Nature 416:279-280. (Pubitemid 34260234)