Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression

Journal of Experimental Medicine

Volumn 209, Issue 9, 2012, Pages 1611-1627

  Reis, Marco ^a   Czupalla, Cathrin J ^a   Ziegler, Nicole ^a   Devraj, Kavi ^a   Zinke, Jenny ^a   Seidel, Sascha ^a   Heck, Rosario ^b   Thom, Sonja ^a   Macas, Jadranka ^a   Bockamp, Ernesto ^b   Fruttiger, Marcus ^c   Taketo, Makoto M ^d   Dimmeler, Stefanie ^a   Plate, Karl H ^a   Liebner, Stefan ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; AXIN; AXIN2; BETA CATENIN; CD31 ANTIGEN; DICKKOPF 1 PROTEIN; DOXYCYCLINE; JAGGED1; NOTCH RECEPTOR; NOTCH1 RECEPTOR; PLATELET DERIVED GROWTH FACTOR B; PROTEIN DLL4; PROTEIN HEY1; PROTEIN NRARP; PROTEIN NRP1; TRANSCRIPTION FACTOR HES 1; TUBULIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; WNT PROTEIN; WNT3A PROTEIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL ADHESION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; GENE INDUCTION; GLIOMA; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PERMEABILITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR GROWTH; TUMOR VASCULARIZATION;

ANIMALS; BETA CATENIN; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CENTRAL NERVOUS SYSTEM NEOPLASMS; ENDOTHELIUM, VASCULAR; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GLIOMA; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, NUDE; NEOPLASM GRADING; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS C-SIS; WNT SIGNALING PATHWAY; WNT1 PROTEIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84866389239     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20111580     Document Type: Article

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