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Volumn 172, Issue 3, 2013, Pages 500-506

Simultaneous blockade of programmed death 1 and vascular endothelial growth factor receptor 2 (VEGFR2) induces synergistic anti-tumour effect in vivo

Author keywords

Anti angiogenesis; Anti tumour immunity; Immune checkpoint; PD 1; VEGFR2

Indexed keywords

MONOCLONAL ANTIBODY DC101; PROGRAMMED DEATH 1 RECEPTOR; VASCULOTROPIN RECEPTOR 2;

EID: 84876717683     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12069     Document Type: Article
Times cited : (243)

References (37)
  • 2
    • 0027087331 scopus 로고
    • Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
    • Schwartz RH. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 1992; 71:1065-1068.
    • (1992) Cell , vol.71 , pp. 1065-1068
    • Schwartz, R.H.1
  • 4
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF etal. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010; 363:711-723.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 6
    • 0034927194 scopus 로고    scopus 로고
    • PD-1: an inhibitory immunoreceptor involved in peripheral tolerance
    • Nishimura H, Honjo T. PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol 2001; 22:265-268.
    • (2001) Trends Immunol , vol.22 , pp. 265-268
    • Nishimura, H.1    Honjo, T.2
  • 7
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y, Agata Y, Shibahara K, Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992; 11:3887-3895.
    • (1992) EMBO J , vol.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 8
    • 34247532726 scopus 로고    scopus 로고
    • Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
    • Nomi T, Sho M, Akahori T etal. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res 2007; 13:2151-2157.
    • (2007) Clin Cancer Res , vol.13 , pp. 2151-2157
    • Nomi, T.1    Sho, M.2    Akahori, T.3
  • 9
    • 20244384862 scopus 로고    scopus 로고
    • Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer
    • Ohigashi Y, Sho M, Yamada Y etal. Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin Cancer Res 2005; 11:2947-2953.
    • (2005) Clin Cancer Res , vol.11 , pp. 2947-2953
    • Ohigashi, Y.1    Sho, M.2    Yamada, Y.3
  • 10
    • 49649114804 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
    • Berger R, Rotem-Yehudar R, Slama G etal. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res 2008; 14:3044-3051.
    • (2008) Clin Cancer Res , vol.14 , pp. 3044-3051
    • Berger, R.1    Rotem-Yehudar, R.2    Slama, G.3
  • 11
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ etal. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012; 366:2455-2465.
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 12
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR etal. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366:2443-2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 13
    • 0026639806 scopus 로고
    • Angiogenesis
    • Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992; 267:10931-10934.
    • (1992) J Biol Chem , vol.267 , pp. 10931-10934
    • Folkman, J.1    Shing, Y.2
  • 14
    • 0348008982 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: a new class of drugs
    • Folkman J. Angiogenesis inhibitors: a new class of drugs. Cancer Biol Ther 2003; 2:S127-133.
    • (2003) Cancer Biol Ther , vol.2
    • Folkman, J.1
  • 15
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86:353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 16
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 17
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 2004; 64:3731-3736.
    • (2004) Cancer Res , vol.64 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 18
    • 34447258681 scopus 로고    scopus 로고
    • Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize
    • Fukumura D, Jain RK. Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. J Cell Biochem 2007; 101:937-949.
    • (2007) J Cell Biochem , vol.101 , pp. 937-949
    • Fukumura, D.1    Jain, R.K.2
  • 19
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • Shrimali RK, Yu Z, Theoret MR, Chinnasamy D, Restifo NP, Rosenberg SA. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res 2010; 70:6171-6180.
    • (2010) Cancer Res , vol.70 , pp. 6171-6180
    • Shrimali, R.K.1    Yu, Z.2    Theoret, M.R.3    Chinnasamy, D.4    Restifo, N.P.5    Rosenberg, S.A.6
  • 20
    • 0141996422 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2: its unique signaling and specific ligand, VEGF-E
    • Shibuya M. Vascular endothelial growth factor receptor-2: its unique signaling and specific ligand, VEGF-E. Cancer Sci 2003; 94:751-756.
    • (2003) Cancer Sci , vol.94 , pp. 751-756
    • Shibuya, M.1
  • 21
    • 34447117552 scopus 로고    scopus 로고
    • A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism
    • Manning EA, Ullman JG, Leatherman JM etal. A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism. Clin Cancer Res 2007; 13:3951-3959.
    • (2007) Clin Cancer Res , vol.13 , pp. 3951-3959
    • Manning, E.A.1    Ullman, J.G.2    Leatherman, J.M.3
  • 22
    • 0032698140 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors
    • Prewett M, Huber J, Li Y etal. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res 1999; 59:5209-5218.
    • (1999) Cancer Res , vol.59 , pp. 5209-5218
    • Prewett, M.1    Huber, J.2    Li, Y.3
  • 23
    • 2542523903 scopus 로고    scopus 로고
    • Halting the interaction between vascular endothelial growth factor and its receptors attenuates liver carcinogenesis in mice
    • Yoshiji H, Kuriyama S, Yoshii J etal. Halting the interaction between vascular endothelial growth factor and its receptors attenuates liver carcinogenesis in mice. Hepatology 2004; 39:1517-1524.
    • (2004) Hepatology , vol.39 , pp. 1517-1524
    • Yoshiji, H.1    Kuriyama, S.2    Yoshii, J.3
  • 24
    • 17744367799 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor KDR/Flk-1 is a major regulator of malignant ascites formation in the mouse hepatocellular carcinoma model
    • Yoshiji H, Kuriyama S, Hicklin DJ etal. The vascular endothelial growth factor receptor KDR/Flk-1 is a major regulator of malignant ascites formation in the mouse hepatocellular carcinoma model. Hepatology 2001; 33:841-847.
    • (2001) Hepatology , vol.33 , pp. 841-847
    • Yoshiji, H.1    Kuriyama, S.2    Hicklin, D.J.3
  • 25
    • 0042170392 scopus 로고    scopus 로고
    • Differential binding properties of B7-H1 and B7-DC to programmed death-1
    • Youngnak P, Kozono Y, Kozono H etal. Differential binding properties of B7-H1 and B7-DC to programmed death-1. Biochem Biophys Res Commun 2003; 307:672-677.
    • (2003) Biochem Biophys Res Commun , vol.307 , pp. 672-677
    • Youngnak, P.1    Kozono, Y.2    Kozono, H.3
  • 26
    • 34547794178 scopus 로고    scopus 로고
    • PD-1 and PD-1 ligands: from discovery to clinical application
    • Okazaki T, Honjo T. PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol 2007; 19:813-824.
    • (2007) Int Immunol , vol.19 , pp. 813-824
    • Okazaki, T.1    Honjo, T.2
  • 27
    • 0035949593 scopus 로고    scopus 로고
    • Immunogene therapy of tumors with vaccine based on Xenopus homologous vascular endothelial growth factor as a model antigen
    • Wei YQ, Huang MJ, Yang L etal. Immunogene therapy of tumors with vaccine based on Xenopus homologous vascular endothelial growth factor as a model antigen. Proc Natl Acad Sci USA 2001; 98:11545-11550.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11545-11550
    • Wei, Y.Q.1    Huang, M.J.2    Yang, L.3
  • 28
    • 0036913333 scopus 로고    scopus 로고
    • A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth
    • Niethammer AG, Xiang R, Becker JC etal. A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth. Nat Med 2002; 8:1369-1375.
    • (2002) Nat Med , vol.8 , pp. 1369-1375
    • Niethammer, A.G.1    Xiang, R.2    Becker, J.C.3
  • 29
    • 33746718151 scopus 로고    scopus 로고
    • Targeting tumor-associated macrophages as a novel strategy against breast cancer
    • Luo Y, Zhou H, Krueger J etal. Targeting tumor-associated macrophages as a novel strategy against breast cancer. J Clin Invest 2006; 116:2132-2141.
    • (2006) J Clin Invest , vol.116 , pp. 2132-2141
    • Luo, Y.1    Zhou, H.2    Krueger, J.3
  • 30
    • 33646231504 scopus 로고    scopus 로고
    • Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors
    • Dirkx AE, oude Egbrink MG, Castermans K etal. Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors. FASEB J 2006; 20:621-630.
    • (2006) FASEB J , vol.20 , pp. 621-630
    • Dirkx, A.E.1    Oude Egbrink, M.G.2    Castermans, K.3
  • 31
    • 0037109023 scopus 로고    scopus 로고
    • Combined therapy of local and metastatic 4T1 breast tumor in mice using SU6668, an inhibitor of angiogenic receptor tyrosine kinases, and the immunostimulator B7.2-IgG fusion protein
    • Huang X, Wong MK, Yi H etal. Combined therapy of local and metastatic 4T1 breast tumor in mice using SU6668, an inhibitor of angiogenic receptor tyrosine kinases, and the immunostimulator B7.2-IgG fusion protein. Cancer Res 2002; 62:5727-5735.
    • (2002) Cancer Res , vol.62 , pp. 5727-5735
    • Huang, X.1    Wong, M.K.2    Yi, H.3
  • 32
    • 74249123434 scopus 로고    scopus 로고
    • VEGFR2 is selectively expressed by FOXP3high CD4+ Treg
    • Suzuki H, Onishi H, Wada J etal. VEGFR2 is selectively expressed by FOXP3high CD4+ Treg. Eur J Immunol 2010; 40:197-203.
    • (2010) Eur J Immunol , vol.40 , pp. 197-203
    • Suzuki, H.1    Onishi, H.2    Wada, J.3
  • 34
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • Woo SR, Turnis ME, Goldberg MV etal. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res 2012; 72:917-927.
    • (2012) Cancer Res , vol.72 , pp. 917-927
    • Woo, S.R.1    Turnis, M.E.2    Goldberg, M.V.3
  • 35
    • 79956103042 scopus 로고    scopus 로고
    • Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors
    • Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ. Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors. Cancer Res 2011; 71:3540-3551.
    • (2011) Cancer Res , vol.71 , pp. 3540-3551
    • Ngiow, S.F.1    von Scheidt, B.2    Akiba, H.3    Yagita, H.4    Teng, M.W.5    Smyth, M.J.6
  • 36
    • 70449534753 scopus 로고    scopus 로고
    • Clinical importance of B7-H3 expression in human pancreatic cancer
    • Yamato I, Sho M, Nomi T etal. Clinical importance of B7-H3 expression in human pancreatic cancer. Br J Cancer 2009; 101:1709-1716.
    • (2009) Br J Cancer , vol.101 , pp. 1709-1716
    • Yamato, I.1    Sho, M.2    Nomi, T.3
  • 37
    • 76249106934 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 in human cancer: concise review and rationale for development of IMC-18F1 (human antibody targeting vascular endothelial growth factor receptor-1)
    • Schwartz JD, Rowinsky EK, Youssoufian H, Pytowski B, Wu Y. Vascular endothelial growth factor receptor-1 in human cancer: concise review and rationale for development of IMC-18F1 (human antibody targeting vascular endothelial growth factor receptor-1). Cancer 2010; 116:1027-1032.
    • (2010) Cancer , vol.116 , pp. 1027-1032
    • Schwartz, J.D.1    Rowinsky, E.K.2    Youssoufian, H.3    Pytowski, B.4    Wu, Y.5


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