메뉴 건너뛰기




Volumn 109, Issue 6, 2014, Pages

Heme oxygenase-1: an emerging therapeutic target to curb cardiac pathology

Author keywords

Cardiac ischemia; Diabetic diet induced cardiomyopathy; HO 1; Ischemia reperfusion injury; Myocardial hypertrophy; Nrf2

Indexed keywords

BILIVERDIN; CARBON MONOXIDE; CARBON MONOXIDE RELEASING MOLECULE 2; CARBON MONOXIDE RELEASING MOLECULE 3; CARBOXYHEMOGLOBIN; CARDIOVASCULAR AGENT; FERRIC ION; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTOPORPHYRIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; VASCULOTROPIN B;

EID: 84911371131     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-014-0450-9     Document Type: Review
Times cited : (39)

References (142)
  • 2
    • 41149177025 scopus 로고    scopus 로고
    • Pharmacological and clinical aspects of heme oxygenase
    • COI: 1:CAS:528:DC%2BD1cXks1Gjsb8%3D, PID: 18323402
    • Abraham NG, Kappas A (2008) Pharmacological and clinical aspects of heme oxygenase. Pharmacol Rev 60:79–127. doi:10.1124/pr.107.07104
    • (2008) Pharmacol Rev , vol.60 , pp. 79-127
    • Abraham, N.G.1    Kappas, A.2
  • 3
    • 0033543566 scopus 로고    scopus 로고
    • Nrf2, a Cap’n’Collar transcription factor, regulates induction of the heme oxygenase-1 gene
    • COI: 1:CAS:528:DyaK1MXmtVKmt7c%3D, PID: 10473555
    • Alam J, Stewart D, Touchard C, Boinapally S, Choi AM, Cook JL (1999) Nrf2, a Cap’n’Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem 274:26071–26078
    • (1999) J Biol Chem , vol.274 , pp. 26071-26078
    • Alam, J.1    Stewart, D.2    Touchard, C.3    Boinapally, S.4    Choi, A.M.5    Cook, J.L.6
  • 4
    • 76749083354 scopus 로고    scopus 로고
    • PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress
    • COI: 1:CAS:528:DC%2BC3cXitVSrtrc%3D, PID: 19903700
    • Ali F, Ali NS, Bauer A, Boyle JJ, Hamdulay SS, Haskard DO, Randi AM, Mason JC (2010) PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress. Cardiovasc Res 85:701–710. doi:10.1093/cvr/cvp365
    • (2010) Cardiovasc Res , vol.85 , pp. 701-710
    • Ali, F.1    Ali, N.S.2    Bauer, A.3    Boyle, J.J.4    Hamdulay, S.S.5    Haskard, D.O.6    Randi, A.M.7    Mason, J.C.8
  • 5
    • 84903726500 scopus 로고    scopus 로고
    • Heme oxygenase-1 overexpression exacerbates heart failure with aging and pressure overload but is protective against isoproterenol-induced cardiomyopathy in mice
    • COI: 1:CAS:528:DC%2BC2cXnslehurw%3D, PID: 24813593
    • Allwood MA, Kinobe RT, Ballantyne L, Romanova N, Melo LG, Ward CA, Brunt KR, Simpson JA (2014) Heme oxygenase-1 overexpression exacerbates heart failure with aging and pressure overload but is protective against isoproterenol-induced cardiomyopathy in mice. Cardiovasc Pathol 23:231–237. doi:10.1016/j.carpath.2014.03.007
    • (2014) Cardiovasc Pathol , vol.23 , pp. 231-237
    • Allwood, M.A.1    Kinobe, R.T.2    Ballantyne, L.3    Romanova, N.4    Melo, L.G.5    Ward, C.A.6    Brunt, K.R.7    Simpson, J.A.8
  • 6
    • 84891890600 scopus 로고    scopus 로고
    • Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation
    • COI: 1:CAS:528:DC%2BC2cXmvVem, PID: 24374218
    • Amano SU, Cohen JL, Vangala P, Tencerova M, Nicoloro SM, Yawe JC, Shen Y, Czech MP, Aouadi M (2014) Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation. Cell Metab 19:162–171. doi:10.1016/j.cmet.2013.11.017
    • (2014) Cell Metab , vol.19 , pp. 162-171
    • Amano, S.U.1    Cohen, J.L.2    Vangala, P.3    Tencerova, M.4    Nicoloro, S.M.5    Yawe, J.C.6    Shen, Y.7    Czech, M.P.8    Aouadi, M.9
  • 10
    • 84873737258 scopus 로고    scopus 로고
    • Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation
    • COI: 1:CAS:528:DC%2BC3sXjvFCks7k%3D, PID: 23353773
    • Bai Y, Cui W, Xin Y, Miao X, Barati MT, Zhang C, Chen Q, Tan Y, Cui T, Zheng Y, Cai L (2013) Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation. J Mol Cell Cardiol 57:82–95. doi:10.1016/j.yjmcc.2013.01.008
    • (2013) J Mol Cell Cardiol , vol.57 , pp. 82-95
    • Bai, Y.1    Cui, W.2    Xin, Y.3    Miao, X.4    Barati, M.T.5    Zhang, C.6    Chen, Q.7    Tan, Y.8    Cui, T.9    Zheng, Y.10    Cai, L.11
  • 12
    • 84895910470 scopus 로고    scopus 로고
    • Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity
    • COI: 1:CAS:528:DC%2BC2cXht1KqtrbI, PID: 24494190
    • Bansal S, Biswas G, Avadhani NG (2014) Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity. Redox Biol 2:273–283. doi:10.1016/j.redox.2013.07.004
    • (2014) Redox Biol , vol.2 , pp. 273-283
    • Bansal, S.1    Biswas, G.2    Avadhani, N.G.3
  • 13
    • 77957882550 scopus 로고    scopus 로고
    • Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus
    • PID: 20811623
    • Bao W, Song F, Li X, Rong S, Yang W, Zhang M, Yao P, Hao L, Yang N, Hu FB, Liu L (2010) Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus. PLoS One 5:e12371. doi:10.1371/journal.pone.0012371
    • (2010) PLoS One , vol.5 , pp. e12371
    • Bao, W.1    Song, F.2    Li, X.3    Rong, S.4    Yang, W.5    Zhang, M.6    Yao, P.7    Hao, L.8    Yang, N.9    Hu, F.B.10    Liu, L.11
  • 14
    • 0037154308 scopus 로고    scopus 로고
    • Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice
    • COI: 1:CAS:528:DC%2BD38XhsFSgtL4%3D, PID: 11804982
    • Bendall JK, Cave AC, Heymes C, Gall N, Shah AM (2002) Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice. Circulation 105:293–296
    • (2002) Circulation , vol.105 , pp. 293-296
    • Bendall, J.K.1    Cave, A.C.2    Heymes, C.3    Gall, N.4    Shah, A.M.5
  • 15
    • 84867576834 scopus 로고    scopus 로고
    • Protecting the heart through delivering DNA encoding for heme oxygenase-1 into skeletal muscle
    • COI: 1:CAS:528:DC%2BC38XhsVKgs77K, PID: 22917518
    • Bilbija D, Gravning JA, Haugen F, Attramadal H, Valen G (2012) Protecting the heart through delivering DNA encoding for heme oxygenase-1 into skeletal muscle. Life Sci 91:828–836. doi:10.1016/j.lfs.2012.08.014
    • (2012) Life Sci , vol.91 , pp. 828-836
    • Bilbija, D.1    Gravning, J.A.2    Haugen, F.3    Attramadal, H.4    Valen, G.5
  • 16
    • 84907907866 scopus 로고    scopus 로고
    • Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2 impacting metabolic and anti-oxidant defenses
    • Biswas C, Shah N, Muthu M, La P, Fernando AP, Sengupta S, Yang G, Dennery PA (2014) Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2 impacting metabolic and anti-oxidant defenses. J Biol Chem. doi:10.1074/jbc.M114.567685
    • (2014) J Biol Chem
    • Biswas, C.1    Shah, N.2    Muthu, M.3    La, P.4    Fernando, A.P.5    Sengupta, S.6    Yang, G.7    Dennery, P.A.8
  • 17
    • 67650232210 scopus 로고    scopus 로고
    • Loss of cardioprotection with ageing
    • COI: 1:CAS:528:DC%2BD1MXnvVOkt7o%3D, PID: 19176601
    • Boengler K, Schulz R, Heusch G (2009) Loss of cardioprotection with ageing. Cardiovasc Res 83:247–261. doi:10.1093/cvr/cvp033
    • (2009) Cardiovasc Res , vol.83 , pp. 247-261
    • Boengler, K.1    Schulz, R.2    Heusch, G.3
  • 20
    • 78651478726 scopus 로고    scopus 로고
    • Epidemiology and risk profile of heart failure
    • PID: 21060326
    • Bui AL, Horwich TB, Fonarow GC (2011) Epidemiology and risk profile of heart failure. Nat Rev Cardiol 8:30–41. doi:10.1038/nrcardio.2010.165
    • (2011) Nat Rev Cardiol , vol.8 , pp. 30-41
    • Bui, A.L.1    Horwich, T.B.2    Fonarow, G.C.3
  • 23
    • 0029392368 scopus 로고
    • Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation
    • COI: 1:CAS:528:DyaK2MXosVyms7s%3D, PID: 7546768
    • Camhi SL, Alam J, Otterbein L, Sylvester SL, Choi AM (1995) Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am J Respir Cell Mol Biol 13:387–398. doi:10.1165/ajrcmb.13.4.7546768
    • (1995) Am J Respir Cell Mol Biol , vol.13 , pp. 387-398
    • Camhi, S.L.1    Alam, J.2    Otterbein, L.3    Sylvester, S.L.4    Choi, A.M.5
  • 24
    • 80052020658 scopus 로고    scopus 로고
    • Systemic heme oxygenase-1 transgenic overexpression aggravates pressure overload-induced cardiac hypertrophy in mice
    • PID: 21865845
    • Chen C, Huo R, Tong Y, Sheng Y, Liu HB, Gao X, Nakajima O, Yang BF, Dong DL (2011) Systemic heme oxygenase-1 transgenic overexpression aggravates pressure overload-induced cardiac hypertrophy in mice. Cell Physiol Biochem 28:25–32. doi:10.1159/000331710
    • (2011) Cell Physiol Biochem , vol.28 , pp. 25-32
    • Chen, C.1    Huo, R.2    Tong, Y.3    Sheng, Y.4    Liu, H.B.5    Gao, X.6    Nakajima, O.7    Yang, B.F.8    Dong, D.L.9
  • 25
    • 49649107044 scopus 로고    scopus 로고
    • Serum bilirubin and ferritin levels link heme oxygenase-1 gene promoter polymorphism and susceptibility to coronary artery disease in diabetic patients
    • COI: 1:CAS:528:DC%2BD1cXhtVWlurrK, PID: 18443197
    • Chen YH, Chau LY, Chen JW, Lin SJ (2008) Serum bilirubin and ferritin levels link heme oxygenase-1 gene promoter polymorphism and susceptibility to coronary artery disease in diabetic patients. Diabetes Care 31:1615–1620. doi:10.2337/dc07-2126
    • (2008) Diabetes Care , vol.31 , pp. 1615-1620
    • Chen, Y.H.1    Chau, L.Y.2    Chen, J.W.3    Lin, S.J.4
  • 26
    • 0346727582 scopus 로고    scopus 로고
    • Heme oxygenase-1 gene promotor microsatellite polymorphism is associated with angiographic restenosis after coronary stenting
    • PID: 14683741, (S0195668X03006845)
    • Chen YH, Chau LY, Lin MW, Chen LC, Yo MH, Chen JW, Lin SJ (2004) Heme oxygenase-1 gene promotor microsatellite polymorphism is associated with angiographic restenosis after coronary stenting. Eur Heart J 25:39–47 (S0195668X03006845)
    • (2004) Eur Heart J , vol.25 , pp. 39-47
    • Chen, Y.H.1    Chau, L.Y.2    Lin, M.W.3    Chen, L.C.4    Yo, M.H.5    Chen, J.W.6    Lin, S.J.7
  • 27
    • 0036664867 scopus 로고    scopus 로고
    • Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients
    • COI: 1:CAS:528:DC%2BD38XltlOnsb4%3D, PID: 12136229
    • Chen YH, Lin SJ, Lin MW, Tsai HL, Kuo SS, Chen JW, Charng MJ, Wu TC, Chen LC, Ding YA, Pan WH, Jou YS, Chau LY (2002) Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum Genet 111:1–8. doi:10.1007/s00439-002-0769-4
    • (2002) Hum Genet , vol.111 , pp. 1-8
    • Chen, Y.H.1    Lin, S.J.2    Lin, M.W.3    Tsai, H.L.4    Kuo, S.S.5    Chen, J.W.6    Charng, M.J.7    Wu, T.C.8    Chen, L.C.9    Ding, Y.A.10    Pan, W.H.11    Jou, Y.S.12    Chau, L.Y.13
  • 29
    • 0041733077 scopus 로고    scopus 로고
    • Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule
    • COI: 1:CAS:528:DC%2BD3sXlsVOntrg%3D, PID: 12842916
    • Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, Foresti R, Motterlini R (2003) Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ Res 93:e2–e8. doi:10.1161/01.RES.0000084381.86567.08
    • (2003) Circ Res , vol.93 , pp. e2-e8
    • Clark, J.E.1    Naughton, P.2    Shurey, S.3    Green, C.J.4    Johnson, T.R.5    Mann, B.E.6    Foresti, R.7    Motterlini, R.8
  • 30
    • 84857048733 scopus 로고    scopus 로고
    • Chronic HO-1 induction with cobalt protoporphyrin (CoPP) treatment increases oxygen consumption, activity, heat production and lowers body weight in obese melanocortin-4 receptor-deficient mice
    • COI: 1:CAS:528:DC%2BC38XisVGhurs%3D
    • Csongradi E, Docarmo JM, Dubinion JH, Vera T, Stec DE (2012) Chronic HO-1 induction with cobalt protoporphyrin (CoPP) treatment increases oxygen consumption, activity, heat production and lowers body weight in obese melanocortin-4 receptor-deficient mice. Int J Obes (Lond) 36:244–253. doi:10.1038/ijo.2011.78
    • (2012) Int J Obes (Lond) , vol.36 , pp. 244-253
    • Csongradi, E.1    Docarmo, J.M.2    Dubinion, J.H.3    Vera, T.4    Stec, D.E.5
  • 31
    • 78149409937 scopus 로고    scopus 로고
    • Complex role of the HIF system in cardiovascular biology
    • COI: 1:CAS:528:DC%2BC3cXhtlSjsbjI
    • Czibik G (2010) Complex role of the HIF system in cardiovascular biology. J Mol Med (Berl) 88:1101–1111. doi:10.1007/s00109-010-0646-x
    • (2010) J Mol Med (Berl) , vol.88 , pp. 1101-1111
    • Czibik, G.1
  • 32
    • 79952438784 scopus 로고    scopus 로고
    • Gene therapy with hypoxia-inducible factor 1 alpha in skeletal muscle is cardioprotective in vivo
    • COI: 1:CAS:528:DC%2BC3MXjsFens7s%3D, PID: 21238463
    • Czibik G, Gravning J, Martinov V, Ishaq B, Knudsen E, Attramadal H, Valen G (2011) Gene therapy with hypoxia-inducible factor 1 alpha in skeletal muscle is cardioprotective in vivo. Life Sci 88:543–550. doi:10.1016/j.lfs.2011.01.006
    • (2011) Life Sci , vol.88 , pp. 543-550
    • Czibik, G.1    Gravning, J.2    Martinov, V.3    Ishaq, B.4    Knudsen, E.5    Attramadal, H.6    Valen, G.7
  • 33
    • 62349083271 scopus 로고    scopus 로고
    • In vivo remote delivery of DNA encoding for hypoxia-inducible factor 1 alpha reduces myocardial infarct size
    • COI: 1:CAS:528:DC%2BD1MXntlGksbg%3D, PID: 20443865
    • Czibik G, Martinov V, Ruusalepp A, Sagave J, Skare O, Valen G (2009) In vivo remote delivery of DNA encoding for hypoxia-inducible factor 1 alpha reduces myocardial infarct size. Clin Transl Sci 2:33–40. doi:10.1111/j.1752-8062.2008.00077.x
    • (2009) Clin Transl Sci , vol.2 , pp. 33-40
    • Czibik, G.1    Martinov, V.2    Ruusalepp, A.3    Sagave, J.4    Skare, O.5    Valen, G.6
  • 34
    • 62349099936 scopus 로고    scopus 로고
    • Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice
    • COI: 1:CAS:528:DC%2BD1MXjt1Clt7w%3D, PID: 19176596
    • Czibik G, Sagave J, Martinov V, Ishaq B, Sohl M, Sefland I, Carlsen H, Farnebo F, Blomhoff R, Valen G (2009) Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice. Cardiovasc Res 82:107–114
    • (2009) Cardiovasc Res , vol.82 , pp. 107-114
    • Czibik, G.1    Sagave, J.2    Martinov, V.3    Ishaq, B.4    Sohl, M.5    Sefland, I.6    Carlsen, H.7    Farnebo, F.8    Blomhoff, R.9    Valen, G.10
  • 35
    • 84911360742 scopus 로고    scopus 로고
    • Citric acid cycle intermediates in cardioprotection
    • COI: 1:CAS:528:DC%2BC2cXhvVWis73M
    • Czibik G, Steeples V, Yavari A, Ashrafian H (2014) Citric acid cycle intermediates in cardioprotection. Circ Cardiovasc Genet 7:711–719
    • (2014) Circ Cardiovasc Genet , vol.7 , pp. 711-719
    • Czibik, G.1    Steeples, V.2    Yavari, A.3    Ashrafian, H.4
  • 36
    • 54949132480 scopus 로고    scopus 로고
    • Human adaptation to ischemia by preconditioning or unstable angina: involvement of nuclear factor kappa B, but not hypoxia-inducible factor 1 alpha in the heart
    • Czibik G, Wu Z, Berne GP, Tarkka M, Vaage J, Laurikka J, Jarvinen O, Valen G (2008) Human adaptation to ischemia by preconditioning or unstable angina: involvement of nuclear factor kappa B, but not hypoxia-inducible factor 1 alpha in the heart. Eur J Cardio-thoracic Surg 34:976–984. doi:10.1016/j.ejcts.2008.07.066
    • (2008) Eur J Cardio-thoracic Surg , vol.34 , pp. 976-984
    • Czibik, G.1    Wu, Z.2    Berne, G.P.3    Tarkka, M.4    Vaage, J.5    Laurikka, J.6    Jarvinen, O.7    Valen, G.8
  • 39
    • 38049132217 scopus 로고    scopus 로고
    • Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis
    • COI: 1:CAS:528:DC%2BD1cXmsF2m, PID: 18195184
    • Dulak J, Deshane J, Jozkowicz A, Agarwal A (2008) Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis. Circulation 117:231–241. doi:10.1161/CIRCULATIONAHA.107.698316
    • (2008) Circulation , vol.117 , pp. 231-241
    • Dulak, J.1    Deshane, J.2    Jozkowicz, A.3    Agarwal, A.4
  • 40
    • 79952276471 scopus 로고    scopus 로고
    • Targeting heme oxygenase-1 in vascular disease
    • COI: 1:CAS:528:DC%2BC3cXhsVKrtrbO, PID: 20704550, BSP/CDT/E-Pub/00146
    • Durante W (2010) Targeting heme oxygenase-1 in vascular disease. Curr Drug Targets 11:1504–1516 BSP/CDT/E-Pub/00146
    • (2010) Curr Drug Targets , vol.11 , pp. 1504-1516
    • Durante, W.1
  • 42
    • 84897394439 scopus 로고    scopus 로고
    • Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy
    • COI: 1:CAS:528:DC%2BC2cXltFejsL4%3D, PID: 24147975
    • Fillmore N, Mori J, Lopaschuk GD (2014) Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy. Br J Pharmacol 171:2080–2090. doi:10.1111/bph.12475
    • (2014) Br J Pharmacol , vol.171 , pp. 2080-2090
    • Fillmore, N.1    Mori, J.2    Lopaschuk, G.D.3
  • 43
    • 33748284288 scopus 로고    scopus 로고
    • Heme oxygenase-1 gene transfer inhibits angiotensin II-mediated rat cardiac myocyte apoptosis but not hypertrophy
    • COI: 1:CAS:528:DC%2BD28Xpt1aku7c%3D, PID: 16826603
    • Foo RS, Siow RC, Brown MJ, Bennett MR (2006) Heme oxygenase-1 gene transfer inhibits angiotensin II-mediated rat cardiac myocyte apoptosis but not hypertrophy. J Cell Physiol 209:1–7. doi:10.1002/jcp.20723
    • (2006) J Cell Physiol , vol.209 , pp. 1-7
    • Foo, R.S.1    Siow, R.C.2    Brown, M.J.3    Bennett, M.R.4
  • 44
    • 84883412049 scopus 로고    scopus 로고
    • Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells
    • COI: 1:CAS:528:DC%2BC3sXhsV2mtr%2FE, PID: 23942037
    • Foresti R, Bains SK, Pitchumony TS, de Castro Bras LE, Drago F, Dubois-Rande JL, Bucolo C, Motterlini R (2013) Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells. Pharmacol Res 76:132–148. doi:10.1016/j.phrs.2013.07.010
    • (2013) Pharmacol Res , vol.76 , pp. 132-148
    • Foresti, R.1    Bains, S.K.2    Pitchumony, T.S.3    de Castro Bras, L.E.4    Drago, F.5    Dubois-Rande, J.L.6    Bucolo, C.7    Motterlini, R.8
  • 45
    • 0035200007 scopus 로고    scopus 로고
    • Role of heme oxygenase-1 in hypoxia-reoxygenation: requirement of substrate heme to promote cardioprotection
    • COI: 1:CAS:528:DC%2BD3MXosFylsLg%3D, PID: 11668058
    • Foresti R, Goatly H, Green CJ, Motterlini R (2001) Role of heme oxygenase-1 in hypoxia-reoxygenation: requirement of substrate heme to promote cardioprotection. Am J Physiol Heart Circ Physiol 281:H1976–H1984
    • (2001) Am J Physiol Heart Circ Physiol , vol.281 , pp. H1976-H1984
    • Foresti, R.1    Goatly, H.2    Green, C.J.3    Motterlini, R.4
  • 46
    • 80051474300 scopus 로고    scopus 로고
    • Heme oxygenase 1 is differentially involved in blood flow-dependent arterial remodeling: role of inflammation, oxidative stress, and nitric oxide
    • COI: 1:CAS:528:DC%2BC3MXptFCksLk%3D, PID: 21690482
    • Freidja ML, Toutain B, Caillon A, Desquiret V, Lambert D, Loufrani L, Procaccio V, Henrion D (2011) Heme oxygenase 1 is differentially involved in blood flow-dependent arterial remodeling: role of inflammation, oxidative stress, and nitric oxide. Hypertension 58:225–231. doi:10.1161/HYPERTENSIONAHA.111.170266
    • (2011) Hypertension , vol.58 , pp. 225-231
    • Freidja, M.L.1    Toutain, B.2    Caillon, A.3    Desquiret, V.4    Lambert, D.5    Loufrani, L.6    Procaccio, V.7    Henrion, D.8
  • 47
    • 5344219609 scopus 로고    scopus 로고
    • Carbon monoxide protects against cardiac ischemia–reperfusion injury in vivo via MAPK and Akt–eNOS pathways
    • COI: 1:CAS:528:DC%2BD2cXotVOnsb0%3D, PID: 15308554
    • Fujimoto H, Ohno M, Ayabe S, Kobayashi H, Ishizaka N, Kimura H, Yoshida K, Nagai R (2004) Carbon monoxide protects against cardiac ischemia–reperfusion injury in vivo via MAPK and Akt–eNOS pathways. Arterioscler Thromb Vasc Biol 24:1848–1853. doi:10.1161/01.ATV.0000142364.85911.0e
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1848-1853
    • Fujimoto, H.1    Ohno, M.2    Ayabe, S.3    Kobayashi, H.4    Ishizaka, N.5    Kimura, H.6    Yoshida, K.7    Nagai, R.8
  • 49
    • 1942437473 scopus 로고    scopus 로고
    • Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo
    • COI: 1:CAS:528:DC%2BD2cXkt1ensb4%3D, PID: 14704226
    • Guo Y, Stein AB, Wu WJ, Tan W, Zhu X, Li QH, Dawn B, Motterlini R, Bolli R (2004) Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo. Am J Physiol Heart Circ Physiol 286:H1649–H1653. doi:10.1152/ajpheart.00971.2003
    • (2004) Am J Physiol Heart Circ Physiol , vol.286 , pp. H1649-H1653
    • Guo, Y.1    Stein, A.B.2    Wu, W.J.3    Tan, W.4    Zhu, X.5    Li, Q.H.6    Dawn, B.7    Motterlini, R.8    Bolli, R.9
  • 51
    • 84872088738 scopus 로고    scopus 로고
    • Cardioprotection: chances and challenges of its translation to the clinic
    • PID: 23095318
    • Heusch G (2013) Cardioprotection: chances and challenges of its translation to the clinic. Lancet 381:166–175. doi:10.1016/S0140-6736(12)60916-7
    • (2013) Lancet , vol.381 , pp. 166-175
    • Heusch, G.1
  • 52
    • 84901831627 scopus 로고    scopus 로고
    • Cardiovascular remodelling in coronary artery disease and heart failure
    • PID: 24831770
    • Heusch G, Libby P, Gersh B, Yellon D, Bohm M, Lopaschuk G, Opie L (2014) Cardiovascular remodelling in coronary artery disease and heart failure. Lancet 383:1933–1943. doi:10.1016/S0140-6736(14)60107-0
    • (2014) Lancet , vol.383 , pp. 1933-1943
    • Heusch, G.1    Libby, P.2    Gersh, B.3    Yellon, D.4    Bohm, M.5    Lopaschuk, G.6    Opie, L.7
  • 53
    • 84870251882 scopus 로고    scopus 로고
    • Cardiovascular events as a function of serum bilirubin levels in a large, statin-treated cohort
    • COI: 1:CAS:528:DC%2BC38XhslGjs73N, PID: 23110860
    • Horsfall LJ, Nazareth I, Petersen I (2012) Cardiovascular events as a function of serum bilirubin levels in a large, statin-treated cohort. Circulation 126:2556–2564. doi:10.1161/CIRCULATIONAHA.112.114066
    • (2012) Circulation , vol.126 , pp. 2556-2564
    • Horsfall, L.J.1    Nazareth, I.2    Petersen, I.3
  • 54
    • 84891824888 scopus 로고    scopus 로고
    • Chronic carbon monoxide treatment attenuates development of obesity and remodels adipocytes in mice fed a high-fat diet
    • COI: 1:CAS:528:DC%2BC2cXmtVCisQ%3D%3D
    • Hosick PA, AlAmodi AA, Storm MV, Gousset MU, Pruett BE, Gray W 3rd, Stout J, Stec DE (2014) Chronic carbon monoxide treatment attenuates development of obesity and remodels adipocytes in mice fed a high-fat diet. Int J Obes (Lond) 38:132–139. doi:10.1038/ijo.2013.61
    • (2014) Int J Obes (Lond) , vol.38 , pp. 132-139
    • Hosick, P.A.1    AlAmodi, A.A.2    Storm, M.V.3    Gousset, M.U.4    Pruett, B.E.5    Gray, W.6    Stout, J.7    Stec, D.E.8
  • 55
    • 3242661655 scopus 로고    scopus 로고
    • Heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo
    • COI: 1:CAS:528:DC%2BD2cXlsFyjtLs%3D, PID: 15226216
    • Hu CM, Chen YH, Chiang MT, Chau LY (2004) Heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo. Circulation 110:309–316. doi:10.1161/01.CIR.0000135475.35758.23
    • (2004) Circulation , vol.110 , pp. 309-316
    • Hu, C.M.1    Chen, Y.H.2    Chiang, M.T.3    Chau, L.Y.4
  • 56
    • 34248182498 scopus 로고    scopus 로고
    • Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice
    • COI: 1:CAS:528:DC%2BD2sXltlantb0%3D, PID: 17303808
    • Hu CM, Lin HH, Chiang MT, Chang PF, Chau LY (2007) Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice. Diabetes 56:1240–1247. doi:10.2337/db06-0495
    • (2007) Diabetes , vol.56 , pp. 1240-1247
    • Hu, C.M.1    Lin, H.H.2    Chiang, M.T.3    Chang, P.F.4    Chau, L.Y.5
  • 57
    • 77954067261 scopus 로고    scopus 로고
    • Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes
    • PID: 20027226
    • Ichikawa T, Li J, Meyer CJ, Janicki JS, Hannink M, Cui T (2009) Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. PLoS One 4:e8391. doi:10.1371/journal.pone.0008391
    • (2009) PLoS One , vol.4 , pp. e8391
    • Ichikawa, T.1    Li, J.2    Meyer, C.J.3    Janicki, J.S.4    Hannink, M.5    Cui, T.6
  • 58
    • 84899072698 scopus 로고    scopus 로고
    • Heme Oxygenase-1 induction improves cardiac function following myocardial ischemia by reducing oxidative stress
    • PID: 24658657
    • Issan Y, Kornowski R, Aravot D, Shainberg A, Laniado-Schwartzman M, Sodhi K, Abraham NG, Hochhauser E (2014) Heme Oxygenase-1 induction improves cardiac function following myocardial ischemia by reducing oxidative stress. PLoS One 9:e92246. doi:10.1371/journal.pone.0092246
    • (2014) PLoS One , vol.9 , pp. e92246
    • Issan, Y.1    Kornowski, R.2    Aravot, D.3    Shainberg, A.4    Laniado-Schwartzman, M.5    Sodhi, K.6    Abraham, N.G.7    Hochhauser, E.8
  • 60
    • 65449185910 scopus 로고    scopus 로고
    • Hemin inhibits hypertensive rat vascular smooth muscle cell proliferation through regulation of cyclin D and p21
    • COI: 1:CAS:528:DC%2BD1MXktFWlsLg%3D, PID: 19387581
    • Jeon EM, Choi HC, Lee KY, Chang KC, Kang YJ (2009) Hemin inhibits hypertensive rat vascular smooth muscle cell proliferation through regulation of cyclin D and p21. Arch Pharm Res 32:375–382. doi:10.1007/s12272-009-1310-2
    • (2009) Arch Pharm Res , vol.32 , pp. 375-382
    • Jeon, E.M.1    Choi, H.C.2    Lee, K.Y.3    Chang, K.C.4    Kang, Y.J.5
  • 61
    • 33750684029 scopus 로고    scopus 로고
    • Heme oxygenase substrates acutely lower blood pressure in hypertensive rats
    • COI: 1:CAS:528:DyaK28XmtFartrs%3D, PID: 8853351
    • Johnson RA, Lavesa M, DeSeyn K, Scholer MJ, Nasjletti A (1996) Heme oxygenase substrates acutely lower blood pressure in hypertensive rats. Am J Physiol 271:H1132–H1138
    • (1996) Am J Physiol , vol.271 , pp. H1132-H1138
    • Johnson, R.A.1    Lavesa, M.2    DeSeyn, K.3    Scholer, M.J.4    Nasjletti, A.5
  • 62
    • 0036792526 scopus 로고    scopus 로고
    • Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors
    • COI: 1:CAS:528:DC%2BD38XnsVKrt70%3D, PID: 12377749
    • Kaneda H, Ohno M, Taguchi J, Togo M, Hashimoto H, Ogasawara K, Aizawa T, Ishizaka N, Nagai R (2002) Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors. Arterioscler Thromb Vasc Biol 22:1680–1685
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 1680-1685
    • Kaneda, H.1    Ohno, M.2    Taguchi, J.3    Togo, M.4    Hashimoto, H.5    Ogasawara, K.6    Aizawa, T.7    Ishizaka, N.8    Nagai, R.9
  • 63
    • 84899490570 scopus 로고    scopus 로고
    • Insulin resistance and hyperglycaemia in cardiovascular disease development
    • COI: 1:CAS:528:DC%2BC2cXkvVGksbY%3D, PID: 24663222
    • Laakso M, Kuusisto J (2014) Insulin resistance and hyperglycaemia in cardiovascular disease development. Nat Rev Endocrinol 10:293–302. doi:10.1038/nrendo.2014.29
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 293-302
    • Laakso, M.1    Kuusisto, J.2
  • 64
    • 77952306257 scopus 로고    scopus 로고
    • Heme oxygenase-1 and carbon monoxide promote neovascularization after myocardial infarction by modulating the expression of HIF-1alpha, SDF-1alpha and VEGF-B
    • COI: 1:CAS:528:DC%2BC3cXlsFGntrk%3D, PID: 20303947
    • Lakkisto P, Kyto V, Forsten H, Siren JM, Segersvard H, Voipio-Pulkki LM, Laine M, Pulkki K, Tikkanen I (2010) Heme oxygenase-1 and carbon monoxide promote neovascularization after myocardial infarction by modulating the expression of HIF-1alpha, SDF-1alpha and VEGF-B. Eur J Pharmacol 635:156–164. doi:10.1016/j.ejphar.2010.02.050
    • (2010) Eur J Pharmacol , vol.635 , pp. 156-164
    • Lakkisto, P.1    Kyto, V.2    Forsten, H.3    Siren, J.M.4    Segersvard, H.5    Voipio-Pulkki, L.M.6    Laine, M.7    Pulkki, K.8    Tikkanen, I.9
  • 67
    • 0028307310 scopus 로고
    • Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene
    • COI: 1:STN:280:DyaK2c3os1GlsQ%3D%3D, PID: 8016102
    • Lavrovsky Y, Schwartzman ML, Levere RD, Kappas A, Abraham NG (1994) Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc Natl Acad Sci USA 91:5987–5991
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5987-5991
    • Lavrovsky, Y.1    Schwartzman, M.L.2    Levere, R.D.3    Kappas, A.4    Abraham, N.G.5
  • 68
    • 0031041377 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
    • COI: 1:CAS:528:DyaK2sXhslamurk%3D, PID: 9038135
    • Lee PJ, Jiang BH, Chin BY, Iyer NV, Alam J, Semenza GL, Choi AM (1997) Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem 272:5375–5381
    • (1997) J Biol Chem , vol.272 , pp. 5375-5381
    • Lee, P.J.1    Jiang, B.H.2    Chin, B.Y.3    Iyer, N.V.4    Alam, J.5    Semenza, G.L.6    Choi, A.M.7
  • 70
    • 33947326097 scopus 로고    scopus 로고
    • Long-lasting expression of HO-1 delays progression of type I diabetes in NOD mice
    • COI: 1:CAS:528:DC%2BD2sXnvFygur0%3D, PID: 17299269, 3917
    • Li M, Peterson S, Husney D, Inaba M, Guo K, Kappas A, Ikehara S, Abraham NG (2007) Long-lasting expression of HO-1 delays progression of type I diabetes in NOD mice. Cell Cycle 6:567–571 3917
    • (2007) Cell Cycle , vol.6 , pp. 567-571
    • Li, M.1    Peterson, S.2    Husney, D.3    Inaba, M.4    Guo, K.5    Kappas, A.6    Ikehara, S.7    Abraham, N.G.8
  • 71
    • 84856702610 scopus 로고    scopus 로고
    • Gene transfer as a strategy to achieve permanent cardioprotection II: rAAV-mediated gene therapy with heme oxygenase-1 limits infarct size 1 year later without adverse functional consequences
    • COI: 1:CAS:528:DC%2BC3MXhsFOns7fF, PID: 21785893
    • Li Q, Guo Y, Ou Q, Wu WJ, Chen N, Zhu X, Tan W, Yuan F, Dawn B, Luo L, Hunt GN, Bolli R (2011) Gene transfer as a strategy to achieve permanent cardioprotection II: rAAV-mediated gene therapy with heme oxygenase-1 limits infarct size 1 year later without adverse functional consequences. Basic Res Cardiol 106:1367–1377. doi:10.1007/s00395-011-0208-6
    • (2011) Basic Res Cardiol , vol.106 , pp. 1367-1377
    • Li, Q.1    Guo, Y.2    Ou, Q.3    Wu, W.J.4    Chen, N.5    Zhu, X.6    Tan, W.7    Yuan, F.8    Dawn, B.9    Luo, L.10    Hunt, G.N.11    Bolli, R.12
  • 72
    • 23044453029 scopus 로고    scopus 로고
    • “heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo
    • Li Volti G (2005) Letter regarding article by Hu et al, “heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo”. Circulation 111:e100; author reply e100. doi:10.1161/01.CIR.0000155250.27345.02
    • (2005) Circulation 111:e100; author reply
    • Li Volti, G.1
  • 73
    • 84879569545 scopus 로고    scopus 로고
    • Immune effec tor mechanisms implicated in atherosclerosis: from mice to humans
    • COI: 1:CAS:528:DC%2BC3sXhtVaitLvM, PID: 23809160
    • Libby P, Lichtman AH, Hansson GK (2013) Immune effec tor mechanisms implicated in atherosclerosis: from mice to humans. Immunity 38:1092–1104. doi:10.1016/j.immuni.2013.06.009
    • (2013) Immunity , vol.38 , pp. 1092-1104
    • Libby, P.1    Lichtman, A.H.2    Hansson, G.K.3
  • 74
    • 45549097135 scopus 로고    scopus 로고
    • Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1
    • COI: 1:CAS:528:DC%2BD1cXnvVOntLw%3D, PID: 18534615
    • Lin HH, Chen YH, Chang PF, Lee YT, Yet SF, Chau LY (2008) Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1. J Mol Cell Cardiol 45:44–55. doi:10.1016/j.yjmcc.2008.04.011
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 44-55
    • Lin, H.H.1    Chen, Y.H.2    Chang, P.F.3    Lee, Y.T.4    Yet, S.F.5    Chau, L.Y.6
  • 78
    • 14644400430 scopus 로고    scopus 로고
    • Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice
    • COI: 1:CAS:528:DC%2BD2MXitlegs7Y%3D, PID: 15734856, (54/3/778)
    • Liu X, Wei J, Peng DH, Layne MD, Yet SF (2005) Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice. Diabetes 54:778–784 (54/3/778)
    • (2005) Diabetes , vol.54 , pp. 778-784
    • Liu, X.1    Wei, J.2    Peng, D.H.3    Layne, M.D.4    Yet, S.F.5
  • 79
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • COI: 1:CAS:528:DC%2BD2sXmvV2quw%3D%3D, PID: 17200717
    • Lumeng CN, Bodzin JL, Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117:175–184. doi:10.1172/JCI29881
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 80
    • 84904394519 scopus 로고    scopus 로고
    • Association of bilirubin with coronary artery calcification and cardiovascular events in the general population without known liver disease: the Heinz Nixdorf Recall study
    • COI: 1:CAS:528:DC%2BC2cXks1Oqt78%3D, PID: 24633678
    • Mahabadi AA, Lehmann N, Mohlenkamp S, Kalsch H, Bauer M, Schulz R, Moebus S, Jockel KH, Erbel R, Heusch G (2014) Association of bilirubin with coronary artery calcification and cardiovascular events in the general population without known liver disease: the Heinz Nixdorf Recall study. Clin Res Cardiol 103:647–653. doi:10.1007/s00392-014-0697-z
    • (2014) Clin Res Cardiol , vol.103 , pp. 647-653
    • Mahabadi, A.A.1    Lehmann, N.2    Mohlenkamp, S.3    Kalsch, H.4    Bauer, M.5    Schulz, R.6    Moebus, S.7    Jockel, K.H.8    Erbel, R.9    Heusch, G.10
  • 81
    • 0022632224 scopus 로고
    • Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible
    • COI: 1:CAS:528:DyaL28XkslGmsA%3D%3D, PID: 3079757
    • Maines MD, Trakshel GM, Kutty RK (1986) Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible. J Biol Chem 261:411–419
    • (1986) J Biol Chem , vol.261 , pp. 411-419
    • Maines, M.D.1    Trakshel, G.M.2    Kutty, R.K.3
  • 83
    • 0014434698 scopus 로고
    • Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan
    • COI: 1:STN:280:DyaF1c7lsF2mtw%3D%3D, PID: 4170654
    • Mansford KR, Opie L (1968) Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan. Lancet 1:670–671
    • (1968) Lancet , vol.1 , pp. 670-671
    • Mansford, K.R.1    Opie, L.2
  • 84
    • 84880401475 scopus 로고    scopus 로고
    • N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1alpha/HO-1 signaling in diabetic rats
    • COI: 1:CAS:528:DC%2BC3sXht1WmtLrJ, PID: 23874823
    • Mao X, Wang T, Liu Y, Irwin MG, Ou JS, Liao XL, Gao X, Xu Y, Ng KF, Vanhoutte PM, Xia Z (2013) N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1alpha/HO-1 signaling in diabetic rats. PLoS One 8:e68949. doi:10.1371/journal.pone.0068949
    • (2013) PLoS One , vol.8 , pp. e68949
    • Mao, X.1    Wang, T.2    Liu, Y.3    Irwin, M.G.4    Ou, J.S.5    Liao, X.L.6    Gao, X.7    Xu, Y.8    Ng, K.F.9    Vanhoutte, P.M.10    Xia, Z.11
  • 85
    • 0020035640 scopus 로고
    • The effect of diabetes on the activities of the peroxide metabolism enzymes
    • COI: 1:CAS:528:DyaL38XksFemsbY%3D, PID: 7068100
    • Matkovics B, Varga SI, Szabo L, Witas H (1982) The effect of diabetes on the activities of the peroxide metabolism enzymes. Horm Metab Res 14:77–79. doi:10.1055/s-2007-1018928
    • (1982) Horm Metab Res , vol.14 , pp. 77-79
    • Matkovics, B.1    Varga, S.I.2    Szabo, L.3    Witas, H.4
  • 87
    • 45849121729 scopus 로고    scopus 로고
    • Myocardial protection against pressure overload in mice lacking Bach1, a transcriptional repressor of heme oxygenase-1
    • COI: 1:CAS:528:DC%2BD1cXlvFaitLg%3D, PID: 18426999
    • Mito S, Ozono R, Oshima T, Yano Y, Watari Y, Yamamoto Y, Brydun A, Igarashi K, Yoshizumi M (2008) Myocardial protection against pressure overload in mice lacking Bach1, a transcriptional repressor of heme oxygenase-1. Hypertension 51:1570–1577. doi:10.1161/HYPERTENSIONAHA.107.102566
    • (2008) Hypertension , vol.51 , pp. 1570-1577
    • Mito, S.1    Ozono, R.2    Oshima, T.3    Yano, Y.4    Watari, Y.5    Yamamoto, Y.6    Brydun, A.7    Igarashi, K.8    Yoshizumi, M.9
  • 88
    • 84863764614 scopus 로고    scopus 로고
    • Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
    • COI: 1:CAS:528:DC%2BC38XhtVSltb3L, PID: 22789539
    • Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M, Motohashi H (2012) Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell 22:66–79. doi:10.1016/j.ccr.2012.05.016
    • (2012) Cancer Cell , vol.22 , pp. 66-79
    • Mitsuishi, Y.1    Taguchi, K.2    Kawatani, Y.3    Shibata, T.4    Nukiwa, T.5    Aburatani, H.6    Yamamoto, M.7    Motohashi, H.8
  • 89
    • 84893116938 scopus 로고    scopus 로고
    • Heme oxygenase-1 as a target for drug discovery
    • COI: 1:CAS:528:DC%2BC2cXkt12jsrk%3D, PID: 24180608
    • Motterlini R, Foresti R (2014) Heme oxygenase-1 as a target for drug discovery. Antioxid Redox Signal 20:1810–1826. doi:10.1089/ars.2013.5658
    • (2014) Antioxid Redox Signal , vol.20 , pp. 1810-1826
    • Motterlini, R.1    Foresti, R.2
  • 90
    • 0032494085 scopus 로고    scopus 로고
    • Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo
    • COI: 1:CAS:528:DyaK1cXlvFCnsr0%3D, PID: 9734480
    • Motterlini R, Gonzales A, Foresti R, Clark JE, Green CJ, Winslow RM (1998) Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo. Circ Res 83:568–577
    • (1998) Circ Res , vol.83 , pp. 568-577
    • Motterlini, R.1    Gonzales, A.2    Foresti, R.3    Clark, J.E.4    Green, C.J.5    Winslow, R.M.6
  • 91
    • 77956323967 scopus 로고    scopus 로고
    • The therapeutic potential of carbon monoxide
    • COI: 1:CAS:528:DC%2BC3cXhtFSisb7I, PID: 20811383
    • Motterlini R, Otterbein LE (2010) The therapeutic potential of carbon monoxide. Nat Rev Drug Discov 9:728–743. doi:10.1038/nrd3228
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 728-743
    • Motterlini, R.1    Otterbein, L.E.2
  • 92
    • 0022970945 scopus 로고
    • Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium
    • COI: 1:STN:280:DyaL2s%2FivVKnuw%3D%3D, PID: 3769170
    • Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124–1136
    • (1986) Circulation , vol.74 , pp. 1124-1136
    • Murry, C.E.1    Jennings, R.B.2    Reimer, K.A.3
  • 93
    • 84897138277 scopus 로고    scopus 로고
    • Expression level and subcellular localization of heme oxygenase-1 modulates its cytoprotective properties in response to lung injury: a mouse model
    • PID: 24599172
    • Namba F, Go H, Murphy JA, La P, Yang G, Sengupta S, Fernando AP, Yohannes M, Biswas C, Wehrli SL, Dennery PA (2014) Expression level and subcellular localization of heme oxygenase-1 modulates its cytoprotective properties in response to lung injury: a mouse model. PLoS ONE 9:e90936. doi:10.1371/journal.pone.0090936
    • (2014) PLoS ONE , vol.9 , pp. e90936
    • Namba, F.1    Go, H.2    Murphy, J.A.3    La, P.4    Yang, G.5    Sengupta, S.6    Fernando, A.P.7    Yohannes, M.8    Biswas, C.9    Wehrli, S.L.10    Dennery, P.A.11
  • 94
    • 84899002012 scopus 로고    scopus 로고
    • Heme oxygenase suppresses markers of heart failure and ameliorates cardiomyopathy in L-NAME-induced hypertension
    • (S0014-2999(14)00232-5)
    • Ndisang JF, Chibbar R, Lane N (2014) Heme oxygenase suppresses markers of heart failure and ameliorates cardiomyopathy in L-NAME-induced hypertension. Eur J Pharmacol 734C:23–34 (S0014-2999(14)00232-5)
    • (2014) Eur J Pharmacol , vol.734C , pp. 23-34
    • Ndisang, J.F.1    Chibbar, R.2    Lane, N.3
  • 95
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart–an engine out of fuel
    • PID: 17360992
    • Neubauer S (2007) The failing heart–an engine out of fuel. N Engl J Med 356:1140–1151. doi:10.1056/NEJMra063052
    • (2007) N Engl J Med , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 97
    • 23744443462 scopus 로고    scopus 로고
    • HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation
    • COI: 1:CAS:528:DC%2BD2MXotFaqtb0%3D, PID: 15805230
    • Ockaili R, Natarajan R, Salloum F, Fisher BJ, Jones D, Fowler AA 3rd, Kukreja RC (2005) HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation. Am J Physiol Heart Circ Physiol 289:H542–H548. doi:10.1152/ajpheart.00089.2005
    • (2005) Am J Physiol Heart Circ Physiol , vol.289 , pp. H542-H548
    • Ockaili, R.1    Natarajan, R.2    Salloum, F.3    Fisher, B.J.4    Jones, D.5    Fowler, A.A.6    Kukreja, R.C.7
  • 98
    • 84856533216 scopus 로고    scopus 로고
    • Increased macrophage migration into adipose tissue in obese mice
    • COI: 1:CAS:528:DC%2BC38XltVOlt7g%3D, PID: 22190646
    • Oh DY, Morinaga H, Talukdar S, Bae EJ, Olefsky JM (2012) Increased macrophage migration into adipose tissue in obese mice. Diabetes 61:346–354. doi:10.2337/db11-0860
    • (2012) Diabetes , vol.61 , pp. 346-354
    • Oh, D.Y.1    Morinaga, H.2    Talukdar, S.3    Bae, E.J.4    Olefsky, J.M.5
  • 100
    • 58149328569 scopus 로고    scopus 로고
    • Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1
    • COI: 1:CAS:528:DC%2BD1cXhtlKrt7fK, PID: 18845810
    • Piantadosi CA, Carraway MS, Babiker A, Suliman HB (2008) Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res 103:1232–1240. doi:10.1161/01.RES.0000338597.71702.ad
    • (2008) Circ Res , vol.103 , pp. 1232-1240
    • Piantadosi, C.A.1    Carraway, M.S.2    Babiker, A.3    Suliman, H.B.4
  • 101
    • 84901367583 scopus 로고    scopus 로고
    • Remote transplantation of mesenchymal stem cells protects the heart against ischemia-reperfusion injury
    • PID: 24578312
    • Preda MB, Ronningen T, Burlacu A, Simionescu M, Moskaug JO, Valen G (2014) Remote transplantation of mesenchymal stem cells protects the heart against ischemia-reperfusion injury. Stem Cells. doi:10.1002/stem.1687
    • (2014) Stem Cells
    • Preda, M.B.1    Ronningen, T.2    Burlacu, A.3    Simionescu, M.4    Moskaug, J.O.5    Valen, G.6
  • 102
    • 84901262265 scopus 로고    scopus 로고
    • Anthracycline-induced cardiotoxicity: a review of pathophysiology, diagnosis, and treatment
    • PID: 24748018
    • Raj S, Franco VI, Lipshultz SE (2014) Anthracycline-induced cardiotoxicity: a review of pathophysiology, diagnosis, and treatment. Curr Treat Options Cardiovasc Med 16:315. doi:10.1007/s11936-014-0315-4
    • (2014) Curr Treat Options Cardiovasc Med , vol.16 , pp. 315
    • Raj, S.1    Franco, V.I.2    Lipshultz, S.E.3
  • 104
    • 79951918162 scopus 로고    scopus 로고
    • Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice
    • COI: 1:CAS:528:DC%2BC3MXitFGnu7Y%3D, PID: 21126175
    • Rajasekaran NS, Varadharaj S, Khanderao GD, Davidson CJ, Kannan S, Firpo MA, Zweier JL, Benjamin IJ (2011) Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice. Antioxid Redox Signal 14:957–971. doi:10.1089/ars.2010.3587
    • (2011) Antioxid Redox Signal , vol.14 , pp. 957-971
    • Rajasekaran, N.S.1    Varadharaj, S.2    Khanderao, G.D.3    Davidson, C.J.4    Kannan, S.5    Firpo, M.A.6    Zweier, J.L.7    Benjamin, I.J.8
  • 105
    • 34547185623 scopus 로고    scopus 로고
    • Oxidative stress and redox signalling in cardiac hypertrophy and heart failure
    • COI: 1:CAS:528:DC%2BD2sXpsFart7o%3D, PID: 16670100, (hrt.2005.068270)
    • Seddon M, Looi YH, Shah AM (2007) Oxidative stress and redox signalling in cardiac hypertrophy and heart failure. Heart 93:903–907 (hrt.2005.068270)
    • (2007) Heart , vol.93 , pp. 903-907
    • Seddon, M.1    Looi, Y.H.2    Shah, A.M.3
  • 106
    • 0034026665 scopus 로고    scopus 로고
    • In situ characterization of dendritic cells occurring in the islets of nonobese diabetic mice during the development of insulitis
    • COI: 1:STN:280:DC%2BD3c3islGgtQ%3D%3D, PID: 10766456
    • Shinomiya M, Nadano S, Shinomiya H, Onji M (2000) In situ characterization of dendritic cells occurring in the islets of nonobese diabetic mice during the development of insulitis. Pancreas 20:290–296
    • (2000) Pancreas , vol.20 , pp. 290-296
    • Shinomiya, M.1    Nadano, S.2    Shinomiya, H.3    Onji, M.4
  • 107
    • 77955925294 scopus 로고    scopus 로고
    • HO-1 modified mesenchymal stem cells modulate MMPs/TIMPs system and adverse remodeling in infarcted myocardium
    • COI: 1:CAS:528:DC%2BC3cXhtVGru7nI, PID: 20684837
    • Shu T, Zeng B, Ren X, Li Y (2010) HO-1 modified mesenchymal stem cells modulate MMPs/TIMPs system and adverse remodeling in infarcted myocardium. Tissue Cell 42:217–222. doi:10.1016/j.tice.2010.04.004
    • (2010) Tissue Cell , vol.42 , pp. 217-222
    • Shu, T.1    Zeng, B.2    Ren, X.3    Li, Y.4
  • 109
    • 84860630714 scopus 로고    scopus 로고
    • Expression of heme oxygenase-1 in thick ascending loop of henle attenuates angiotensin II-dependent hypertension
    • COI: 1:CAS:528:DC%2BC38Xns12isLc%3D, PID: 22323644
    • Stec DE, Drummond HA, Gousette MU, Storm MV, Abraham NG, Csongradi E (2012) Expression of heme oxygenase-1 in thick ascending loop of henle attenuates angiotensin II-dependent hypertension. J Am Soc Nephrol 23:834–841. doi:10.1681/ASN.2011050455
    • (2012) J Am Soc Nephrol , vol.23 , pp. 834-841
    • Stec, D.E.1    Drummond, H.A.2    Gousette, M.U.3    Storm, M.V.4    Abraham, N.G.5    Csongradi, E.6
  • 110
    • 84155188802 scopus 로고    scopus 로고
    • Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium
    • COI: 1:CAS:528:DC%2BC3MXhs1Omu7zN, PID: 22119801
    • Stein AB, Bolli R, Dawn B, Sanganalmath SK, Zhu Y, Wang OL, Guo Y, Motterlini R, Xuan YT (2012) Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium. J Mol Cell Cardiol 52:228–236. doi:10.1016/j.yjmcc.2011.11.005
    • (2012) J Mol Cell Cardiol , vol.52 , pp. 228-236
    • Stein, A.B.1    Bolli, R.2    Dawn, B.3    Sanganalmath, S.K.4    Zhu, Y.5    Wang, O.L.6    Guo, Y.7    Motterlini, R.8    Xuan, Y.T.9
  • 111
    • 19944371683 scopus 로고    scopus 로고
    • Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction
    • COI: 1:CAS:528:DC%2BD2cXhtFGgs7rP, PID: 15623429
    • Stein AB, Guo Y, Tan W, Wu WJ, Zhu X, Li Q, Luo C, Dawn B, Johnson TR, Motterlini R, Bolli R (2005) Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction. J Mol Cell Cardiol 38:127–134. doi:10.1016/j.yjmcc.2004.10.006
    • (2005) J Mol Cell Cardiol , vol.38 , pp. 127-134
    • Stein, A.B.1    Guo, Y.2    Tan, W.3    Wu, W.J.4    Zhu, X.5    Li, Q.6    Luo, C.7    Dawn, B.8    Johnson, T.R.9    Motterlini, R.10    Bolli, R.11
  • 112
    • 0023132858 scopus 로고
    • Bilirubin is an antioxidant of possible physiological importance
    • COI: 1:CAS:528:DyaL2sXitV2mtb0%3D, PID: 3029864
    • Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN (1987) Bilirubin is an antioxidant of possible physiological importance. Science 235:1043–1046
    • (1987) Science , vol.235 , pp. 1043-1046
    • Stocker, R.1    Yamamoto, Y.2    McDonagh, A.F.3    Glazer, A.N.4    Ames, B.N.5
  • 113
    • 36849079020 scopus 로고    scopus 로고
    • The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy
    • COI: 1:CAS:528:DC%2BD2sXhsValsL7O, PID: 18037988
    • Suliman HB, Carraway MS, Ali AS, Reynolds CM, Welty-Wolf KE, Piantadosi CA (2007) The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy. J Clin Invest 117:3730–3741. doi:10.1172/JCI32967
    • (2007) J Clin Invest , vol.117 , pp. 3730-3741
    • Suliman, H.B.1    Carraway, M.S.2    Ali, A.S.3    Reynolds, C.M.4    Welty-Wolf, K.E.5    Piantadosi, C.A.6
  • 114
    • 3142581994 scopus 로고    scopus 로고
    • Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability
    • COI: 1:CAS:528:DC%2BD2cXlt1CksLY%3D, PID: 15123630
    • Taille C, El-Benna J, Lanone S, Dang MC, Ogier-Denis E, Aubier M, Boczkowski J (2004) Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability. J Biol Chem 279:28681–28688. doi:10.1074/jbc.M310661200
    • (2004) J Biol Chem , vol.279 , pp. 28681-28688
    • Taille, C.1    El-Benna, J.2    Lanone, S.3    Dang, M.C.4    Ogier-Denis, E.5    Aubier, M.6    Boczkowski, J.7
  • 115
    • 33846418746 scopus 로고    scopus 로고
    • Role of oxidative stress in cardiac hypertrophy and remodeling
    • COI: 1:CAS:528:DC%2BD2sXivFKrtg%3D%3D, PID: 17190878
    • Takimoto E, Kass DA (2007) Role of oxidative stress in cardiac hypertrophy and remodeling. Hypertension 49:241–248. doi:10.1161/01.HYP.0000254415.31362.a7
    • (2007) Hypertension , vol.49 , pp. 241-248
    • Takimoto, E.1    Kass, D.A.2
  • 116
    • 23744451791 scopus 로고    scopus 로고
    • A hypoxia-inducible vigilant vector system for activating therapeutic genes in ischemia
    • COI: 1:CAS:528:DC%2BD2MXmtlCrsrc%3D, PID: 15800659, (3302513)
    • Tang YL, Tang Y, Zhang YC, Agarwal A, Kasahara H, Qian K, Shen L, Phillips MI (2005) A hypoxia-inducible vigilant vector system for activating therapeutic genes in ischemia. Gene Ther 12:1163–1170 (3302513)
    • (2005) Gene Ther , vol.12 , pp. 1163-1170
    • Tang, Y.L.1    Tang, Y.2    Zhang, Y.C.3    Agarwal, A.4    Kasahara, H.5    Qian, K.6    Shen, L.7    Phillips, M.I.8
  • 117
    • 27744505661 scopus 로고    scopus 로고
    • Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector
    • COI: 1:CAS:528:DC%2BD2MXhtlarsr%2FI, PID: 16198853, (S0735-1097(05)01656-6)
    • Tang YL, Tang Y, Zhang YC, Qian K, Shen L, Phillips MI (2005) Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol 46:1339–1350 (S0735-1097(05)01656-6)
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1339-1350
    • Tang, Y.L.1    Tang, Y.2    Zhang, Y.C.3    Qian, K.4    Shen, L.5    Phillips, M.I.6
  • 118
    • 1642501642 scopus 로고    scopus 로고
    • Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system
    • COI: 1:CAS:528:DC%2BD2cXit12mtr8%3D, PID: 14981066
    • Tang YL, Tang Y, Zhang YC, Qian K, Shen L, Phillips MI (2004) Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system. Hypertension 43:746–751. doi:10.1161/01.HYP.0000120152.27263.87
    • (2004) Hypertension , vol.43 , pp. 746-751
    • Tang, Y.L.1    Tang, Y.2    Zhang, Y.C.3    Qian, K.4    Shen, L.5    Phillips, M.I.6
  • 121
    • 77953741269 scopus 로고    scopus 로고
    • Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
    • COI: 1:CAS:528:DC%2BC3cXpsVOrsrg%3D, PID: 20418481
    • Ungvari Z, Bagi Z, Feher A, Recchia FA, Sonntag WE, Pearson K, de Cabo R, Csiszar A (2010) Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol 299:H18–H24. doi:10.1152/ajpheart.00260.2010
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , pp. H18-H24
    • Ungvari, Z.1    Bagi, Z.2    Feher, A.3    Recchia, F.A.4    Sonntag, W.E.5    Pearson, K.6    de Cabo, R.7    Csiszar, A.8
  • 123
    • 54749140147 scopus 로고    scopus 로고
    • Kidney-specific induction of heme oxygenase-1 prevents angiotensin II hypertension
    • COI: 1:CAS:528:DC%2BD1cXhtV2jsr3O, PID: 18695146
    • Vera T, Kelsen S, Stec DE (2008) Kidney-specific induction of heme oxygenase-1 prevents angiotensin II hypertension. Hypertension 52:660–665. doi:10.1161/HYPERTENSIONAHA.108.114884
    • (2008) Hypertension , vol.52 , pp. 660-665
    • Vera, T.1    Kelsen, S.2    Stec, D.E.3
  • 124
    • 0027458551 scopus 로고
    • Carbon monoxide: a putative neural messenger
    • COI: 1:CAS:528:DyaK3sXnsFSgtQ%3D%3D, PID: 7678352
    • Verma A, Hirsch DJ, Glatt CE, Ronnett GV, Snyder SH (1993) Carbon monoxide: a putative neural messenger. Science 259:381–384
    • (1993) Science , vol.259 , pp. 381-384
    • Verma, A.1    Hirsch, D.J.2    Glatt, C.E.3    Ronnett, G.V.4    Snyder, S.H.5
  • 125
    • 0036070456 scopus 로고    scopus 로고
    • Cardioselective overexpression of HO-1 prevents I/R-induced cardiac dysfunction and apoptosis
    • COI: 1:CAS:528:DC%2BD38XmslShsrk%3D, PID: 12124217
    • Vulapalli SR, Chen Z, Chua BH, Wang T, Liang CS (2002) Cardioselective overexpression of HO-1 prevents I/R-induced cardiac dysfunction and apoptosis. Am J Physiol Heart Circ Physiol 283:H688–H694. doi:10.1152/ajpheart.00133.2002
    • (2002) Am J Physiol Heart Circ Physiol , vol.283 , pp. H688-H694
    • Vulapalli, S.R.1    Chen, Z.2    Chua, B.H.3    Wang, T.4    Liang, C.S.5
  • 127
    • 79955519460 scopus 로고    scopus 로고
    • Inherited cardiomyopathies
    • COI: 1:CAS:528:DC%2BC3MXlsFeltLk%3D, PID: 21524215
    • Watkins H, Ashrafian H, Redwood C (2011) Inherited cardiomyopathies. N Engl J Med 364:1643–1656. doi:10.1056/NEJMra0902923
    • (2011) N Engl J Med , vol.364 , pp. 1643-1656
    • Watkins, H.1    Ashrafian, H.2    Redwood, C.3
  • 128
    • 84870542800 scopus 로고    scopus 로고
    • Mechanisms of lipotoxicity in the cardiovascular system
    • COI: 1:CAS:528:DC%2BC38Xhs1ekurzP, PID: 23054891
    • Wende AR, Symons JD, Abel ED (2012) Mechanisms of lipotoxicity in the cardiovascular system. Curr Hypertens Rep 14:517–531. doi:10.1007/s11906-012-0307-2
    • (2012) Curr Hypertens Rep , vol.14 , pp. 517-531
    • Wende, A.R.1    Symons, J.D.2    Abel, E.D.3
  • 129
    • 77954249680 scopus 로고    scopus 로고
    • Pro-inflammatory CD11c + CD206 + adipose tissue macrophages are associated with insulin resistance in human obesity
    • COI: 1:CAS:528:DC%2BC3cXpsVOlsrY%3D, PID: 20357360
    • Wentworth JM, Naselli G, Brown WA, Doyle L, Phipson B, Smyth GK, Wabitsch M, O’Brien PE, Harrison LC (2010) Pro-inflammatory CD11c + CD206 + adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes 59:1648–1656. doi:10.2337/db09-0287
    • (2010) Diabetes , vol.59 , pp. 1648-1656
    • Wentworth, J.M.1    Naselli, G.2    Brown, W.A.3    Doyle, L.4    Phipson, B.5    Smyth, G.K.6    Wabitsch, M.7    O’Brien, P.E.8    Harrison, L.C.9
  • 131
    • 0023576328 scopus 로고
    • Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat effects of insulin treatment
    • COI: 1:CAS:528:DyaL2sXlsFaiurg%3D, PID: 3301471
    • Wohaieb SA, Godin DV (1987) Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat effects of insulin treatment. Diabetes 36:1014–1018
    • (1987) Diabetes , vol.36 , pp. 1014-1018
    • Wohaieb, S.A.1    Godin, D.V.2
  • 132
    • 79959925200 scopus 로고    scopus 로고
    • Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signalling
    • COI: 1:CAS:528:DC%2BC3MXosVOmt7g%3D, PID: 21406596
    • Worou ME, Belmokhtar K, Bonnet P, Vourc’h P, Machet MC, Khamis G, Eder V (2011) Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signalling. Cardiovasc Res 91:320–329. doi:10.1093/cvr/cvr072
    • (2011) Cardiovasc Res , vol.91 , pp. 320-329
    • Worou, M.E.1    Belmokhtar, K.2    Bonnet, P.3    Vourc’h, P.4    Machet, M.C.5    Khamis, G.6    Eder, V.7
  • 133
    • 80051962945 scopus 로고    scopus 로고
    • A central role of heme oxygenase-1 in cardiovascular protection
    • COI: 1:CAS:528:DC%2BC3MXhtVGltb7P, PID: 21091076
    • Wu ML, Ho YC, Yet SF (2011) A central role of heme oxygenase-1 in cardiovascular protection. Antioxid Redox Signal 15:1835–1846. doi:10.1089/ars.2010.3726
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1835-1846
    • Wu, M.L.1    Ho, Y.C.2    Yet, S.F.3
  • 134
    • 84866456998 scopus 로고    scopus 로고
    • Triterpenoid dihydro-CDDO-trifluoroethyl amide protects against maladaptive cardiac remodeling and dysfunction in mice: a critical role of Nrf2
    • COI: 1:CAS:528:DC%2BC38XhsVWls7nN, PID: 23028668
    • Xing Y, Niu T, Wang W, Li J, Li S, Janicki JS, Ruiz S, Meyer CJ, Wang XL, Tang D, Zhao Y, Cui T (2012) Triterpenoid dihydro-CDDO-trifluoroethyl amide protects against maladaptive cardiac remodeling and dysfunction in mice: a critical role of Nrf2. PLoS One 7:e44899. doi:10.1371/journal.pone.0044899
    • (2012) PLoS One , vol.7 , pp. e44899
    • Xing, Y.1    Niu, T.2    Wang, W.3    Li, J.4    Li, S.5    Janicki, J.S.6    Ruiz, S.7    Meyer, C.J.8    Wang, X.L.9    Tang, D.10    Zhao, Y.11    Cui, T.12
  • 135
    • 34548746306 scopus 로고    scopus 로고
    • Myocardial reperfusion injury
    • COI: 1:CAS:528:DC%2BD2sXhtVKgtLzF, PID: 17855673
    • Yellon DM, Hausenloy DJ (2007) Myocardial reperfusion injury. N Engl J Med 357:1121–1135. doi:10.1056/NEJMra071667
    • (2007) N Engl J Med , vol.357 , pp. 1121-1135
    • Yellon, D.M.1    Hausenloy, D.J.2
  • 137
    • 0023928278 scopus 로고
    • Human heme oxygenase cDNA and induction of its mRNA by hemin
    • COI: 1:CAS:528:DyaL1cXksV2gtLc%3D, PID: 3345742
    • Yoshida T, Biro P, Cohen T, Muller RM, Shibahara S (1988) Human heme oxygenase cDNA and induction of its mRNA by hemin. Eur J Biochem 171:457–461
    • (1988) Eur J Biochem , vol.171 , pp. 457-461
    • Yoshida, T.1    Biro, P.2    Cohen, T.3    Muller, R.M.4    Shibahara, S.5
  • 138
    • 0035957249 scopus 로고    scopus 로고
    • H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: a study with transgenic mice heterozygous for targeted disruption of the Heme oxygenase-1 gene
    • COI: 1:CAS:528:DC%2BD3MXjtFWktbs%3D, PID: 11273999
    • Yoshida T, Maulik N, Ho YS, Alam J, Das DK (2001) H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: a study with transgenic mice heterozygous for targeted disruption of the Heme oxygenase-1 gene. Circulation 103:1695–1701
    • (2001) Circulation , vol.103 , pp. 1695-1701
    • Yoshida, T.1    Maulik, N.2    Ho, Y.S.3    Alam, J.4    Das, D.K.5
  • 139
    • 70449347444 scopus 로고    scopus 로고
    • Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population
    • COI: 1:CAS:528:DC%2BD1MXhsVCqtbrM, PID: 19886851
    • Yun L, Xiaoli L, Qi Z, Laiyuan W, Xiangfeng L, Chong S, Jianfeng H, Shufeng C, Hongfan L, Gu D (2009) Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population. Clin Exp Hypertens 31:534–543. doi:10.3109/10641960902825461
    • (2009) Clin Exp Hypertens , vol.31 , pp. 534-543
    • Yun, L.1    Xiaoli, L.2    Qi, Z.3    Laiyuan, W.4    Xiangfeng, L.5    Chong, S.6    Jianfeng, H.7    Shufeng, C.8    Hongfan, L.9    Gu, D.10
  • 140
    • 77957348619 scopus 로고    scopus 로고
    • Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium
    • PID: 20925964
    • Zeng B, Lin G, Ren X, Zhang Y, Chen H (2010) Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium. J Biomed Sci 17:80. doi:10.1186/1423-0127-17-80
    • (2010) J Biomed Sci , vol.17 , pp. 80
    • Zeng, B.1    Lin, G.2    Ren, X.3    Zhang, Y.4    Chen, H.5
  • 141
    • 52949094613 scopus 로고    scopus 로고
    • Paracrine action of HO-1-modified mesenchymal stem cells mediates cardiac protection and functional improvement
    • COI: 1:CAS:528:DC%2BD1cXhtF2rsL%2FL, PID: 18692581
    • Zeng B, Ren X, Lin G, Zhu C, Chen H, Yin J, Jiang H, Yang B, Ding D (2008) Paracrine action of HO-1-modified mesenchymal stem cells mediates cardiac protection and functional improvement. Cell Biol Int 32:1256–1264. doi:10.1016/j.cellbi.2008.07.010
    • (2008) Cell Biol Int , vol.32 , pp. 1256-1264
    • Zeng, B.1    Ren, X.2    Lin, G.3    Zhu, C.4    Chen, H.5    Yin, J.6    Jiang, H.7    Yang, B.8    Ding, D.9
  • 142
    • 84884562299 scopus 로고    scopus 로고
    • Heme oxygenase-1 prevents cardiac dysfunction in streptozotocin-diabetic mice by reducing inflammation, oxidative stress, apoptosis and enhancing autophagy
    • COI: 1:CAS:528:DC%2BC3sXhsFKit7nF, PID: 24086665
    • Zhao Y, Zhang L, Qiao Y, Zhou X, Wu G, Wang L, Peng Y, Dong X, Huang H, Si L, Zhang X, Li J, Wang W, Zhou L, Gao X (2013) Heme oxygenase-1 prevents cardiac dysfunction in streptozotocin-diabetic mice by reducing inflammation, oxidative stress, apoptosis and enhancing autophagy. PLoS One 8:e75927. doi:10.1371/journal.pone.0075927
    • (2013) PLoS One , vol.8 , pp. e75927
    • Zhao, Y.1    Zhang, L.2    Qiao, Y.3    Zhou, X.4    Wu, G.5    Wang, L.6    Peng, Y.7    Dong, X.8    Huang, H.9    Si, L.10    Zhang, X.11    Li, J.12    Wang, W.13    Zhou, L.14    Gao, X.15


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.