Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

Pharmacological Research

Volumn 76, Issue , 2013, Pages 132-148

  Foresti, Roberta ^a,b   Bains, Sandip K ^c   Pitchumony, Tamil Selvi ^c   De Castro Brás, Lisandra E ^c,f   Drago, Filippo ^d   Dubois Randé, Jean Luc ^a,e   Bucolo, Claudio ^d   Motterlini, Roberto ^a,b  

^a UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^b INSERM U955   (France)

^c ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^d UNIVERSITY OF CATANIA   (Italy)

^e HENRI MONDOR HOSPITAL   (France)

^f Jackson Center for Heart Research at UMMC   (United States)

Author keywords

BV2 microglia; Heme metabolism; HO 1; Inflammation; Nrf2; Small molecule activators

Indexed keywords

ACETYLCARNITINE; ALLYL ISOTHIOCYANATE; ALLYL SULFIDE; BAICALEIN; CAPSAICIN; CARNOSIC ACID; CARNOSOL; CELASTROL; CELECOXIB; CILOSTAZOL; CINNAMALDEHYDE; COSTUNOLIDE; CURCUMIN; DEHYDROCOSTUS LACTONE; ENTEROLACTONE; EPIBATIDINE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; ERIODICTYOL; FUMARIC ACID DIMETHYL ESTER; HEME; HEME OXYGENASE 1; HESPERIDIN; LANSOPRAZOLE; PARACETAMOL; PROTOPORPHYRIN COBALT; SILDENAFIL; SUPERCURCUMIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; HEME SYNTHESIS; IMMUNOMODULATION; IN VITRO STUDY; INFLAMMATION; MICROGLIA; MOUSE; NONHUMAN; PORPHYRIN METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

2,2-DIHYDROXYCHALCONE; ALAS 1; ANTIOXIDANT RESPONSIVE ELEMENT; ARE; BILIVERDIN REDUCTASE; BV2 MICROGLIA; BVR; CA; CAA; CARBON MONOXIDE-RELEASING MOLECULES; CARNOSIC ACID; CARNOSOL; CO-RMS; COBALT PROTOPORPHYRIN IX; COPP; DELTA-AMINOLEVULINATE SYNTHASE 1; DHC; DIMETHYL FUMARATE; DMF; H; HEME METABOLISM; HEME OXYGENASE-1; HEMIN; HF-E2 P45-RELATED FACTOR 2; HO-1; INF-Γ; INFLAMMATION; INTERFERON-Γ; ISL; ISOLIQUIRITIGENIN; KEAP-1; KELCH-LIKE ECH-ASSOCIATED PROTEIN-1; LIPOPOLYSACCHARIDE; LPS; NRF2; PGE2; PROSTGLANDIN E2; S; SC; SHRNA; SMALL HAIRPIN RNA; SMALL MOLECULE ACTIVATORS; SNPPIX; SULFORAPHANE; SUPERCURCUMIN; TBH; TERT-BUTYL HYDROQUINONE; TIN PROTOPORPHYRIN IX; TNF-Α; TUMOR NECROSIS FACTOR ALPHA;

ANIMALS; ANTIOXIDANTS; BILIRUBIN; CELL LINE; CELL SURVIVAL; GENE EXPRESSION REGULATION; HEME; HEME OXYGENASE-1; INFLAMMATION; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NF-E2-RELATED FACTOR 2; SMALL MOLECULE LIBRARIES;

EID: 84883412049     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.07.010     Document Type: Article

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