Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signalling

Cardiovascular Research

Volumn 91, Issue 2, 2011, Pages 320-329

  Worou, Morel Elvis ^a   Belmokhtar, Karim ^a   Bonnet, Pierre ^a   Vourch, Patrick ^b   MacHet, Marie Christine ^a   Khamis, Georges ^a   Eder, Vronique ^a  

^a UNIVERSITÉ DE TOURS   (France)

^b CHU BRETONNEAU   (France)

Author keywords

Cardiomyopathy; Fibrosis; Hemin; Hypertension; NADPH oxidase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BILIVERDIN; CASPASE 3; COLLAGEN TYPE 1; HEME OXYGENASE 1; HEMIN; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART MUSCLE FIBROSIS; HEMODYNAMICS; HYPERTENSION; IMMUNOHISTOCHEMISTRY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TRANSTHORACIC ECHOCARDIOGRAPHY; TREATMENT DURATION;

ANALYSIS OF VARIANCE; ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; ANIMALS, NEWBORN; ANTIHYPERTENSIVE AGENTS; ANTIOXIDANTS; APOPTOSIS; CARDIOMYOPATHIES; CASPASE 3; CELLS, CULTURED; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FIBROSIS; HEME OXYGENASE (DECYCLIZING); HEMIN; HEMODYNAMICS; HYPERTENSION, RENOVASCULAR; LOSARTAN; MALE; MYOCYTES, CARDIAC; NADPH OXIDASE; OXIDATIVE STRESS; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RAC1 GTP-BINDING PROTEIN; RATS; RATS, WISTAR; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 79959925200     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvr072     Document Type: Article

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