Hemin inhibits hypertensive rat vascular smooth muscle cell proliferation through regulation of cyclin D and p21

Archives of Pharmacal Research

Volumn 32, Issue 3, 2009, Pages 375-382

  Jeon, Eun Mi ^a   Choi, Hyoung Chul ^a   Lee, Kwang Youn ^a   Chang, Ki Churl ^b,c   Kang, Young Jin ^a,d  

^a Yeungnam University College of Medicine   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

^c Gyeongsang National University   (South Korea)

^d Yeungnam University   (South Korea)

Author keywords

Cyclin D; Heme oxygenase 1; Hypertension; P21; Proliferation; Vascular smooth muscle

Indexed keywords

CYCLIN D; CYCLIN DEPENDENT KINASE INHIBITOR 1A; HEME OXYGENASE 1; HEMIN; MESSENGER RNA; PROTEIN P21; PROTOPORPHYRIN TIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GENETIC TRANSFECTION; HYPERTENSION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; UPREGULATION; VASCULAR SMOOTH MUSCLE; WISTAR KYOTO RAT;

ANIMALS; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEME OXYGENASE (DECYCLIZING); HEMIN; HYPERTENSION; MALE; METALLOPORPHYRINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PROTOPORPHYRINS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY; TRANSFECTION;

EID: 65449185910     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-009-1310-2     Document Type: Article

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