Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 20, 2013, Pages 8278-8283

  Aouadi, Myriam ^a   Tencerova, Michaela ^a   Vangala, Pranitha ^a   Yawe, Joseph C ^a   Nicoloro, Sarah M ^a   Amano, Shinya U ^a   Cohen, Jessica L ^a   Czech, Michael P ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Immune cells; Obesity; RNAi

Indexed keywords

GLUCAN; GLUCOSE; OSTEOPONTIN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE MACROPHAGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE SILENCING; GLUCOSE TOLERANCE; MACROPHAGE; METABOLIC REGULATION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RNA INTERFERENCE; TREATMENT OUTCOME;

IMMUNE CELLS; OBESITY; RNAI;

ADIPOSE TISSUE; ANIMALS; CYTOKINES; EPIDIDYMIS; GENE SILENCING; GLUCOSE INTOLERANCE; INFLAMMATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MICROSCOPY, FLUORESCENCE; OBESITY; OSTEOPONTIN; PHAGOCYTOSIS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84877841706     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1300492110     Document Type: Article

References (43)

1. Chen L, Magliano DJ, Zimmet PZ (2011) [The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives.] Nat Rev Endocrinol 8(4):228-236.
2. Guilherme A, Virbasius JV, Puri V, Czech MP (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 9(5):367-377. (Pubitemid 351574198)
3. Kusminski CM, Shetty S, Orci L, Unger RH, Scherer PE (2009) Diabetes and apoptosis: Lipotoxicity. Apoptosis 14(12):1484-1495.
4. Samuel VT, Petersen KF, Shulman GI (2010) Lipid-induced insulin resistance: Unravelling the mechanism. Lancet 375(9733):2267-2277.
5. Lumeng CN, Saltiel AR (2011) Inflammatory links between obesity and metabolic disease. J Clin Invest 121(6):2111-2117.
6. Olefsky JM, Glass CK (2010) Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72:219-246.
7. Weisberg SP, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112(12):1796-1808. (Pubitemid 38063703)
8. Blüher M (2010) The distinction of metabolically 'healthy' from 'unhealthy' obese individuals. Curr Opin Lipidol 21(1):38-43.
9. Hardy OT, et al. [Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity.] Surg Obes Relat Dis 7(1): 60-67.
10. Burke JR, Gregor KR, Tramposch KM (1995) Mechanism of inhibition of human nonpancreatic secreted phospholipase A2 by the anti-inflammatory agent BMS-181162. J Biol Chem 270(1):274-280.
11. Yuan M, et al. (2001) Reversal of obesity-and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293(5535):1673-1677. (Pubitemid 32807849)
12. Romeo GR, Lee J, Shoelson SE (2012) Metabolic syndrome, insulin resistance, and roles of inflammation-mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol 32(8):1771-1776.
13. Aouadi M, et al. (2009) Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature 458(7242):1180-1184.
14. Herre J, Gordon S, Brown GD (2004) Dectin-1 and its role in the recognition of betaglucans by macrophages. Mol Immunol 40(12):869-876. (Pubitemid 38032810)
15. Tesz GJ, et al. (2011) Glucan particles for selective delivery of siRNA to phagocytic cells in mice. Biochem J 436(2):351-362.
16. De Taeye BM, et al. (2007) Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity. Am J Physiol Endocrinol Metab 293(3): E713-E725. (Pubitemid 47358983)
17. Hotamisligil GS (1999) Mechanisms of TNF-alpha-induced insulin resistance. Exp Clin Endocrinol Diabetes 107(2):119-125.
18. Horrillo R, et al. (2010) 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity. J Immunol 184(7): 3978-3987.
19. Mamane Y, et al. (2009) The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation. Diabetes 58(9):2006-2017.
20. Plomgaard P, Fischer CP, Ibfelt T, Pedersen BK, van Hall G (2008) Tumor necrosis factor-alpha modulates human in vivo lipolysis. J Clin Endocrinol Metab 93(2): 543-549. (Pubitemid 351240829)
21. Kiefer FW, et al. (2010) Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance. Diabetes 59(4):935-946.
22. Nomiyama T, et al. (2007) Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest 117(10): 2877-2888. (Pubitemid 47529618)
23. Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E (2009) Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology 150(11):4931-4940.
24. Fisher FM, et al. (2012) FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 26(3):271-281.
25. Alvehus M, Burén J, Sjöström M, Goedecke J, Olsson T (2010) The human visceral fat depot has a unique inflammatory profile. Obesity (Silver Spring) 18(5):879-883.
26. Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S (2007) Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56(4): 1010-1013. (Pubitemid 46525079)
27. Chen A, et al. (2005) Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. Obes Res 13(8):1311-1320.
28. Kamei N, et al. (2006) Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 281(36):26602-26614. (Pubitemid 44401869)
29. Binkhathlan Z, Alshamsan A (2012) Emerging nanodelivery strategies of RNAi molecules for colon cancer therapy: Preclinical developments. Ther Deliv 3(9):1117-1130.
30. Gavrilov K, Saltzman WM (2012) Therapeutic siRNA: Principles, challenges, and strategies. Yale J Biol Med 85(2):187-200.
31. Leuschner F, et al. (2011) Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol 29(11):1005-1010.
32. Bernstein LE, Berry J, Kim S, Canavan B, Grinspoon SK (2006) Effects of etanercept in patients with the metabolic syndrome. Arch Intern Med 166(8):902-908.
33. Larsen CM, et al. (2007) Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 356(15):1517-1526. (Pubitemid 46588416)
34. Ofei F, Hurel S, Newkirk J, Sopwith M, Taylor R (1996) Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes 45(7):881-885. (Pubitemid 26225502)
35. van Asseldonk EJ, et al. (2011) Treatment with Anakinra improves disposition index but not insulin sensitivity in nondiabetic subjects with the metabolic syndrome: A randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 96(7): 2119-2126.
36. Di Rocco P, Manco M, Rosa G, Greco AV, Mingrone G (2004) Lowered tumor necrosis factor receptors, but not increased insulin sensitivity, with infliximab. Obes Res 12(4): 734-739. (Pubitemid 41132519)
37. Gordon S (2012) Innate immune functions of macrophages in different tissue environments. J Innate Immun 4(5-6):409-410.
38. Stanley TL, et al. (2011) TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome. J Clin Endocrinol Metab 96(1):E146-E150.
39. Solomon DH, et al. (2011) Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis. JAMA 305 (24):2525-2531.
40. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95(5):2409-2415.
41. Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 259 (5091):87-91. (Pubitemid 23036092)
42. Borst SE, Bagby GJ (2002) Neutralization of tumor necrosis factor reverses ageinduced impairment of insulin responsiveness in skeletal muscle of Sprague-Dawley rats. Metabolism 51(8):1061-1064.
43. Huang W, et al. (2011) Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature 470(7334):414-418.