Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis

Hepatology

Volumn 53, Issue 6, 2011, Pages 2027-2041

  Fredriksson, Lisa ^a   Herpers, Bram ^a   Benedetti, Giulia ^a   Matadin, Quraisha ^a   Puigvert, Jordi C ^a   de Bont, Hans ^a   Dragovic, Sanja ^b   Vermeulen, Nico P E ^b   Commandeur, Jan N M ^b   Danen, Erik ^a   De Graauw, Marjo ^a   Van de Water, Bob ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 8; DICLOFENAC; GREEN FLUORESCENT PROTEIN; I KAPPA B BETA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BID; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CASPASE 8; CELL LINE, TUMOR; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; DRUG SYNERGISM; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MAP KINASE KINASE 4; MICE; NF-KAPPA B; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79957439731     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24314     Document Type: Article

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