Inhibition of microglial inflammation by the MLK inhibitor CEP-1347

Journal of Neurochemistry

Volumn 92, Issue 6, 2005, Pages 1439-1451

  Lund, Søren ^a   Porzgen, Peter ^a   Mortensen, Anne Louise ^a   Hasseldam, Henrik ^a   Bozyczko Coyne, Donna ^b   Morath, Siegfried ^c   Hartung, Thomas ^c,d   Bianchi, Marina ^e   Ghezzi, Pietro ^e   Bsibsi, Malika ^f   Dijkstra, Sipke ^f   Leist, Marcel ^a  

^a H LUNDBECK A S   (Denmark)

^b CEPHALON INC   (United States)

^c UNIVERSITY OF KONSTANZ   (Germany)

^d ECVAM   (Italy)

^e MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^f TNO   (Netherlands)

Author keywords

Alzheimer's disease; Central nervous system; CEP 1347; Inflammation; Microglia; Mixed lineage kinase; TNF

Indexed keywords

CEP 1347; CYTOKINE; ENDOTOXIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; INFLAMMATION; MACROPHAGE; MALE; MICROGLIA; MONOCYTE; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARBAZOLES; CELL LINE; CELLS, CULTURED; CYTOKINES; DOWN-REGULATION; ENCEPHALITIS; ENZYME INHIBITORS; GLIOSIS; HUMANS; INDOLES; INFLAMMATION MEDIATORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASES; MICE; MICE, INBRED C57BL; MICROGLIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TRANS-ACTIVATION (GENETICS); TUMOR NECROSIS FACTOR-ALPHA;

EID: 20144367957     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03014.x     Document Type: Article

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