High content screening applied to large-scale cell biology

Trends in Biotechnology

Volumn 22, Issue 1, 2004, Pages 15-22

  Abraham, Vivek C ^a   Taylor, D Lansing ^a   Haskins, Jeffrey R ^a  

^a Cellomics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOMEDICAL ENGINEERING; DRUG PRODUCTS; FLUORESCENCE; GENES; IMAGE ANALYSIS; INFORMATION MANAGEMENT; KNOWLEDGE ACQUISITION; PROTEINS;

CYTOTOXICITY; HIGH CONTENT SCREENING (HCS);

CYTOLOGY;

FLUORESCENT DYE;

BIOTECHNOLOGY; DRUG DEVELOPMENT;

ANALYTIC METHOD; BIOTECHNOLOGY; CELL FUNCTION; CYTOLOGY; CYTOTOXICITY; GENE FUNCTION; GENETIC ANALYSIS; HIGH CONTENT SCREENING; IMAGE ANALYSIS; IMAGE PROCESSING; IMAGING; INFORMATION PROCESSING; MEDICAL RESEARCH; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; SAMPLING;

EID: 0346158531     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibtech.2003.10.012     Document Type: Review

References (32)

1. Giuliano K.A., Taylor D.L. Fluorescent-protein biosensors: new tools for drug discovery. Trends Biotechnol. 16:1998;135-140.
2. Farkas D.L., et al. Multimode light microscopy and the dynamics of molecules, cells, and tissues. Annu. Rev. Physiol. 55:1993;785-817.
3. DeBiasio R.L., et al. Myosin II transport, organization, and phosphorylation: evidence for cortical flow/solation-contraction coupling during cytokinesis and cell locomotion. Mol. Biol. Cell. 7:1996;1259-1282.
4. Zhang J., et al. Creating new fluorescent probes for cell biology. Nat. Rev. Mol. Cell Biol. 3:2002;906-918.
5. Hahn K., et al. Patterns of elevated free calcium and calmodulin activation in living cells. Nature. 359:1992;736-738.
6. Waterman-Storer C.M., et al. Fluorescent speckle microscopy, a method to visualize the dynamics of protein assemblies in living cells. Curr. Biol. 8:1998;1227-1230.
7. Plymale D.R., et al. Monitoring simultaneous subcellular events in vitro by means of coherent multiprobe fluorescence. Nat. Med. 5:1999;351-355.
8. Giuliano K.A., et al. High-content screening: a new approach to easing key bottlenecks in the drug discovery process. J. Biomol. Screen. 2:1997;249-259.
9. Ding G.J., et al. Characterization and quantitation of NF-kappaB nuclear translocation induced by interleukin-1 and tumor necrosis factor-alpha. Development and use of a high capacity fluorescence cytometric system. J. Biol. Chem. 273:1998;28897-28905.
10. Conway B.R., et al. Quantification of G-protein coupled receptor internalization using G-protein coupled receptor-green fluorescent protein conjugates with the ArrayScan™ high-content screening system. J. Biomol. Screen. 4:1999;75-86.
11. Vogt A., et al. Spatial analysis of key signaling proteins by high-content solid-phase cytometry in Hep3B cells treated with an inhibitor of Cdc25 dual-specificity phosphatases. J. Biol. Chem. 276:2001;20544-20550.
12. Taylor D.L., et al. Real-time molecular and cellular analysis: the new frontier of drug discovery. Curr. Opin. Biotechnol. 12:2001;75-81.
13. Minguez J.M., et al. Synthesis and high content cell-based profiling of simplified analogues of the microtubule stabilizer (+)-discodermolide. Mol. Cancer Ther. 1:2002;1305-1313.
14. Haskins J.R., et al. Thiazolidinedione toxicity to isolated hepatocytes revealed by coherent multiprobe fluorescence microscopy and correlated with multiparameter flow cytometry of peripheral leukocytes. Arch. Toxicol. 75:2001;425-438.
15. Papetti M., Herman I.M. Mechanisms of normal and tumor-derived angiogenesis. Am. J. Physiol. Cell Physiol. 282:2002;C947-C970.
16. Aridor M., Hannan L.A. Traffic jam: a compendium of human diseases that affect intracellular transport processes. Traffic. 1:2000;836-851.
17. Schwartz M.A. Integrins, oncogenes, and anchorage independence. J. Cell Biol. 139:1997;575-578.
18. Ziauddin J., Sabatini D.M. Microarrays of cells expressing defined cDNAs. Nature. 411:2001;107-110.
19. Giuliano K.A., et al. Advances in high content screening for drug discovery. ASSAY Drug Develop. Technol. 1:2003;565-577.
20. Hahn K., Toutchkine A. Live-cell fluorescent biosensors for activated signaling proteins. Curr. Opin. Cell Biol. 14:2002;167-172.
21. Stenger D.A., et al. Detection of physiologically active compounds using cell-based biosensors. Trends Biotechnol. 19:2001;304-309.
22. Trump B.F., Berezesky I.K. Calcium-mediated cell injury and cell death. FASEB J. 9:1995;219-228.
23. Afanas'ev V.N., et al. Flow cytometry and biochemical analysis of DNA degradation characteristic of two types of cell death. FEBS Lett. 194:1986;347-350.
24. Dong Z., et al. Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases. Am. J. Pathol. 151:1997;1205-1213.
25. Wiegele G., et al. Apoptosis and necrosis during ischaemia in renal tubular cells (LLC-PK1 and MDCK). Nephrol. Dial. Transplant. 13:1998;1158-1167.
26. Leist M., Nicotera P. The shape of cell death. Biochem. Biophys. Res. Commun. 236:1997;1-9.
27. Zamzami N., et al. Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J. Bioenerg. Biomembr. 29:1997;185-193.
28. Zakeri Z. The study of cell death by the use of cellular and developmental models. Lockshin R.A., et al. When Cells Die. 1998;97-129.
29. 2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk. EMBO J. 18:1999;522-533.
30. Yamaguchi D.T., et al. Characterization of volume-sensitive, calcium-permeating pathways in the osteosarcoma cell line UMR-106-01. J. Biol. Chem. 264:1989;4383-4390.
31. Kidd J.F., et al. Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition pore. J. Biol. Chem. 277:2002;6504-6510.
32. Karbowski M., et al. Opposite effects of microtubule-stabilizing and microtubule-destabilizing drugs on biogenesis of mitochondria in mammalian cells. J. Cell Sci. 114:2001;281-291.